## require("DoseFinding") ## ## commented out for time reasons ## resp <- c(1.23, 1.31, 1.32, 1.36, 1.38) ## dose <- c(0, 1.25, 2.5, 5, 10) ## sdev <- c(0.015, 0.014, 0.015, 0.016, 0.015) ## V <- diag(sdev^2) ## mods <- Mods(emax=c(2.65, 12.5), linear=NULL, linInt = c(1, 1, 1, 1), ## logistic=c(29, 9.55), quadratic = -0.0075, ## doses=dose) ## mmfit <- MCPMod(dose, resp, S=V, type="general", models=mods, Delta=0.12) ## efit <- mmfit$mods$emax ## plot(efit, plotData = "meansCI", CI=TRUE) ## plot(efit, plotData = "meansCI", CI=FALSE) ## ## plot(efit, plotData = "raw") # should throw an error ## plot(efit, plotData = "means", CI = TRUE) ## plot(efit, plotData = "means", CI = FALSE) ## plot(efit, plotData = "none", CI =TRUE) ## plot(efit, plotData = "none", CI =FALSE) ## plot(mmfit, plotData = "meansCI", CI=TRUE) ## plot(mmfit, plotData = "meansCI", CI=FALSE) ## ## plot(mmfit, plotData = "raw") # should throw an error ## plot(mmfit, plotData = "means", CI = TRUE) ## plot(mmfit, plotData = "means", CI = FALSE) ## plot(mmfit, plotData = "none", CI =TRUE) ## plot(mmfit, plotData = "none", CI =FALSE) ## data(IBScovars) ## models <- Mods(emax = c(0.5, 1), betaMod=c(1,1), linear = NULL, doses=c(0,4)) ## mmfit <- MCPMod(dose, resp, data=IBScovars, models=models, Delta=0.12) ## efit <- mmfit$mods$emax ## plot(efit, plotData = "meansCI", CI=TRUE) ## plot(efit, plotData = "meansCI", CI=FALSE) ## plot(efit, plotData = "raw", CI=FALSE) ## plot(efit, plotData = "raw", CI=TRUE) ## plot(efit, plotData = "means", CI = TRUE) ## plot(efit, plotData = "means", CI = FALSE) ## plot(efit, plotData = "none", CI =TRUE) ## plot(efit, plotData = "none", CI =FALSE) ## plot(mmfit, plotData = "meansCI", CI=TRUE) ## plot(mmfit, plotData = "meansCI", CI=FALSE) ## plot(mmfit, plotData = "raw", CI=TRUE) ## plot(mmfit, plotData = "raw", CI=FALSE) ## plot(mmfit, plotData = "means", CI = TRUE) ## plot(mmfit, plotData = "means", CI = FALSE) ## plot(mmfit, plotData = "none", CI =TRUE) ## plot(mmfit, plotData = "none", CI =FALSE) ## data(IBScovars) ## models <- Mods(emax = c(0.5, 1), betaMod=c(1,1), linInt = c(1, 1, 1, 1), ## linear = NULL, doses=0:4) ## anovaMod <- lm(resp~factor(dose)+gender, data=IBScovars) ## drFit <- coef(anovaMod)[2:5] # placebo adjusted estimates at doses ## vCov <- vcov(anovaMod)[2:5,2:5] ## dose <- sort(unique(IBScovars$dose))[-1] ## mmfit <- MCPMod(dose, drFit, S=vCov, type = "general", models=models, Delta=0.12, placAdj=TRUE) ## efit <- mmfit$mods$emax ## plot(efit, plotData = "meansCI", CI=TRUE) ## plot(efit, plotData = "meansCI", CI=FALSE) ## ## plot(efit, plotData = "raw", CI=FALSE) # should throw an error ## ## plot(efit, plotData = "raw", CI=TRUE) # should throw an error ## plot(efit, plotData = "means", CI = TRUE) ## plot(efit, plotData = "means", CI = FALSE) ## plot(efit, plotData = "none", CI =TRUE) ## plot(efit, plotData = "none", CI =FALSE) ## plot(mmfit, plotData = "meansCI", CI=TRUE) ## plot(mmfit, plotData = "meansCI", CI=FALSE) ## ## plot(mmfit, plotData = "raw", CI=TRUE) # should throw an error ## ## plot(mmfit, plotData = "raw", CI=FALSE) # should throw an error ## plot(mmfit, plotData = "means", CI = TRUE) ## plot(mmfit, plotData = "means", CI = FALSE) ## plot(mmfit, plotData = "none", CI =TRUE) ## plot(mmfit, plotData = "none", CI =FALSE) ## ## neurodeg example (in 0.9-6 not all means were visible) ## doses <- c(0,1,3,10,30) ## muH <- c(-5.099, -4.581, -3.22, -2.879, -3.52) # estimated slope ## covH <- structure(c(0.149, 0.009, 0.009, 0.009, 0.009, 0.009, 0.149, ## 0.009, 0.009, 0.009, 0.009, 0.009, 0.149, 0.009, ## 0.009, 0.009, 0.009, 0.009, 0.149, 0.009, 0.009, ## 0.009, 0.009, 0.009, 0.149), .Dim = c(5L, 5L)) ## fit <- fitMod(doses, muH, S=covH, model="emax", type = "general") ## plot(fit, plotData="meansCI", CI=TRUE)