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Type 'q()' to quit R. > # This file is part of the standard setup for testthat. > # It is recommended that you do not modify it. > # > # Where should you do additional test configuration? > # Learn more about the roles of various files in: > # * https://r-pkgs.org/tests.html > # * https://testthat.r-lib.org/reference/test_package.html#special-files > > library(testthat) > library(Colossus) > > test_check("Colossus") Note: Starting Censoring weight Plot Function Note: 901 risk groups Saving 7 x 7 in image 153.499294651964 Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Note: 2 risk groups Note: Starting Plot Function Note: Getting Plot Info Error: no events Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Error: Plot type not given Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Error: Stratification Column not in dataframe Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Error: Stratification Column not given Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Error: dose column not given Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Error: dose column not given Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Error: ID column is not in the dataframe Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Error: ID column not given Note: Starting Plot Function Note: Getting Plot Info Note: 3 risk groups Note: 3 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:08:50 2024 C++ Note: Term checked 0 C++ Note: df99,29,Starting C++ Note: Current Time, Wed Apr 3 17:08:50 2024 C++ Note: Grouping Start C++ Note: df100 69 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:08:50 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: ending guess 0 C++ Note: df501 0 C++ Note: df504 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1, 0<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: Exiting Regression C++ Note: df501 0 C++ Note: df504 -0.1 Note: starting ph_plot Note: nonStratified survival curve calculation C++ Note: START_PLOT C++ Note: Current Time, Wed Apr 3 17:08:50 2024 C++ Note: Term checked 0 C++ Note: df99,25,Starting C++ Note: Current Time, Wed Apr 3 17:08:50 2024 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Grouping Start C++ Note: df100 249 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:08:50 2024 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan Note: writing survival data Note: Plotting Survival Curves Saving 7 x 7 in image Saving 7 x 7 in image Saving 7 x 7 in image Saving 7 x 7 in image Note: Starting Plot Function Note: Getting Plot Info Note: 3 risk groups Note: 3 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:08:52 2024 C++ Note: Term checked 0 C++ Note: df99,47,Starting C++ Note: Current Time, Wed Apr 3 17:08:52 2024 C++ Note: Grouping Start C++ Note: df100 117 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:08:52 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 7.11207 C++ Note: risk1r checked 41.5001 C++ Note: risk2r checked 269.583 C++ Note: riskl checked 2.29326 C++ Note: risk1l checked 12.3258 C++ Note: risk2l checked 74.9204 C++ Note: df101 -5.824 C++ Note: df102 -0.705933 C++ Note: df103 -15.0512 C++ Note: df104 -0.1 C++ Note: df105 0.046902 C++ Note: df106 8.25007 C++ Note: riskr checked 7.11207 C++ Note: risk1r checked 41.5001 C++ Note: risk2r checked 269.583 C++ Note: riskl checked 2.29326 C++ Note: risk1l checked 12.3258 C++ Note: risk2l checked 74.9204 C++ Note: df101 -5.824 C++ Note: df102 -0.705933 C++ Note: df103 -15.0512 C++ Note: df104 -0.1 C++ Note: df105 0.046902 C++ Note: df106 8.25007 C++ Note: ending guess 0 C++ Note: df501 -5.823998 C++ Note: df504 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1, -5.823998<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 7.11207 C++ Note: risk1r checked 41.5001 C++ Note: risk2r checked 269.583 C++ Note: riskl checked 2.29326 C++ Note: risk1l checked 12.3258 C++ Note: risk2l checked 74.9204 C++ Note: df101 -5.824 C++ Note: df102 -0.705933 C++ Note: df103 -15.0512 C++ Note: df104 -0.1 C++ Note: df105 0.046902 C++ Note: df106 8.25007 C++ Note: riskr checked 7.11207 C++ Note: risk1r checked 41.5001 C++ Note: risk2r checked 269.583 C++ Note: riskl checked 2.29326 C++ Note: risk1l checked 12.3258 C++ Note: risk2l checked 74.9204 C++ Note: df101 -5.824 C++ Note: df102 -0.705933 C++ Note: df103 -15.0512 C++ Note: df104 -0.1 C++ Note: df105 0.046902 C++ Note: df106 8.25007 C++ Note: Exiting Regression C++ Note: df501 -5.823998 C++ Note: df504 -0.1 Note: starting ph_plot Note: Stratified survival curve calculation Note: 2 strata used Note: 2 strata used Note: 3 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:08:52 2024 C++ Note: Term checked 0 C++ Note: df99,44,Starting C++ Note: Current Time, Wed Apr 3 17:08:52 2024 C++ Note: Grouping Start C++ Note: df100 120 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:08:52 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2.2112 3.88777 C++ Note: riskl checked 1.05586 1.2374 C++ Note: df101 -3.56531 C++ Note: df102 0.377208 C++ Note: df103 -10.9514 C++ Note: df104 -0.1 C++ Note: df105 -0.0344437 C++ Note: df106 -9.45185 C++ Note: riskr checked 2.2112 3.88777 C++ Note: riskl checked 1.05586 1.2374 C++ Note: df101 -3.56531 C++ Note: df102 0.377208 C++ Note: df103 -10.9514 C++ Note: df104 -0.1 C++ Note: df105 -0.0344437 C++ Note: df106 -9.45185 C++ Note: ending guess 0 C++ Note: df501 -3.56531 C++ Note: df504 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1, -3.56531<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2.2112 3.88777 C++ Note: riskl checked 1.05586 1.2374 C++ Note: df101 -3.56531 C++ Note: df102 0.377208 C++ Note: df103 -10.9514 C++ Note: df104 -0.1 C++ Note: df105 -0.0344437 C++ Note: df106 -9.45185 C++ Note: riskr checked 2.2112 3.88777 C++ Note: riskl checked 1.05586 1.2374 C++ Note: df101 -3.56531 C++ Note: df102 0.377208 C++ Note: df103 -10.9514 C++ Note: df104 -0.1 C++ Note: df105 -0.0344437 C++ Note: df106 -9.45185 C++ Note: Exiting Regression C++ Note: df501 -3.56531 C++ Note: df504 -0.1 Note: Starting Stratification: Calculation C++ Note: START_PLOT C++ Note: Current Time, Wed Apr 3 17:08:52 2024 C++ Note: Term checked 0 C++ Note: df99,28,Starting C++ Note: Current Time, Wed Apr 3 17:08:52 2024 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Grouping Start C++ Note: df100 255 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:08:52 2024 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2.2112 3.88777 C++ Note: riskl checked 1.05586 1.2374 C++ Note: df101 -3.56531 C++ Note: df102 0.377208 C++ Note: df103 -10.9514 C++ Note: df104 -0.1 C++ Note: df105 -0.0344437 C++ Note: df106 -9.45185 Note: Starting Stratification calculation 1 Note: Starting Stratification calculation 2 Saving 7 x 7 in image Note: Starting Plot Function Note: Getting Plot Info Note: 3 risk groups Note: 3 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:08:53 2024 C++ Note: Term checked 0 C++ Note: df99,54,Starting C++ Note: Current Time, Wed Apr 3 17:08:53 2024 C++ Note: Grouping Start C++ Note: df100 131 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:08:53 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: ending guess 0 C++ Note: df501 0 C++ Note: df504 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1, 0<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: Exiting Regression C++ Note: df501 0 C++ Note: df504 -0.1 C++ Note: START_PLOT C++ Note: Current Time, Wed Apr 3 17:08:53 2024 C++ Note: Term checked 0 C++ Note: df99,42,Starting C++ Note: Current Time, Wed Apr 3 17:08:53 2024 C++ Note: values checked -0.1 C++ Note: sums checked 5.29005 C++ Note: dose checked 7 C++ Note: non-dose checked 5.29005 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 5.29005 C++ Note: risk checked 5.29005 Saving 7 x 7 in image Note: Starting Plot Function Note: Getting Plot Info Note: 86 risk groups Note: 86 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:08:53 2024 C++ Note: Term checked 0 1 C++ Note: df99,55,Starting C++ Note: Current Time, Wed Apr 3 17:08:53 2024 C++ Note: Grouping Start C++ Note: df100 3617 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:08:53 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.95 3328 C++ Note: derivs checked 3813.95 0.000939732 C++ Note: second derivs checked 3813.95 0.000939732 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.95 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.95 3328 C++ Note: risk checked 9787.82 C++ Note: risk1 checked 6011.82 0.000944651 C++ Note: risk2 checked 6011.82 0.000944651 C++ Note: Made Risk Side Lists C++ Note: riskr checked 6489.99 C++ Note: risk1r checked 4018.99 0.000575324 C++ Note: risk2r checked 4018.99 0.000575324 C++ Note: riskl checked 119.492 C++ Note: risk1l checked 49.4925 1.62651e-05 C++ Note: risk2l checked 49.4925 1.62651e-05 C++ Note: df101 -329.891 -329.891 C++ Note: df102 -21.7852 9.27193e-06 C++ Note: df103 -19.521 9.27193e-06 C++ Note: df104 0.01 -15 C++ Note: df105 1.11599 1 C++ Note: df106 15.1429 -3.55796e+07 C++ Note: riskr checked 6489.99 C++ Note: risk1r checked 4018.99 0.000575324 C++ Note: risk2r checked 4018.99 0.000575324 C++ Note: riskl checked 119.492 C++ Note: risk1l checked 49.4925 1.62651e-05 C++ Note: risk2l checked 49.4925 1.62651e-05 C++ Note: df101 -329.891 -329.891 C++ Note: df102 -21.7852 9.27193e-06 C++ Note: df103 -19.521 9.27193e-06 C++ Note: df104 0.01 -15 C++ Note: df105 1.11599 1 C++ Note: df106 15.1429 -3.55796e+07 C++ Note: ending guess 0 C++ Note: df501 -329.8914 C++ Note: df504 0.01 -15 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.01 -15, -329.8914<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.95 3328 C++ Note: derivs checked 3813.95 0.000939732 C++ Note: second derivs checked 3813.95 0.000939732 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.95 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.95 3328 C++ Note: risk checked 9787.82 C++ Note: risk1 checked 6011.82 0.000944651 C++ Note: risk2 checked 6011.82 0.000944651 C++ Note: Made Risk Side Lists C++ Note: riskr checked 6489.99 C++ Note: risk1r checked 4018.99 0.000575324 C++ Note: risk2r checked 4018.99 0.000575324 C++ Note: riskl checked 119.492 C++ Note: risk1l checked 49.4925 1.62651e-05 C++ Note: risk2l checked 49.4925 1.62651e-05 C++ Note: df101 -329.891 -329.891 C++ Note: df102 -21.7852 9.27193e-06 C++ Note: df103 -19.521 9.27193e-06 C++ Note: df104 0.01 -15 C++ Note: df105 1.11599 1 C++ Note: df106 15.1429 -3.55796e+07 C++ Note: riskr checked 6489.99 C++ Note: risk1r checked 4018.99 0.000575324 C++ Note: risk2r checked 4018.99 0.000575324 C++ Note: riskl checked 119.492 C++ Note: risk1l checked 49.4925 1.62651e-05 C++ Note: risk2l checked 49.4925 1.62651e-05 C++ Note: df101 -329.891 -329.891 C++ Note: df102 -21.7852 9.27193e-06 C++ Note: df103 -19.521 9.27193e-06 C++ Note: df104 0.01 -15 C++ Note: df105 1.11599 1 C++ Note: df106 15.1429 -3.55796e+07 C++ Note: Exiting Regression C++ Note: df501 -329.8914 C++ Note: df504 0.01 -15 Note: 86 risk groups C++ Note: START_PLOT C++ Note: Current Time, Wed Apr 3 17:08:53 2024 C++ Note: Term checked 0 1 C++ Note: df99,37,Starting C++ Note: Current Time, Wed Apr 3 17:08:53 2024 C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.95 3328 C++ Note: derivs checked 3813.95 0.000939732 C++ Note: second derivs checked 3813.95 0.000939732 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.95 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.95 3328 C++ Note: risk checked 9787.82 C++ Note: risk1 checked 6011.82 0.000944651 C++ Note: risk2 checked 6011.82 0.000944651 C++ Note: Grouping Start C++ Note: df100 2916 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:08:53 2024 C++ Note: Made Risk Side Lists C++ Note: riskr checked 6489.99 C++ Note: risk1r checked 4018.99 0.000575324 C++ Note: risk2r checked 4018.99 0.000575324 C++ Note: riskl checked 119.492 C++ Note: risk1l checked 49.4925 1.62651e-05 C++ Note: risk2l checked 49.4925 1.62651e-05 C++ Note: df101 -329.891 -329.891 C++ Note: df102 -21.7852 9.27193e-06 C++ Note: df103 -19.521 9.27193e-06 C++ Note: df104 0.01 -15 C++ Note: df105 1.11599 1 C++ Note: df106 15.1429 -3.55796e+07 C++ Note: starting plot data Saving 7 x 7 in image Saving 7 x 7 in image Saving 7 x 7 in image Saving 7 x 7 in image Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Note: 2 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:08:54 2024 C++ Note: Term checked 0 C++ Note: df99,48,Starting C++ Note: Current Time, Wed Apr 3 17:08:54 2024 C++ Note: Grouping Start C++ Note: df100 135 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:08:54 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.11965 C++ Note: risk1r checked 6.27591 C++ Note: risk2r checked 39.4822 C++ Note: riskl checked 1.11965 C++ Note: risk1l checked 6.27591 C++ Note: risk2l checked 39.4822 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: riskr checked 1.11965 C++ Note: risk1r checked 6.27591 C++ Note: risk2r checked 39.4822 C++ Note: riskl checked 1.11965 C++ Note: risk1l checked 6.27591 C++ Note: risk2l checked 39.4822 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: ending guess 0 C++ Note: df501 0 C++ Note: df504 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1, 0<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.11965 C++ Note: risk1r checked 6.27591 C++ Note: risk2r checked 39.4822 C++ Note: riskl checked 1.11965 C++ Note: risk1l checked 6.27591 C++ Note: risk2l checked 39.4822 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: riskr checked 1.11965 C++ Note: risk1r checked 6.27591 C++ Note: risk2r checked 39.4822 C++ Note: riskl checked 1.11965 C++ Note: risk1l checked 6.27591 C++ Note: risk2l checked 39.4822 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: Exiting Regression C++ Note: df501 0 C++ Note: df504 -0.1 Note: starting ph_plot Note: nonStratified survival curve calculation C++ Note: START_PLOT C++ Note: Current Time, Wed Apr 3 17:08:54 2024 C++ Note: Term checked 0 C++ Note: df99,44,Starting C++ Note: Current Time, Wed Apr 3 17:08:54 2024 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Grouping Start C++ Note: df100 428 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:08:54 2024 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.11965 C++ Note: risk1r checked 6.27591 C++ Note: risk2r checked 39.4822 C++ Note: riskl checked 1.11965 C++ Note: risk1l checked 6.27591 C++ Note: risk2l checked 39.4822 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan Note: writing survival data Note: Plotting Martingale Residuals Note: Martingale Plot: d Saving 7 x 7 in image Saving 7 x 7 in image Note: Starting Plot Function Note: Getting Plot Info Note: 3 risk groups Note: 3 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:08:55 2024 C++ Note: Term checked 0 C++ Note: df99,54,Starting C++ Note: Current Time, Wed Apr 3 17:08:55 2024 C++ Note: Grouping Start C++ Note: df100 125 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:08:55 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: ending guess 0 C++ Note: df501 0 C++ Note: df504 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1, 0<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: Exiting Regression C++ Note: df501 0 C++ Note: df504 -0.1 Note: starting ph_plot Note: nonStratified survival curve calculation C++ Note: START_PLOT C++ Note: Current Time, Wed Apr 3 17:08:55 2024 C++ Note: Term checked 0 C++ Note: df99,51,Starting C++ Note: Current Time, Wed Apr 3 17:08:55 2024 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Grouping Start C++ Note: df100 484 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:08:55 2024 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan Note: writing survival data Note: Plotting Survival Curves Saving 7 x 7 in image Saving 7 x 7 in image Saving 7 x 7 in image Saving 7 x 7 in image Note: Plotting Kaplan-Meier Curve Saving 7 x 7 in image Saving 7 x 7 in image Saving 7 x 7 in image Warning: Term_n expects nonnegative integer values and a minimum of 0, minimum value was 1. Minimum value set to 0, others shifted by -1 Warning: Term_n expects nonnegative integer values and a minimum of 0, minimum value was 1. Minimum value set to 0, others shifted by -1 Error: Cores Requested: 196 , Cores Available: 2 Warning: a and e are equal Warning: a and e are equal Warning: b and f are equal Warning: a and d are equal Warning: a and f are equal Warning: a and b are equal Warning: a and c are equal Warning: a and b are equal Warning: a and c are equal Warning: a and b are equal Warning: a and c are equal Error: e not in data.table Error: e not in data.table Error: Iteration: a?+?b?+c has incorrect length of 4 but should be 3. Error: Incorrect operation of ++ Error: Terms used: 2 , Terms with gmix types available: 1 Error: Model formula FAILING_CHOICE not in acceptable list Error: Model formula MA not in acceptable list Error: Model formula EA not in acceptable list Note: Number of factors:1 Note: Number of factors:7 Error: a0 arguement was negative Error: a0 arguement was not a number Error: a0 arguement was not a number Error: a0 arguement was negative Error: a0 arguement was not a number Error: a0 arguement was not a number Error: a0 arguement was not a number Error: goal is too low Error: a0 arguement was negative Error: e missing from column names Error: The missing-value replacement is also NA Note: Column b had replaced values Note: Column b had replaced values Warning: Parameters used: 4, Covariates used: 5, Remaining filled with 0.01 Error: Atleast one parameter must be free Error: Parameters used: 6, Covariates used: 5 Error: Terms used: 4, Covariates used: 5 Error: Terms used: 6, Covariates used: 5 Error: Term types used: 4, Covariates used: 5 Error: Term types used: 6, Covariates used: 5 Error: lin_int missing Error: step_int missing Error: loglin_top missing Error: lin_quad_int missing Error: lin_exp_int missing Error: lin_exp_exp_slope missing Error: step_slope missing Error: lin_slope missing Error: lin_quad_slope missing Error: lin_exp_slope missing Error: lin_exp_int missing Error: Parameters used in first option: 5, Parameters used in different option: 4, please fix parameter length Warning: Parameters used: 4, Covariates used: 5, Remaining filled with 0.01 Error: Parameters used: 6, Covariates used: 5 Error: Terms used: 4, Covariates used: 5 Error: Terms used: 6, Covariates used: 5 Error: Term types used: 4, Covariates used: 5 Error: Term types used: 6, Covariates used: 5 Error: verbosity arguement not valid Error: verbosity arguement not valid Error: verbosity arguement not valid Error: keep_constant expects 0/1 values, minimum value was -1 Error: keep_constant expects 0/1 values, maximum value was 10 Error: keep_constant expects 0/1 values, atleast one value was noninteger Warning: Term_n expects nonnegative integer values and a minimum of 0, minimum value was -1. Minimum value set to 0, others shifted by 1 Error: Term_n expects integer values, atleast one value was noninteger Error: Term_n expects no missing integer values. Term numbers range from 0 to 3 but Term_n has 3 unique values instead of 4 Warning: Term_n expects nonnegative integer values and a minimum of 0, minimum value was -1. Minimum value set to 0, others shifted by 1 Error: Missing tform items: missing fake Warning: Term_n expects nonnegative integer values and a minimum of 0, minimum value was -1. Minimum value set to 0, others shifted by 1 Error: Missing tform items: missing fake missing bad C++ Error: A non-positive risk was detected: -0.3510469 C++ Warning: final failing values -0.1 -0.1 6 0.1 C++ Warning: final failing terms loglin lin_exp_slope lin_exp_int lin_exp_exp_slope C++ Error: A non-positive risk was detected: -0.3510469 C++ Warning: final failing values -0.1 -0.1 6 0.1 C++ Warning: final failing terms loglin lin_exp_slope lin_exp_int lin_exp_exp_slope Error: Default Parameters used: 7, Covariates used: 4 Error: Terms used: 1, Covariates used: 4 Error: Terms used: 8, Covariates used: 4 Error: Term types used: 1, Covariates used: 4 Error: Term types used: 5, Covariates used: 4 C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 1 1 2 C++ Note: df99,76,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 3 C++ Note: values checked -0.75 0.1 -0.05 -1.5 C++ Note: sums checked 4.889466 -2.95 -2.95 1 C++ Note: dose checked 7 7 7 C++ Note: non-dose checked 4.889466 -2.95 1 C++ Note: LIN_non-dose checked 7 -2.95 7 C++ Note: PLIN_non-dose checked 7 7 1 C++ Note: LOGLIN_non-dose checked 4.889466 7 7 C++ Note: df99,542,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Note: 2 risk groups C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 1 1 2 C++ Note: df99,45,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 3 C++ Note: values checked 0.1 0.1 0.1 0.1 C++ Note: sums checked 7.420684 8.15 8.15 7.4 C++ Note: dose checked 7 7 7 C++ Note: non-dose checked 7.420684 8.15 7.4 C++ Note: LIN_non-dose checked 7 8.15 7 C++ Note: PLIN_non-dose checked 7 7 7.4 C++ Note: LOGLIN_non-dose checked 7.420684 7 7 C++ Note: df99,315,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,72,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.1 6 0.1 0.1 C++ Note: sums checked 6.978181e+23 6.978181e+23 6.978181e+23 6.978181e+23 C++ Note: dose checked 7 C++ Note: non-dose checked 6.978181e+23 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 6.978181e+23 C++ Note: df99,398,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Note: 1 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,79,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.01090596 6.087854 0.847481 -0.4248441 C++ Note: sums checked 3.093857e+25 3.093857e+25 3.093857e+25 3.093857e+25 C++ Note: dose checked 7 C++ Note: non-dose checked 3.093857e+25 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.093857e+25 C++ Note: df99,408,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Note: 2 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,67,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.1519373 5.829461 0.8987316 -0.8502692 C++ Note: sums checked 2.411556e+22 2.411556e+22 2.411556e+22 2.411556e+22 C++ Note: dose checked 7 C++ Note: non-dose checked 2.411556e+22 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 2.411556e+22 C++ Note: df99,381,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Note: 3 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,66,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -1.071536 5.774168 -0.1205539 0.8786485 C++ Note: sums checked 2.217784e+21 2.217784e+21 2.217784e+21 2.217784e+21 C++ Note: dose checked 7 C++ Note: non-dose checked 2.217784e+21 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 2.217784e+21 C++ Note: df99,385,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Note: 4 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,70,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.8503434 5.646287 0.1785074 -0.8859784 C++ Note: sums checked 4.25725e+22 4.25725e+22 4.25725e+22 4.25725e+22 C++ Note: dose checked 7 C++ Note: non-dose checked 4.25725e+22 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 4.25725e+22 C++ Note: df99,370,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Note: 5 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,64,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.8337583 5.910324 0.5189549 -0.677053 C++ Note: sums checked 1.689496e+19 1.689496e+19 1.689496e+19 1.689496e+19 C++ Note: dose checked 7 C++ Note: non-dose checked 1.689496e+19 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 1.689496e+19 C++ Note: df99,400,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Note: 6 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,64,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.6353882 5.196322 0.7496425 0.6454969 C++ Note: sums checked 1.911318e+23 1.911318e+23 1.911318e+23 1.911318e+23 C++ Note: dose checked 7 C++ Note: non-dose checked 1.911318e+23 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 1.911318e+23 C++ Note: df99,364,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Note: 7 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,65,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.8429711 5.757306 -0.4603452 -0.2271187 C++ Note: sums checked 3.370912e+16 3.370912e+16 3.370912e+16 3.370912e+16 C++ Note: dose checked 7 C++ Note: non-dose checked 3.370912e+16 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.370912e+16 C++ Note: df99,358,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Note: 8 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,63,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.432517 6.524211 -0.3805216 -0.301394 C++ Note: sums checked 3.364079e+24 3.364079e+24 3.364079e+24 3.364079e+24 C++ Note: dose checked 7 C++ Note: non-dose checked 3.364079e+24 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.364079e+24 C++ Note: df99,377,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Note: 9 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,64,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.4881905 6.766039 0.7505801 -0.5462716 C++ Note: sums checked 2.173449e+25 2.173449e+25 2.173449e+25 2.173449e+25 C++ Note: dose checked 7 C++ Note: non-dose checked 2.173449e+25 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 2.173449e+25 C++ Note: df99,362,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,66,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.1 6 0.1 0.1 C++ Note: sums checked 6.978181e+23 6.978181e+23 6.978181e+23 6.978181e+23 C++ Note: dose checked 7 C++ Note: non-dose checked 6.978181e+23 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 6.978181e+23 C++ Note: df99,366,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Note: 1 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,66,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.09866424 5.601341 0.1424459 0.1238266 C++ Note: sums checked 3.549488e+22 3.549488e+22 3.549488e+22 3.549488e+22 C++ Note: dose checked 7 C++ Note: non-dose checked 3.549488e+22 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.549488e+22 C++ Note: df99,381,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Note: 2 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,70,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.1857835 6.130523 0.1364278 0.1811213 C++ Note: sums checked 3.005546e+24 3.005546e+24 3.005546e+24 3.005546e+24 C++ Note: dose checked 7 C++ Note: non-dose checked 3.005546e+24 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.005546e+24 C++ Note: df99,378,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Note: 3 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,71,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.1253267 6.379346 0.1102204 0.1998309 C++ Note: sums checked 4.542249e+25 4.542249e+25 4.542249e+25 4.542249e+25 C++ Note: dose checked 7 C++ Note: non-dose checked 4.542249e+25 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 4.542249e+25 C++ Note: df99,392,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Note: 4 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,63,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.182686 5.230943 0.174033 0.1687405 C++ Note: sums checked 1.184779e+21 1.184779e+21 1.184779e+21 1.184779e+21 C++ Note: dose checked 7 C++ Note: non-dose checked 1.184779e+21 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 1.184779e+21 C++ Note: df99,353,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Note: 5 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,65,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.04923907 5.483363 0.1219742 0.1095504 C++ Note: sums checked 1.401351e+22 1.401351e+22 1.401351e+22 1.401351e+22 C++ Note: dose checked 7 C++ Note: non-dose checked 1.401351e+22 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 1.401351e+22 C++ Note: df99,354,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Note: 6 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,71,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.1933991 6.731845 0.02545002 0.1197524 C++ Note: sums checked 1.332251e+26 1.332251e+26 1.332251e+26 1.332251e+26 C++ Note: dose checked 7 C++ Note: non-dose checked 1.332251e+26 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 1.332251e+26 C++ Note: df99,363,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Note: 7 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,64,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.02537214 6.140731 0.01180784 0.1110899 C++ Note: sums checked 2.421105e+24 2.421105e+24 2.421105e+24 2.421105e+24 C++ Note: dose checked 7 C++ Note: non-dose checked 2.421105e+24 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 2.421105e+24 C++ Note: df99,348,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Note: 8 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,64,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.1563258 6.299512 0.07763999 0.1861431 C++ Note: sums checked 1.104889e+25 1.104889e+25 1.104889e+25 1.104889e+25 C++ Note: dose checked 7 C++ Note: non-dose checked 1.104889e+25 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 1.104889e+25 C++ Note: df99,353,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Note: 9 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,64,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.11285 6.627491 0.1048361 0.1760912 C++ Note: sums checked 3.647438e+26 3.647438e+26 3.647438e+26 3.647438e+26 C++ Note: dose checked 7 C++ Note: non-dose checked 3.647438e+26 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.647438e+26 C++ Note: df99,358,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Error: tform not implemented bad_bad Error: der_iden should be within 0:(length(tform)-1) Error: der_iden should be within 0:(length(tform)-1) Error: Constraint matrix has incorrect number of columns Error: Constraint rows and constant lengths do not match Error: verbosity arguement not valid Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 1 2 C++ Note: df99,71,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 3 in guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1227.33 1227.33 1016.5 C++ Note: derivs checked 2637.17 2637.17 1673.67 C++ Note: second derivs checked 8121.24 8121.24 4753.83 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1227.33 1227.33 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1227.33 1227.33 1016.5 C++ Note: risk checked 4011.58 C++ Note: risk1 checked 8923.07 3605.53 2051.22 C++ Note: risk2 checked 27821.1 11445.5 5822.44 C++ Note: df101 -4475.03 -4475.03 -4475.03 C++ Note: df102 -9939.98 -4018.91 -2236.07 C++ Note: df103 -31717.6 -12898.5 -6422.07 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8722.06 C++ Note: df105 0.31339 0.31158 0.348186 C++ Note: df106 0.450205 1.11349 2.00129 C++ Note: Starting Halves C++ Note: df501 -4475.029 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked -0.135042 -0.133685 -0.251139 C++ Note: sums checked 782.754 784.543 703.077 C++ Note: derivs checked 1316 1321.06 843.011 C++ Note: second derivs checked 3723.61 3739.97 2038.13 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 782.754 784.543 703.077 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 782.754 784.543 703.077 C++ Note: risk checked 1968.52 C++ Note: risk1 checked 3154.34 910.853 660.463 C++ Note: risk2 checked 8785.17 2435.97 1600.59 C++ Note: df101 -2239.25 -2239.25 -2239.25 C++ Note: df102 -3370.4 -970.755 -690.148 C++ Note: df103 -10014.5 -2646.43 -1703.61 C++ Note: df104 -0.135042 -0.133685 -0.251139 C++ Note: Checking Deviance 4250.51 C++ Note: df105 0.336551 0.366816 0.405108 C++ Note: df106 0.664388 2.30672 3.2446 C++ Note: df100 3030 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 3095 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -2239.255 -2239.255 -2239.255 C++ Note: df102 -3370.403 -970.7545 -690.1478 C++ Note: df103 -10014.54 -2646.433 -1703.615 C++ Note: df104 -0.1350423 -0.1336853 -0.2511393 C++ Note: Checking Deviance 4250.51 C++ Note: df105 0.3365511 0.3668162 0.405108 C++ Note: df106 0.6643879 2.306716 3.244602 C++ Note: df101 -2239.25 -2239.25 -2239.25 C++ Note: df102 -3370.4 -970.755 -690.148 C++ Note: df103 -10014.5 -2646.43 -1703.61 C++ Note: df104 -0.135042 -0.133685 -0.251139 C++ Note: Checking Deviance 4250.51 C++ Note: df105 0.336551 0.366816 0.405108 C++ Note: df106 0.664388 2.30672 3.2446 C++ Note: ending guess 0 C++ Note: df501 -2239.255 C++ Note: df504 -0.1350423 -0.1336853 -0.2511393 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1350423 -0.1336853 -0.2511393, -2239.255<-- Best Guess C++ Note: starting subterms 3 in best guess 0 C++ Note: values checked -0.135042 -0.133685 -0.251139 C++ Note: sums checked 782.754 784.543 703.077 C++ Note: derivs checked 1316 1321.06 843.011 C++ Note: second derivs checked 3723.61 3739.97 2038.13 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 782.754 784.543 703.077 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 782.754 784.543 703.077 C++ Note: risk checked 1968.52 C++ Note: risk1 checked 3154.34 910.853 660.463 C++ Note: risk2 checked 8785.17 2435.97 1600.59 C++ Note: Made Risk Side Lists C++ Note: df101 -2239.25 -2239.25 -2239.25 C++ Note: df102 -3370.4 -970.755 -690.148 C++ Note: df103 -10014.5 -2646.43 -1703.61 C++ Note: df104 -0.135042 -0.133685 -0.251139 C++ Note: Checking Deviance 4250.51 C++ Note: df105 0.336551 0.366816 0.405108 C++ Note: df106 0.664388 2.30672 3.2446 C++ Note: Starting Halves C++ Note: df501 -2239.255 C++ Note: df504 -0.1350423 -0.1336853 -0.2511393 C++ Note: values checked -0.387456 -0.408797 -0.55497 C++ Note: sums checked 542.92 529.028 518.181 C++ Note: derivs checked 668.649 633.643 432.658 C++ Note: second derivs checked 1693.32 1588.4 859.434 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 542.92 529.028 518.181 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 542.92 529.028 518.181 C++ Note: risk checked 1191.84 C++ Note: risk1 checked 1277.69 262.168 233.881 C++ Note: risk2 checked 3114.06 539.25 469.419 C++ Note: df101 -1440.13 -1440.13 -1440.13 C++ Note: df102 -1235.57 -256.285 -228.331 C++ Note: df103 -3546.4 -528.889 -469.297 C++ Note: df104 -0.387456 -0.408797 -0.55497 C++ Note: Checking Deviance 2652.26 C++ Note: df105 0.348402 0.484572 0.486537 C++ Note: df106 1.16556 5.61925 6.3072 C++ Note: df100 6770 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 6832 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -1440.128 -1440.128 -1440.128 C++ Note: df102 -1235.572 -256.2848 -228.3307 C++ Note: df103 -3546.399 -528.8889 -469.2973 C++ Note: df104 -0.3874556 -0.4087974 -0.5549703 C++ Note: Checking Deviance 2652.256 C++ Note: df105 0.348402 0.484572 0.4865373 C++ Note: df106 1.165555 5.61925 6.307205 C++ Note: df101 -1440.13 -1440.13 -1440.13 C++ Note: df102 -1235.57 -256.285 -228.331 C++ Note: df103 -3546.4 -528.889 -469.297 C++ Note: df104 -0.387456 -0.408797 -0.55497 C++ Note: Checking Deviance 2652.26 C++ Note: df105 0.348402 0.484572 0.486537 C++ Note: df106 1.16556 5.61925 6.3072 C++ Note: df501 -1440.128 C++ Note: df504 -0.3874556 -0.4087974 -0.5549703 Error: Atleast one parameter must be free Warning: model covariate order changed Error: no events Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 1 2 C++ Note: df99,61,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 3 in guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1105.17 1227.33 1016.5 C++ Note: derivs checked 1105.17 2637.17 1673.67 C++ Note: second derivs checked 1105.17 8121.24 4753.83 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1105.17 1227.33 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1105.17 1227.33 1016.5 C++ Note: risk checked 3584.99 C++ Note: risk1 checked 3584.99 2914.53 1849.69 C++ Note: risk2 checked 3584.99 8975.36 5253.79 C++ Note: df101 -3997.5 -3997.5 -3997.5 C++ Note: df102 -3940.95 -3230.38 -2006.99 C++ Note: df103 -4054.95 -10080.2 -5775.47 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7767 C++ Note: df105 0.971886 0.320467 0.347502 C++ Note: df106 1.01435 1.23747 1.99179 C++ Note: Starting Halves C++ Note: df501 -3997.502 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked -0.628915 -0.14035 -0.250626 C++ Note: sums checked 533.17 775.821 703.51 C++ Note: derivs checked 533.17 1296.4 844.058 C++ Note: second derivs checked 533.17 3660.36 2041.33 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 533.17 775.821 703.51 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 533.17 775.821 703.51 C++ Note: risk checked 1321.91 C++ Note: risk1 checked 1321.91 691.203 450.027 C++ Note: risk2 checked 1321.91 1951.59 1088.37 C++ Note: df101 -1553.8 -1553.8 -1553.8 C++ Note: df102 -1381.53 -723.484 -455.609 C++ Note: df103 -1495.53 -2097.82 -1131.34 C++ Note: df104 -0.628915 -0.14035 -0.250626 C++ Note: Checking Deviance 2879.6 C++ Note: df105 0.923773 0.344875 0.402717 C++ Note: df106 1.12469 2.14766 3.41038 C++ Note: df100 2868 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 2927 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -1553.801 -1553.801 -1553.801 C++ Note: df102 -1381.532 -723.4844 -455.6093 C++ Note: df103 -1495.532 -2097.818 -1131.338 C++ Note: df104 -0.6289146 -0.1403505 -0.2506262 C++ Note: Checking Deviance 2879.601 C++ Note: df105 0.9237729 0.3448748 0.4027172 C++ Note: df106 1.124694 2.147663 3.41038 C++ Note: df101 -1553.8 -1553.8 -1553.8 C++ Note: df102 -1381.53 -723.484 -455.609 C++ Note: df103 -1495.53 -2097.82 -1131.34 C++ Note: df104 -0.628915 -0.14035 -0.250626 C++ Note: Checking Deviance 2879.6 C++ Note: df105 0.923773 0.344875 0.402717 C++ Note: df106 1.12469 2.14766 3.41038 C++ Note: ending guess 0 C++ Note: df501 -1553.801 C++ Note: df504 -0.6289146 -0.1403505 -0.2506262 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.6289146 -0.1403505 -0.2506262, -1553.801<-- Best Guess C++ Note: starting subterms 3 in best guess 0 C++ Note: values checked -0.628915 -0.14035 -0.250626 C++ Note: sums checked 533.17 775.821 703.51 C++ Note: derivs checked 533.17 1296.4 844.058 C++ Note: second derivs checked 533.17 3660.36 2041.33 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 533.17 775.821 703.51 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 533.17 775.821 703.51 C++ Note: risk checked 1321.91 C++ Note: risk1 checked 1321.91 691.203 450.027 C++ Note: risk2 checked 1321.91 1951.59 1088.37 C++ Note: Made Risk Side Lists C++ Note: df101 -1553.8 -1553.8 -1553.8 C++ Note: df102 -1381.53 -723.484 -455.609 C++ Note: df103 -1495.53 -2097.82 -1131.34 C++ Note: df104 -0.628915 -0.14035 -0.250626 C++ Note: Checking Deviance 2879.6 C++ Note: df105 0.923773 0.344875 0.402717 C++ Note: df106 1.12469 2.14766 3.41038 C++ Note: Starting Halves C++ Note: df501 -1553.801 C++ Note: df504 -0.6289146 -0.1403505 -0.2506262 C++ Note: values checked -1.32174 -0.399007 -0.552664 C++ Note: sums checked 266.67 535.309 519.182 C++ Note: derivs checked 266.67 649.425 434.646 C++ Note: second derivs checked 266.67 1635.61 864.671 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 266.67 535.309 519.182 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 266.67 535.309 519.182 C++ Note: risk checked 547.87 C++ Note: risk1 checked 547.87 173.182 115.907 C++ Note: risk2 checked 547.87 436.169 230.582 C++ Note: df101 -782.448 -782.448 -782.448 C++ Note: df102 -506.262 -155.99 -97.6971 C++ Note: df103 -620.262 -412.181 -204.283 C++ Note: df104 -1.32174 -0.399007 -0.552664 C++ Note: Checking Deviance 1336.9 C++ Note: df105 0.816207 0.378449 0.478245 C++ Note: df106 1.54554 5.01603 8.00892 C++ Note: df100 6474 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 6533 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -782.448 -782.448 -782.448 C++ Note: df102 -506.262 -155.9896 -97.6971 C++ Note: df103 -620.262 -412.1813 -204.2827 C++ Note: df104 -1.321744 -0.3990065 -0.5526641 C++ Note: Checking Deviance 1336.896 C++ Note: df105 0.8162067 0.3784491 0.4782445 C++ Note: df106 1.54554 5.016025 8.008917 C++ Note: df101 -782.448 -782.448 -782.448 C++ Note: df102 -506.262 -155.99 -97.6971 C++ Note: df103 -620.262 -412.181 -204.283 C++ Note: df104 -1.32174 -0.399007 -0.552664 C++ Note: Checking Deviance 1336.9 C++ Note: df105 0.816207 0.378449 0.478245 C++ Note: df106 1.54554 5.01603 8.00892 C++ Note: df501 -782.448 C++ Note: df504 -1.321744 -0.3990065 -0.5526641 Warning: model covariate order changed Error: guesses: 100 , iterations per guess: c(1, 1) Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 1 C++ Note: df99,43,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 2 C++ Note: values checked 0.01 C++ Note: sums checked 10679.25 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 10679.25 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 10679.25 C++ Note: df99,631,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Note: 1 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 1 C++ Note: df99,35,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 2 C++ Note: values checked -0.6567497 C++ Note: sums checked 0.001525544 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 0.001525544 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 0.001525544 C++ Note: df99,590,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Warning: Term_n expects nonnegative integer values and a minimum of 0, minimum value was 1. Minimum value set to 0, others shifted by -1 C++ Note: START_POIS_GUESS C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 C++ Note: df99,42,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 10679.3 C++ Note: derivs checked 564819 C++ Note: second derivs checked 3.34438e+07 C++ Note: dose checked 6400 C++ Note: non-dose checked 10679.3 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 10679.3 C++ Note: risk checked 151.98 C++ Note: risk1 checked 8038.14 C++ Note: risk2 checked 475950 C++ Note: df101 -465.227 C++ Note: df102 -3042.76 C++ Note: df103 -449401 C++ Note: df104 0.01 C++ Note: Checking Deviance 758.454 C++ Note: df105 0.0067707 C++ Note: df106 0.152896 C++ Note: Starting Halves C++ Note: df501 -465.2272 C++ Note: df504 0.01 C++ Note: values checked 0.00492198 C++ Note: sums checked 8199.44 C++ Note: derivs checked 419622 C++ Note: second derivs checked 2.42591e+07 C++ Note: dose checked 6400 C++ Note: non-dose checked 8199.44 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 8199.44 C++ Note: risk checked 116.689 C++ Note: risk1 checked 5971.78 C++ Note: risk2 checked 345240 C++ Note: df101 -454.994 C++ Note: df102 -1091.66 C++ Note: df103 -325982 C++ Note: df104 0.00492198 C++ Note: Checking Deviance 737.989 C++ Note: df105 0.00334885 C++ Note: df106 0.41679 C++ Note: df100 3727 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 3787 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -454.9945 C++ Note: df102 -1091.664 C++ Note: df103 -325982.2 C++ Note: df104 0.004921975 C++ Note: Checking Deviance 737.989 C++ Note: df105 0.003348847 C++ Note: df106 0.4167897 C++ Note: Starting Halves C++ Note: df501 -454.9945 C++ Note: df504 0.004921975 C++ Note: values checked 0.00241034 C++ Note: sums checked 7218.17 C++ Note: derivs checked 363234 C++ Note: second derivs checked 2.0739e+07 C++ Note: dose checked 6400 C++ Note: non-dose checked 7218.17 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 7218.17 C++ Note: risk checked 102.724 C++ Note: risk1 checked 5169.31 C++ Note: risk2 checked 295144 C++ Note: df101 -453.229 C++ Note: df102 -333.957 C++ Note: df103 -278680 C++ Note: df104 0.00241034 C++ Note: Checking Deviance 734.458 C++ Note: df105 0.00119835 C++ Note: df106 1.35715 C++ Note: df100 5322 1 2 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 5381 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -453.229 C++ Note: df102 -333.957 C++ Note: df103 -278680.4 C++ Note: df104 0.00241034 C++ Note: Checking Deviance 734.458 C++ Note: df105 0.001198351 C++ Note: df106 1.357148 C++ Note: Starting Halves C++ Note: df501 -453.229 C++ Note: df504 0.00241034 C++ Note: values checked 0.00151158 C++ Note: sums checked 6899.93 C++ Note: derivs checked 345105 C++ Note: second derivs checked 1.96142e+07 C++ Note: dose checked 6400 C++ Note: non-dose checked 6899.93 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 6899.93 C++ Note: risk checked 98.1952 C++ Note: risk1 checked 4911.31 C++ Note: risk2 checked 279136 C++ Note: df101 -453.039 C++ Note: df102 -90.3484 C++ Note: df103 -263566 C++ Note: df104 0.00151158 C++ Note: Checking Deviance 734.079 C++ Note: df105 0.000342793 C++ Note: df106 5.01436 C++ Note: df100 6919 1 3 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 6980 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -453.0394 C++ Note: df102 -90.34835 C++ Note: df103 -263565.6 C++ Note: df104 0.001511576 C++ Note: Checking Deviance 734.0787 C++ Note: df105 0.0003427927 C++ Note: df106 5.014362 C++ Note: Starting Halves C++ Note: df501 -453.0394 C++ Note: df504 0.001511576 C++ Note: values checked 0.00125448 C++ Note: sums checked 6811.85 C++ Note: derivs checked 340102 C++ Note: second derivs checked 1.93044e+07 C++ Note: dose checked 6400 C++ Note: non-dose checked 6811.85 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 6811.85 C++ Note: risk checked 96.9417 C++ Note: risk1 checked 4840.11 C++ Note: risk2 checked 274728 C++ Note: df101 -453.025 C++ Note: df102 -23.1236 C++ Note: df103 -259403 C++ Note: df104 0.00125448 C++ Note: Checking Deviance 734.05 C++ Note: df105 8.91416e-05 C++ Note: df106 19.5914 C++ Note: df100 8518 1 4 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 8578 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -453.0248 C++ Note: df102 -23.12364 C++ Note: df103 -259403.3 C++ Note: df104 0.001254482 C++ Note: Checking Deviance 734.0496 C++ Note: df105 8.914164e-05 C++ Note: df106 19.59142 C++ Note: Starting Halves C++ Note: df501 -453.0248 C++ Note: df504 0.001254482 C++ Note: values checked 0.00118763 C++ Note: sums checked 6789.15 C++ Note: derivs checked 338814 C++ Note: second derivs checked 1.92247e+07 C++ Note: dose checked 6400 C++ Note: non-dose checked 6789.15 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 6789.15 C++ Note: risk checked 96.6187 C++ Note: risk1 checked 4821.78 C++ Note: risk2 checked 273594 C++ Note: df101 -453.024 C++ Note: df102 -5.81673 C++ Note: df103 -258332 C++ Note: df104 0.00118763 C++ Note: Checking Deviance 734.048 C++ Note: df105 2.25165e-05 C++ Note: df106 77.8828 C++ Note: df100 10134 1 5 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 10199 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -453.0238 C++ Note: df102 -5.816735 C++ Note: df103 -258332.4 C++ Note: df104 0.001187626 C++ Note: Checking Deviance 734.0477 C++ Note: df105 2.251647e-05 C++ Note: df106 77.88285 C++ Note: df101 -453.024 C++ Note: df102 -5.81673 C++ Note: df103 -258332 C++ Note: df104 0.00118763 C++ Note: Checking Deviance 734.048 C++ Note: df105 2.25165e-05 C++ Note: df106 77.8828 C++ Note: ending guess 0 C++ Note: df501 -453.0238 C++ Note: df504 0.001187626 C++ Note: starting subterms 1 in guess 1 C++ Note: values checked -0.65675 C++ Note: sums checked 0.00152554 C++ Note: derivs checked 0.0291028 C++ Note: second derivs checked 0.558606 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00152554 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00152554 C++ Note: risk checked 2.17105e-05 C++ Note: risk1 checked 0.000414172 C++ Note: risk2 checked 0.00794971 C++ Note: df101 -3353.44 C++ Note: df102 4547 C++ Note: df103 -0.00750627 C++ Note: df104 -0.65675 C++ Note: Checking Deviance 6534.87 C++ Note: df105 -605760 C++ Note: df106 -0.737505 C++ Note: Starting Halves C++ Note: df501 -453.0238 C++ Note: df504 0.001187626 C++ Note: values checked 0.34325 C++ Note: sums checked 4.08888e+14 C++ Note: derivs checked 3.21215e+16 C++ Note: second derivs checked 2.52684e+18 C++ Note: dose checked 6400 C++ Note: non-dose checked 4.08888e+14 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 4.08888e+14 C++ Note: risk checked 5.81902e+12 C++ Note: risk1 checked 4.57132e+14 C++ Note: risk2 checked 3.59603e+16 C++ Note: df101 -5.49443e+12 C++ Note: df102 -4.31632e+14 C++ Note: df103 -3.39544e+16 C++ Note: df104 0.34325 C++ Note: Checking Deviance 1.09889e+13 C++ Note: df105 0.0127121 C++ Note: df106 0.0127294 C++ Note: df100 13684 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked -0.15675 C++ Note: sums checked 41.0212 C++ Note: derivs checked 979.989 C++ Note: second derivs checked 25070.5 C++ Note: dose checked 6400 C++ Note: non-dose checked 41.0212 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 41.0212 C++ Note: risk checked 0.583786 C++ Note: risk1 checked 13.9466 C++ Note: risk2 checked 356.787 C++ Note: df101 -1080.49 C++ Note: df102 4533.83 C++ Note: df103 -336.885 C++ Note: df104 -0.15675 C++ Note: Checking Deviance 1988.97 C++ Note: df105 -13.4581 C++ Note: df106 -0.238316 C++ Note: df100 15075 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked -0.40675 C++ Note: sums checked 0.197844 C++ Note: derivs checked 3.95536 C++ Note: second derivs checked 80.2563 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.197844 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.197844 C++ Note: risk checked 0.00281559 C++ Note: risk1 checked 0.0562901 C++ Note: risk2 checked 1.14216 C++ Note: df101 -2216.69 C++ Note: df102 4546.95 C++ Note: df103 -1.07844 C++ Note: df104 -0.40675 C++ Note: Checking Deviance 4261.38 C++ Note: df105 -4216.21 C++ Note: df106 -0.487511 C++ Note: df100 16459 3 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked -0.53175 C++ Note: sums checked 0.016897 C++ Note: derivs checked 0.328218 C++ Note: second derivs checked 6.43391 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.016897 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.016897 C++ Note: risk checked 0.000240467 C++ Note: risk1 checked 0.00467099 C++ Note: risk2 checked 0.0915632 C++ Note: df101 -2785.06 C++ Note: df102 4547 C++ Note: df103 -0.0864557 C++ Note: df104 -0.53175 C++ Note: Checking Deviance 5398.12 C++ Note: df105 -52593.4 C++ Note: df106 -0.612506 C++ Note: df100 17815 4 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked -0.59425 C++ Note: sums checked 0.00504976 C++ Note: derivs checked 0.0971171 C++ Note: second derivs checked 1.88165 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00504976 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00504976 C++ Note: risk checked 7.18649e-05 C++ Note: risk1 checked 0.00138211 C++ Note: risk2 checked 0.0267783 C++ Note: df101 -3069.25 C++ Note: df102 4547 C++ Note: df103 -0.0252846 C++ Note: df104 -0.59425 C++ Note: Checking Deviance 5966.5 C++ Note: df105 -179833 C++ Note: df106 -0.675005 C++ Note: df100 19159 5 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Changing back to best C++ Note: values checked -0.65675 C++ Note: sums checked 0.00152554 C++ Note: derivs checked 0.0291028 C++ Note: second derivs checked 0.558606 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00152554 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00152554 C++ Note: risk checked 2.17105e-05 C++ Note: risk1 checked 0.000414172 C++ Note: risk2 checked 0.00794971 C++ Note: df101 -3353.44 C++ Note: df102 4547 C++ Note: df103 -0.00750627 C++ Note: df104 -0.65675 C++ Note: Checking Deviance 6534.87 C++ Note: df105 -605760 C++ Note: df106 -0.737505 C++ Note: df100 20558 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -3353.436 C++ Note: df102 4547 C++ Note: df103 -0.007506268 C++ Note: df104 -0.6567497 C++ Note: Checking Deviance 6534.871 C++ Note: df105 -605760.4 C++ Note: df106 -0.7375051 C++ Note: Starting Halves C++ Note: df501 -453.0238 C++ Note: df504 0.001187626 C++ Note: values checked -0.6255 C++ Note: sums checked 0.00277219 C++ Note: derivs checked 0.0530888 C++ Note: second derivs checked 1.02354 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00277219 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00277219 C++ Note: risk checked 3.94519e-05 C++ Note: risk1 checked 0.000755524 C++ Note: risk2 checked 0.0145663 C++ Note: df101 -3211.34 C++ Note: df102 4547 C++ Note: df103 -0.0137538 C++ Note: df104 -0.6255 C++ Note: Checking Deviance 6250.68 C++ Note: df105 -330600 C++ Note: df106 -0.706255 C++ Note: df100 22129 1 2 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked -0.641125 C++ Note: sums checked 0.00205589 C++ Note: derivs checked 0.0392938 C++ Note: second derivs checked 0.755849 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00205589 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00205589 C++ Note: risk checked 2.9258e-05 C++ Note: risk1 checked 0.000559203 C++ Note: risk2 checked 0.0107567 C++ Note: df101 -3282.39 C++ Note: df102 4547 C++ Note: df103 -0.0101567 C++ Note: df104 -0.641125 C++ Note: Checking Deviance 6392.78 C++ Note: df105 -447684 C++ Note: df106 -0.72188 C++ Note: df100 23478 2 2 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked -0.648937 C++ Note: sums checked 0.00177085 C++ Note: derivs checked 0.0338138 C++ Note: second derivs checked 0.649724 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00177085 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00177085 C++ Note: risk checked 2.52015e-05 C++ Note: risk1 checked 0.000481216 C++ Note: risk2 checked 0.00924645 C++ Note: df101 -3317.91 C++ Note: df102 4547 C++ Note: df103 -0.00873067 C++ Note: df104 -0.648937 C++ Note: Checking Deviance 6463.82 C++ Note: df105 -520808 C++ Note: df106 -0.729693 C++ Note: df100 24844 3 2 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked -0.652843 C++ Note: sums checked 0.0016436 C++ Note: derivs checked 0.0313693 C++ Note: second derivs checked 0.602431 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.0016436 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.0016436 C++ Note: risk checked 2.33906e-05 C++ Note: risk1 checked 0.000446428 C++ Note: risk2 checked 0.0085734 C++ Note: df101 -3335.67 C++ Note: df102 4547 C++ Note: df103 -0.00809516 C++ Note: df104 -0.652843 C++ Note: Checking Deviance 6499.35 C++ Note: df105 -561693 C++ Note: df106 -0.733599 C++ Note: df100 26217 4 2 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked -0.654797 C++ Note: sums checked 0.00158346 C++ Note: derivs checked 0.0302147 C++ Note: second derivs checked 0.580101 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00158346 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00158346 C++ Note: risk checked 2.25348e-05 C++ Note: risk1 checked 0.000429995 C++ Note: risk2 checked 0.00825562 C++ Note: df101 -3344.55 C++ Note: df102 4547 C++ Note: df103 -0.00779511 C++ Note: df104 -0.654797 C++ Note: Checking Deviance 6517.11 C++ Note: df105 -583314 C++ Note: df106 -0.735552 C++ Note: df100 27581 5 2 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Changing back to best C++ Note: values checked -0.65675 C++ Note: sums checked 0.00152554 C++ Note: derivs checked 0.0291028 C++ Note: second derivs checked 0.558606 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00152554 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00152554 C++ Note: risk checked 2.17105e-05 C++ Note: risk1 checked 0.000414172 C++ Note: risk2 checked 0.00794971 C++ Note: df101 -3353.44 C++ Note: df102 4547 C++ Note: df103 -0.00750627 C++ Note: df104 -0.65675 C++ Note: Checking Deviance 6534.87 C++ Note: df105 -605760 C++ Note: df106 -0.737505 C++ Note: df100 28983 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -3353.436 C++ Note: df102 4547 C++ Note: df103 -0.007506268 C++ Note: df104 -0.6567497 C++ Note: Checking Deviance 6534.871 C++ Note: df105 -605760.4 C++ Note: df106 -0.7375051 C++ Note: Starting Halves C++ Note: df501 -453.0238 C++ Note: df504 0.001187626 C++ Note: values checked -0.655773 C++ Note: sums checked 0.00155423 C++ Note: derivs checked 0.0296535 C++ Note: second derivs checked 0.569251 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00155423 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00155423 C++ Note: risk checked 2.21188e-05 C++ Note: risk1 checked 0.000422009 C++ Note: risk2 checked 0.00810121 C++ Note: df101 -3349 C++ Note: df102 4547 C++ Note: df103 -0.00764932 C++ Note: df104 -0.655773 C++ Note: Checking Deviance 6525.99 C++ Note: df105 -594432 C++ Note: df106 -0.736529 C++ Note: df100 30554 1 3 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked -0.656261 C++ Note: sums checked 0.00153982 C++ Note: derivs checked 0.0293768 C++ Note: second derivs checked 0.563903 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00153982 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00153982 C++ Note: risk checked 2.19137e-05 C++ Note: risk1 checked 0.000418072 C++ Note: risk2 checked 0.0080251 C++ Note: df101 -3351.22 C++ Note: df102 4547 C++ Note: df103 -0.00757745 C++ Note: df104 -0.656261 C++ Note: Checking Deviance 6530.43 C++ Note: df105 -600070 C++ Note: df106 -0.737017 C++ Note: df100 31933 2 3 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked -0.656506 C++ Note: sums checked 0.00153267 C++ Note: derivs checked 0.0292395 C++ Note: second derivs checked 0.561248 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00153267 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00153267 C++ Note: risk checked 2.18119e-05 C++ Note: risk1 checked 0.000416117 C++ Note: risk2 checked 0.00798732 C++ Note: df101 -3352.33 C++ Note: df102 4547 C++ Note: df103 -0.00754177 C++ Note: df104 -0.656506 C++ Note: Checking Deviance 6532.65 C++ Note: df105 -602908 C++ Note: df106 -0.737261 C++ Note: df100 33349 3 3 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked -0.656628 C++ Note: sums checked 0.0015291 C++ Note: derivs checked 0.0291711 C++ Note: second derivs checked 0.559926 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.0015291 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.0015291 C++ Note: risk checked 2.17611e-05 C++ Note: risk1 checked 0.000415143 C++ Note: risk2 checked 0.00796849 C++ Note: df101 -3352.88 C++ Note: df102 4547 C++ Note: df103 -0.007524 C++ Note: df104 -0.656628 C++ Note: Checking Deviance 6533.76 C++ Note: df105 -604333 C++ Note: df106 -0.737383 C++ Note: df100 34748 4 3 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked -0.656689 C++ Note: sums checked 0.00152732 C++ Note: derivs checked 0.0291369 C++ Note: second derivs checked 0.559265 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00152732 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00152732 C++ Note: risk checked 2.17358e-05 C++ Note: risk1 checked 0.000414657 C++ Note: risk2 checked 0.0079591 C++ Note: df101 -3353.16 C++ Note: df102 4547 C++ Note: df103 -0.00751513 C++ Note: df104 -0.656689 C++ Note: Checking Deviance 6534.32 C++ Note: df105 -605046 C++ Note: df106 -0.737444 C++ Note: df100 36174 5 3 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Changing back to best C++ Note: values checked -0.65675 C++ Note: sums checked 0.00152554 C++ Note: derivs checked 0.0291028 C++ Note: second derivs checked 0.558606 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00152554 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00152554 C++ Note: risk checked 2.17105e-05 C++ Note: risk1 checked 0.000414172 C++ Note: risk2 checked 0.00794971 C++ Note: df101 -3353.44 C++ Note: df102 4547 C++ Note: df103 -0.00750627 C++ Note: df104 -0.65675 C++ Note: Checking Deviance 6534.87 C++ Note: df105 -605760 C++ Note: df106 -0.737505 C++ Note: df100 37611 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -3353.436 C++ Note: df102 4547 C++ Note: df103 -0.007506268 C++ Note: df104 -0.6567497 C++ Note: Checking Deviance 6534.871 C++ Note: df105 -605760.4 C++ Note: df106 -0.7375051 C++ Note: Starting Halves C++ Note: df501 -453.0238 C++ Note: df504 0.001187626 C++ Note: values checked -0.656719 C++ Note: sums checked 0.00152643 C++ Note: derivs checked 0.0291198 C++ Note: second derivs checked 0.558936 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00152643 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00152643 C++ Note: risk checked 2.17232e-05 C++ Note: risk1 checked 0.000414414 C++ Note: risk2 checked 0.0079544 C++ Note: df101 -3353.3 C++ Note: df102 4547 C++ Note: df103 -0.0075107 C++ Note: df104 -0.656719 C++ Note: Checking Deviance 6534.59 C++ Note: df105 -605403 C++ Note: df106 -0.737475 C++ Note: df100 39240 1 4 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked -0.656734 C++ Note: sums checked 0.00152599 C++ Note: derivs checked 0.0291113 C++ Note: second derivs checked 0.558771 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00152599 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00152599 C++ Note: risk checked 2.17169e-05 C++ Note: risk1 checked 0.000414293 C++ Note: risk2 checked 0.00795206 C++ Note: df101 -3353.37 C++ Note: df102 4547 C++ Note: df103 -0.00750848 C++ Note: df104 -0.656734 C++ Note: Checking Deviance 6534.73 C++ Note: df105 -605582 C++ Note: df106 -0.73749 C++ Note: df100 40657 2 4 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked -0.656742 C++ Note: sums checked 0.00152577 C++ Note: derivs checked 0.029107 C++ Note: second derivs checked 0.558688 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00152577 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00152577 C++ Note: risk checked 2.17137e-05 C++ Note: risk1 checked 0.000414232 C++ Note: risk2 checked 0.00795088 C++ Note: df101 -3353.4 C++ Note: df102 4547 C++ Note: df103 -0.00750737 C++ Note: df104 -0.656742 C++ Note: Checking Deviance 6534.8 C++ Note: df105 -605671 C++ Note: df106 -0.737498 C++ Note: df100 42148 3 4 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked -0.656746 C++ Note: sums checked 0.00152565 C++ Note: derivs checked 0.0291049 C++ Note: second derivs checked 0.558647 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00152565 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00152565 C++ Note: risk checked 2.17121e-05 C++ Note: risk1 checked 0.000414202 C++ Note: risk2 checked 0.0079503 C++ Note: df101 -3353.42 C++ Note: df102 4547 C++ Note: df103 -0.00750682 C++ Note: df104 -0.656746 C++ Note: Checking Deviance 6534.84 C++ Note: df105 -605716 C++ Note: df106 -0.737501 C++ Note: df100 43669 4 4 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked -0.656748 C++ Note: sums checked 0.0015256 C++ Note: derivs checked 0.0291038 C++ Note: second derivs checked 0.558627 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.0015256 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.0015256 C++ Note: risk checked 2.17113e-05 C++ Note: risk1 checked 0.000414187 C++ Note: risk2 checked 0.00795 C++ Note: df101 -3353.43 C++ Note: df102 4547 C++ Note: df103 -0.00750654 C++ Note: df104 -0.656748 C++ Note: Checking Deviance 6534.85 C++ Note: df105 -605738 C++ Note: df106 -0.737503 C++ Note: df100 45087 5 4 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Changing back to best C++ Note: values checked -0.65675 C++ Note: sums checked 0.00152554 C++ Note: derivs checked 0.0291028 C++ Note: second derivs checked 0.558606 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00152554 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00152554 C++ Note: risk checked 2.17105e-05 C++ Note: risk1 checked 0.000414172 C++ Note: risk2 checked 0.00794971 C++ Note: df101 -3353.44 C++ Note: df102 4547 C++ Note: df103 -0.00750627 C++ Note: df104 -0.65675 C++ Note: Checking Deviance 6534.87 C++ Note: df105 -605760 C++ Note: df106 -0.737505 C++ Note: df100 46601 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -3353.436 C++ Note: df102 4547 C++ Note: df103 -0.007506268 C++ Note: df104 -0.6567497 C++ Note: Checking Deviance 6534.871 C++ Note: df105 -605760.4 C++ Note: df106 -0.7375051 C++ Note: Starting Halves C++ Note: df501 -453.0238 C++ Note: df504 0.001187626 C++ Note: values checked -0.656749 C++ Note: sums checked 0.00152557 C++ Note: derivs checked 0.0291033 C++ Note: second derivs checked 0.558616 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00152557 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00152557 C++ Note: risk checked 2.17109e-05 C++ Note: risk1 checked 0.000414179 C++ Note: risk2 checked 0.00794986 C++ Note: df101 -3353.43 C++ Note: df102 4547 C++ Note: df103 -0.00750641 C++ Note: df104 -0.656749 C++ Note: Checking Deviance 6534.86 C++ Note: df105 -605749 C++ Note: df106 -0.737504 C++ Note: df100 48273 1 5 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked -0.656749 C++ Note: sums checked 0.00152556 C++ Note: derivs checked 0.029103 C++ Note: second derivs checked 0.558611 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00152556 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00152556 C++ Note: risk checked 2.17107e-05 C++ Note: risk1 checked 0.000414175 C++ Note: risk2 checked 0.00794978 C++ Note: df101 -3353.43 C++ Note: df102 4547 C++ Note: df103 -0.00750634 C++ Note: df104 -0.656749 C++ Note: Checking Deviance 6534.87 C++ Note: df105 -605755 C++ Note: df106 -0.737505 C++ Note: df100 49676 2 5 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked -0.656749 C++ Note: sums checked 0.00152555 C++ Note: derivs checked 0.0291029 C++ Note: second derivs checked 0.558609 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00152555 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00152555 C++ Note: risk checked 2.17106e-05 C++ Note: risk1 checked 0.000414173 C++ Note: risk2 checked 0.00794975 C++ Note: df101 -3353.43 C++ Note: df102 4547 C++ Note: df103 -0.0075063 C++ Note: df104 -0.656749 C++ Note: Checking Deviance 6534.87 C++ Note: df105 -605758 C++ Note: df106 -0.737505 C++ Note: df100 51102 3 5 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked -0.65675 C++ Note: sums checked 0.00152555 C++ Note: derivs checked 0.0291028 C++ Note: second derivs checked 0.558607 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00152555 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00152555 C++ Note: risk checked 2.17106e-05 C++ Note: risk1 checked 0.000414173 C++ Note: risk2 checked 0.00794973 C++ Note: df101 -3353.44 C++ Note: df102 4547 C++ Note: df103 -0.00750628 C++ Note: df104 -0.65675 C++ Note: Checking Deviance 6534.87 C++ Note: df105 -605759 C++ Note: df106 -0.737505 C++ Note: df100 52511 4 5 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked -0.65675 C++ Note: sums checked 0.00152555 C++ Note: derivs checked 0.0291028 C++ Note: second derivs checked 0.558607 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00152555 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00152555 C++ Note: risk checked 2.17106e-05 C++ Note: risk1 checked 0.000414172 C++ Note: risk2 checked 0.00794972 C++ Note: df101 -3353.44 C++ Note: df102 4547 C++ Note: df103 -0.00750628 C++ Note: df104 -0.65675 C++ Note: Checking Deviance 6534.87 C++ Note: df105 -605760 C++ Note: df106 -0.737505 C++ Note: df100 53927 5 5 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Changing back to best C++ Note: values checked -0.65675 C++ Note: sums checked 0.00152554 C++ Note: derivs checked 0.0291028 C++ Note: second derivs checked 0.558606 C++ Note: dose checked 6400 C++ Note: non-dose checked 0.00152554 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 0.00152554 C++ Note: risk checked 2.17105e-05 C++ Note: risk1 checked 0.000414172 C++ Note: risk2 checked 0.00794971 C++ Note: df101 -3353.44 C++ Note: df102 4547 C++ Note: df103 -0.00750627 C++ Note: df104 -0.65675 C++ Note: Checking Deviance 6534.87 C++ Note: df105 -605760 C++ Note: df106 -0.737505 C++ Note: df100 55241 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -3353.436 C++ Note: df102 4547 C++ Note: df103 -0.007506268 C++ Note: df104 -0.6567497 C++ Note: Checking Deviance 6534.871 C++ Note: df105 -605760.4 C++ Note: df106 -0.7375051 C++ Note: df101 -3353.44 C++ Note: df102 4547 C++ Note: df103 -0.00750627 C++ Note: df104 -0.65675 C++ Note: Checking Deviance 6534.87 C++ Note: df105 -605760 C++ Note: df106 -0.737505 C++ Note: ending guess 1 C++ Note: df501 -453.0238 C++ Note: df504 0.001187626 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.001187626, -453.0238<-- Best Guess 1, -0.6567497, -3353.436 C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.00118763 C++ Note: sums checked 6789.15 C++ Note: derivs checked 338814 C++ Note: second derivs checked 1.92247e+07 C++ Note: dose checked 6400 C++ Note: non-dose checked 6789.15 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 6789.15 C++ Note: risk checked 96.6187 C++ Note: risk1 checked 4821.78 C++ Note: risk2 checked 273594 C++ Note: Made Risk Side Lists C++ Note: df101 -453.024 C++ Note: df102 -5.81673 C++ Note: df103 -258332 C++ Note: df104 0.00118763 C++ Note: Checking Deviance 734.048 C++ Note: df105 2.25165e-05 C++ Note: df106 77.8828 C++ Note: Starting Halves C++ Note: df501 -453.0238 C++ Note: df504 0.001187626 C++ Note: values checked 0.00117074 C++ Note: sums checked 6783.43 C++ Note: derivs checked 338490 C++ Note: second derivs checked 1.92047e+07 C++ Note: dose checked 6400 C++ Note: non-dose checked 6783.43 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 6783.43 C++ Note: risk checked 96.5373 C++ Note: risk1 checked 4817.16 C++ Note: risk2 checked 273308 C++ Note: df101 -453.024 C++ Note: df102 -1.45646 C++ Note: df103 -258063 C++ Note: df104 0.00117074 C++ Note: Checking Deviance 734.048 C++ Note: df105 5.64383e-06 C++ Note: df106 311.044 C++ Note: df100 58708 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 58777 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -453.0238 C++ Note: df102 -1.456462 C++ Note: df103 -258062.6 C++ Note: df104 0.001170738 C++ Note: Checking Deviance 734.0475 C++ Note: df105 5.643831e-06 C++ Note: df106 311.044 C++ Note: df101 -453.024 C++ Note: df102 -1.45646 C++ Note: df103 -258063 C++ Note: df104 0.00117074 C++ Note: Checking Deviance 734.048 C++ Note: df105 5.64383e-06 C++ Note: df106 311.044 C++ Note: df501 -453.0238 C++ Note: df504 0.001170738 Note: INITIAL TERM COMPLETE -453.023771775741-1.45646188135377-258062.6192906570.001170738260005380.00196850920303236736.047543551483914.81159682083734.047543551483list(Term_n = 0, tforms = "loglin", names = "t0")list(Iteration = 1, `Maximum Step` = 1, `Derivative Limiting` = 1.45646188135377)FALSE Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 1 2 C++ Note: df99,47,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 3 C++ Note: values checked 0.001170738 -15 C++ Note: sums checked 6783.433 2624.001 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 6783.433 2624.001 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 6783.433 2624.001 C++ Note: df99,1119,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Note: 1 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 1 2 C++ Note: df99,47,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 3 C++ Note: values checked 0.001170738 -14.70875 C++ Note: sums checked 6783.433 2624.002 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 6783.433 2624.002 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 6783.433 2624.002 C++ Note: df99,762,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 Warning: Term_n expects nonnegative integer values and a minimum of 0, minimum value was 1. Minimum value set to 0, others shifted by -1 C++ Note: START_POIS_GUESS C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 1 C++ Note: df99,33,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.00117074 -15 C++ Note: sums checked 6783.43 2624 C++ Note: derivs checked 338490 0.00115509 C++ Note: second derivs checked 1.92047e+07 0.00115509 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6783.43 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6783.43 2624 C++ Note: risk checked 68.9427 C++ Note: risk1 checked 3440.2 8.44128e-06 C++ Note: risk2 checked 195184 8.44128e-06 C++ Note: df101 -449.786 -449.786 C++ Note: df102 1301.49 2.10724e-06 C++ Note: df103 -184138 2.10723e-06 C++ Note: df104 0.00117074 -15 C++ Note: Checking Deviance 727.572 C++ Note: df105 -0.00706799 1 C++ Note: df106 -0.345594 -2.13449e+08 C++ Note: Starting Halves C++ Note: df501 -449.7862 C++ Note: df504 0.001170738 -15 C++ Note: values checked 0.00647173 -14.7473 C++ Note: sums checked 8879.85 2624 C++ Note: derivs checked 459108 0.00148711 C++ Note: second derivs checked 2.67413e+07 0.00148711 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 8879.85 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 8879.85 2624 C++ Note: risk checked 90.2494 C++ Note: risk1 checked 4666.09 1.42263e-05 C++ Note: risk2 checked 271782 1.42263e-05 C++ Note: df101 -445.784 -445.784 C++ Note: df102 144.977 -4.6517e-07 C++ Note: df103 -256401 -4.65175e-07 C++ Note: df104 0.00647173 -14.7473 C++ Note: Checking Deviance 719.567 C++ Note: df105 -0.000565432 0.999989 C++ Note: df106 -3.07485 9.58323e+08 C++ Note: df100 5216 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 5259 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -445.7835 -445.7835 C++ Note: df102 144.9775 -4.651702e-07 C++ Note: df103 -256401.3 -4.651753e-07 C++ Note: df104 0.006471732 -14.74734 C++ Note: Checking Deviance 719.567 C++ Note: df105 -0.0005654319 0.999989 C++ Note: df106 -3.074847 9.583235e+08 C++ Note: Starting Halves C++ Note: df501 -445.7835 C++ Note: df504 0.006471732 -14.74734 C++ Note: values checked 0.00689581 -15.7473 C++ Note: sums checked 9076.98 2624 C++ Note: derivs checked 470601 0.000547078 C++ Note: second derivs checked 2.74662e+07 0.000547078 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 9076.98 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 9076.98 2624 C++ Note: risk checked 92.2528 C++ Note: risk1 checked 4782.9 5.34976e-06 C++ Note: risk2 checked 279149 5.34976e-06 C++ Note: df101 -445.745 -445.745 C++ Note: df102 34.7771 -2.8106e-07 C++ Note: df103 -263351 -2.81061e-07 C++ Note: df104 0.00689581 -15.7473 C++ Note: Checking Deviance 719.491 C++ Note: df105 -0.000132056 0.999998 C++ Note: df106 -12.8172 1.58594e+09 C++ Note: df100 7113 1 2 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 7151 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -445.7453 -445.7453 C++ Note: df102 34.77706 -2.810604e-07 C++ Note: df103 -263351.4 -2.810611e-07 C++ Note: df104 0.00689581 -15.74734 C++ Note: Checking Deviance 719.4906 C++ Note: df105 -0.0001320557 0.9999975 C++ Note: df106 -12.81722 1.585941e+09 C++ Note: Starting Halves C++ Note: df501 -445.7453 C++ Note: df504 0.00689581 -15.74734 C++ Note: values checked 0.00699485 -16.5898 C++ Note: sums checked 9123.72 2624 C++ Note: derivs checked 473330 0.000235593 C++ Note: second derivs checked 2.76384e+07 0.000235593 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 9123.72 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 9123.72 2624 C++ Note: risk checked 92.7279 C++ Note: risk1 checked 4810.64 2.31568e-06 C++ Note: risk2 checked 280900 2.31568e-06 C++ Note: df101 -445.743 -445.743 C++ Note: df102 8.61249 -1.32262e-07 C++ Note: df103 -265003 -1.32262e-07 C++ Note: df104 0.00699485 -16.5898 C++ Note: Checking Deviance 719.486 C++ Note: df105 -3.24996e-05 0.999999 C++ Note: df106 -51.7554 3.37015e+09 C++ Note: df100 8957 1 3 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 8996 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -445.7431 -445.7431 C++ Note: df102 8.612495 -1.322621e-07 C++ Note: df103 -265003 -1.322622e-07 C++ Note: df104 0.006994853 -16.58982 C++ Note: Checking Deviance 719.4863 C++ Note: df105 -3.249961e-05 0.999999 C++ Note: df106 -51.7554 3.370151e+09 C++ Note: Starting Halves C++ Note: df501 -445.7431 C++ Note: df504 0.006994853 -16.58982 C++ Note: values checked 0.00701923 -17.3608 C++ Note: sums checked 9135.27 2624 C++ Note: derivs checked 474004 0.000108979 C++ Note: second derivs checked 2.7681e+07 0.000108979 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 9135.27 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 9135.27 2624 C++ Note: risk checked 92.8452 C++ Note: risk1 checked 4817.49 1.07253e-06 C++ Note: risk2 checked 281333 1.07253e-06 C++ Note: df101 -445.743 -445.743 C++ Note: df102 2.14812 -6.24636e-08 C++ Note: df103 -265411 -6.24636e-08 C++ Note: df104 0.00701923 -17.3608 C++ Note: Checking Deviance 719.486 C++ Note: df105 -8.09357e-06 1 C++ Note: df106 -207.503 7.13605e+09 C++ Note: df100 10838 1 4 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 10878 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -445.743 -445.743 C++ Note: df102 2.148124 -6.246358e-08 C++ Note: df103 -265411.2 -6.246361e-08 C++ Note: df104 0.007019228 -17.36077 C++ Note: Checking Deviance 719.486 C++ Note: df105 -8.093573e-06 0.9999996 C++ Note: df106 -207.5033 7.136046e+09 C++ Note: Starting Halves C++ Note: df501 -445.743 C++ Note: df504 0.007019228 -17.36077 C++ Note: values checked 0.0070253 -18.1159 C++ Note: sums checked 9138.14 2624 C++ Note: derivs checked 474172 5.12154e-05 C++ Note: second derivs checked 2.76916e+07 5.12154e-05 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 9138.14 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 9138.14 2624 C++ Note: risk checked 92.8745 C++ Note: risk1 checked 4819.2 5.042e-07 C++ Note: risk2 checked 281440 5.042e-07 C++ Note: df101 -445.743 -445.743 C++ Note: df102 0.53671 -2.95054e-08 C++ Note: df103 -265513 -2.95054e-08 C++ Note: df104 0.0070253 -18.1159 C++ Note: Checking Deviance 719.486 C++ Note: df105 -2.02141e-06 1 C++ Note: df106 -830.509 1.51072e+10 C++ Note: df100 12709 1 5 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 12744 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -445.743 -445.743 C++ Note: df102 0.5367105 -2.950535e-08 C++ Note: df103 -265512.9 -2.950536e-08 C++ Note: df104 0.007025298 -18.11589 C++ Note: Checking Deviance 719.486 C++ Note: df105 -2.02141e-06 0.9999998 C++ Note: df106 -830.5092 1.510719e+10 C++ Note: df101 -445.743 -445.743 C++ Note: df102 0.53671 -2.95054e-08 C++ Note: df103 -265513 -2.95054e-08 C++ Note: df104 0.0070253 -18.1159 C++ Note: Checking Deviance 719.486 C++ Note: df105 -2.02141e-06 1 C++ Note: df106 -830.509 1.51072e+10 C++ Note: ending guess 0 C++ Note: df501 -445.743 C++ Note: df504 0.007025298 -18.11589 C++ Note: starting subterms 2 in guess 1 C++ Note: values checked 0.00117074 -14.7087 C++ Note: sums checked 6783.43 2624 C++ Note: derivs checked 338490 0.00154562 C++ Note: second derivs checked 1.92047e+07 0.00154562 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6783.43 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6783.43 2624 C++ Note: risk checked 68.9427 C++ Note: risk1 checked 3440.2 1.12953e-05 C++ Note: risk2 checked 195184 1.12953e-05 C++ Note: df101 -449.786 -449.786 C++ Note: df102 1301.49 2.81969e-06 C++ Note: df103 -184138 2.81969e-06 C++ Note: df104 0.00117074 -14.7087 C++ Note: Checking Deviance 727.572 C++ Note: df105 -0.00706799 1 C++ Note: df106 -0.345594 -1.59516e+08 C++ Note: Starting Halves C++ Note: df501 -445.743 C++ Note: df504 0.007025298 -18.11589 C++ Note: values checked 0.00647173 -14.4561 C++ Note: sums checked 8879.85 2624 C++ Note: derivs checked 459108 0.00198991 C++ Note: second derivs checked 2.67413e+07 0.00198991 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 8879.85 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 8879.85 2624 C++ Note: risk checked 90.2494 C++ Note: risk1 checked 4666.09 1.90363e-05 C++ Note: risk2 checked 271782 1.90363e-05 C++ Note: df101 -445.784 -445.784 C++ Note: df102 144.977 -6.22447e-07 C++ Note: df103 -256401 -6.22456e-07 C++ Note: df104 0.00647173 -14.4561 C++ Note: Checking Deviance 719.567 C++ Note: df105 -0.000565432 0.999985 C++ Note: df106 -3.07485 7.16179e+08 C++ Note: df100 16672 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked 0.00382123 -14.5824 C++ Note: sums checked 7751.91 2624 C++ Note: derivs checked 393818 0.00175375 C++ Note: second derivs checked 2.26445e+07 0.00175375 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 7751.91 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 7751.91 2624 C++ Note: risk checked 78.7857 C++ Note: risk1 checked 4002.52 1.46461e-05 C++ Note: risk2 checked 230144 1.46461e-05 C++ Note: df101 -447.02 -447.02 C++ Note: df102 770.99 1.46795e-06 C++ Note: df103 -217120 1.46794e-06 C++ Note: df104 0.00382123 -14.5824 C++ Note: Checking Deviance 722.041 C++ Note: df105 -0.00355099 1 C++ Note: df106 -0.579801 -3.0452e+08 C++ Note: df100 18358 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked 0.00249599 -14.6456 C++ Note: sums checked 7249.35 2624 C++ Note: derivs checked 365015 0.0016464 C++ Note: second derivs checked 2.08497e+07 0.0016464 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 7249.35 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 7249.35 2624 C++ Note: risk checked 73.678 C++ Note: risk1 checked 3709.79 1.28582e-05 C++ Note: risk2 checked 211904 1.28582e-05 C++ Note: df101 -448.228 -448.228 C++ Note: df102 1047.16 2.22157e-06 C++ Note: df103 -199911 2.22156e-06 C++ Note: df104 0.00249599 -14.6456 C++ Note: Checking Deviance 724.455 C++ Note: df105 -0.00523812 1 C++ Note: df106 -0.428042 -2.01762e+08 C++ Note: df100 19999 3 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked 0.00183336 -14.6772 C++ Note: sums checked 7012 2624 C++ Note: derivs checked 351480 0.00159522 C++ Note: second derivs checked 2.00093e+07 0.00159522 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 7012 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 7012 2624 C++ Note: risk checked 71.2657 C++ Note: risk1 checked 3572.23 1.20505e-05 C++ Note: risk2 checked 203362 1.20505e-05 C++ Note: df101 -448.965 -448.965 C++ Note: df102 1176.94 2.53848e-06 C++ Note: df103 -191853 2.53847e-06 C++ Note: df104 0.00183336 -14.6772 C++ Note: Checking Deviance 725.93 C++ Note: df105 -0.00613456 1 C++ Note: df106 -0.381469 -1.76864e+08 C++ Note: df100 21640 4 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked 0.00150205 -14.693 C++ Note: sums checked 6896.64 2624 C++ Note: derivs checked 344918 0.00157023 C++ Note: second derivs checked 1.96026e+07 0.00157023 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6896.64 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6896.64 2624 C++ Note: risk checked 70.0932 C++ Note: risk1 checked 3505.54 1.16666e-05 C++ Note: risk2 checked 199229 1.16666e-05 C++ Note: df101 -449.365 -449.365 C++ Note: df102 1239.85 2.68336e-06 C++ Note: df103 -187954 2.68336e-06 C++ Note: df104 0.00150205 -14.693 C++ Note: Checking Deviance 726.73 C++ Note: df105 -0.00659657 1 C++ Note: df106 -0.362435 -1.67463e+08 C++ Note: df100 23488 5 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Changing back to best C++ Note: values checked 0.00117074 -14.7087 C++ Note: sums checked 6783.43 2624 C++ Note: derivs checked 338490 0.00154562 C++ Note: second derivs checked 1.92047e+07 0.00154562 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6783.43 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6783.43 2624 C++ Note: risk checked 68.9427 C++ Note: risk1 checked 3440.2 1.12953e-05 C++ Note: risk2 checked 195184 1.12953e-05 C++ Note: df101 -449.786 -449.786 C++ Note: df102 1301.49 2.81969e-06 C++ Note: df103 -184138 2.81969e-06 C++ Note: df104 0.00117074 -14.7087 C++ Note: Checking Deviance 727.572 C++ Note: df105 -0.00706799 1 C++ Note: df106 -0.345594 -1.59516e+08 C++ Note: df100 25146 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -449.7862 -449.7862 C++ Note: df102 1301.488 2.819695e-06 C++ Note: df103 -184138.3 2.819689e-06 C++ Note: df104 0.001170738 -14.70875 C++ Note: Checking Deviance 727.5724 C++ Note: df105 -0.007067992 1.000002 C++ Note: df106 -0.3455937 -1.595159e+08 C++ Note: Starting Halves C++ Note: df501 -445.743 C++ Note: df504 0.007025298 -18.11589 C++ Note: values checked 0.00647173 -14.6775 C++ Note: sums checked 8879.85 2624 C++ Note: derivs checked 459108 0.00159469 C++ Note: second derivs checked 2.67413e+07 0.00159469 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 8879.85 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 8879.85 2624 C++ Note: risk checked 90.2494 C++ Note: risk1 checked 4666.09 1.52555e-05 C++ Note: risk2 checked 271782 1.52555e-05 C++ Note: df101 -445.784 -445.784 C++ Note: df102 144.978 -4.9882e-07 C++ Note: df103 -256401 -4.98826e-07 C++ Note: df104 0.00647173 -14.6775 C++ Note: Checking Deviance 719.567 C++ Note: df105 -0.000565433 0.999988 C++ Note: df106 -3.07484 8.93676e+08 C++ Note: df100 26992 1 2 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked 0.00382123 -14.6931 C++ Note: sums checked 7751.91 2624 C++ Note: derivs checked 393818 0.00156996 C++ Note: second derivs checked 2.26445e+07 0.00156996 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 7751.91 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 7751.91 2624 C++ Note: risk checked 78.7857 C++ Note: risk1 checked 4002.52 1.31112e-05 C++ Note: risk2 checked 230144 1.31112e-05 C++ Note: df101 -447.02 -447.02 C++ Note: df102 770.99 1.31411e-06 C++ Note: df103 -217120 1.31411e-06 C++ Note: df104 0.00382123 -14.6931 C++ Note: Checking Deviance 722.041 C++ Note: df105 -0.00355099 1 C++ Note: df106 -0.5798 -3.40169e+08 C++ Note: df100 28598 2 2 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked 0.00249599 -14.7009 C++ Note: sums checked 7249.35 2624 C++ Note: derivs checked 365015 0.00155775 C++ Note: second derivs checked 2.08497e+07 0.00155775 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 7249.35 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 7249.35 2624 C++ Note: risk checked 73.678 C++ Note: risk1 checked 3709.79 1.21658e-05 C++ Note: risk2 checked 211904 1.21658e-05 C++ Note: df101 -448.228 -448.228 C++ Note: df102 1047.16 2.10194e-06 C++ Note: df103 -199911 2.10193e-06 C++ Note: df104 0.00249599 -14.7009 C++ Note: Checking Deviance 724.455 C++ Note: df105 -0.00523812 1 C++ Note: df106 -0.428042 -2.13245e+08 C++ Note: df100 30237 3 2 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked 0.00183336 -14.7048 C++ Note: sums checked 7012 2624 C++ Note: derivs checked 351480 0.00155167 C++ Note: second derivs checked 2.00093e+07 0.00155167 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 7012 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 7012 2624 C++ Note: risk checked 71.2657 C++ Note: risk1 checked 3572.23 1.17216e-05 C++ Note: risk2 checked 203362 1.17216e-05 C++ Note: df101 -448.965 -448.965 C++ Note: df102 1176.94 2.46919e-06 C++ Note: df103 -191853 2.46918e-06 C++ Note: df104 0.00183336 -14.7048 C++ Note: Checking Deviance 725.93 C++ Note: df105 -0.00613456 1 C++ Note: df106 -0.381469 -1.81827e+08 C++ Note: df100 32411 4 2 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked 0.00150205 -14.7068 C++ Note: sums checked 6896.64 2624 C++ Note: derivs checked 344918 0.00154865 C++ Note: second derivs checked 1.96026e+07 0.00154865 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6896.64 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6896.64 2624 C++ Note: risk checked 70.0932 C++ Note: risk1 checked 3505.54 1.15063e-05 C++ Note: risk2 checked 199229 1.15063e-05 C++ Note: df101 -449.365 -449.365 C++ Note: df102 1239.85 2.64649e-06 C++ Note: df103 -187954 2.64648e-06 C++ Note: df104 0.00150205 -14.7068 C++ Note: Checking Deviance 726.73 C++ Note: df105 -0.00659657 1 C++ Note: df106 -0.362435 -1.69797e+08 C++ Note: df100 34155 5 2 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Changing back to best C++ Note: values checked 0.00117074 -14.7087 C++ Note: sums checked 6783.43 2624 C++ Note: derivs checked 338490 0.00154562 C++ Note: second derivs checked 1.92047e+07 0.00154562 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6783.43 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6783.43 2624 C++ Note: risk checked 68.9427 C++ Note: risk1 checked 3440.2 1.12953e-05 C++ Note: risk2 checked 195184 1.12953e-05 C++ Note: df101 -449.786 -449.786 C++ Note: df102 1301.49 2.81969e-06 C++ Note: df103 -184138 2.81969e-06 C++ Note: df104 0.00117074 -14.7087 C++ Note: Checking Deviance 727.572 C++ Note: df105 -0.00706799 1 C++ Note: df106 -0.345594 -1.59516e+08 C++ Note: df100 35806 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -449.7862 -449.7862 C++ Note: df102 1301.488 2.819695e-06 C++ Note: df103 -184138.3 2.819689e-06 C++ Note: df104 0.001170738 -14.70875 C++ Note: Checking Deviance 727.5724 C++ Note: df105 -0.007067992 1.000002 C++ Note: df106 -0.3455937 -1.595159e+08 C++ Note: Starting Halves C++ Note: df501 -445.743 C++ Note: df504 0.007025298 -18.11589 C++ Note: values checked 0.0021473 -14.7078 C++ Note: sums checked 7123.33 2624 C++ Note: derivs checked 357823 0.00154714 C++ Note: second derivs checked 2.04029e+07 0.00154714 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 7123.33 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 7123.33 2624 C++ Note: risk checked 72.3972 C++ Note: risk1 checked 3636.7 1.18729e-05 C++ Note: risk2 checked 207363 1.18729e-05 C++ Note: df101 -448.605 -448.605 C++ Note: df102 1116.12 2.28637e-06 C++ Note: df103 -195627 2.28636e-06 C++ Note: df104 0.0021473 -14.7078 C++ Note: Checking Deviance 725.21 C++ Note: df105 -0.00570531 1 C++ Note: df106 -0.401934 -1.96208e+08 C++ Note: df100 37680 1 3 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked 0.00165902 -14.7083 C++ Note: sums checked 6951.02 2624 C++ Note: derivs checked 348010 0.00154638 C++ Note: second derivs checked 1.97942e+07 0.00154638 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6951.02 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6951.02 2624 C++ Note: risk checked 70.646 C++ Note: risk1 checked 3536.96 1.158e-05 C++ Note: risk2 checked 201176 1.158e-05 C++ Note: df101 -449.173 -449.173 C++ Note: df102 1210.2 2.55688e-06 C++ Note: df103 -189791 2.55688e-06 C++ Note: df104 0.00165902 -14.7083 C++ Note: Checking Deviance 726.346 C++ Note: df105 -0.00637651 1 C++ Note: df106 -0.371155 -1.75672e+08 C++ Note: df100 39633 2 3 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked 0.00141488 -14.7085 C++ Note: sums checked 6866.65 2624 C++ Note: derivs checked 343214 0.001546 C++ Note: second derivs checked 1.94971e+07 0.001546 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6866.65 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6866.65 2624 C++ Note: risk checked 69.7884 C++ Note: risk1 checked 3488.22 1.14367e-05 C++ Note: risk2 checked 198156 1.14367e-05 C++ Note: df101 -449.474 -449.474 C++ Note: df102 1256.19 2.68924e-06 C++ Note: df103 -186942 2.68923e-06 C++ Note: df104 0.00141488 -14.7085 C++ Note: Checking Deviance 726.948 C++ Note: df105 -0.00671968 1 C++ Note: df106 -0.357807 -1.67138e+08 C++ Note: df100 42275 3 3 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked 0.00129281 -14.7086 C++ Note: sums checked 6824.9 2624 C++ Note: derivs checked 340843 0.00154581 C++ Note: second derivs checked 1.93503e+07 0.00154581 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6824.9 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6824.9 2624 C++ Note: risk checked 69.3641 C++ Note: risk1 checked 3464.12 1.13657e-05 C++ Note: risk2 checked 196664 1.13657e-05 C++ Note: df101 -449.629 -449.629 C++ Note: df102 1278.93 2.7547e-06 C++ Note: df103 -185535 2.7547e-06 C++ Note: df104 0.00129281 -14.7086 C++ Note: Checking Deviance 727.257 C++ Note: df105 -0.00689319 1 C++ Note: df106 -0.351568 -1.63222e+08 C++ Note: df100 44860 4 3 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked 0.00123177 -14.7087 C++ Note: sums checked 6804.13 2624 C++ Note: derivs checked 339664 0.00154572 C++ Note: second derivs checked 1.92773e+07 0.00154572 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6804.13 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6804.13 2624 C++ Note: risk checked 69.153 C++ Note: risk1 checked 3452.14 1.13305e-05 C++ Note: risk2 checked 195923 1.13305e-05 C++ Note: df101 -449.707 -449.707 C++ Note: df102 1290.23 2.78726e-06 C++ Note: df103 -184835 2.78725e-06 C++ Note: df104 0.00123177 -14.7087 C++ Note: Checking Deviance 727.414 C++ Note: df105 -0.00698043 1 C++ Note: df106 -0.348549 -1.61344e+08 C++ Note: df100 47545 5 3 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Changing back to best C++ Note: values checked 0.00117074 -14.7087 C++ Note: sums checked 6783.43 2624 C++ Note: derivs checked 338490 0.00154562 C++ Note: second derivs checked 1.92047e+07 0.00154562 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6783.43 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6783.43 2624 C++ Note: risk checked 68.9427 C++ Note: risk1 checked 3440.2 1.12953e-05 C++ Note: risk2 checked 195184 1.12953e-05 C++ Note: df101 -449.786 -449.786 C++ Note: df102 1301.49 2.81969e-06 C++ Note: df103 -184138 2.81969e-06 C++ Note: df104 0.00117074 -14.7087 C++ Note: Checking Deviance 727.572 C++ Note: df105 -0.00706799 1 C++ Note: df106 -0.345594 -1.59516e+08 C++ Note: df100 50048 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -449.7862 -449.7862 C++ Note: df102 1301.488 2.819695e-06 C++ Note: df103 -184138.3 2.819689e-06 C++ Note: df104 0.001170738 -14.70875 C++ Note: Checking Deviance 727.5724 C++ Note: df105 -0.007067992 1.000002 C++ Note: df106 -0.3455937 -1.595159e+08 C++ Note: Starting Halves C++ Note: df501 -445.743 C++ Note: df504 0.007025298 -18.11589 C++ Note: values checked 0.00120126 -14.7087 C++ Note: sums checked 6793.77 2624 C++ Note: derivs checked 339076 0.00154567 C++ Note: second derivs checked 1.9241e+07 0.00154567 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6793.77 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6793.77 2624 C++ Note: risk checked 69.0477 C++ Note: risk1 checked 3446.17 1.13129e-05 C++ Note: risk2 checked 195553 1.13129e-05 C++ Note: df101 -449.747 -449.747 C++ Note: df102 1295.86 2.80349e-06 C++ Note: df103 -184486 2.80348e-06 C++ Note: df104 0.00120126 -14.7087 C++ Note: Checking Deviance 727.493 C++ Note: df105 -0.00702417 1 C++ Note: df106 -0.347063 -1.60424e+08 C++ Note: df100 51925 1 4 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked 0.001186 -14.7087 C++ Note: sums checked 6788.6 2624 C++ Note: derivs checked 338783 0.00154565 C++ Note: second derivs checked 1.92228e+07 0.00154565 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6788.6 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6788.6 2624 C++ Note: risk checked 68.9952 C++ Note: risk1 checked 3443.18 1.13041e-05 C++ Note: risk2 checked 195369 1.13041e-05 C++ Note: df101 -449.766 -449.766 C++ Note: df102 1298.68 2.8116e-06 C++ Note: df103 -184312 2.81159e-06 C++ Note: df104 0.001186 -14.7087 C++ Note: Checking Deviance 727.533 C++ Note: df105 -0.00704607 1 C++ Note: df106 -0.346327 -1.59968e+08 C++ Note: df100 53609 2 4 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked 0.00117837 -14.7087 C++ Note: sums checked 6786.02 2624 C++ Note: derivs checked 338636 0.00154564 C++ Note: second derivs checked 1.92137e+07 0.00154564 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6786.02 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6786.02 2624 C++ Note: risk checked 68.9689 C++ Note: risk1 checked 3441.69 1.12997e-05 C++ Note: risk2 checked 195277 1.12997e-05 C++ Note: df101 -449.776 -449.776 C++ Note: df102 1300.08 2.81565e-06 C++ Note: df103 -184225 2.81564e-06 C++ Note: df104 0.00117837 -14.7087 C++ Note: Checking Deviance 727.553 C++ Note: df105 -0.00705703 1 C++ Note: df106 -0.34596 -1.59742e+08 C++ Note: df100 55236 3 4 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked 0.00117455 -14.7087 C++ Note: sums checked 6784.72 2624 C++ Note: derivs checked 338563 0.00154563 C++ Note: second derivs checked 1.92092e+07 0.00154563 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6784.72 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6784.72 2624 C++ Note: risk checked 68.9558 C++ Note: risk1 checked 3440.95 1.12975e-05 C++ Note: risk2 checked 195230 1.12975e-05 C++ Note: df101 -449.781 -449.781 C++ Note: df102 1300.79 2.81767e-06 C++ Note: df103 -184182 2.81767e-06 C++ Note: df104 0.00117455 -14.7087 C++ Note: Checking Deviance 727.563 C++ Note: df105 -0.00706251 1 C++ Note: df106 -0.345777 -1.59629e+08 C++ Note: df100 56960 4 4 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked 0.00117265 -14.7087 C++ Note: sums checked 6784.08 2624 C++ Note: derivs checked 338526 0.00154563 C++ Note: second derivs checked 1.92069e+07 0.00154563 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6784.08 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6784.08 2624 C++ Note: risk checked 68.9492 C++ Note: risk1 checked 3440.58 1.12964e-05 C++ Note: risk2 checked 195207 1.12964e-05 C++ Note: df101 -449.784 -449.784 C++ Note: df102 1301.14 2.81868e-06 C++ Note: df103 -184160 2.81868e-06 C++ Note: df104 0.00117265 -14.7087 C++ Note: Checking Deviance 727.567 C++ Note: df105 -0.00706525 1 C++ Note: df106 -0.345685 -1.59572e+08 C++ Note: df100 58592 5 4 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Changing back to best C++ Note: values checked 0.00117074 -14.7087 C++ Note: sums checked 6783.43 2624 C++ Note: derivs checked 338490 0.00154562 C++ Note: second derivs checked 1.92047e+07 0.00154562 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6783.43 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6783.43 2624 C++ Note: risk checked 68.9427 C++ Note: risk1 checked 3440.2 1.12953e-05 C++ Note: risk2 checked 195184 1.12953e-05 C++ Note: df101 -449.786 -449.786 C++ Note: df102 1301.49 2.81969e-06 C++ Note: df103 -184138 2.81969e-06 C++ Note: df104 0.00117074 -14.7087 C++ Note: Checking Deviance 727.572 C++ Note: df105 -0.00706799 1 C++ Note: df106 -0.345594 -1.59516e+08 C++ Note: df100 60252 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -449.7862 -449.7862 C++ Note: df102 1301.488 2.819695e-06 C++ Note: df103 -184138.3 2.819689e-06 C++ Note: df104 0.001170738 -14.70875 C++ Note: Checking Deviance 727.5724 C++ Note: df105 -0.007067992 1.000002 C++ Note: df106 -0.3455937 -1.595159e+08 C++ Note: Starting Halves C++ Note: df501 -445.743 C++ Note: df504 0.007025298 -18.11589 C++ Note: values checked 0.00117169 -14.7087 C++ Note: sums checked 6783.76 2624 C++ Note: derivs checked 338508 0.00154563 C++ Note: second derivs checked 1.92058e+07 0.00154563 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6783.76 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6783.76 2624 C++ Note: risk checked 68.9459 C++ Note: risk1 checked 3440.39 1.12958e-05 C++ Note: risk2 checked 195196 1.12958e-05 C++ Note: df101 -449.785 -449.785 C++ Note: df102 1301.31 2.81919e-06 C++ Note: df103 -184149 2.81918e-06 C++ Note: df104 0.00117169 -14.7087 C++ Note: Checking Deviance 727.57 C++ Note: df105 -0.00706662 1 C++ Note: df106 -0.345639 -1.59544e+08 C++ Note: df100 62121 1 5 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked 0.00117122 -14.7087 C++ Note: sums checked 6783.59 2624 C++ Note: derivs checked 338499 0.00154563 C++ Note: second derivs checked 1.92052e+07 0.00154563 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6783.59 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6783.59 2624 C++ Note: risk checked 68.9443 C++ Note: risk1 checked 3440.3 1.12956e-05 C++ Note: risk2 checked 195190 1.12956e-05 C++ Note: df101 -449.786 -449.786 C++ Note: df102 1301.4 2.81944e-06 C++ Note: df103 -184144 2.81944e-06 C++ Note: df104 0.00117122 -14.7087 C++ Note: Checking Deviance 727.571 C++ Note: df105 -0.00706731 1 C++ Note: df106 -0.345617 -1.5953e+08 C++ Note: df100 63802 2 5 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked 0.00117098 -14.7087 C++ Note: sums checked 6783.51 2624 C++ Note: derivs checked 338494 0.00154563 C++ Note: second derivs checked 1.92049e+07 0.00154563 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6783.51 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6783.51 2624 C++ Note: risk checked 68.9435 C++ Note: risk1 checked 3440.25 1.12954e-05 C++ Note: risk2 checked 195187 1.12954e-05 C++ Note: df101 -449.786 -449.786 C++ Note: df102 1301.44 2.81957e-06 C++ Note: df103 -184141 2.81956e-06 C++ Note: df104 0.00117098 -14.7087 C++ Note: Checking Deviance 727.572 C++ Note: df105 -0.00706765 1 C++ Note: df106 -0.345605 -1.59523e+08 C++ Note: df100 65506 3 5 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked 0.00117086 -14.7087 C++ Note: sums checked 6783.47 2624 C++ Note: derivs checked 338492 0.00154563 C++ Note: second derivs checked 1.92048e+07 0.00154563 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6783.47 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6783.47 2624 C++ Note: risk checked 68.9431 C++ Note: risk1 checked 3440.23 1.12954e-05 C++ Note: risk2 checked 195186 1.12954e-05 C++ Note: df101 -449.786 -449.786 C++ Note: df102 1301.47 2.81963e-06 C++ Note: df103 -184140 2.81963e-06 C++ Note: df104 0.00117086 -14.7087 C++ Note: Checking Deviance 727.572 C++ Note: df105 -0.00706782 1 C++ Note: df106 -0.345599 -1.59519e+08 C++ Note: df100 67148 4 5 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked 0.0011708 -14.7087 C++ Note: sums checked 6783.45 2624 C++ Note: derivs checked 338491 0.00154562 C++ Note: second derivs checked 1.92047e+07 0.00154562 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6783.45 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6783.45 2624 C++ Note: risk checked 68.9429 C++ Note: risk1 checked 3440.21 1.12953e-05 C++ Note: risk2 checked 195185 1.12953e-05 C++ Note: df101 -449.786 -449.786 C++ Note: df102 1301.48 2.81966e-06 C++ Note: df103 -184139 2.81966e-06 C++ Note: df104 0.0011708 -14.7087 C++ Note: Checking Deviance 727.572 C++ Note: df105 -0.00706791 1 C++ Note: df106 -0.345597 -1.59518e+08 C++ Note: df100 68785 5 5 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Changing back to best C++ Note: values checked 0.00117074 -14.7087 C++ Note: sums checked 6783.43 2624 C++ Note: derivs checked 338490 0.00154562 C++ Note: second derivs checked 1.92047e+07 0.00154562 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6783.43 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6783.43 2624 C++ Note: risk checked 68.9427 C++ Note: risk1 checked 3440.2 1.12953e-05 C++ Note: risk2 checked 195184 1.12953e-05 C++ Note: df101 -449.786 -449.786 C++ Note: df102 1301.49 2.81969e-06 C++ Note: df103 -184138 2.81969e-06 C++ Note: df104 0.00117074 -14.7087 C++ Note: Checking Deviance 727.572 C++ Note: df105 -0.00706799 1 C++ Note: df106 -0.345594 -1.59516e+08 C++ Note: df100 70442 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -449.7862 -449.7862 C++ Note: df102 1301.488 2.819695e-06 C++ Note: df103 -184138.3 2.819689e-06 C++ Note: df104 0.001170738 -14.70875 C++ Note: Checking Deviance 727.5724 C++ Note: df105 -0.007067992 1.000002 C++ Note: df106 -0.3455937 -1.595159e+08 C++ Note: df101 -449.786 -449.786 C++ Note: df102 1301.49 2.81969e-06 C++ Note: df103 -184138 2.81969e-06 C++ Note: df104 0.00117074 -14.7087 C++ Note: Checking Deviance 727.572 C++ Note: df105 -0.00706799 1 C++ Note: df106 -0.345594 -1.59516e+08 C++ Note: ending guess 1 C++ Note: df501 -445.743 C++ Note: df504 0.007025298 -18.11589 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.007025298 -18.11589, -445.743<-- Best Guess 1, 0.001170738 -14.70875, -449.7862 C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.0070253 -18.1159 C++ Note: sums checked 9138.14 2624 C++ Note: derivs checked 474172 5.12154e-05 C++ Note: second derivs checked 2.76916e+07 5.12154e-05 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 9138.14 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 9138.14 2624 C++ Note: risk checked 92.8745 C++ Note: risk1 checked 4819.2 5.042e-07 C++ Note: risk2 checked 281440 5.042e-07 C++ Note: Made Risk Side Lists C++ Note: df101 -445.743 -445.743 C++ Note: df102 0.53671 -2.95054e-08 C++ Note: df103 -265513 -2.95054e-08 C++ Note: df104 0.0070253 -18.1159 C++ Note: Checking Deviance 719.486 C++ Note: df105 -2.02141e-06 1 C++ Note: df106 -830.509 1.51072e+10 C++ Note: Starting Halves C++ Note: df501 -445.743 C++ Note: df504 0.007025298 -18.11589 C++ Note: values checked 0.00702681 -18.8672 C++ Note: sums checked 9138.86 2624 C++ Note: derivs checked 474214 2.41617e-05 C++ Note: second derivs checked 2.76943e+07 2.41617e-05 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 9138.86 2624 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 9138.86 2624 C++ Note: risk checked 92.8818 C++ Note: risk1 checked 4819.62 2.37883e-07 C++ Note: risk2 checked 281467 2.37883e-07 C++ Note: df101 -445.743 -445.743 C++ Note: df102 0.134153 -1.39373e-08 C++ Note: df103 -265538 -1.39373e-08 C++ Note: df104 0.00702681 -18.8672 C++ Note: Checking Deviance 719.486 C++ Note: df105 -5.05211e-07 1 C++ Note: df106 -3322.65 3.19819e+10 C++ Note: df100 74658 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 74694 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -445.743 -445.743 C++ Note: df102 0.1341528 -1.393733e-08 C++ Note: df103 -265538.3 -1.393733e-08 C++ Note: df104 0.007026814 -18.86716 C++ Note: Checking Deviance 719.486 C++ Note: df105 -5.052108e-07 0.9999999 C++ Note: df106 -3322.651 3.198195e+10 C++ Note: df101 -445.743 -445.743 C++ Note: df102 0.134153 -1.39373e-08 C++ Note: df103 -265538 -1.39373e-08 C++ Note: df104 0.00702681 -18.8672 C++ Note: Checking Deviance 719.486 C++ Note: df105 -5.05211e-07 1 C++ Note: df106 -3322.65 3.19819e+10 C++ Note: df501 -445.743 C++ Note: df504 0.007026814 -18.86716 Error: Atleast one parameter must be free Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 1 C++ Note: df99,34,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 2 C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.949 3328.001 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.949 3328.001 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.949 3328.001 C++ Note: df99,512,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: START_POIS_GUESS C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 1 C++ Note: df99,52,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.95 3328 C++ Note: derivs checked 3813.95 0.000939732 C++ Note: second derivs checked 3813.95 0.000939732 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.95 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.95 3328 C++ Note: risk checked 9787.82 C++ Note: risk1 checked 6011.82 0.000944651 C++ Note: risk2 checked 6011.82 0.000944651 C++ Note: df101 -493394 -493394 C++ Note: df102 -303241 -0.047634 C++ Note: df103 -303274 -0.047634 C++ Note: df104 0.01 -15 C++ Note: Checking Deviance 986616 C++ Note: df105 0.999891 1 C++ Note: df106 1.62707 1.0358e+07 C++ Note: Starting Halves C++ Note: df501 -493394.2 C++ Note: df504 0.01 -15 C++ Note: values checked -0.739918 -15.3574 C++ Note: sums checked 4425.73 3328 C++ Note: derivs checked 1801.73 0.000657348 C++ Note: second derivs checked 1801.73 0.000657348 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 4425.73 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 4425.73 3328 C++ Note: risk checked 6616.01 C++ Note: risk1 checked 2840.01 0.000478342 C++ Note: risk2 checked 2840.01 0.000478342 C++ Note: df101 -333413 -333413 C++ Note: df102 -143235 -0.0241165 C++ Note: df103 -143268 -0.0241165 C++ Note: df104 -0.739918 -15.3574 C++ Note: Checking Deviance 666655 C++ Note: df105 0.99977 1 C++ Note: df106 2.32774 1.38251e+07 C++ Note: df100 5847 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 5925 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -333413.3 -333413.3 C++ Note: df102 -143235 -0.02411648 C++ Note: df103 -143268 -0.02411648 C++ Note: df104 -0.7399184 -15.35738 C++ Note: Checking Deviance 666654.6 C++ Note: df105 0.9997697 1 C++ Note: df106 2.327736 1.382512e+07 C++ Note: Starting Halves C++ Note: df501 -333413.3 C++ Note: df504 -0.7399184 -15.35738 C++ Note: values checked -1.48975 -15.8512 C++ Note: sums checked 3475.22 3328 C++ Note: derivs checked 851.224 0.000401193 C++ Note: second derivs checked 851.224 0.000401193 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 3475.22 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 3475.22 3328 C++ Note: risk checked 5117.76 C++ Note: risk1 checked 1341.76 0.000239343 C++ Note: risk2 checked 1341.76 0.000239343 C++ Note: df101 -257857 -257857 C++ Note: df102 -67653.7 -0.0120654 C++ Note: df103 -67686.7 -0.0120654 C++ Note: df104 -1.48975 -15.8512 C++ Note: Checking Deviance 515541 C++ Note: df105 0.999512 1 C++ Note: df106 3.81142 2.13716e+07 C++ Note: df100 8827 1 2 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 8894 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -257856.7 -257856.7 C++ Note: df102 -67653.71 -0.01206537 C++ Note: df103 -67686.71 -0.01206537 C++ Note: df104 -1.489746 -15.85115 C++ Note: Checking Deviance 515541.4 C++ Note: df105 0.9995125 1 C++ Note: df106 3.81142 2.137163e+07 C++ Note: Starting Halves C++ Note: df501 -257856.7 C++ Note: df504 -1.489746 -15.85115 C++ Note: values checked -2.23938 -16.4535 C++ Note: sums checked 3026.24 3328 C++ Note: derivs checked 402.237 0.00021966 C++ Note: second derivs checked 402.237 0.00021966 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 3026.24 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 3026.24 3328 C++ Note: risk checked 4410.03 C++ Note: risk1 checked 634.034 0.000117441 C++ Note: risk2 checked 634.034 0.000117441 C++ Note: df101 -222179 -222179 C++ Note: df102 -31951.6 -0.00591976 C++ Note: df103 -31984.6 -0.00591976 C++ Note: df104 -2.23938 -16.4535 C++ Note: Checking Deviance 444187 C++ Note: df105 0.998968 1 C++ Note: df106 6.95362 3.75318e+07 C++ Note: df100 11797 1 3 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 11868 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -222179.4 -222179.4 C++ Note: df102 -31951.63 -0.005919756 C++ Note: df103 -31984.63 -0.005919756 C++ Note: df104 -2.23938 -16.45351 C++ Note: Checking Deviance 444186.7 C++ Note: df105 0.9989683 1 C++ Note: df106 6.953616 3.753185e+07 C++ Note: Starting Halves C++ Note: df501 -222179.4 C++ Note: df504 -2.23938 -16.45351 C++ Note: values checked -2.98861 -17.1257 C++ Note: sums checked 2814.15 3328 C++ Note: derivs checked 190.15 0.000112156 C++ Note: second derivs checked 190.15 0.000112156 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2814.15 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2814.15 3328 C++ Note: risk checked 4075.73 C++ Note: risk1 checked 299.728 5.66831e-05 C++ Note: risk2 checked 299.728 5.66831e-05 C++ Note: df101 -205340 -205340 C++ Note: df102 -15087.2 -0.00285705 C++ Note: df103 -15120.2 -0.00285705 C++ Note: df104 -2.98861 -17.1257 C++ Note: Checking Deviance 410507 C++ Note: df105 0.997817 1 C++ Note: df106 13.6102 7.18712e+07 C++ Note: df100 14675 1 4 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 14748 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -205339.6 -205339.6 C++ Note: df102 -15087.16 -0.002857052 C++ Note: df103 -15120.16 -0.002857052 C++ Note: df104 -2.988606 -17.1257 C++ Note: Checking Deviance 410507.3 C++ Note: df105 0.9978175 1 C++ Note: df106 13.61022 7.187117e+07 C++ Note: Starting Halves C++ Note: df501 -205339.6 C++ Note: df504 -2.988606 -17.1257 C++ Note: values checked -3.73697 -17.8368 C++ Note: sums checked 2713.97 3328 C++ Note: derivs checked 89.9678 5.50787e-05 C++ Note: second derivs checked 89.9678 5.50787e-05 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2713.97 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2713.97 3328 C++ Note: risk checked 3917.81 C++ Note: risk1 checked 141.814 2.70754e-05 C++ Note: risk2 checked 141.814 2.70754e-05 C++ Note: df101 -197398 -197398 C++ Note: df102 -7120.96 -0.00136467 C++ Note: df103 -7153.96 -0.00136467 C++ Note: df104 -3.73697 -17.8368 C++ Note: Checking Deviance 394624 C++ Note: df105 0.995387 1 C++ Note: df106 27.7207 1.44649e+08 C++ Note: df100 17534 1 5 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 17606 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -197398.1 -197398.1 C++ Note: df102 -7120.961 -0.001364671 C++ Note: df103 -7153.961 -0.001364671 C++ Note: df104 -3.736969 -17.83683 C++ Note: Checking Deviance 394624.2 C++ Note: df105 0.9953872 1 C++ Note: df106 27.72071 1.446488e+08 C++ Note: df101 -197398 -197398 C++ Note: df102 -7120.96 -0.00136467 C++ Note: df103 -7153.96 -0.00136467 C++ Note: df104 -3.73697 -17.8368 C++ Note: Checking Deviance 394624 C++ Note: df105 0.995387 1 C++ Note: df106 27.7207 1.44649e+08 C++ Note: ending guess 0 C++ Note: df501 -197398.1 C++ Note: df504 -3.736969 -17.83683 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -3.736969 -17.83683, -197398.1<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked -3.73697 -17.8368 C++ Note: sums checked 2713.97 3328 C++ Note: derivs checked 89.9678 5.50787e-05 C++ Note: second derivs checked 89.9678 5.50787e-05 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2713.97 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2713.97 3328 C++ Note: risk checked 3917.81 C++ Note: risk1 checked 141.814 2.70754e-05 C++ Note: risk2 checked 141.814 2.70754e-05 C++ Note: Made Risk Side Lists C++ Note: df101 -197398 -197398 C++ Note: df102 -7120.96 -0.00136467 C++ Note: df103 -7153.96 -0.00136467 C++ Note: df104 -3.73697 -17.8368 C++ Note: Checking Deviance 394624 C++ Note: df105 0.995387 1 C++ Note: df106 27.7207 1.44649e+08 C++ Note: Starting Halves C++ Note: df501 -197398.1 C++ Note: df504 -3.736969 -17.83683 C++ Note: values checked -4.48351 -18.568 C++ Note: sums checked 2666.65 3328 C++ Note: derivs checked 42.645 2.65127e-05 C++ Note: second derivs checked 42.645 2.65127e-05 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2666.65 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2666.65 3328 C++ Note: risk checked 3843.22 C++ Note: risk1 checked 67.2201 1.286e-05 C++ Note: risk2 checked 67.2201 1.286e-05 C++ Note: df101 -193660 -193660 C++ Note: df102 -3358 -0.000648169 C++ Note: df103 -3391 -0.000648169 C++ Note: df104 -4.48351 -18.568 C++ Note: Checking Deviance 387148 C++ Note: df105 0.990268 1 C++ Note: df106 57.6711 2.9878e+08 C++ Note: df100 21977 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 22015 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -193659.8 -193659.8 C++ Note: df102 -3358.003 -0.0006481694 C++ Note: df103 -3391.003 -0.0006481694 C++ Note: df104 -4.48351 -18.56797 C++ Note: Checking Deviance 387147.6 C++ Note: df105 0.9902684 1 C++ Note: df106 57.67112 2.987796e+08 C++ Note: df101 -193660 -193660 C++ Note: df102 -3358 -0.000648169 C++ Note: df103 -3391 -0.000648169 C++ Note: df104 -4.48351 -18.568 C++ Note: Checking Deviance 387148 C++ Note: df105 0.990268 1 C++ Note: df106 57.6711 2.9878e+08 C++ Note: df501 -193659.8 C++ Note: df504 -4.48351 -18.56797 Error: guesses_control and model_control have different strata options Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 1 C++ Note: df99,55,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 2 C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.949 3328.001 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.949 3328.001 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.949 3328.001 C++ Note: df99,729,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: START_POIS_GUESS C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 1 C++ Note: df99,65,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.95 3328 C++ Note: derivs checked 3813.95 0.000939732 C++ Note: second derivs checked 3813.95 0.000939732 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.95 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.95 3328 C++ Note: risk checked 9787.82 C++ Note: risk1 checked 6011.82 0.000944651 C++ Note: risk2 checked 6011.82 0.000944651 C++ Note: df101 -493394 -493394 C++ Note: df102 -303241 -0.047634 C++ Note: df103 -303274 -0.047634 C++ Note: df104 0.01 -15 C++ Note: Checking Deviance 986616 C++ Note: df105 0.999891 1 C++ Note: df106 1.62707 1.0358e+07 C++ Note: Starting Halves C++ Note: df501 -493394.2 C++ Note: df504 0.01 -15 C++ Note: values checked -0.739918 -15.3574 C++ Note: sums checked 4425.73 3328 C++ Note: derivs checked 1801.73 0.000657348 C++ Note: second derivs checked 1801.73 0.000657348 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 4425.73 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 4425.73 3328 C++ Note: risk checked 6616.01 C++ Note: risk1 checked 2840.01 0.000478342 C++ Note: risk2 checked 2840.01 0.000478342 C++ Note: df101 -333413 -333413 C++ Note: df102 -143235 -0.0241165 C++ Note: df103 -143268 -0.0241165 C++ Note: df104 -0.739918 -15.3574 C++ Note: Checking Deviance 666655 C++ Note: df105 0.99977 1 C++ Note: df106 2.32774 1.38251e+07 C++ Note: df100 6063 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 6135 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -333413.3 -333413.3 C++ Note: df102 -143235 -0.02411648 C++ Note: df103 -143268 -0.02411648 C++ Note: df104 -0.7399184 -15.35738 C++ Note: Checking Deviance 666654.6 C++ Note: df105 0.9997697 1 C++ Note: df106 2.327736 1.382512e+07 C++ Note: Starting Halves C++ Note: df501 -333413.3 C++ Note: df504 -0.7399184 -15.35738 C++ Note: values checked -1.48975 -15.8512 C++ Note: sums checked 3475.22 3328 C++ Note: derivs checked 851.224 0.000401193 C++ Note: second derivs checked 851.224 0.000401193 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 3475.22 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 3475.22 3328 C++ Note: risk checked 5117.76 C++ Note: risk1 checked 1341.76 0.000239343 C++ Note: risk2 checked 1341.76 0.000239343 C++ Note: df101 -257857 -257857 C++ Note: df102 -67653.7 -0.0120654 C++ Note: df103 -67686.7 -0.0120654 C++ Note: df104 -1.48975 -15.8512 C++ Note: Checking Deviance 515541 C++ Note: df105 0.999512 1 C++ Note: df106 3.81142 2.13716e+07 C++ Note: df100 9003 1 2 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 9080 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -257856.7 -257856.7 C++ Note: df102 -67653.71 -0.01206537 C++ Note: df103 -67686.71 -0.01206537 C++ Note: df104 -1.489746 -15.85115 C++ Note: Checking Deviance 515541.4 C++ Note: df105 0.9995125 1 C++ Note: df106 3.81142 2.137163e+07 C++ Note: Starting Halves C++ Note: df501 -257856.7 C++ Note: df504 -1.489746 -15.85115 C++ Note: values checked -2.23938 -16.4535 C++ Note: sums checked 3026.24 3328 C++ Note: derivs checked 402.237 0.00021966 C++ Note: second derivs checked 402.237 0.00021966 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 3026.24 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 3026.24 3328 C++ Note: risk checked 4410.03 C++ Note: risk1 checked 634.034 0.000117441 C++ Note: risk2 checked 634.034 0.000117441 C++ Note: df101 -222179 -222179 C++ Note: df102 -31951.6 -0.00591976 C++ Note: df103 -31984.6 -0.00591976 C++ Note: df104 -2.23938 -16.4535 C++ Note: Checking Deviance 444187 C++ Note: df105 0.998968 1 C++ Note: df106 6.95362 3.75318e+07 C++ Note: df100 11910 1 3 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 11988 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -222179.4 -222179.4 C++ Note: df102 -31951.63 -0.005919756 C++ Note: df103 -31984.63 -0.005919756 C++ Note: df104 -2.23938 -16.45351 C++ Note: Checking Deviance 444186.7 C++ Note: df105 0.9989683 1 C++ Note: df106 6.953616 3.753185e+07 C++ Note: Starting Halves C++ Note: df501 -222179.4 C++ Note: df504 -2.23938 -16.45351 C++ Note: values checked -2.98861 -17.1257 C++ Note: sums checked 2814.15 3328 C++ Note: derivs checked 190.15 0.000112156 C++ Note: second derivs checked 190.15 0.000112156 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2814.15 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2814.15 3328 C++ Note: risk checked 4075.73 C++ Note: risk1 checked 299.728 5.66831e-05 C++ Note: risk2 checked 299.728 5.66831e-05 C++ Note: df101 -205340 -205340 C++ Note: df102 -15087.2 -0.00285705 C++ Note: df103 -15120.2 -0.00285705 C++ Note: df104 -2.98861 -17.1257 C++ Note: Checking Deviance 410507 C++ Note: df105 0.997817 1 C++ Note: df106 13.6102 7.18712e+07 C++ Note: df100 14744 1 4 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 14823 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -205339.6 -205339.6 C++ Note: df102 -15087.16 -0.002857052 C++ Note: df103 -15120.16 -0.002857052 C++ Note: df104 -2.988606 -17.1257 C++ Note: Checking Deviance 410507.3 C++ Note: df105 0.9978175 1 C++ Note: df106 13.61022 7.187117e+07 C++ Note: Starting Halves C++ Note: df501 -205339.6 C++ Note: df504 -2.988606 -17.1257 C++ Note: values checked -3.73697 -17.8368 C++ Note: sums checked 2713.97 3328 C++ Note: derivs checked 89.9678 5.50787e-05 C++ Note: second derivs checked 89.9678 5.50787e-05 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2713.97 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2713.97 3328 C++ Note: risk checked 3917.81 C++ Note: risk1 checked 141.814 2.70754e-05 C++ Note: risk2 checked 141.814 2.70754e-05 C++ Note: df101 -197398 -197398 C++ Note: df102 -7120.96 -0.00136467 C++ Note: df103 -7153.96 -0.00136467 C++ Note: df104 -3.73697 -17.8368 C++ Note: Checking Deviance 394624 C++ Note: df105 0.995387 1 C++ Note: df106 27.7207 1.44649e+08 C++ Note: df100 17553 1 5 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 17623 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -197398.1 -197398.1 C++ Note: df102 -7120.961 -0.001364671 C++ Note: df103 -7153.961 -0.001364671 C++ Note: df104 -3.736969 -17.83683 C++ Note: Checking Deviance 394624.2 C++ Note: df105 0.9953872 1 C++ Note: df106 27.72071 1.446488e+08 C++ Note: df101 -197398 -197398 C++ Note: df102 -7120.96 -0.00136467 C++ Note: df103 -7153.96 -0.00136467 C++ Note: df104 -3.73697 -17.8368 C++ Note: Checking Deviance 394624 C++ Note: df105 0.995387 1 C++ Note: df106 27.7207 1.44649e+08 C++ Note: ending guess 0 C++ Note: df501 -197398.1 C++ Note: df504 -3.736969 -17.83683 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -3.736969 -17.83683, -197398.1<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked -3.73697 -17.8368 C++ Note: sums checked 2713.97 3328 C++ Note: derivs checked 89.9678 5.50787e-05 C++ Note: second derivs checked 89.9678 5.50787e-05 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2713.97 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2713.97 3328 C++ Note: risk checked 3917.81 C++ Note: risk1 checked 141.814 2.70754e-05 C++ Note: risk2 checked 141.814 2.70754e-05 C++ Note: Made Risk Side Lists C++ Note: df101 -197398 -197398 C++ Note: df102 -7120.96 -0.00136467 C++ Note: df103 -7153.96 -0.00136467 C++ Note: df104 -3.73697 -17.8368 C++ Note: Checking Deviance 394624 C++ Note: df105 0.995387 1 C++ Note: df106 27.7207 1.44649e+08 C++ Note: Starting Halves C++ Note: df501 -197398.1 C++ Note: df504 -3.736969 -17.83683 C++ Note: values checked -4.48351 -18.568 C++ Note: sums checked 2666.65 3328 C++ Note: derivs checked 42.645 2.65127e-05 C++ Note: second derivs checked 42.645 2.65127e-05 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2666.65 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2666.65 3328 C++ Note: risk checked 3843.22 C++ Note: risk1 checked 67.2201 1.286e-05 C++ Note: risk2 checked 67.2201 1.286e-05 C++ Note: df101 -193660 -193660 C++ Note: df102 -3358 -0.000648169 C++ Note: df103 -3391 -0.000648169 C++ Note: df104 -4.48351 -18.568 C++ Note: Checking Deviance 387148 C++ Note: df105 0.990268 1 C++ Note: df106 57.6711 2.9878e+08 C++ Note: df100 23578 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 23659 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -193659.8 -193659.8 C++ Note: df102 -3358.003 -0.0006481694 C++ Note: df103 -3391.003 -0.0006481694 C++ Note: df104 -4.48351 -18.56797 C++ Note: Checking Deviance 387147.6 C++ Note: df105 0.9902684 1 C++ Note: df106 57.67112 2.987796e+08 C++ Note: df101 -193660 -193660 C++ Note: df102 -3358 -0.000648169 C++ Note: df103 -3391 -0.000648169 C++ Note: df104 -4.48351 -18.568 C++ Note: Checking Deviance 387148 C++ Note: df105 0.990268 1 C++ Note: df106 57.6711 2.9878e+08 C++ Note: df501 -193659.8 C++ Note: df504 -4.48351 -18.56797 Error: Atleast one parameter must be free Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 1 C++ Note: df99,60,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 2 C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.949 0.001957775 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.949 0.001957775 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.949 0.001957775 C++ Note: df99,920,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: START_POIS_GUESS C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 1 C++ Note: df99,61,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.95 0.00195777 C++ Note: derivs checked 3813.95 0.00195777 C++ Note: second derivs checked 3813.95 0.00195777 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.95 0.00195777 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.95 0.00195777 C++ Note: risk checked 6437.95 C++ Note: risk1 checked 3813.95 0.00196938 C++ Note: risk2 checked 3813.95 0.00196938 C++ Note: df101 -324424 -324424 C++ Note: df102 -192366 -0.0993192 C++ Note: df103 -192399 -0.0993192 C++ Note: df104 0.01 -15 C++ Note: Checking Deviance 648676 C++ Note: df105 0.999828 1 C++ Note: df106 1.68649 3.26648e+06 C++ Note: Starting Halves C++ Note: df501 -324424.1 C++ Note: df504 0.01 -15 C++ Note: values checked -0.739871 -15.3056 C++ Note: sums checked 4425.81 0.00144221 C++ Note: derivs checked 1801.81 0.00144221 C++ Note: second derivs checked 1801.81 0.00144221 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 4425.81 0.00144221 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 4425.81 0.00144221 C++ Note: risk checked 4425.82 C++ Note: risk1 checked 1801.81 0.000997333 C++ Note: risk2 checked 1801.81 0.000997333 C++ Note: df101 -222944 -222944 C++ Note: df102 -90861.8 -0.0502905 C++ Note: df103 -90894.8 -0.0502905 C++ Note: df104 -0.739871 -15.3056 C++ Note: Checking Deviance 445716 C++ Note: df105 0.999637 1 C++ Note: df106 2.45366 4.43313e+06 C++ Note: df100 5529 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 5590 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -222944.2 -222944.2 C++ Note: df102 -90861.77 -0.05029052 C++ Note: df103 -90894.77 -0.05029052 C++ Note: df104 -0.7398713 -15.30563 C++ Note: Checking Deviance 445716.4 C++ Note: df105 0.9996369 1 C++ Note: df106 2.453663 4433125 C++ Note: Starting Halves C++ Note: df501 -222944.2 C++ Note: df504 -0.7398713 -15.30563 C++ Note: values checked -1.4896 -15.7503 C++ Note: sums checked 3475.35 0.000924527 C++ Note: derivs checked 851.349 0.000924527 C++ Note: second derivs checked 851.349 0.000924527 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 3475.35 0.000924527 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 3475.35 0.000924527 C++ Note: risk checked 3475.35 C++ Note: risk1 checked 851.349 0.00050204 C++ Note: risk2 checked 851.349 0.00050204 C++ Note: df101 -175021 -175021 C++ Note: df102 -42914.3 -0.0253124 C++ Note: df103 -42947.3 -0.0253124 C++ Note: df104 -1.4896 -15.7503 C++ Note: Checking Deviance 349871 C++ Note: df105 0.999232 1 C++ Note: df106 4.07839 6.91445e+06 C++ Note: df100 8155 1 2 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 8218 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -175021.5 -175021.5 C++ Note: df102 -42914.34 -0.02531243 C++ Note: df103 -42947.34 -0.02531243 C++ Note: df104 -1.489599 -15.75028 C++ Note: Checking Deviance 349871 C++ Note: df105 0.9992316 1 C++ Note: df106 4.078392 6914448 C++ Note: Starting Halves C++ Note: df501 -175021.5 C++ Note: df504 -1.489599 -15.75028 C++ Note: values checked -2.23902 -16.3166 C++ Note: sums checked 3026.38 0.000524773 C++ Note: derivs checked 402.38 0.000524773 C++ Note: second derivs checked 402.38 0.000524773 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 3026.38 0.000524773 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 3026.38 0.000524773 C++ Note: risk checked 3026.38 C++ Note: risk1 checked 402.38 0.00024815 C++ Note: risk2 checked 402.38 0.00024815 C++ Note: df101 -152397 -152397 C++ Note: df102 -20265.6 -0.0125105 C++ Note: df103 -20298.6 -0.0125105 C++ Note: df104 -2.23902 -16.3166 C++ Note: Checking Deviance 304623 C++ Note: df105 0.998374 1 C++ Note: df106 7.52001 1.21815e+07 C++ Note: df100 10670 1 3 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 10730 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -152397.5 -152397.5 C++ Note: df102 -20265.58 -0.01251054 C++ Note: df103 -20298.58 -0.01251054 C++ Note: df104 -2.239023 -16.3166 C++ Note: Checking Deviance 304622.9 C++ Note: df105 0.9983743 1 C++ Note: df106 7.520014 1.218152e+07 C++ Note: Starting Halves C++ Note: df501 -152397.5 C++ Note: df504 -2.239023 -16.3166 C++ Note: values checked -2.9878 -16.967 C++ Note: sums checked 2814.3 0.000273851 C++ Note: derivs checked 190.303 0.000273851 C++ Note: second derivs checked 190.303 0.000273851 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2814.3 0.000273851 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2814.3 0.000273851 C++ Note: risk checked 2814.3 C++ Note: risk1 checked 190.303 0.000120422 C++ Note: risk2 checked 190.303 0.000120422 C++ Note: df101 -141724 -141724 C++ Note: df102 -9567.07 -0.0060708 C++ Note: df103 -9600.07 -0.0060708 C++ Note: df104 -2.9878 -16.967 C++ Note: Checking Deviance 283275 C++ Note: df105 0.996563 1 C++ Note: df106 14.8137 2.33451e+07 C++ Note: df100 13226 1 4 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 13287 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -141723.6 -141723.6 C++ Note: df102 -9567.07 -0.006070799 C++ Note: df103 -9600.07 -0.006070799 C++ Note: df104 -2.987803 -16.96698 C++ Note: Checking Deviance 283275.3 C++ Note: df105 0.9965625 1 C++ Note: df106 14.81369 2.334514e+07 C++ Note: Starting Halves C++ Note: df501 -141723.6 C++ Note: df504 -2.987803 -16.96698 C++ Note: values checked -3.73523 -17.6664 C++ Note: sums checked 2714.12 0.000136068 C++ Note: derivs checked 90.1248 0.000136068 C++ Note: second derivs checked 90.1248 0.000136068 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2714.12 0.000136068 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2714.12 0.000136068 C++ Note: risk checked 2714.12 C++ Note: risk1 checked 90.1248 5.77042e-05 C++ Note: risk2 checked 90.1248 5.77042e-05 C++ Note: df101 -136695 -136695 C++ Note: df102 -4513.46 -0.00290896 C++ Note: df103 -4546.46 -0.00290896 C++ Note: df104 -3.73523 -17.6664 C++ Note: Checking Deviance 273217 C++ Note: df105 0.992742 1 C++ Note: df106 30.286 4.6991e+07 C++ Note: df100 15785 1 5 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 15845 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -136694.7 -136694.7 C++ Note: df102 -4513.458 -0.002908957 C++ Note: df103 -4546.458 -0.002908957 C++ Note: df104 -3.735225 -17.66641 C++ Note: Checking Deviance 273217.4 C++ Note: df105 0.9927416 1 C++ Note: df106 30.28602 4.699096e+07 C++ Note: df101 -136695 -136695 C++ Note: df102 -4513.46 -0.00290896 C++ Note: df103 -4546.46 -0.00290896 C++ Note: df104 -3.73523 -17.6664 C++ Note: Checking Deviance 273217 C++ Note: df105 0.992742 1 C++ Note: df106 30.286 4.6991e+07 C++ Note: ending guess 0 C++ Note: df501 -136694.7 C++ Note: df504 -3.735225 -17.66641 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -3.735225 -17.66641, -136694.7<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked -3.73523 -17.6664 C++ Note: sums checked 2714.12 0.000136068 C++ Note: derivs checked 90.1248 0.000136068 C++ Note: second derivs checked 90.1248 0.000136068 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2714.12 0.000136068 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2714.12 0.000136068 C++ Note: risk checked 2714.12 C++ Note: risk1 checked 90.1248 5.77042e-05 C++ Note: risk2 checked 90.1248 5.77042e-05 C++ Note: Made Risk Side Lists C++ Note: df101 -136695 -136695 C++ Note: df102 -4513.46 -0.00290896 C++ Note: df103 -4546.46 -0.00290896 C++ Note: df104 -3.73523 -17.6664 C++ Note: Checking Deviance 273217 C++ Note: df105 0.992742 1 C++ Note: df106 30.286 4.6991e+07 C++ Note: Starting Halves C++ Note: df501 -136694.7 C++ Note: df504 -3.735225 -17.66641 C++ Note: values checked -4.47978 -18.3917 C++ Note: sums checked 2666.8 6.58842e-05 C++ Note: derivs checked 42.8043 6.58842e-05 C++ Note: second derivs checked 42.8043 6.58842e-05 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2666.8 6.58842e-05 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2666.8 6.58842e-05 C++ Note: risk checked 2666.8 C++ Note: risk1 checked 42.8043 2.74532e-05 C++ Note: risk2 checked 42.8043 2.74532e-05 C++ Note: df101 -134332 -134332 C++ Note: df102 -2126.32 -0.00138394 C++ Note: df103 -2159.32 -0.00138394 C++ Note: df104 -4.47978 -18.3917 C++ Note: Checking Deviance 268492 C++ Note: df105 0.984717 1 C++ Note: df106 63.1759 9.7065e+07 C++ Note: df100 21392 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df100 21454 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: df101 -134332.1 -134332.1 C++ Note: df102 -2126.318 -0.00138394 C++ Note: df103 -2159.318 -0.00138394 C++ Note: df104 -4.479781 -18.39167 C++ Note: Checking Deviance 268492.2 C++ Note: df105 0.9847174 1 C++ Note: df106 63.17594 9.706499e+07 C++ Note: df101 -134332 -134332 C++ Note: df102 -2126.32 -0.00138394 C++ Note: df103 -2159.32 -0.00138394 C++ Note: df104 -4.47978 -18.3917 C++ Note: Checking Deviance 268492 C++ Note: df105 0.984717 1 C++ Note: df106 63.1759 9.7065e+07 C++ Note: df501 -134332.1 C++ Note: df504 -4.479781 -18.39167 Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Note: 2 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 C++ Note: df99,49,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Grouping Start C++ Note: df100 116 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.11965 C++ Note: risk1r checked 6.27591 C++ Note: risk2r checked 39.4822 C++ Note: riskl checked 1.11965 C++ Note: risk1l checked 6.27591 C++ Note: risk2l checked 39.4822 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: riskr checked 1.11965 C++ Note: risk1r checked 6.27591 C++ Note: risk2r checked 39.4822 C++ Note: riskl checked 1.11965 C++ Note: risk1l checked 6.27591 C++ Note: risk2l checked 39.4822 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: ending guess 0 C++ Note: df501 0 C++ Note: df504 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1, 0<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.11965 C++ Note: risk1r checked 6.27591 C++ Note: risk2r checked 39.4822 C++ Note: riskl checked 1.11965 C++ Note: risk1l checked 6.27591 C++ Note: risk2l checked 39.4822 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: riskr checked 1.11965 C++ Note: risk1r checked 6.27591 C++ Note: risk2r checked 39.4822 C++ Note: riskl checked 1.11965 C++ Note: risk1l checked 6.27591 C++ Note: risk2l checked 39.4822 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: Exiting Regression C++ Note: df501 0 C++ Note: df504 -0.1 Note: starting ph_plot Note: nonStratified survival curve calculation C++ Note: START_PLOT C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Term checked 0 C++ Note: df99,44,Starting C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Grouping Start C++ Note: df100 428 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:07 2024 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.11965 C++ Note: risk1r checked 6.27591 C++ Note: risk2r checked 39.4822 C++ Note: riskl checked 1.11965 C++ Note: risk1l checked 6.27591 C++ Note: risk2l checked 39.4822 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan Note: writing survival data Note: Plotting Martingale Residuals Note: Martingale Plot: d Saving 7 x 7 in image Saving 7 x 7 in image Note: Starting Censoring weight Plot Function Note: 908 risk groups Note: 908 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:08 2024 C++ Note: Term checked 0 0 C++ Note: df99,56,Starting C++ Note: Current Time, Wed Apr 3 17:09:08 2024 C++ Note: Grouping Start C++ Note: df100 8279 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:08 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0 0 C++ Note: sums checked 1000 1000 C++ Note: derivs checked 3524.8 501 C++ Note: second derivs checked 19954.8 501 C++ Note: dose checked 1000 C++ Note: non-dose checked 1000 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 3524.8 501 C++ Note: risk2 checked 19954.8 501 C++ Note: Made Risk Side Lists C++ Note: riskr checked 494240 C++ Note: risk1r checked 2.44264e+06 246462 C++ Note: risk2r checked 1.56997e+07 246462 C++ Note: riskl checked 908 C++ Note: risk1l checked 2745.2 459 C++ Note: risk2l checked 13223.2 459 C++ Note: df101 -5536.33 -5536.33 C++ Note: df102 -2409.98 12.6913 C++ Note: df103 -4481.29 -226.265 C++ Note: df104 0 0 C++ Note: df105 0.537787 -0.0560903 C++ Note: df106 2.29725 -436.231 C++ Note: Starting Halves C++ Note: df501 -5536.328 C++ Note: df504 0 0 C++ Note: riskr checked 494240 C++ Note: risk1r checked 2.44264e+06 246462 C++ Note: risk2r checked 1.56997e+07 246462 C++ Note: riskl checked 908 C++ Note: risk1l checked 2745.2 459 C++ Note: risk2l checked 13223.2 459 C++ Note: df101 -5536.33 -5536.33 C++ Note: df102 -2409.98 12.6913 C++ Note: df103 -4481.29 -226.265 C++ Note: df104 0 0 C++ Note: df105 0.537787 -0.0560903 C++ Note: df106 2.29725 -436.231 C++ Note: ending guess 0 C++ Note: df501 -5536.328 C++ Note: df504 0 0 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0 0, -5536.328<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0 0 C++ Note: sums checked 1000 1000 C++ Note: derivs checked 3524.8 501 C++ Note: second derivs checked 19954.8 501 C++ Note: dose checked 1000 C++ Note: non-dose checked 1000 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 3524.8 501 C++ Note: risk2 checked 19954.8 501 C++ Note: Made Risk Side Lists C++ Note: riskr checked 494240 C++ Note: risk1r checked 2.44264e+06 246462 C++ Note: risk2r checked 1.56997e+07 246462 C++ Note: riskl checked 908 C++ Note: risk1l checked 2745.2 459 C++ Note: risk2l checked 13223.2 459 C++ Note: df101 -5536.33 -5536.33 C++ Note: df102 -2409.98 12.6913 C++ Note: df103 -4481.29 -226.265 C++ Note: df104 0 0 C++ Note: df105 0.537787 -0.0560903 C++ Note: df106 2.29725 -436.231 C++ Note: riskr checked 494240 C++ Note: risk1r checked 2.44264e+06 246462 C++ Note: risk2r checked 1.56997e+07 246462 C++ Note: riskl checked 908 C++ Note: risk1l checked 2745.2 459 C++ Note: risk2l checked 13223.2 459 C++ Note: df101 -5536.33 -5536.33 C++ Note: df102 -2409.98 12.6913 C++ Note: df103 -4481.29 -226.265 C++ Note: df104 0 0 C++ Note: df105 0.537787 -0.0560903 C++ Note: df106 2.29725 -436.231 C++ Note: Exiting Regression C++ Note: df501 -5536.328 C++ Note: df504 0 0 C++ Note: START_PLOT C++ Note: Current Time, Wed Apr 3 17:09:08 2024 C++ Note: Term checked 0 0 C++ Note: df99,54,Starting C++ Note: Current Time, Wed Apr 3 17:09:08 2024 C++ Note: values checked 0 0 C++ Note: sums checked 1000 1000 C++ Note: derivs checked 3524.8 501 C++ Note: second derivs checked 19954.8 501 C++ Note: dose checked 1000 C++ Note: non-dose checked 1000 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 3524.8 501 C++ Note: risk2 checked 19954.8 501 C++ Note: Grouping Start C++ Note: df100 8132 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:08 2024 C++ Note: Made Risk Side Lists C++ Note: riskr checked 494240 C++ Note: risk1r checked 2.44264e+06 246462 C++ Note: risk2r checked 1.56997e+07 246462 C++ Note: riskl checked 908 C++ Note: risk1l checked 2745.2 459 C++ Note: risk2l checked 13223.2 459 C++ Note: df101 -5536.33 -5536.33 C++ Note: df102 -2409.98 12.6913 C++ Note: df103 -4481.29 -226.265 C++ Note: df104 0 0 C++ Note: df105 0.537787 -0.0560903 C++ Note: df106 2.29725 -436.231 Saving 7 x 7 in image Note: Starting Censoring weight Plot Function Error: Atleast one parameter must be free Note: Starting Censoring weight Plot Function Error: no events Note: Starting Plot Function Note: Getting Plot Info Note: 3 risk groups Note: 3 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:09 2024 C++ Note: Term checked 0 C++ Note: df99,55,Starting C++ Note: Current Time, Wed Apr 3 17:09:09 2024 C++ Note: Grouping Start C++ Note: df100 137 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:09 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 133.308 C++ Note: derivs checked 64.6907 C++ Note: second derivs checked 43.4901 C++ Note: dose checked 140 C++ Note: non-dose checked 133.308 C++ Note: LIN_non-dose checked 140 C++ Note: PLIN_non-dose checked 140 C++ Note: LOGLIN_non-dose checked 133.308 C++ Note: risk checked 133.308 C++ Note: risk1 checked 64.6907 C++ Note: risk2 checked 43.4901 C++ Note: Made Risk Side Lists C++ Note: riskr checked 57.3026 C++ Note: risk1r checked 26.144 C++ Note: risk2r checked 16.2108 C++ Note: riskl checked 57.3026 C++ Note: risk1l checked 26.144 C++ Note: risk2l checked 16.2108 C++ Note: df101 -179.766 C++ Note: df102 0.439186 C++ Note: df103 -4.37887 C++ Note: df104 -0.1 C++ Note: df105 -0.100297 C++ Note: df106 -409.316 C++ Note: riskr checked 57.3026 C++ Note: risk1r checked 26.144 C++ Note: risk2r checked 16.2108 C++ Note: riskl checked 57.3026 C++ Note: risk1l checked 26.144 C++ Note: risk2l checked 16.2108 C++ Note: df101 -179.766 C++ Note: df102 0.439186 C++ Note: df103 -4.37887 C++ Note: df104 -0.1 C++ Note: df105 -0.100297 C++ Note: df106 -409.316 C++ Note: ending guess 0 C++ Note: df501 -179.7659 C++ Note: df504 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1, -179.7659<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 133.308 C++ Note: derivs checked 64.6907 C++ Note: second derivs checked 43.4901 C++ Note: dose checked 140 C++ Note: non-dose checked 133.308 C++ Note: LIN_non-dose checked 140 C++ Note: PLIN_non-dose checked 140 C++ Note: LOGLIN_non-dose checked 133.308 C++ Note: risk checked 133.308 C++ Note: risk1 checked 64.6907 C++ Note: risk2 checked 43.4901 C++ Note: Made Risk Side Lists C++ Note: riskr checked 57.3026 C++ Note: risk1r checked 26.144 C++ Note: risk2r checked 16.2108 C++ Note: riskl checked 57.3026 C++ Note: risk1l checked 26.144 C++ Note: risk2l checked 16.2108 C++ Note: df101 -179.766 C++ Note: df102 0.439186 C++ Note: df103 -4.37887 C++ Note: df104 -0.1 C++ Note: df105 -0.100297 C++ Note: df106 -409.316 C++ Note: riskr checked 57.3026 C++ Note: risk1r checked 26.144 C++ Note: risk2r checked 16.2108 C++ Note: riskl checked 57.3026 C++ Note: risk1l checked 26.144 C++ Note: risk2l checked 16.2108 C++ Note: df101 -179.766 C++ Note: df102 0.439186 C++ Note: df103 -4.37887 C++ Note: df104 -0.1 C++ Note: df105 -0.100297 C++ Note: df106 -409.316 C++ Note: Exiting Regression C++ Note: df501 -179.7659 C++ Note: df504 -0.1 C++ Note: START_PLOT C++ Note: Current Time, Wed Apr 3 17:09:09 2024 C++ Note: Term checked 0 C++ Note: df99,48,Starting C++ Note: Current Time, Wed Apr 3 17:09:09 2024 C++ Note: values checked -0.1 C++ Note: sums checked 95.1954 C++ Note: dose checked 100 C++ Note: non-dose checked 95.1954 C++ Note: LIN_non-dose checked 100 C++ Note: PLIN_non-dose checked 100 C++ Note: LOGLIN_non-dose checked 95.1954 C++ Note: risk checked 95.1954 Saving 7 x 7 in image Warning: model covariate order changed Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,62,Starting C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Grouping Start C++ Note: df100 450 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: Made Risk Side Lists C++ Note: riskr checked 45411.7 C++ Note: risk1r checked 28767.4 144720 52387.3 C++ Note: risk2r checked 28767.4 514964 151495 C++ Note: riskl checked 498.666 C++ Note: risk1l checked 304.226 1582.04 793.308 C++ Note: risk2l checked 304.226 5554.38 2609.55 C++ Note: df101 -124.812 -124.812 -124.812 C++ Note: df102 -0.467622 -22.6674 2.97163 C++ Note: df103 -6.02126 -30.6469 -1.27345 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: df105 0.0776618 0.739632 -2.33354 C++ Note: df106 266.907 5.50621 -42.001 C++ Note: Starting Halves C++ Note: df501 -124.8115 C++ Note: df504 0.4260961 0.646539 0.1572781 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: df100 4938 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: ending guess 0 C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.6007434 0.09652814 1.157278, -118.395<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: Made Risk Side Lists C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: Starting Halves C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: values checked 0.469257 0.102151 0.78977 C++ Note: sums checked 1647.84 1647.84 7760.94 C++ Note: derivs checked 1060.93 3775.1 27203.7 C++ Note: second derivs checked 1060.93 11977.1 111988 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1647.84 7760.94 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1647.84 7760.94 C++ Note: risk checked 14328.5 C++ Note: risk1 checked 8953.84 33119.7 44341.6 C++ Note: risk2 checked 8953.84 104570 182492 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: df100 10820 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: Exiting Regression C++ Note: df501 -117.3104 C++ Note: df504 0.4692569 0.1021509 0.7897698 Error: Atleast one parameter must be free Warning: model covariate order changed Error: no events Warning: model covariate order changed Note: 26 risk groups Note: Initial starts: 1 , Number of iterations provided: 4 . Colossus requires one more iteration counts than number of guesses (for best guess) C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,65,Starting C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Grouping Start C++ Note: df100 461 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: Made Risk Side Lists C++ Note: riskr checked 45411.7 C++ Note: risk1r checked 28767.4 144720 52387.3 C++ Note: risk2r checked 28767.4 514964 151495 C++ Note: riskl checked 498.666 C++ Note: risk1l checked 304.226 1582.04 793.308 C++ Note: risk2l checked 304.226 5554.38 2609.55 C++ Note: df101 -124.812 -124.812 -124.812 C++ Note: df102 -0.467622 -22.6674 2.97163 C++ Note: df103 -6.02126 -30.6469 -1.27345 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: df105 0.0776618 0.739632 -2.33354 C++ Note: df106 266.907 5.50621 -42.001 C++ Note: Starting Halves C++ Note: df501 -124.8115 C++ Note: df504 0.4260961 0.646539 0.1572781 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: df100 3458 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: ending guess 0 C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.6007434 0.09652814 1.157278, -118.395<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: Made Risk Side Lists C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: Starting Halves C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: values checked 0.469257 0.102151 0.78977 C++ Note: sums checked 1647.84 1647.84 7760.94 C++ Note: derivs checked 1060.93 3775.1 27203.7 C++ Note: second derivs checked 1060.93 11977.1 111988 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1647.84 7760.94 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1647.84 7760.94 C++ Note: risk checked 14328.5 C++ Note: risk1 checked 8953.84 33119.7 44341.6 C++ Note: risk2 checked 8953.84 104570 182492 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: df100 6985 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: Exiting Regression C++ Note: df501 -117.3104 C++ Note: df504 0.4692569 0.1021509 0.7897698 Warning: model covariate order changed Note: 26 risk groups Note: Initial starts: 3 , Number of iterations provided: 2 . Colossus requires one more iteration counts than number of guesses (for best guess) C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,66,Starting C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Grouping Start C++ Note: df100 426 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: Made Risk Side Lists C++ Note: riskr checked 45411.7 C++ Note: risk1r checked 28767.4 144720 52387.3 C++ Note: risk2r checked 28767.4 514964 151495 C++ Note: riskl checked 498.666 C++ Note: risk1l checked 304.226 1582.04 793.308 C++ Note: risk2l checked 304.226 5554.38 2609.55 C++ Note: df101 -124.812 -124.812 -124.812 C++ Note: df102 -0.467622 -22.6674 2.97163 C++ Note: df103 -6.02126 -30.6469 -1.27345 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: df105 0.0776618 0.739632 -2.33354 C++ Note: df106 266.907 5.50621 -42.001 C++ Note: Starting Halves C++ Note: df501 -124.8115 C++ Note: df504 0.4260961 0.646539 0.1572781 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: df100 5060 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: ending guess 0 C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: starting subterms 2 in guess 1 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: Made Risk Side Lists C++ Note: riskr checked 45411.7 C++ Note: risk1r checked 28767.4 144720 52387.3 C++ Note: risk2r checked 28767.4 514964 151495 C++ Note: riskl checked 498.666 C++ Note: risk1l checked 304.226 1582.04 793.308 C++ Note: risk2l checked 304.226 5554.38 2609.55 C++ Note: df101 -124.812 -124.812 -124.812 C++ Note: df102 -0.467622 -22.6674 2.97163 C++ Note: df103 -6.02126 -30.6469 -1.27345 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: df105 0.0776618 0.739632 -2.33354 C++ Note: df106 266.907 5.50621 -42.001 C++ Note: Starting Halves C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: df100 11097 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: values checked 0.51342 0.371534 0.657278 C++ Note: sums checked 3370.53 3370.53 4972.82 C++ Note: derivs checked 2201.24 9415.6 15965.6 C++ Note: second derivs checked 2201.24 31933.3 62675 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3370.53 4972.82 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3370.53 4972.82 C++ Note: risk checked 20026.8 C++ Note: risk1 checked 12767.6 55905.5 53475 C++ Note: risk2 checked 12767.6 188523 210555 C++ Note: riskr checked 50427.9 C++ Note: risk1r checked 32128.2 141448 121549 C++ Note: risk2r checked 32128.2 477449 432448 C++ Note: riskl checked 694.008 C++ Note: risk1l checked 419.149 2059.62 1976.96 C++ Note: risk2l checked 419.149 7123.47 7257.54 C++ Note: df101 -119.04 -119.04 -119.04 C++ Note: df102 -0.595098 -12.7024 -0.0570081 C++ Note: df103 -5.99518 -41.9658 -9.15921 C++ Note: df104 0.51342 0.371534 0.657278 C++ Note: df105 0.0992627 0.302686 0.00622413 C++ Note: df106 200.035 9.37145 2088.13 C++ Note: df100 13368 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Changing back to best C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: riskr checked 45411.7 C++ Note: risk1r checked 28767.4 144720 52387.3 C++ Note: risk2r checked 28767.4 514964 151495 C++ Note: riskl checked 498.666 C++ Note: risk1l checked 304.226 1582.04 793.308 C++ Note: risk2l checked 304.226 5554.38 2609.55 C++ Note: df101 -124.812 -124.812 -124.812 C++ Note: df102 -0.467622 -22.6674 2.97163 C++ Note: df103 -6.02126 -30.6469 -1.27345 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: df105 0.0776618 0.739632 -2.33354 C++ Note: df106 266.907 5.50621 -42.001 C++ Note: ending guess 1 C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: starting subterms 2 in guess 2 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: Made Risk Side Lists C++ Note: riskr checked 45411.7 C++ Note: risk1r checked 28767.4 144720 52387.3 C++ Note: risk2r checked 28767.4 514964 151495 C++ Note: riskl checked 498.666 C++ Note: risk1l checked 304.226 1582.04 793.308 C++ Note: risk2l checked 304.226 5554.38 2609.55 C++ Note: df101 -124.812 -124.812 -124.812 C++ Note: df102 -0.467622 -22.6674 2.97163 C++ Note: df103 -6.02126 -30.6469 -1.27345 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: df105 0.0776618 0.739632 -2.33354 C++ Note: df106 266.907 5.50621 -42.001 C++ Note: Starting Halves C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: df100 20153 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: values checked 0.51342 0.371534 0.657278 C++ Note: sums checked 3370.53 3370.53 4972.82 C++ Note: derivs checked 2201.24 9415.6 15965.6 C++ Note: second derivs checked 2201.24 31933.3 62675 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3370.53 4972.82 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3370.53 4972.82 C++ Note: risk checked 20026.8 C++ Note: risk1 checked 12767.6 55905.5 53475 C++ Note: risk2 checked 12767.6 188523 210555 C++ Note: riskr checked 50427.9 C++ Note: risk1r checked 32128.2 141448 121549 C++ Note: risk2r checked 32128.2 477449 432448 C++ Note: riskl checked 694.008 C++ Note: risk1l checked 419.149 2059.62 1976.96 C++ Note: risk2l checked 419.149 7123.47 7257.54 C++ Note: df101 -119.04 -119.04 -119.04 C++ Note: df102 -0.595098 -12.7024 -0.0570081 C++ Note: df103 -5.99518 -41.9658 -9.15921 C++ Note: df104 0.51342 0.371534 0.657278 C++ Note: df105 0.0992627 0.302686 0.00622413 C++ Note: df106 200.035 9.37145 2088.13 C++ Note: df100 22454 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Changing back to best C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: riskr checked 45411.7 C++ Note: risk1r checked 28767.4 144720 52387.3 C++ Note: risk2r checked 28767.4 514964 151495 C++ Note: riskl checked 498.666 C++ Note: risk1l checked 304.226 1582.04 793.308 C++ Note: risk2l checked 304.226 5554.38 2609.55 C++ Note: df101 -124.812 -124.812 -124.812 C++ Note: df102 -0.467622 -22.6674 2.97163 C++ Note: df103 -6.02126 -30.6469 -1.27345 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: df105 0.0776618 0.739632 -2.33354 C++ Note: df106 266.907 5.50621 -42.001 C++ Note: ending guess 2 C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.6007434 0.09652814 1.157278, -118.395<-- Best Guess 1, 0.4260961 0.646539 0.1572781, -124.8115 2, 0.4260961 0.646539 0.1572781, -124.8115 C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: Made Risk Side Lists C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: Starting Halves C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: values checked 0.469257 0.102151 0.78977 C++ Note: sums checked 1647.84 1647.84 7760.94 C++ Note: derivs checked 1060.93 3775.1 27203.7 C++ Note: second derivs checked 1060.93 11977.1 111988 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1647.84 7760.94 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1647.84 7760.94 C++ Note: risk checked 14328.5 C++ Note: risk1 checked 8953.84 33119.7 44341.6 C++ Note: risk2 checked 8953.84 104570 182492 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: df100 29667 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: Exiting Regression C++ Note: df501 -117.3104 C++ Note: df504 0.4692569 0.1021509 0.7897698 Warning: model covariate order changed Note: 26 risk groups Error: guesses: 50 , iterations per guess: c(1, 1) Warning: model covariate order changed Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,65,Starting C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Grouping Start C++ Note: df100 448 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: Made Risk Side Lists C++ Note: riskr checked 45411.7 C++ Note: risk1r checked 28767.4 144720 52387.3 C++ Note: risk2r checked 28767.4 514964 151495 C++ Note: riskl checked 498.666 C++ Note: risk1l checked 304.226 1582.04 793.308 C++ Note: risk2l checked 304.226 5554.38 2609.55 C++ Note: df101 -124.812 -124.812 -124.812 C++ Note: df102 -0.467622 -22.6674 2.97163 C++ Note: df103 -6.02126 -30.6469 -1.27345 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: df105 0.0776618 0.739632 -2.33354 C++ Note: df106 266.907 5.50621 -42.001 C++ Note: Starting Halves C++ Note: df501 -124.8115 C++ Note: df504 0.4260961 0.646539 0.1572781 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: df100 5073 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: ending guess 0 C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.6007434 0.09652814 1.157278, -118.395<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: Made Risk Side Lists C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: Starting Halves C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: values checked 0.469257 0.102151 0.78977 C++ Note: sums checked 1647.84 1647.84 7760.94 C++ Note: derivs checked 1060.93 3775.1 27203.7 C++ Note: second derivs checked 1060.93 11977.1 111988 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1647.84 7760.94 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1647.84 7760.94 C++ Note: risk checked 14328.5 C++ Note: risk1 checked 8953.84 33119.7 44341.6 C++ Note: risk2 checked 8953.84 104570 182492 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: df100 11131 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: Exiting Regression C++ Note: df501 -117.3104 C++ Note: df504 0.4692569 0.1021509 0.7897698 Warning: model covariate order changed Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,102,Starting C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Grouping Start C++ Note: df100 560 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: Made Risk Side Lists C++ Note: riskr checked 45411.7 C++ Note: risk1r checked 28767.4 144720 52387.3 C++ Note: risk2r checked 28767.4 514964 151495 C++ Note: riskl checked 498.666 C++ Note: risk1l checked 304.226 1582.04 793.308 C++ Note: risk2l checked 304.226 5554.38 2609.55 C++ Note: df101 -124.812 -124.812 -124.812 C++ Note: df102 -0.467622 -22.6674 2.97163 C++ Note: df103 -6.02126 -30.6469 -1.27345 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: df105 0.0776618 0.739632 -2.33354 C++ Note: df106 266.907 5.50621 -42.001 C++ Note: Starting Halves C++ Note: df501 -124.8115 C++ Note: df504 0.4260961 0.646539 0.1572781 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: df100 6289 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: ending guess 0 C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.6007434 0.09652814 1.157278, -118.395<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: Made Risk Side Lists C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: Starting Halves C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: values checked 0.469257 0.102151 0.78977 C++ Note: sums checked 1647.84 1647.84 7760.94 C++ Note: derivs checked 1060.93 3775.1 27203.7 C++ Note: second derivs checked 1060.93 11977.1 111988 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1647.84 7760.94 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1647.84 7760.94 C++ Note: risk checked 14328.5 C++ Note: risk1 checked 8953.84 33119.7 44341.6 C++ Note: risk2 checked 8953.84 104570 182492 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: df100 12981 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: Exiting Regression C++ Note: df501 -117.3104 C++ Note: df504 0.4692569 0.1021509 0.7897698 Warning: model covariate order changed Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,69,Starting C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Grouping Start C++ Note: df100 459 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked -0.1 -0.1 0.2 C++ Note: sums checked -261.4 -261.4 341.682 C++ Note: derivs checked 531 2083 1708.41 C++ Note: second derivs checked 0 0 0 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked -261.4 341.682 C++ Note: LIN_non-dose checked -261.4 341.682 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1000 1000 C++ Error: A non-positive risk was detected: -1.111148 C++ Warning: final failing values -0.1 -0.1 0.2 Invalid risk Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,41,Starting C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: df101 -18942.2 -18942.2 -18942.2 C++ Note: df102 -12053.5 -60927.3 -21843.1 C++ Note: df103 -12141.5 -218114 -69007.6 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: Checking Deviance 37742.9 C++ Note: df105 0.992752 0.279337 0.316532 C++ Note: df106 1.57151 0.310899 0.867193 C++ Note: Starting Halves C++ Note: df501 -18942.23 C++ Note: df504 0.4260961 0.646539 0.1572781 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: df100 1673 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: df100 1710 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: df101 -9722.072 -9722.072 -9722.072 C++ Note: df102 -5791.513 -29075.02 -10520.68 C++ Note: df103 -5879.513 -101991.2 -32827.7 C++ Note: df104 0.2541947 0.4783037 0.1233221 C++ Note: Checking Deviance 19302.54 C++ Note: df105 0.9850328 0.2850738 0.3204818 C++ Note: df106 1.678676 0.3343789 0.9240916 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: ending guess 0 C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.2541947 0.4783037 0.1233221, -9722.072<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: Made Risk Side Lists C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: Starting Halves C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: values checked 0.0500616 0.312566 0.0802485 C++ Note: sums checked 2172.57 2172.57 1154.38 C++ Note: derivs checked 1178.37 5851.84 2160.22 C++ Note: second derivs checked 1178.37 19594.1 6459.87 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 2172.57 1154.38 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 2172.57 1154.38 C++ Note: risk checked 4679.98 C++ Note: risk1 checked 2533.3 12602.3 4687.51 C++ Note: risk2 checked 2533.3 42177.5 14076.6 C++ Note: df101 -5164.53 -5164.53 -5164.53 C++ Note: df102 -2787.43 -13890.9 -5084.88 C++ Note: df103 -2875.43 -47831.4 -15650.9 C++ Note: df104 0.0500616 0.312566 0.0802485 C++ Note: Checking Deviance 10187.5 C++ Note: df105 0.969396 0.290413 0.324893 C++ Note: df106 1.85279 0.371793 1.01567 C++ Note: df100 3767 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: df100 3803 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: df101 -5164.534 -5164.534 -5164.534 C++ Note: df102 -2787.432 -13890.89 -5084.875 C++ Note: df103 -2875.432 -47831.43 -15650.91 C++ Note: df104 0.05006156 0.3125659 0.0802485 C++ Note: Checking Deviance 10187.47 C++ Note: df105 0.9693959 0.2904134 0.3248932 C++ Note: df106 1.852793 0.371793 1.015666 C++ Note: df101 -5164.53 -5164.53 -5164.53 C++ Note: df102 -2787.43 -13890.9 -5084.88 C++ Note: df103 -2875.43 -47831.4 -15650.9 C++ Note: df104 0.0500616 0.312566 0.0802485 C++ Note: Checking Deviance 10187.5 C++ Note: df105 0.969396 0.290413 0.324893 C++ Note: df106 1.85279 0.371793 1.01567 C++ Note: df501 -5164.534 C++ Note: df504 0.05006156 0.3125659 0.0802485 Error: Atleast one parameter must be free Warning: model covariate order changed Error: no events Warning: model covariate order changed Note: Initial starts: 1 , Number of iterations provided: 4 . Colossus requires one more iteration counts than number of guesses (for best guess) C++ Note: START_POIS_GUESS C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,37,Starting C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: df101 -18942.2 -18942.2 -18942.2 C++ Note: df102 -12053.5 -60927.3 -21843.1 C++ Note: df103 -12141.5 -218114 -69007.6 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: Checking Deviance 37742.9 C++ Note: df105 0.992752 0.279337 0.316532 C++ Note: df106 1.57151 0.310899 0.867193 C++ Note: Starting Halves C++ Note: df501 -18942.23 C++ Note: df504 0.4260961 0.646539 0.1572781 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: df100 1685 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: df100 1727 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: df101 -9722.072 -9722.072 -9722.072 C++ Note: df102 -5791.513 -29075.02 -10520.68 C++ Note: df103 -5879.513 -101991.2 -32827.7 C++ Note: df104 0.2541947 0.4783037 0.1233221 C++ Note: Checking Deviance 19302.54 C++ Note: df105 0.9850328 0.2850738 0.3204818 C++ Note: df106 1.678676 0.3343789 0.9240916 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: ending guess 0 C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.2541947 0.4783037 0.1233221, -9722.072<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: Made Risk Side Lists C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: Starting Halves C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: values checked 0.0500616 0.312566 0.0802485 C++ Note: sums checked 2172.57 2172.57 1154.38 C++ Note: derivs checked 1178.37 5851.84 2160.22 C++ Note: second derivs checked 1178.37 19594.1 6459.87 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 2172.57 1154.38 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 2172.57 1154.38 C++ Note: risk checked 4679.98 C++ Note: risk1 checked 2533.3 12602.3 4687.51 C++ Note: risk2 checked 2533.3 42177.5 14076.6 C++ Note: df101 -5164.53 -5164.53 -5164.53 C++ Note: df102 -2787.43 -13890.9 -5084.88 C++ Note: df103 -2875.43 -47831.4 -15650.9 C++ Note: df104 0.0500616 0.312566 0.0802485 C++ Note: Checking Deviance 10187.5 C++ Note: df105 0.969396 0.290413 0.324893 C++ Note: df106 1.85279 0.371793 1.01567 C++ Note: df100 4035 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: df100 4073 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: df101 -5164.534 -5164.534 -5164.534 C++ Note: df102 -2787.432 -13890.89 -5084.875 C++ Note: df103 -2875.432 -47831.43 -15650.91 C++ Note: df104 0.05006156 0.3125659 0.0802485 C++ Note: Checking Deviance 10187.47 C++ Note: df105 0.9693959 0.2904134 0.3248932 C++ Note: df106 1.852793 0.371793 1.015666 C++ Note: df101 -5164.53 -5164.53 -5164.53 C++ Note: df102 -2787.43 -13890.9 -5084.88 C++ Note: df103 -2875.43 -47831.4 -15650.9 C++ Note: df104 0.0500616 0.312566 0.0802485 C++ Note: Checking Deviance 10187.5 C++ Note: df105 0.969396 0.290413 0.324893 C++ Note: df106 1.85279 0.371793 1.01567 C++ Note: df501 -5164.534 C++ Note: df504 0.05006156 0.3125659 0.0802485 Warning: model covariate order changed Note: Initial starts: 3 , Number of iterations provided: 2 . Colossus requires one more iteration counts than number of guesses (for best guess) C++ Note: START_POIS_GUESS C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,65,Starting C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: df101 -18942.2 -18942.2 -18942.2 C++ Note: df102 -12053.5 -60927.3 -21843.1 C++ Note: df103 -12141.5 -218114 -69007.6 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: Checking Deviance 37742.9 C++ Note: df105 0.992752 0.279337 0.316532 C++ Note: df106 1.57151 0.310899 0.867193 C++ Note: Starting Halves C++ Note: df501 -18942.23 C++ Note: df504 0.4260961 0.646539 0.1572781 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: df100 2793 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: df100 2857 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: df101 -9722.072 -9722.072 -9722.072 C++ Note: df102 -5791.513 -29075.02 -10520.68 C++ Note: df103 -5879.513 -101991.2 -32827.7 C++ Note: df104 0.2541947 0.4783037 0.1233221 C++ Note: Checking Deviance 19302.54 C++ Note: df105 0.9850328 0.2850738 0.3204818 C++ Note: df106 1.678676 0.3343789 0.9240916 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: ending guess 0 C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: starting subterms 2 in guess 1 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: df101 -18942.2 -18942.2 -18942.2 C++ Note: df102 -12053.5 -60927.3 -21843.1 C++ Note: df103 -12141.5 -218114 -69007.6 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: Checking Deviance 37742.9 C++ Note: df105 0.992752 0.279337 0.316532 C++ Note: df106 1.57151 0.310899 0.867193 C++ Note: Starting Halves C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: df100 6212 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: values checked 0.340145 0.562421 0.1403 C++ Note: sums checked 5296.79 5296.79 1296.63 C++ Note: derivs checked 3244.35 16318.8 2592.93 C++ Note: second derivs checked 3244.35 57346.2 8013.16 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 5296.79 1296.63 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 5296.79 1296.63 C++ Note: risk checked 12148.9 C++ Note: risk1 checked 7411.88 37396.1 13604.8 C++ Note: risk2 checked 7411.88 131289 42203 C++ Note: df101 -13490.5 -13490.5 -13490.5 C++ Note: df102 -8318.73 -41981.5 -15084.1 C++ Note: df103 -8406.73 -148787 -47345.2 C++ Note: df104 0.340145 0.562421 0.1403 C++ Note: Checking Deviance 26839.3 C++ Note: df105 0.989532 0.282158 0.318597 C++ Note: df106 1.6217 0.321343 0.894353 C++ Note: df100 7449 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Changing back to best C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: df101 -18942.2 -18942.2 -18942.2 C++ Note: df102 -12053.5 -60927.3 -21843.1 C++ Note: df103 -12141.5 -218114 -69007.6 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: Checking Deviance 37742.9 C++ Note: df105 0.992752 0.279337 0.316532 C++ Note: df106 1.57151 0.310899 0.867193 C++ Note: df100 8786 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: df101 -18942.23 -18942.23 -18942.23 C++ Note: df102 -12053.55 -60927.32 -21843.14 C++ Note: df103 -12141.55 -218114.1 -69007.65 C++ Note: df104 0.4260961 0.646539 0.1572781 C++ Note: Checking Deviance 37742.86 C++ Note: df105 0.9927522 0.2793369 0.3165322 C++ Note: df106 1.571507 0.3108988 0.8671935 C++ Note: df101 -18942.2 -18942.2 -18942.2 C++ Note: df102 -12053.5 -60927.3 -21843.1 C++ Note: df103 -12141.5 -218114 -69007.6 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: Checking Deviance 37742.9 C++ Note: df105 0.992752 0.279337 0.316532 C++ Note: df106 1.57151 0.310899 0.867193 C++ Note: ending guess 1 C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: starting subterms 2 in guess 2 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: df101 -18942.2 -18942.2 -18942.2 C++ Note: df102 -12053.5 -60927.3 -21843.1 C++ Note: df103 -12141.5 -218114 -69007.6 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: Checking Deviance 37742.9 C++ Note: df105 0.992752 0.279337 0.316532 C++ Note: df106 1.57151 0.310899 0.867193 C++ Note: Starting Halves C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: df100 12507 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: values checked 0.340145 0.562421 0.1403 C++ Note: sums checked 5296.79 5296.79 1296.63 C++ Note: derivs checked 3244.35 16318.8 2592.93 C++ Note: second derivs checked 3244.35 57346.2 8013.16 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 5296.79 1296.63 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 5296.79 1296.63 C++ Note: risk checked 12148.9 C++ Note: risk1 checked 7411.88 37396.1 13604.8 C++ Note: risk2 checked 7411.88 131289 42203 C++ Note: df101 -13490.5 -13490.5 -13490.5 C++ Note: df102 -8318.73 -41981.5 -15084.1 C++ Note: df103 -8406.73 -148787 -47345.2 C++ Note: df104 0.340145 0.562421 0.1403 C++ Note: Checking Deviance 26839.3 C++ Note: df105 0.989532 0.282158 0.318597 C++ Note: df106 1.6217 0.321343 0.894353 C++ Note: df100 14617 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Changing back to best C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: df101 -18942.2 -18942.2 -18942.2 C++ Note: df102 -12053.5 -60927.3 -21843.1 C++ Note: df103 -12141.5 -218114 -69007.6 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: Checking Deviance 37742.9 C++ Note: df105 0.992752 0.279337 0.316532 C++ Note: df106 1.57151 0.310899 0.867193 C++ Note: df100 16267 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: df101 -18942.23 -18942.23 -18942.23 C++ Note: df102 -12053.55 -60927.32 -21843.14 C++ Note: df103 -12141.55 -218114.1 -69007.65 C++ Note: df104 0.4260961 0.646539 0.1572781 C++ Note: Checking Deviance 37742.86 C++ Note: df105 0.9927522 0.2793369 0.3165322 C++ Note: df106 1.571507 0.3108988 0.8671935 C++ Note: df101 -18942.2 -18942.2 -18942.2 C++ Note: df102 -12053.5 -60927.3 -21843.1 C++ Note: df103 -12141.5 -218114 -69007.6 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: Checking Deviance 37742.9 C++ Note: df105 0.992752 0.279337 0.316532 C++ Note: df106 1.57151 0.310899 0.867193 C++ Note: ending guess 2 C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.2541947 0.4783037 0.1233221, -9722.072<-- Best Guess 1, 0.4260961 0.646539 0.1572781, -18942.23 2, 0.4260961 0.646539 0.1572781, -18942.23 C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: Made Risk Side Lists C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: Starting Halves C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: values checked 0.0500616 0.312566 0.0802485 C++ Note: sums checked 2172.57 2172.57 1154.38 C++ Note: derivs checked 1178.37 5851.84 2160.22 C++ Note: second derivs checked 1178.37 19594.1 6459.87 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 2172.57 1154.38 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 2172.57 1154.38 C++ Note: risk checked 4679.98 C++ Note: risk1 checked 2533.3 12602.3 4687.51 C++ Note: risk2 checked 2533.3 42177.5 14076.6 C++ Note: df101 -5164.53 -5164.53 -5164.53 C++ Note: df102 -2787.43 -13890.9 -5084.88 C++ Note: df103 -2875.43 -47831.4 -15650.9 C++ Note: df104 0.0500616 0.312566 0.0802485 C++ Note: Checking Deviance 10187.5 C++ Note: df105 0.969396 0.290413 0.324893 C++ Note: df106 1.85279 0.371793 1.01567 C++ Note: df100 20957 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: df100 21044 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: df101 -5164.534 -5164.534 -5164.534 C++ Note: df102 -2787.432 -13890.89 -5084.875 C++ Note: df103 -2875.432 -47831.43 -15650.91 C++ Note: df104 0.05006156 0.3125659 0.0802485 C++ Note: Checking Deviance 10187.47 C++ Note: df105 0.9693959 0.2904134 0.3248932 C++ Note: df106 1.852793 0.371793 1.015666 C++ Note: df101 -5164.53 -5164.53 -5164.53 C++ Note: df102 -2787.43 -13890.9 -5084.88 C++ Note: df103 -2875.43 -47831.4 -15650.9 C++ Note: df104 0.0500616 0.312566 0.0802485 C++ Note: Checking Deviance 10187.5 C++ Note: df105 0.969396 0.290413 0.324893 C++ Note: df106 1.85279 0.371793 1.01567 C++ Note: df501 -5164.534 C++ Note: df504 0.05006156 0.3125659 0.0802485 Warning: model covariate order changed Error: guesses: 50 , iterations per guess: c(1, 1) Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,85,Starting C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: df101 -18942.2 -18942.2 -18942.2 C++ Note: df102 -12053.5 -60927.3 -21843.1 C++ Note: df103 -12141.5 -218114 -69007.6 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: Checking Deviance 37742.9 C++ Note: df105 0.992752 0.279337 0.316532 C++ Note: df106 1.57151 0.310899 0.867193 C++ Note: Starting Halves C++ Note: df501 -18942.23 C++ Note: df504 0.4260961 0.646539 0.1572781 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: df100 3422 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: df100 3502 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: df101 -9722.072 -9722.072 -9722.072 C++ Note: df102 -5791.513 -29075.02 -10520.68 C++ Note: df103 -5879.513 -101991.2 -32827.7 C++ Note: df104 0.2541947 0.4783037 0.1233221 C++ Note: Checking Deviance 19302.54 C++ Note: df105 0.9850328 0.2850738 0.3204818 C++ Note: df106 1.678676 0.3343789 0.9240916 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: ending guess 0 C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.2541947 0.4783037 0.1233221, -9722.072<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: Made Risk Side Lists C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: Starting Halves C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: values checked 0.0500616 0.312566 0.0802485 C++ Note: sums checked 2172.57 2172.57 1154.38 C++ Note: derivs checked 1178.37 5851.84 2160.22 C++ Note: second derivs checked 1178.37 19594.1 6459.87 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 2172.57 1154.38 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 2172.57 1154.38 C++ Note: risk checked 4679.98 C++ Note: risk1 checked 2533.3 12602.3 4687.51 C++ Note: risk2 checked 2533.3 42177.5 14076.6 C++ Note: df101 -5164.53 -5164.53 -5164.53 C++ Note: df102 -2787.43 -13890.9 -5084.88 C++ Note: df103 -2875.43 -47831.4 -15650.9 C++ Note: df104 0.0500616 0.312566 0.0802485 C++ Note: Checking Deviance 10187.5 C++ Note: df105 0.969396 0.290413 0.324893 C++ Note: df106 1.85279 0.371793 1.01567 C++ Note: df100 7792 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: df100 7873 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: df101 -5164.534 -5164.534 -5164.534 C++ Note: df102 -2787.432 -13890.89 -5084.875 C++ Note: df103 -2875.432 -47831.43 -15650.91 C++ Note: df104 0.05006156 0.3125659 0.0802485 C++ Note: Checking Deviance 10187.47 C++ Note: df105 0.9693959 0.2904134 0.3248932 C++ Note: df106 1.852793 0.371793 1.015666 C++ Note: df101 -5164.53 -5164.53 -5164.53 C++ Note: df102 -2787.43 -13890.9 -5084.88 C++ Note: df103 -2875.43 -47831.4 -15650.9 C++ Note: df104 0.0500616 0.312566 0.0802485 C++ Note: Checking Deviance 10187.5 C++ Note: df105 0.969396 0.290413 0.324893 C++ Note: df106 1.85279 0.371793 1.01567 C++ Note: df501 -5164.534 C++ Note: df504 0.05006156 0.3125659 0.0802485 Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,81,Starting C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: df101 -18942.2 -18942.2 -18942.2 C++ Note: df102 -12053.5 -60927.3 -21843.1 C++ Note: df103 -12141.5 -218114 -69007.6 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: Checking Deviance 37742.9 C++ Note: df105 0.992752 0.279337 0.316532 C++ Note: df106 1.57151 0.310899 0.867193 C++ Note: Starting Halves C++ Note: df501 -18942.23 C++ Note: df504 0.4260961 0.646539 0.1572781 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: df100 3435 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: df100 3518 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: df101 -9722.072 -9722.072 -9722.072 C++ Note: df102 -5791.513 -29075.02 -10520.68 C++ Note: df103 -5879.513 -101991.2 -32827.7 C++ Note: df104 0.2541947 0.4783037 0.1233221 C++ Note: Checking Deviance 19302.54 C++ Note: df105 0.9850328 0.2850738 0.3204818 C++ Note: df106 1.678676 0.3343789 0.9240916 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: ending guess 0 C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.2541947 0.4783037 0.1233221, -9722.072<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: Made Risk Side Lists C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: Starting Halves C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: values checked 0.0500616 0.312566 0.0802485 C++ Note: sums checked 2172.57 2172.57 1154.38 C++ Note: derivs checked 1178.37 5851.84 2160.22 C++ Note: second derivs checked 1178.37 19594.1 6459.87 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 2172.57 1154.38 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 2172.57 1154.38 C++ Note: risk checked 4679.98 C++ Note: risk1 checked 2533.3 12602.3 4687.51 C++ Note: risk2 checked 2533.3 42177.5 14076.6 C++ Note: df101 -5164.53 -5164.53 -5164.53 C++ Note: df102 -2787.43 -13890.9 -5084.88 C++ Note: df103 -2875.43 -47831.4 -15650.9 C++ Note: df104 0.0500616 0.312566 0.0802485 C++ Note: Checking Deviance 10187.5 C++ Note: df105 0.969396 0.290413 0.324893 C++ Note: df106 1.85279 0.371793 1.01567 C++ Note: df100 7904 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: df100 7987 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: df101 -5164.534 -5164.534 -5164.534 C++ Note: df102 -2787.432 -13890.89 -5084.875 C++ Note: df103 -2875.432 -47831.43 -15650.91 C++ Note: df104 0.05006156 0.3125659 0.0802485 C++ Note: Checking Deviance 10187.47 C++ Note: df105 0.9693959 0.2904134 0.3248932 C++ Note: df106 1.852793 0.371793 1.015666 C++ Note: df101 -5164.53 -5164.53 -5164.53 C++ Note: df102 -2787.43 -13890.9 -5084.88 C++ Note: df103 -2875.43 -47831.4 -15650.9 C++ Note: df104 0.0500616 0.312566 0.0802485 C++ Note: Checking Deviance 10187.5 C++ Note: df105 0.969396 0.290413 0.324893 C++ Note: df106 1.85279 0.371793 1.01567 C++ Note: df501 -5164.534 C++ Note: df504 0.05006156 0.3125659 0.0802485 Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,81,Starting C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked -0.1 -0.1 0.2 C++ Note: sums checked -261.4 -261.4 341.682 C++ Note: derivs checked 531 2083 1708.41 C++ Note: second derivs checked 0 0 0 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked -261.4 341.682 C++ Note: LIN_non-dose checked -261.4 341.682 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1000 1000 C++ Error: A non-positive risk was detected: -1.111148 C++ Warning: final failing values -0.1 -0.1 0.2 C++ Warning: final failing terms lin lin lin Invalid risk Error: Atleast one parameter must be free Note: 2 risk groups C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Term checked 0 1 1 2 C++ Note: df99,97,Starting C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: starting subterms 3 C++ Note: values checked 0.1 0.1 0.1 0.1 C++ Note: sums checked 7.420684 1.45 1.45 7.4 C++ Note: dose checked 7 7 7 C++ Note: non-dose checked 7.420684 1.45 7.4 C++ Note: LIN_non-dose checked 7 1.45 7 C++ Note: PLIN_non-dose checked 7 7 7.4 C++ Note: LOGLIN_non-dose checked 7.420684 7 7 C++ Note: df99,684,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:10 2024 Error: no events Error: Atleast one parameter must be free C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Term checked 0 1 1 2 C++ Note: df99,89,Starting C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: starting subterms 3 C++ Note: values checked 0.1 0.1 0.1 0.1 C++ Note: sums checked 7.420684 1.45 1.45 7.4 C++ Note: dose checked 7 7 7 C++ Note: non-dose checked 7.420684 1.45 7.4 C++ Note: LIN_non-dose checked 7 1.45 7 C++ Note: PLIN_non-dose checked 7 7 7.4 C++ Note: LOGLIN_non-dose checked 7.420684 7 7 C++ Note: df99,621,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:10 2024 Error: no events Error: Atleast one parameter must be free C++ Note: START_PLOT C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Term checked 0 0 C++ Note: df99,55,Starting C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: values checked 0.1 -0.1 C++ Note: sums checked 4.33113 4.33113 C++ Note: dose checked 7 C++ Note: non-dose checked 4.33113 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 4.33113 C++ Note: risk checked 4.33113 Error: Atleast one parameter must be free Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Warning: model covariate order changed Note: 2 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Term checked 0 0 C++ Note: df99,66,Starting C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Grouping Start C++ Note: df100 158 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0.1 -0.1 C++ Note: sums checked 4.33113 4.33113 C++ Note: derivs checked 4.33113 24.2686 C++ Note: second derivs checked 4.33113 152.884 C++ Note: dose checked 7 C++ Note: non-dose checked 4.33113 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 4.33113 C++ Note: risk checked 4.33113 C++ Note: risk1 checked 4.33113 24.2686 C++ Note: risk2 checked 4.33113 152.884 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.2374 C++ Note: risk1r checked 1.2374 6.93596 C++ Note: risk2r checked 1.2374 43.6346 C++ Note: riskl checked 1.2374 C++ Note: risk1l checked 1.2374 6.93596 C++ Note: risk2l checked 1.2374 43.6346 C++ Note: df101 0 0 C++ Note: df102 0 0 C++ Note: df103 0 0 C++ Note: df104 0.1 -0.1 C++ Note: df105 nan nan C++ Note: df106 nan nan C++ Note: riskr checked 1.2374 C++ Note: risk1r checked 1.2374 6.93596 C++ Note: risk2r checked 1.2374 43.6346 C++ Note: riskl checked 1.2374 C++ Note: risk1l checked 1.2374 6.93596 C++ Note: risk2l checked 1.2374 43.6346 C++ Note: df101 0 0 C++ Note: df102 0 0 C++ Note: df103 0 0 C++ Note: df104 0.1 -0.1 C++ Note: df105 nan nan C++ Note: df106 nan nan C++ Note: ending guess 0 C++ Note: df501 0 C++ Note: df504 0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.1 -0.1, 0<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.1 -0.1 C++ Note: sums checked 4.33113 4.33113 C++ Note: derivs checked 4.33113 24.2686 C++ Note: second derivs checked 4.33113 152.884 C++ Note: dose checked 7 C++ Note: non-dose checked 4.33113 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 4.33113 C++ Note: risk checked 4.33113 C++ Note: risk1 checked 4.33113 24.2686 C++ Note: risk2 checked 4.33113 152.884 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.2374 C++ Note: risk1r checked 1.2374 6.93596 C++ Note: risk2r checked 1.2374 43.6346 C++ Note: riskl checked 1.2374 C++ Note: risk1l checked 1.2374 6.93596 C++ Note: risk2l checked 1.2374 43.6346 C++ Note: df101 0 0 C++ Note: df102 0 0 C++ Note: df103 0 0 C++ Note: df104 0.1 -0.1 C++ Note: df105 nan nan C++ Note: df106 nan nan C++ Note: riskr checked 1.2374 C++ Note: risk1r checked 1.2374 6.93596 C++ Note: risk2r checked 1.2374 43.6346 C++ Note: riskl checked 1.2374 C++ Note: risk1l checked 1.2374 6.93596 C++ Note: risk2l checked 1.2374 43.6346 C++ Note: df101 0 0 C++ Note: df102 0 0 C++ Note: df103 0 0 C++ Note: df104 0.1 -0.1 C++ Note: df105 nan nan C++ Note: df106 nan nan C++ Note: Exiting Regression C++ Note: df501 0 C++ Note: df504 0.1 -0.1 Note: starting ph_plot Note: nonStratified survival curve calculation C++ Note: START_PLOT C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Term checked 0 0 C++ Note: df99,62,Starting C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: values checked -0.1 0.1 C++ Note: sums checked 4.33113 4.33113 C++ Note: derivs checked 24.2686 4.33113 C++ Note: second derivs checked 152.884 4.33113 C++ Note: dose checked 7 C++ Note: non-dose checked 4.33113 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 4.33113 C++ Note: risk checked 4.33113 C++ Note: risk1 checked 24.2686 4.33113 C++ Note: risk2 checked 152.884 4.33113 C++ Note: Grouping Start C++ Note: df100 610 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:10 2024 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.2374 C++ Note: risk1r checked 6.93596 1.2374 C++ Note: risk2r checked 43.6346 1.2374 C++ Note: riskl checked 1.2374 C++ Note: risk1l checked 6.93596 1.2374 C++ Note: risk2l checked 43.6346 1.2374 C++ Note: df101 0 0 C++ Note: df102 0 0 C++ Note: df103 0 0 C++ Note: df104 -0.1 0.1 C++ Note: df105 nan nan C++ Note: df106 nan nan Note: writing survival data Note: Plotting Martingale Residuals Note: Martingale Plot: d Saving 7 x 7 in image Saving 7 x 7 in image Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Note: Starting Plot Function Note: Getting Plot Info Error: no events Error: Atleast one parameter must be free Warning: rmin/rmax not equal size, lin/loglin min/max used Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 C++ Note: df99,43,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.01 C++ Note: sums checked 6437.949 C++ Note: dose checked 6400 C++ Note: non-dose checked 6437.949 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 6437.949 C++ Note: df99,681,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Note: 86 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 C++ Note: df99,39,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Grouping Start C++ Note: df100 3507 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 6437.95 C++ Note: derivs checked 3813.95 C++ Note: second derivs checked 3813.95 C++ Note: dose checked 6400 C++ Note: non-dose checked 6437.95 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 6437.95 C++ Note: risk checked 6437.95 C++ Note: risk1 checked 3813.95 C++ Note: risk2 checked 3813.95 C++ Note: Made Risk Side Lists C++ Note: riskr checked 4185.37 C++ Note: risk1r checked 2549.37 C++ Note: risk2r checked 2549.37 C++ Note: riskl checked 86.3317 C++ Note: risk1l checked 33.3317 C++ Note: risk2l checked 33.3317 C++ Note: df101 -313.163 C++ Note: df102 -21.7172 C++ Note: df103 -19.4313 C++ Note: df104 0.01 C++ Note: df105 1.11764 C++ Note: df106 14.42 C++ Note: Starting Halves C++ Note: df501 -313.1627 C++ Note: df504 0.01 C++ Note: values checked -0.828233 C++ Note: sums checked 4273.43 C++ Note: derivs checked 1649.43 C++ Note: second derivs checked 1649.43 C++ Note: dose checked 6400 C++ Note: non-dose checked 4273.43 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 4273.43 C++ Note: risk checked 4273.43 C++ Note: risk1 checked 1649.43 C++ Note: risk2 checked 1649.43 C++ Note: riskr checked 2738.53 C++ Note: risk1r checked 1102.53 C++ Note: risk2r checked 1102.53 C++ Note: riskl checked 67.4151 C++ Note: risk1l checked 14.4151 C++ Note: risk2l checked 14.4151 C++ Note: df101 -302.091 C++ Note: df102 -4.55996 C++ Note: df103 -20.4044 C++ Note: df104 -0.828233 C++ Note: df105 0.22348 C++ Note: df106 66.2487 C++ Note: df100 6733 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Starting Halves C++ Note: df501 -302.0913 C++ Note: df504 -0.828233 C++ Note: values checked -0.995843 C++ Note: sums checked 4018.9 C++ Note: derivs checked 1394.9 C++ Note: second derivs checked 1394.9 C++ Note: dose checked 6400 C++ Note: non-dose checked 4018.9 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 4018.9 C++ Note: risk checked 4018.9 C++ Note: risk1 checked 1394.9 C++ Note: risk2 checked 1394.9 C++ Note: riskr checked 2568.4 C++ Note: risk1r checked 932.396 C++ Note: risk2r checked 932.396 C++ Note: riskl checked 65.1906 C++ Note: risk1l checked 12.1906 C++ Note: risk2l checked 12.1906 C++ Note: df101 -301.611 C++ Note: df102 -1.18635 C++ Note: df103 -19.8114 C++ Note: df104 -0.995843 C++ Note: df105 0.0598821 C++ Note: df106 254.236 C++ Note: df100 8241 1 2 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Starting Halves C++ Note: df501 -301.6112 C++ Note: df504 -0.9958427 C++ Note: values checked -1.04075 C++ Note: sums checked 3957.64 C++ Note: derivs checked 1333.64 C++ Note: second derivs checked 1333.64 C++ Note: dose checked 6400 C++ Note: non-dose checked 3957.64 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 3957.64 C++ Note: risk checked 3957.64 C++ Note: risk1 checked 1333.64 C++ Note: risk2 checked 1333.64 C++ Note: riskr checked 2527.45 C++ Note: risk1r checked 891.447 C++ Note: risk2r checked 891.447 C++ Note: riskl checked 64.6552 C++ Note: risk1l checked 11.6552 C++ Note: risk2l checked 11.6552 C++ Note: df101 -301.578 C++ Note: df102 -0.300978 C++ Note: df103 -19.6132 C++ Note: df104 -1.04075 C++ Note: df105 0.0153457 C++ Note: df106 1001.99 C++ Note: df100 9760 1 3 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Starting Halves C++ Note: df501 -301.5778 C++ Note: df504 -1.040754 C++ Note: values checked -1.05226 C++ Note: sums checked 3942.38 C++ Note: derivs checked 1318.38 C++ Note: second derivs checked 1318.38 C++ Note: dose checked 6400 C++ Note: non-dose checked 3942.38 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 3942.38 C++ Note: risk checked 3942.38 C++ Note: risk1 checked 1318.38 C++ Note: risk2 checked 1318.38 C++ Note: riskr checked 2517.25 C++ Note: risk1r checked 881.246 C++ Note: risk2r checked 881.246 C++ Note: riskl checked 64.5218 C++ Note: risk1l checked 11.5218 C++ Note: risk2l checked 11.5218 C++ Note: df101 -301.576 C++ Note: df102 -0.0755501 C++ Note: df103 -19.5599 C++ Note: df104 -1.05226 C++ Note: df105 0.0038625 C++ Note: df106 3991.73 C++ Note: df100 11350 1 4 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Starting Halves C++ Note: df501 -301.5756 C++ Note: df504 -1.052263 C++ Note: values checked -1.05516 C++ Note: sums checked 3938.56 C++ Note: derivs checked 1314.56 C++ Note: second derivs checked 1314.56 C++ Note: dose checked 6400 C++ Note: non-dose checked 3938.56 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 3938.56 C++ Note: risk checked 3938.56 C++ Note: risk1 checked 1314.56 C++ Note: risk2 checked 1314.56 C++ Note: riskr checked 2514.7 C++ Note: risk1r checked 878.697 C++ Note: risk2r checked 878.697 C++ Note: riskl checked 64.4885 C++ Note: risk1l checked 11.4885 C++ Note: risk2l checked 11.4885 C++ Note: df101 -301.576 C++ Note: df102 -0.0189072 C++ Note: df103 -19.5463 C++ Note: df104 -1.05516 C++ Note: df105 0.0009673 C++ Note: df106 15950.3 C++ Note: df100 12894 1 5 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: riskr checked 2514.7 C++ Note: risk1r checked 878.697 C++ Note: risk2r checked 878.697 C++ Note: riskl checked 64.4885 C++ Note: risk1l checked 11.4885 C++ Note: risk2l checked 11.4885 C++ Note: df101 -301.576 C++ Note: df102 -0.0189072 C++ Note: df103 -19.5463 C++ Note: df104 -1.05516 C++ Note: df105 0.0009673 C++ Note: df106 15950.3 C++ Note: ending guess 0 C++ Note: df501 -301.5755 C++ Note: df504 -1.05516 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -1.05516, -301.5755<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -1.05516 C++ Note: sums checked 3938.56 C++ Note: derivs checked 1314.56 C++ Note: second derivs checked 1314.56 C++ Note: dose checked 6400 C++ Note: non-dose checked 3938.56 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 3938.56 C++ Note: risk checked 3938.56 C++ Note: risk1 checked 1314.56 C++ Note: risk2 checked 1314.56 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2514.7 C++ Note: risk1r checked 878.697 C++ Note: risk2r checked 878.697 C++ Note: riskl checked 64.4885 C++ Note: risk1l checked 11.4885 C++ Note: risk2l checked 11.4885 C++ Note: df101 -301.576 C++ Note: df102 -0.0189072 C++ Note: df103 -19.5463 C++ Note: df104 -1.05516 C++ Note: df105 0.0009673 C++ Note: df106 15950.3 C++ Note: Starting Halves C++ Note: df501 -301.5755 C++ Note: df504 -1.05516 C++ Note: values checked -1.05589 C++ Note: sums checked 3937.61 C++ Note: derivs checked 1313.61 C++ Note: second derivs checked 1313.61 C++ Note: dose checked 6400 C++ Note: non-dose checked 3937.61 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 3937.61 C++ Note: risk checked 3937.61 C++ Note: risk1 checked 1313.61 C++ Note: risk2 checked 1313.61 C++ Note: riskr checked 2514.06 C++ Note: risk1r checked 878.06 C++ Note: risk2r checked 878.06 C++ Note: riskl checked 64.4802 C++ Note: risk1l checked 11.4802 C++ Note: risk2l checked 11.4802 C++ Note: df101 -301.575 C++ Note: df102 -0.00472803 C++ Note: df103 -19.5429 C++ Note: df104 -1.05589 C++ Note: df105 0.00024193 C++ Note: df106 63784.6 C++ Note: df100 16835 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: riskr checked 2514.06 C++ Note: risk1r checked 878.06 C++ Note: risk2r checked 878.06 C++ Note: riskl checked 64.4802 C++ Note: risk1l checked 11.4802 C++ Note: risk2l checked 11.4802 C++ Note: df101 -301.575 C++ Note: df102 -0.00472803 C++ Note: df103 -19.5429 C++ Note: df104 -1.05589 C++ Note: df105 0.00024193 C++ Note: df106 63784.6 C++ Note: riskr checked 2514.06 C++ Note: risk1r checked 878.06 C++ Note: risk2r checked 878.06 C++ Note: riskl checked 64.4802 C++ Note: risk1l checked 11.4802 C++ Note: risk2l checked 11.4802 C++ Note: df101 -301.575 C++ Note: df102 -0.00472803 C++ Note: df103 -19.5429 C++ Note: df104 -1.05589 C++ Note: df105 0.00024193 C++ Note: df106 63784.6 C++ Note: Exiting Regression C++ Note: df501 -301.5755 C++ Note: df504 -1.055886 Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 1 C++ Note: df99,53,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 2 C++ Note: values checked -1.055886 -15 C++ Note: sums checked 3937.61 0.001957775 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 3937.61 0.001957775 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 3937.61 0.001957775 C++ Note: df99,1240,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Note: 86 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 1 C++ Note: df99,54,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Grouping Start C++ Note: df100 3731 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked -1.05589 -15 C++ Note: sums checked 3937.61 0.00195777 C++ Note: derivs checked 1313.61 0.00195777 C++ Note: second derivs checked 1313.61 0.00195777 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 3937.61 0.00195777 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 3937.61 0.00195777 C++ Note: risk checked 3937.61 C++ Note: risk1 checked 1313.61 0.00120452 C++ Note: risk2 checked 1313.61 0.00120452 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2514.06 C++ Note: risk1r checked 878.06 0.000769057 C++ Note: risk2r checked 878.06 0.000769057 C++ Note: riskl checked 64.4802 C++ Note: risk1l checked 11.4802 1.97246e-05 C++ Note: risk2l checked 11.4802 1.97246e-05 C++ Note: df101 -301.575 -301.575 C++ Note: df102 -0.00472803 -9.79382e-21 C++ Note: df103 -19.5429 -1.14349e-20 C++ Note: df104 -1.05589 -15 C++ Note: df105 0.00024193 0.856481 C++ Note: df106 63784.6 3.07924e+22 C++ Note: Starting Halves C++ Note: df501 -301.5755 C++ Note: df504 -1.055886 -15 C++ Note: values checked -1.05607 -15 C++ Note: sums checked 3937.37 0.00195777 C++ Note: derivs checked 1313.37 0.00195777 C++ Note: second derivs checked 1313.37 0.00195777 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 3937.37 0.00195777 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 3937.37 0.00195777 C++ Note: risk checked 3937.37 C++ Note: risk1 checked 1313.37 0.00120445 C++ Note: risk2 checked 1313.37 0.00120445 C++ Note: riskr checked 2513.9 C++ Note: risk1r checked 877.901 0.000769008 C++ Note: risk2r checked 877.901 0.000769008 C++ Note: riskl checked 64.4781 C++ Note: risk1l checked 11.4781 1.9724e-05 C++ Note: risk2l checked 11.4781 1.9724e-05 C++ Note: df101 -301.575 -301.575 C++ Note: df102 -0.00118208 5.45277e-21 C++ Note: df103 -19.5421 5.50571e-21 C++ Note: df104 -1.05607 -15 C++ Note: df105 6.04892e-05 0.990385 C++ Note: df106 255122 -5.53068e+22 C++ Note: df100 9776 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: riskr checked 2513.9 C++ Note: risk1r checked 877.901 0.000769008 C++ Note: risk2r checked 877.901 0.000769008 C++ Note: riskl checked 64.4781 C++ Note: risk1l checked 11.4781 1.9724e-05 C++ Note: risk2l checked 11.4781 1.9724e-05 C++ Note: df101 -301.575 -301.575 C++ Note: df102 -0.00118208 5.45277e-21 C++ Note: df103 -19.5421 5.50571e-21 C++ Note: df104 -1.05607 -15 C++ Note: df105 6.04892e-05 0.990385 C++ Note: df106 255122 -5.53068e+22 C++ Note: ending guess 0 C++ Note: df501 -301.5755 C++ Note: df504 -1.056067 -15 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -1.056067 -15, -301.5755<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked -1.05607 -15 C++ Note: sums checked 3937.37 0.00195777 C++ Note: derivs checked 1313.37 0.00195777 C++ Note: second derivs checked 1313.37 0.00195777 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 3937.37 0.00195777 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 3937.37 0.00195777 C++ Note: risk checked 3937.37 C++ Note: risk1 checked 1313.37 0.00120445 C++ Note: risk2 checked 1313.37 0.00120445 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2513.9 C++ Note: risk1r checked 877.901 0.000769008 C++ Note: risk2r checked 877.901 0.000769008 C++ Note: riskl checked 64.4781 C++ Note: risk1l checked 11.4781 1.9724e-05 C++ Note: risk2l checked 11.4781 1.9724e-05 C++ Note: df101 -301.575 -301.575 C++ Note: df102 -0.00118208 5.45277e-21 C++ Note: df103 -19.5421 5.50571e-21 C++ Note: df104 -1.05607 -15 C++ Note: df105 6.04892e-05 0.990385 C++ Note: df106 255122 -5.53068e+22 C++ Note: Starting Halves C++ Note: df501 -301.5755 C++ Note: df504 -1.056067 -15 C++ Note: values checked -1.05611 -15 C++ Note: sums checked 3937.31 0.00195777 C++ Note: derivs checked 1313.31 0.00195777 C++ Note: second derivs checked 1313.31 0.00195777 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 3937.31 0.00195777 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 3937.31 0.00195777 C++ Note: risk checked 3937.31 C++ Note: risk1 checked 1313.31 0.00120443 C++ Note: risk2 checked 1313.31 0.00120443 C++ Note: riskr checked 2513.86 C++ Note: risk1r checked 877.861 0.000768996 C++ Note: risk2r checked 877.861 0.000768996 C++ Note: riskl checked 64.4776 C++ Note: risk1l checked 11.4776 1.97238e-05 C++ Note: risk2l checked 11.4776 1.97238e-05 C++ Note: df101 -301.575 -301.575 C++ Note: df102 -0.000295526 -3.22931e-21 C++ Note: df103 -19.5419 -1.58819e-21 C++ Note: df104 -1.05611 -15 C++ Note: df105 1.51227e-05 2.03333 C++ Note: df106 1.02047e+06 9.33869e+22 C++ Note: df100 16761 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: riskr checked 2513.86 C++ Note: risk1r checked 877.861 0.000768996 C++ Note: risk2r checked 877.861 0.000768996 C++ Note: riskl checked 64.4776 C++ Note: risk1l checked 11.4776 1.97238e-05 C++ Note: risk2l checked 11.4776 1.97238e-05 C++ Note: df101 -301.575 -301.575 C++ Note: df102 -0.000295526 -3.22931e-21 C++ Note: df103 -19.5419 -1.58819e-21 C++ Note: df104 -1.05611 -15 C++ Note: df105 1.51227e-05 2.03333 C++ Note: df106 1.02047e+06 9.33869e+22 C++ Note: riskr checked 2513.86 C++ Note: risk1r checked 877.861 0.000768996 C++ Note: risk2r checked 877.861 0.000768996 C++ Note: riskl checked 64.4776 C++ Note: risk1l checked 11.4776 1.97238e-05 C++ Note: risk2l checked 11.4776 1.97238e-05 C++ Note: df101 -301.575 -301.575 C++ Note: df102 -0.000295526 -3.22931e-21 C++ Note: df103 -19.5419 -1.58819e-21 C++ Note: df104 -1.05611 -15 C++ Note: df105 1.51227e-05 2.03333 C++ Note: df106 1.02047e+06 9.33869e+22 C++ Note: Exiting Regression C++ Note: df501 -301.5755 C++ Note: df504 -1.056113 -15 Error: guesses_control and model_control have different strata options Note: 2 strata used Note: 86 risk groups Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 1 C++ Note: df99,51,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 2 C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.949 0.001957775 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.949 0.001957775 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.949 0.001957775 C++ Note: df99,705,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Note: 1 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 1 C++ Note: df99,42,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 2 C++ Note: values checked -0.4291924 -15.30179 C++ Note: sums checked 5082.307 0.001447756 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5082.307 0.001447756 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5082.307 0.001447756 C++ Note: df99,622,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Note: 2 strata used Note: 86 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 1 C++ Note: df99,28,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Grouping Start C++ Note: df100 6471 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.95 0.00195777 C++ Note: derivs checked 3813.95 0.00195777 C++ Note: second derivs checked 3813.95 0.00195777 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.95 0.00195777 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.95 0.00195777 C++ Note: risk checked 6437.95 C++ Note: risk1 checked 3813.95 0.00196938 C++ Note: risk2 checked 3813.95 0.00196938 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1135 832.282 C++ Note: riskl checked 53 33.3317 C++ Note: df101 -248.958 -248.958 C++ Note: df102 2.22045e-16 -1.11173e-21 C++ Note: df103 -2.22045e-16 -1.11173e-21 C++ Note: df104 0.01 -15 C++ Note: df105 -1 1 C++ Note: df106 -1.12121e+18 2.23937e+23 C++ Note: Starting Halves C++ Note: df501 -248.9581 C++ Note: df504 0.01 -15 C++ Note: values checked 0.76 -15.8214 C++ Note: sums checked 10698.1 0.000861035 C++ Note: derivs checked 8074.13 0.000861035 C++ Note: second derivs checked 8074.13 0.000861035 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 10698.1 0.000861035 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 10698.1 0.000861035 C++ Note: risk checked 10698.1 C++ Note: risk1 checked 8074.14 0.00143929 C++ Note: risk2 checked 8074.14 0.00143929 C++ Note: riskr checked 1135 1761.94 C++ Note: riskl checked 53 70.5632 C++ Note: df101 -248.958 -248.958 C++ Note: df102 5.55112e-16 8.73503e-22 C++ Note: df103 -5.55112e-16 8.73503e-22 C++ Note: df104 0.76 -15.8214 C++ Note: df105 -1 1 C++ Note: df106 -4.48483e+17 -2.85011e+23 C++ Note: df100 13326 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: riskr checked 1135 1761.94 C++ Note: riskl checked 53 70.5632 C++ Note: df101 -248.958 -248.958 C++ Note: df102 5.55112e-16 8.73503e-22 C++ Note: df103 -5.55112e-16 8.73503e-22 C++ Note: df104 0.76 -15.8214 C++ Note: df105 -1 1 C++ Note: df106 -4.48483e+17 -2.85011e+23 C++ Note: ending guess 0 C++ Note: df501 -248.9581 C++ Note: df504 0.7600004 -15.82143 C++ Note: starting subterms 2 in guess 1 C++ Note: values checked -0.429192 -15.3018 C++ Note: sums checked 5082.31 0.00144776 C++ Note: derivs checked 2458.31 0.00144776 C++ Note: second derivs checked 2458.31 0.00144776 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5082.31 0.00144776 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5082.31 0.00144776 C++ Note: risk checked 5082.31 C++ Note: risk1 checked 2458.31 0.00114968 C++ Note: risk2 checked 2458.31 0.00114968 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1135 536.453 C++ Note: riskl checked 53 21.4841 C++ Note: df101 -248.958 -248.958 C++ Note: df102 5.55112e-16 -3.70577e-22 C++ Note: df103 -5.55112e-16 -3.70577e-22 C++ Note: df104 -0.429192 -15.3018 C++ Note: df105 -1 1 C++ Note: df106 -4.48483e+17 6.71812e+23 C++ Note: Starting Halves C++ Note: df501 -248.9581 C++ Note: df504 0.7600004 -15.82143 C++ Note: values checked 0.320808 -16.3018 C++ Note: sums checked 7828.24 0.0005326 C++ Note: derivs checked 5204.24 0.0005326 C++ Note: second derivs checked 5204.24 0.0005326 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 7828.24 0.0005326 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 7828.24 0.0005326 C++ Note: risk checked 7828.24 C++ Note: risk1 checked 5204.24 0.000651456 C++ Note: risk2 checked 5204.24 0.000651456 C++ Note: riskr checked 1135 1135.67 C++ Note: riskl checked 53 45.4819 C++ Note: df101 -248.958 -248.958 C++ Note: df102 3.33067e-16 4.49986e-22 C++ Note: df103 -3.33067e-16 4.49986e-22 C++ Note: df104 0.320808 -16.3018 C++ Note: df105 -1 1 C++ Note: df106 -7.47472e+17 -5.53257e+23 C++ Note: df100 20035 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: values checked -0.0541923 -15.8018 C++ Note: sums checked 6200.82 0.000878109 C++ Note: derivs checked 3576.82 0.000878109 C++ Note: second derivs checked 3576.82 0.000878109 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6200.82 0.000878109 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6200.82 0.000878109 C++ Note: risk checked 6200.82 C++ Note: risk1 checked 3576.82 0.00085078 C++ Note: risk2 checked 3576.82 0.00085078 C++ Note: riskr checked 1135 780.534 C++ Note: riskl checked 53 31.2593 C++ Note: df101 -248.958 -248.958 C++ Note: df102 -3.33067e-15 -1.11173e-21 C++ Note: df103 3.33067e-15 -1.00585e-21 C++ Note: df104 -0.0541923 -15.8018 C++ Note: df105 -1 1.10526 C++ Note: df106 7.47472e+16 2.23937e+23 C++ Note: df100 22583 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: values checked -0.241692 -15.5518 C++ Note: sums checked 5589.28 0.00112751 C++ Note: derivs checked 2965.28 0.00112751 C++ Note: second derivs checked 2965.28 0.00112751 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5589.28 0.00112751 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5589.28 0.00112751 C++ Note: risk checked 5589.29 C++ Note: risk1 checked 2965.28 0.000984687 C++ Note: risk2 checked 2965.28 0.000984687 C++ Note: riskr checked 1135 647.085 C++ Note: riskl checked 53 25.9148 C++ Note: df101 -248.958 -248.958 C++ Note: df102 4.55191e-15 2.09111e-21 C++ Note: df103 -8.65974e-15 2.09111e-21 C++ Note: df104 -0.241692 -15.5518 C++ Note: df105 -0.525641 1 C++ Note: df106 -5.4693e+16 -1.19055e+23 C++ Note: df100 25168 3 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: values checked -0.335442 -15.4268 C++ Note: sums checked 5323.92 0.00127764 C++ Note: derivs checked 2699.92 0.00127764 C++ Note: second derivs checked 2699.92 0.00127764 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5323.92 0.00127764 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5323.92 0.00127764 C++ Note: risk checked 5323.92 C++ Note: risk1 checked 2699.92 0.00106282 C++ Note: risk2 checked 2699.92 0.00106282 C++ Note: riskr checked 1135 589.178 C++ Note: riskl checked 53 23.5957 C++ Note: df101 -248.958 -248.958 C++ Note: df102 3.33067e-16 1.16467e-21 C++ Note: df103 -3.33067e-16 1.27055e-21 C++ Note: df104 -0.335442 -15.4268 C++ Note: df105 -1 0.916667 C++ Note: df106 -7.47472e+17 -2.13758e+23 C++ Note: df100 29607 4 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: values checked -0.382317 -15.3643 C++ Note: sums checked 5200.28 0.00136004 C++ Note: derivs checked 2576.28 0.00136004 C++ Note: second derivs checked 2576.28 0.00136004 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5200.28 0.00136004 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5200.28 0.00136004 C++ Note: risk checked 5200.28 C++ Note: risk1 checked 2576.28 0.00110509 C++ Note: risk2 checked 2576.28 0.00110509 C++ Note: riskr checked 1135 562.198 C++ Note: riskl checked 53 22.5152 C++ Note: df101 -248.958 -248.958 C++ Note: df102 4.44089e-16 -1.32349e-21 C++ Note: df103 -4.44089e-16 -1.32349e-21 C++ Note: df104 -0.382317 -15.3643 C++ Note: df105 -1 1 C++ Note: df106 -5.60604e+17 1.88107e+23 C++ Note: df100 33221 5 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Changing back to best C++ Note: values checked -0.429192 -15.3018 C++ Note: sums checked 5082.31 0.00144776 C++ Note: derivs checked 2458.31 0.00144776 C++ Note: second derivs checked 2458.31 0.00144776 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5082.31 0.00144776 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5082.31 0.00144776 C++ Note: risk checked 5082.31 C++ Note: risk1 checked 2458.31 0.00114968 C++ Note: risk2 checked 2458.31 0.00114968 C++ Note: riskr checked 1135 536.453 C++ Note: riskl checked 53 21.4841 C++ Note: df101 -248.958 -248.958 C++ Note: df102 5.55112e-16 -3.70577e-22 C++ Note: df103 -5.55112e-16 -3.70577e-22 C++ Note: df104 -0.429192 -15.3018 C++ Note: df105 -1 1 C++ Note: df106 -4.48483e+17 6.71812e+23 C++ Note: ending guess 1 C++ Note: df501 -248.9581 C++ Note: df504 0.7600004 -15.82143 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.7600004 -15.82143, -248.9581<-- Best Guess 1, -0.4291924 -15.30179, -248.9581 C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.76 -15.8214 C++ Note: sums checked 10698.1 0.000861035 C++ Note: derivs checked 8074.13 0.000861035 C++ Note: second derivs checked 8074.13 0.000861035 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 10698.1 0.000861035 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 10698.1 0.000861035 C++ Note: risk checked 10698.1 C++ Note: risk1 checked 8074.14 0.00143929 C++ Note: risk2 checked 8074.14 0.00143929 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1135 1761.94 C++ Note: riskl checked 53 70.5632 C++ Note: df101 -248.958 -248.958 C++ Note: df102 5.55112e-16 8.73503e-22 C++ Note: df103 -5.55112e-16 8.73503e-22 C++ Note: df104 0.76 -15.8214 C++ Note: df105 -1 1 C++ Note: df106 -4.48483e+17 -2.85011e+23 C++ Note: Starting Halves C++ Note: df501 -248.9581 C++ Note: df504 0.7600004 -15.82143 C++ Note: values checked 1.51 -16.4578 C++ Note: sums checked 19716.9 0.000455671 C++ Note: derivs checked 17092.9 0.000455671 C++ Note: second derivs checked 17092.9 0.000455671 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 19716.9 0.000455671 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 19716.9 0.000455671 C++ Note: risk checked 19716.9 C++ Note: risk1 checked 17092.9 0.00140382 C++ Note: risk2 checked 17092.9 0.00140382 C++ Note: riskr checked 1135 3730.03 C++ Note: riskl checked 53 149.382 C++ Note: df101 -248.958 -248.958 C++ Note: df102 3.55271e-15 8.86738e-22 C++ Note: df103 -6.66134e-15 9.39677e-22 C++ Note: df104 1.51 -16.4578 C++ Note: df105 -0.533333 0.943662 C++ Note: df106 -7.00755e+16 -2.80757e+23 C++ Note: df100 43237 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: values checked 1.135 -16.1396 C++ Note: sums checked 14371.8 0.000626378 C++ Note: derivs checked 11747.8 0.000626378 C++ Note: second derivs checked 11747.8 0.000626378 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 14371.8 0.000626378 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 14371.8 0.000626378 C++ Note: risk checked 14371.8 C++ Note: risk1 checked 11747.8 0.00140659 C++ Note: risk2 checked 11747.8 0.00140659 C++ Note: riskr checked 1135 2563.61 C++ Note: riskl checked 53 102.669 C++ Note: df101 -248.958 -248.958 C++ Note: df102 -2.77556e-15 3.97047e-23 C++ Note: df103 2.77556e-15 4.36751e-22 C++ Note: df104 1.135 -16.1396 C++ Note: df105 -1 0.0909091 C++ Note: df106 8.96966e+16 -6.27025e+24 C++ Note: df100 46066 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: values checked 0.9475 -15.9805 C++ Note: sums checked 12363.3 0.000734393 C++ Note: derivs checked 9739.27 0.000734393 C++ Note: second derivs checked 9739.27 0.000734393 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 12363.3 0.000734393 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 12363.3 0.000734393 C++ Note: risk checked 12363.3 C++ Note: risk1 checked 9739.27 0.00141867 C++ Note: risk2 checked 9739.27 0.00141867 C++ Note: riskr checked 1135 2125.31 C++ Note: riskl checked 53 85.1154 C++ Note: df101 -248.958 -248.958 C++ Note: df102 1.11022e-16 -3.44107e-22 C++ Note: df103 -4.66294e-15 -3.44107e-22 C++ Note: df104 0.9475 -15.9805 C++ Note: df105 -0.0238095 1 C++ Note: df106 -2.24241e+18 7.2349e+23 C++ Note: df100 49530 3 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: values checked 0.85375 -15.901 C++ Note: sums checked 11491.7 0.000795197 C++ Note: derivs checked 8867.7 0.000795197 C++ Note: second derivs checked 8867.7 0.000795197 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 11491.7 0.000795197 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 11491.7 0.000795197 C++ Note: risk checked 11491.7 C++ Note: risk1 checked 8867.7 0.00142784 C++ Note: risk2 checked 8867.7 0.00142784 C++ Note: riskr checked 1135 1935.11 C++ Note: riskl checked 53 77.4985 C++ Note: df101 -248.958 -248.958 C++ Note: df102 3.33067e-16 8.99973e-22 C++ Note: df103 -3.33067e-16 1.58819e-21 C++ Note: df104 0.85375 -15.901 C++ Note: df105 -1 0.566667 C++ Note: df106 -7.47472e+17 -2.76629e+23 C++ Note: df100 53782 4 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: values checked 0.806875 -15.8612 C++ Note: sums checked 11085.6 0.000827461 C++ Note: derivs checked 8461.62 0.000827461 C++ Note: second derivs checked 8461.62 0.000827461 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 11085.6 0.000827461 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 11085.6 0.000827461 C++ Note: risk checked 11085.6 C++ Note: risk1 checked 8461.62 0.00143327 C++ Note: risk2 checked 8461.62 0.00143327 C++ Note: riskr checked 1135 1846.5 C++ Note: riskl checked 53 73.9495 C++ Note: df101 -248.958 -248.958 C++ Note: df102 -1.77636e-15 -1.4029e-21 C++ Note: df103 3.66374e-15 -1.98523e-21 C++ Note: df104 0.806875 -15.8612 C++ Note: df105 -0.484848 0.706667 C++ Note: df106 1.40151e+17 1.7746e+23 C++ Note: df100 58275 5 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Changing back to best C++ Note: values checked 0.76 -15.8214 C++ Note: sums checked 10698.1 0.000861035 C++ Note: derivs checked 8074.13 0.000861035 C++ Note: second derivs checked 8074.13 0.000861035 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 10698.1 0.000861035 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 10698.1 0.000861035 C++ Note: risk checked 10698.1 C++ Note: risk1 checked 8074.14 0.00143929 C++ Note: risk2 checked 8074.14 0.00143929 C++ Note: riskr checked 1135 1761.94 C++ Note: riskl checked 53 70.5632 C++ Note: df101 -248.958 -248.958 C++ Note: df102 5.55112e-16 8.73503e-22 C++ Note: df103 -5.55112e-16 8.73503e-22 C++ Note: df104 0.76 -15.8214 C++ Note: df105 -1 1 C++ Note: df106 -4.48483e+17 -2.85011e+23 C++ Note: Starting Halves C++ Note: df501 -248.9581 C++ Note: df504 0.7600004 -15.82143 C++ Note: values checked 0.79125 -15.8527 C++ Note: sums checked 10954.4 0.000834544 C++ Note: derivs checked 8330.43 0.000834544 C++ Note: second derivs checked 8330.43 0.000834544 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 10954.4 0.000834544 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 10954.4 0.000834544 C++ Note: risk checked 10954.4 C++ Note: risk1 checked 8330.44 0.00142843 C++ Note: risk2 checked 8330.44 0.00142843 C++ Note: riskr checked 1135 1817.87 C++ Note: riskl checked 53 72.8031 C++ Note: df101 -248.958 -248.958 C++ Note: df102 4.44089e-16 -4.49986e-22 C++ Note: df103 -4.44089e-16 -4.49986e-22 C++ Note: df104 0.79125 -15.8527 C++ Note: df105 -1 1 C++ Note: df106 -5.60604e+17 5.53257e+23 C++ Note: df100 67353 1 2 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: values checked 0.775625 -15.8371 C++ Note: sums checked 10825.3 0.000847686 C++ Note: derivs checked 8201.28 0.000847686 C++ Note: second derivs checked 8201.28 0.000847686 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 10825.3 0.000847686 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 10825.3 0.000847686 C++ Note: risk checked 10825.3 C++ Note: risk1 checked 8201.28 0.00143382 C++ Note: risk2 checked 8201.28 0.00143382 C++ Note: riskr checked 1135 1789.69 C++ Note: riskl checked 53 71.6744 C++ Note: df101 -248.958 -248.958 C++ Note: df102 4.44089e-16 -1.93229e-21 C++ Note: df103 -4.44089e-16 -1.93229e-21 C++ Note: df104 0.775625 -15.8371 C++ Note: df105 -1 1 C++ Note: df106 -5.60604e+17 1.28841e+23 C++ Note: df100 71855 2 2 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: values checked 0.767813 -15.8292 C++ Note: sums checked 10761.5 0.000854334 C++ Note: derivs checked 8137.46 0.000854334 C++ Note: second derivs checked 8137.46 0.000854334 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 10761.5 0.000854334 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 10761.5 0.000854334 C++ Note: risk checked 10761.5 C++ Note: risk1 checked 8137.46 0.00143654 C++ Note: risk2 checked 8137.46 0.00143654 C++ Note: riskr checked 1135 1775.76 C++ Note: riskl checked 53 71.1166 C++ Note: df101 -248.958 -248.958 C++ Note: df102 4.44089e-16 5.29396e-22 C++ Note: df103 -4.44089e-16 1.95876e-21 C++ Note: df104 0.767813 -15.8292 C++ Note: df105 -1 0.27027 C++ Note: df106 -5.60604e+17 -4.70269e+23 C++ Note: df100 76391 3 2 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: values checked 0.763907 -15.8253 C++ Note: sums checked 10729.7 0.000857678 C++ Note: derivs checked 8105.74 0.000857678 C++ Note: second derivs checked 8105.74 0.000857678 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 10729.7 0.000857678 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 10729.7 0.000857678 C++ Note: risk checked 10729.7 C++ Note: risk1 checked 8105.74 0.00143792 C++ Note: risk2 checked 8105.74 0.00143792 C++ Note: riskr checked 1135 1768.84 C++ Note: riskl checked 53 70.8393 C++ Note: df101 -248.958 -248.958 C++ Note: df102 -2.22045e-15 -1.61466e-21 C++ Note: df103 2.22045e-15 -1.61466e-21 C++ Note: df104 0.763907 -15.8253 C++ Note: df105 -1 1 C++ Note: df106 1.12121e+17 1.54186e+23 C++ Note: df100 80885 4 2 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: values checked 0.761954 -15.8234 C++ Note: sums checked 10713.9 0.000859355 C++ Note: derivs checked 8089.92 0.000859355 C++ Note: second derivs checked 8089.92 0.000859355 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 10713.9 0.000859355 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 10713.9 0.000859355 C++ Note: risk checked 10713.9 C++ Note: risk1 checked 8089.92 0.0014386 C++ Note: risk2 checked 8089.92 0.0014386 C++ Note: riskr checked 1135 1765.39 C++ Note: riskl checked 53 70.7011 C++ Note: df101 -248.958 -248.958 C++ Note: df102 5.55112e-16 -9.26442e-22 C++ Note: df103 -5.55112e-16 -1.03232e-21 C++ Note: df104 0.761954 -15.8234 C++ Note: df105 -1 0.897436 C++ Note: df106 -4.48483e+17 2.68725e+23 C++ Note: df100 85799 5 2 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Changing back to best C++ Note: values checked 0.76 -15.8214 C++ Note: sums checked 10698.1 0.000861035 C++ Note: derivs checked 8074.13 0.000861035 C++ Note: second derivs checked 8074.13 0.000861035 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 10698.1 0.000861035 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 10698.1 0.000861035 C++ Note: risk checked 10698.1 C++ Note: risk1 checked 8074.14 0.00143929 C++ Note: risk2 checked 8074.14 0.00143929 C++ Note: riskr checked 1135 1761.94 C++ Note: riskl checked 53 70.5632 C++ Note: df101 -248.958 -248.958 C++ Note: df102 5.55112e-16 8.73503e-22 C++ Note: df103 -5.55112e-16 8.73503e-22 C++ Note: df104 0.76 -15.8214 C++ Note: df105 -1 1 C++ Note: df106 -4.48483e+17 -2.85011e+23 C++ Note: Starting Halves C++ Note: df501 -248.9581 C++ Note: df504 0.7600004 -15.82143 C++ Note: values checked 0.760977 -15.8224 C++ Note: sums checked 10706 0.000860195 C++ Note: derivs checked 8082.02 0.000860195 C++ Note: second derivs checked 8082.02 0.000860195 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 10706 0.000860195 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 10706 0.000860195 C++ Note: risk checked 10706 C++ Note: risk1 checked 8082.02 0.00143895 C++ Note: risk2 checked 8082.02 0.00143895 C++ Note: riskr checked 1135 1763.66 C++ Note: riskl checked 53 70.6321 C++ Note: df101 -248.958 -248.958 C++ Note: df102 7.77156e-16 3.97047e-22 C++ Note: df103 -7.77156e-16 3.97047e-22 C++ Note: df104 0.760977 -15.8224 C++ Note: df105 -1 1 C++ Note: df106 -3.20345e+17 -6.27025e+23 C++ Note: df100 92693 1 3 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: values checked 0.760489 -15.8219 C++ Note: sums checked 10702.1 0.000860615 C++ Note: derivs checked 8078.08 0.000860615 C++ Note: second derivs checked 8078.08 0.000860615 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 10702.1 0.000860615 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 10702.1 0.000860615 C++ Note: risk checked 10702.1 C++ Note: risk1 checked 8078.08 0.00143912 C++ Note: risk2 checked 8078.08 0.00143912 C++ Note: riskr checked 1135 1762.8 C++ Note: riskl checked 53 70.5976 C++ Note: df101 -248.958 -248.958 C++ Note: df102 3.33067e-16 -9.26442e-22 C++ Note: df103 -3.33067e-16 -1.03232e-21 C++ Note: df104 0.760489 -15.8219 C++ Note: df105 -1 0.897436 C++ Note: df106 -7.47472e+17 2.68725e+23 C++ Note: df100 95233 2 3 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: values checked 0.760245 -15.8217 C++ Note: sums checked 10700.1 0.000860825 C++ Note: derivs checked 8076.11 0.000860825 C++ Note: second derivs checked 8076.11 0.000860825 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 10700.1 0.000860825 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 10700.1 0.000860825 C++ Note: risk checked 10700.1 C++ Note: risk1 checked 8076.11 0.00143921 C++ Note: risk2 checked 8076.11 0.00143921 C++ Note: riskr checked 1135 1762.37 C++ Note: riskl checked 53 70.5804 C++ Note: df101 -248.958 -248.958 C++ Note: df102 2.22045e-16 6.61744e-22 C++ Note: df103 -2.22045e-16 1.85288e-22 C++ Note: df104 0.760245 -15.8217 C++ Note: df105 -1 3.57143 C++ Note: df106 -1.12121e+18 -3.76215e+23 C++ Note: df100 97982 3 3 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: values checked 0.760122 -15.8216 C++ Note: sums checked 10699.1 0.00086093 C++ Note: derivs checked 8075.12 0.00086093 C++ Note: second derivs checked 8075.12 0.00086093 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 10699.1 0.00086093 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 10699.1 0.00086093 C++ Note: risk checked 10699.1 C++ Note: risk1 checked 8075.12 0.00143925 C++ Note: risk2 checked 8075.12 0.00143925 C++ Note: riskr checked 1135 1762.16 C++ Note: riskl checked 53 70.5718 C++ Note: df101 -248.958 -248.958 C++ Note: df102 3.33067e-16 2.77933e-21 C++ Note: df103 -3.33067e-16 2.96462e-21 C++ Note: df104 0.760122 -15.8216 C++ Note: df105 -1 0.9375 C++ Note: df106 -7.47472e+17 -8.9575e+22 C++ Note: df100 100975 4 3 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: values checked 0.760061 -15.8215 C++ Note: sums checked 10698.6 0.000860983 C++ Note: derivs checked 8074.63 0.000860983 C++ Note: second derivs checked 8074.63 0.000860983 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 10698.6 0.000860983 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 10698.6 0.000860983 C++ Note: risk checked 10698.6 C++ Note: risk1 checked 8074.63 0.00143927 C++ Note: risk2 checked 8074.63 0.00143927 C++ Note: riskr checked 1135 1762.05 C++ Note: riskl checked 53 70.5675 C++ Note: df101 -248.958 -248.958 C++ Note: df102 1.11022e-16 2.59404e-21 C++ Note: df103 -1.11022e-16 2.77933e-21 C++ Note: df104 0.760061 -15.8215 C++ Note: df105 -1 0.933333 C++ Note: df106 -2.24241e+18 -9.59732e+22 C++ Note: df100 104801 5 3 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Changing back to best C++ Note: values checked 0.76 -15.8214 C++ Note: sums checked 10698.1 0.000861035 C++ Note: derivs checked 8074.13 0.000861035 C++ Note: second derivs checked 8074.13 0.000861035 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 10698.1 0.000861035 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 10698.1 0.000861035 C++ Note: risk checked 10698.1 C++ Note: risk1 checked 8074.14 0.00143929 C++ Note: risk2 checked 8074.14 0.00143929 C++ Note: riskr checked 1135 1761.94 C++ Note: riskl checked 53 70.5632 C++ Note: df101 -248.958 -248.958 C++ Note: df102 5.55112e-16 8.73503e-22 C++ Note: df103 -5.55112e-16 8.73503e-22 C++ Note: df104 0.76 -15.8214 C++ Note: df105 -1 1 C++ Note: df106 -4.48483e+17 -2.85011e+23 C++ Note: riskr checked 1135 1761.94 C++ Note: riskl checked 53 70.5632 C++ Note: df101 -248.958 -248.958 C++ Note: df102 5.55112e-16 8.73503e-22 C++ Note: df103 -5.55112e-16 8.73503e-22 C++ Note: df104 0.76 -15.8214 C++ Note: df105 -1 1 C++ Note: df106 -4.48483e+17 -2.85011e+23 C++ Note: Exiting Regression C++ Note: df501 -248.9581 C++ Note: df504 0.7600004 -15.82143 Error: Atleast one parameter must be free Error: no events Error: Default Parameters used: 4, Covariates used: 6 Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,82,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.1 6 0.1 0.1 C++ Note: sums checked 254.8 254.8 8.4 8.4 C++ Note: dose checked 7 C++ Note: non-dose checked 338.8 C++ Note: LIN_non-dose checked 8.4 C++ Note: PLIN_non-dose checked 254.8 C++ Note: LOGLIN_non-dose checked 7 C++ Note: df99,442,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Note: 1 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,76,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.2215742 6.617788 0.7390184 0.9740044 C++ Note: sums checked 294.2532 294.2532 71.94696 71.94696 C++ Note: dose checked 7 C++ Note: non-dose checked 3352.422 C++ Note: LIN_non-dose checked 71.94696 C++ Note: PLIN_non-dose checked 294.2532 C++ Note: LOGLIN_non-dose checked 7 C++ Note: df99,419,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Note: 2 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,77,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.5654312 6.279162 0.3661973 1.023089 C++ Note: sums checked 294.4729 294.4729 58.35 58.35 C++ Note: dose checked 7 C++ Note: non-dose checked 2720.897 C++ Note: LIN_non-dose checked 58.35 C++ Note: PLIN_non-dose checked 294.4729 C++ Note: LOGLIN_non-dose checked 7 C++ Note: df99,430,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Note: 3 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,77,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.4540596 6.915258 0.7989374 1.006046 C++ Note: sums checked 316.5113 316.5113 75.80929 75.80929 C++ Note: dose checked 7 C++ Note: non-dose checked 3800.228 C++ Note: LIN_non-dose checked 75.80929 C++ Note: PLIN_non-dose checked 316.5113 C++ Note: LOGLIN_non-dose checked 7 C++ Note: df99,433,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Note: 4 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,78,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.005602757 6.392582 0.9584111 0.8517844 C++ Note: sums checked 275.7237 275.7237 76.02821 76.02821 C++ Note: dose checked 7 C++ Note: non-dose checked 3318.978 C++ Note: LIN_non-dose checked 76.02821 C++ Note: PLIN_non-dose checked 275.7237 C++ Note: LOGLIN_non-dose checked 7 C++ Note: df99,430,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Note: 5 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,77,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.4204453 6.836265 0.9252424 0.4260211 C++ Note: sums checked 311.7818 311.7818 56.75307 56.75307 C++ Note: dose checked 7 C++ Note: non-dose checked 2802.357 C++ Note: LIN_non-dose checked 56.75307 C++ Note: PLIN_non-dose checked 311.7818 C++ Note: LOGLIN_non-dose checked 7 C++ Note: df99,438,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Note: 6 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,72,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.05800769 6.850922 0.6988397 0.5647598 C++ Note: sums checked 297.175 297.175 53.07118 53.07118 C++ Note: dose checked 7 C++ Note: non-dose checked 2497.505 C++ Note: LIN_non-dose checked 53.07118 C++ Note: PLIN_non-dose checked 297.175 C++ Note: LOGLIN_non-dose checked 7 C++ Note: df99,418,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Note: 7 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,70,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.5803103 6.831288 0.469853 0.5463882 C++ Note: sums checked 318.2871 318.2871 42.68213 42.68213 C++ Note: dose checked 7 C++ Note: non-dose checked 2151.634 C++ Note: LIN_non-dose checked 42.68213 C++ Note: PLIN_non-dose checked 318.2871 C++ Note: LOGLIN_non-dose checked 7 C++ Note: df99,403,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Note: 8 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,73,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.004723529 6.147166 1.021718 0.6426009 C++ Note: sums checked 265.3794 265.3794 69.9014 69.9014 C++ Note: dose checked 7 C++ Note: non-dose checked 2936.739 C++ Note: LIN_non-dose checked 69.9014 C++ Note: PLIN_non-dose checked 265.3794 C++ Note: LOGLIN_non-dose checked 7 C++ Note: df99,426,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Note: 9 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,73,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.569784 6.401194 1.070144 0.3297178 C++ Note: sums checked 299.7811 299.7811 58.7942 58.7942 C++ Note: dose checked 7 C++ Note: non-dose checked 2791.148 C++ Note: LIN_non-dose checked 58.7942 C++ Note: PLIN_non-dose checked 299.7811 C++ Note: LOGLIN_non-dose checked 7 C++ Note: df99,428,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Error: tform not implemented Not Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,76,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.1 6 0.1 0.1 C++ Note: sums checked 6.978181e+23 6.978181e+23 6.978181e+23 6.978181e+23 C++ Note: dose checked 7 C++ Note: non-dose checked 6.978181e+23 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 6.978181e+23 C++ Note: df99,434,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Note: 1 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,76,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 1 C++ Note: values checked -1.078912 6.381868 -0.6204552 0.1403137 C++ Note: sums checked 7.148279e+18 7.148279e+18 7.148279e+18 7.148279e+18 C++ Note: dose checked 7 C++ Note: non-dose checked 7.148279e+18 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 7.148279e+18 C++ Note: df99,429,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Note: 2 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,74,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.124094 5.233358 0.7481482 0.8674378 C++ Note: sums checked 1.801258e+27 1.801258e+27 1.801258e+27 1.801258e+27 C++ Note: dose checked 7 C++ Note: non-dose checked 1.801258e+27 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 1.801258e+27 C++ Note: df99,425,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Note: 3 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,79,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.723155 5.889726 0.2044639 -0.4021117 C++ Note: sums checked 1.190181e+25 1.190181e+25 1.190181e+25 1.190181e+25 C++ Note: dose checked 7 C++ Note: non-dose checked 1.190181e+25 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 1.190181e+25 C++ Note: df99,427,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Note: 4 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,79,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.9384565 5.491963 -0.4929961 0.02297141 C++ Note: sums checked 9.295681e+15 9.295681e+15 9.295681e+15 9.295681e+15 C++ Note: dose checked 7 C++ Note: non-dose checked 9.295681e+15 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 9.295681e+15 C++ Note: df99,428,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Note: 5 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,77,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.7582357 5.622153 0.1475021 -0.6665197 C++ Note: sums checked 8.152489e+22 8.152489e+22 8.152489e+22 8.152489e+22 C++ Note: dose checked 7 C++ Note: non-dose checked 8.152489e+22 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 8.152489e+22 C++ Note: df99,410,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Note: 6 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,74,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.3285743 6.883413 -0.7341383 -0.6765644 C++ Note: sums checked 1.285792e+20 1.285792e+20 1.285792e+20 1.285792e+20 C++ Note: dose checked 7 C++ Note: non-dose checked 1.285792e+20 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 1.285792e+20 C++ Note: df99,416,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Note: 7 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,89,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.3835654 5.580549 0.8623136 0.6676176 C++ Note: sums checked 1.966433e+26 1.966433e+26 1.966433e+26 1.966433e+26 C++ Note: dose checked 7 C++ Note: non-dose checked 1.966433e+26 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 1.966433e+26 C++ Note: df99,435,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Note: 8 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,45,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.5220103 6.580932 0.07026672 0.2925053 C++ Note: sums checked 1.517451e+29 1.517451e+29 1.517451e+29 1.517451e+29 C++ Note: dose checked 7 C++ Note: non-dose checked 1.517451e+29 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 1.517451e+29 C++ Note: df99,295,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Note: 9 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,40,Starting C++ Note: Current Time, Wed Apr 3 17:09:11 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.7559232 5.684553 -0.3870322 -0.194844 C++ Note: sums checked 9.899231e+16 9.899231e+16 9.899231e+16 9.899231e+16 C++ Note: dose checked 7 C++ Note: non-dose checked 9.899231e+16 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 9.899231e+16 C++ Note: df99,238,Prep_Terms C++ Note: Current Time, Wed Apr 3 17:09:11 2024 Error: verbosity arguement not valid Error: verbosity arguement not valid Error: a0 arguement was not a number Error: a0 arguement was not a number Error: a0 arguement was not a number Error: item e1 in name_list has 1 items, but same item in Term_n_list has 6 items. Omit entry in Term_n_list to set to default of term 0 or add missing values Error: item e1 in name_list has 1 items, but same item in tform_list has 6 items. Omit entry in tform_list to set to default of 'loglin' or add missing values Error: item e1 in name_list has 1 items, but same item in keep_constant_list has 6 items. Omit entry in tform_list to set to default of 0 or add missing values Error: item e1 in name_list has 1 items, but same item in a_n_list has 6 items. Omit entry in a_n_list to set to default of 0 or add missing values Note: 2 strata used Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 2092 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 3237 C++ Note: riskl checked 59 Note: 2 strata used Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Term checked 0 C++ Note: df99,41,Starting C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 2143 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: Made Risk Side Lists C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: Starting Halves C++ Note: df501 -447.4645 C++ Note: df504 0.01 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: df100 4620 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: ending guess 0 C++ Note: df501 -447.4645 C++ Note: df504 0.01 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.01, -447.4645<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: Made Risk Side Lists C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: Starting Halves C++ Note: df501 -447.4645 C++ Note: df504 0.01 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: df100 8091 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: Exiting Regression C++ Note: df501 -447.4645 C++ Note: df504 0.01 Note: 2 strata used Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 2088 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 3237 C++ Note: riskl checked 59 Note: 2 strata used Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Term checked 0 C++ Note: df99,39,Starting C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 2140 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: Made Risk Side Lists C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df102 -4.51629 C++ Note: df103 -38.8061 C++ Note: df104 0.01 C++ Note: df105 0.116381 C++ Note: df106 99.0778 C++ Note: Starting Halves C++ Note: df501 -447.4645 C++ Note: df504 0.01 C++ Note: values checked -0.0772857 C++ Note: sums checked 886.858 C++ Note: risk checked 886.858 C++ Note: risk1 checked 1314.48 C++ Note: risk2 checked 3543.11 C++ Note: riskr checked 2906.58 2520.49 C++ Note: riskl checked 51.6944 47.43 C++ Note: df101 -447.218 C++ Note: df102 -1.11664 C++ Note: df103 -39.0819 C++ Note: df104 -0.0772857 C++ Note: df105 0.0285718 C++ Note: df106 400.504 C++ Note: df100 8038 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 2906.58 2520.49 C++ Note: riskl checked 51.6944 47.43 C++ Note: df101 -447.218 C++ Note: df102 -1.11664 C++ Note: df103 -39.0819 C++ Note: df104 -0.0772857 C++ Note: df105 0.0285718 C++ Note: df106 400.504 C++ Note: ending guess 0 C++ Note: df501 -447.2185 C++ Note: df504 -0.07728569 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.07728569, -447.2185<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.0772857 C++ Note: sums checked 886.858 C++ Note: risk checked 886.858 C++ Note: risk1 checked 1314.48 C++ Note: risk2 checked 3543.11 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2906.58 2520.49 C++ Note: riskl checked 51.6944 47.43 C++ Note: df101 -447.218 C++ Note: df102 -1.11664 C++ Note: df103 -39.0819 C++ Note: df104 -0.0772857 C++ Note: df105 0.0285718 C++ Note: df106 400.504 C++ Note: Starting Halves C++ Note: df501 -447.2185 C++ Note: df504 -0.07728569 C++ Note: values checked -0.0987146 C++ Note: sums checked 859.484 C++ Note: risk checked 859.484 C++ Note: risk1 checked 1241.17 C++ Note: risk2 checked 3301.92 C++ Note: riskr checked 2824.77 2437.74 C++ Note: riskl checked 49.9037 45.6007 C++ Note: df101 -447.204 C++ Note: df102 -0.27852 C++ Note: df103 -39.141 C++ Note: df104 -0.0987146 C++ Note: df105 0.00711582 C++ Note: df106 1605.64 C++ Note: df100 16660 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 2824.77 2437.74 C++ Note: riskl checked 49.9037 45.6007 C++ Note: df101 -447.204 C++ Note: df102 -0.27852 C++ Note: df103 -39.141 C++ Note: df104 -0.0987146 C++ Note: df105 0.00711582 C++ Note: df106 1605.64 C++ Note: riskr checked 2824.77 2437.74 C++ Note: riskl checked 49.9037 45.6007 C++ Note: df101 -447.204 C++ Note: df102 -0.27852 C++ Note: df103 -39.141 C++ Note: df104 -0.0987146 C++ Note: df105 0.00711582 C++ Note: df106 1605.64 C++ Note: Exiting Regression C++ Note: df501 -447.2035 C++ Note: df504 -0.09871455 Note: 2 strata used Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 2049 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 3237 C++ Note: riskl checked 59 Note: 2 strata used Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Term checked 0 C++ Note: df99,52,Starting C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 2127 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: dose checked 1000 C++ Note: non-dose checked 1016.5 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: Made Risk Side Lists C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: Starting Halves C++ Note: df501 -447.4645 C++ Note: df504 0.01 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: dose checked 1000 C++ Note: non-dose checked 1016.5 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: df100 4847 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: ending guess 0 C++ Note: df501 -447.4645 C++ Note: df504 0.01 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.01, -447.4645<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: dose checked 1000 C++ Note: non-dose checked 1016.5 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: Made Risk Side Lists C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: Starting Halves C++ Note: df501 -447.4645 C++ Note: df504 0.01 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: dose checked 1000 C++ Note: non-dose checked 1016.5 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: df100 8647 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: Exiting Regression C++ Note: df501 -447.4645 C++ Note: df504 0.01 Note: 2 strata used Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 2030 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 3237 C++ Note: riskl checked 59 Note: 2 strata used Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Term checked 0 C++ Note: df99,52,Starting C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 2132 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: derivs checked 1673.67 C++ Note: second derivs checked 4753.83 C++ Note: dose checked 1000 C++ Note: non-dose checked 1016.5 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: Made Risk Side Lists C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df102 -4.51629 C++ Note: df103 -38.8061 C++ Note: df104 0.01 C++ Note: df105 0.116381 C++ Note: df106 99.0778 C++ Note: Starting Halves C++ Note: df501 -447.4645 C++ Note: df504 0.01 C++ Note: values checked -0.0772857 C++ Note: sums checked 886.858 C++ Note: derivs checked 1314.48 C++ Note: second derivs checked 3543.11 C++ Note: dose checked 1000 C++ Note: non-dose checked 886.858 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 886.858 C++ Note: risk checked 886.858 C++ Note: risk1 checked 1314.48 C++ Note: risk2 checked 3543.11 C++ Note: riskr checked 2906.58 2520.49 C++ Note: riskl checked 51.6944 47.43 C++ Note: df101 -447.218 C++ Note: df102 -1.11664 C++ Note: df103 -39.0819 C++ Note: df104 -0.0772857 C++ Note: df105 0.0285718 C++ Note: df106 400.504 C++ Note: df100 8899 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 2906.58 2520.49 C++ Note: riskl checked 51.6944 47.43 C++ Note: df101 -447.218 C++ Note: df102 -1.11664 C++ Note: df103 -39.0819 C++ Note: df104 -0.0772857 C++ Note: df105 0.0285718 C++ Note: df106 400.504 C++ Note: ending guess 0 C++ Note: df501 -447.2185 C++ Note: df504 -0.07728569 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.07728569, -447.2185<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.0772857 C++ Note: sums checked 886.858 C++ Note: derivs checked 1314.48 C++ Note: second derivs checked 3543.11 C++ Note: dose checked 1000 C++ Note: non-dose checked 886.858 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 886.858 C++ Note: risk checked 886.858 C++ Note: risk1 checked 1314.48 C++ Note: risk2 checked 3543.11 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2906.58 2520.49 C++ Note: riskl checked 51.6944 47.43 C++ Note: df101 -447.218 C++ Note: df102 -1.11664 C++ Note: df103 -39.0819 C++ Note: df104 -0.0772857 C++ Note: df105 0.0285718 C++ Note: df106 400.504 C++ Note: Starting Halves C++ Note: df501 -447.2185 C++ Note: df504 -0.07728569 C++ Note: values checked -0.0987146 C++ Note: sums checked 859.484 C++ Note: derivs checked 1241.17 C++ Note: second derivs checked 3301.92 C++ Note: dose checked 1000 C++ Note: non-dose checked 859.484 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 859.484 C++ Note: risk checked 859.484 C++ Note: risk1 checked 1241.17 C++ Note: risk2 checked 3301.92 C++ Note: riskr checked 2824.77 2437.74 C++ Note: riskl checked 49.9037 45.6007 C++ Note: df101 -447.204 C++ Note: df102 -0.27852 C++ Note: df103 -39.141 C++ Note: df104 -0.0987146 C++ Note: df105 0.00711582 C++ Note: df106 1605.64 C++ Note: df100 18536 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 2824.77 2437.74 C++ Note: riskl checked 49.9037 45.6007 C++ Note: df101 -447.204 C++ Note: df102 -0.27852 C++ Note: df103 -39.141 C++ Note: df104 -0.0987146 C++ Note: df105 0.00711582 C++ Note: df106 1605.64 C++ Note: riskr checked 2824.77 2437.74 C++ Note: riskl checked 49.9037 45.6007 C++ Note: df101 -447.204 C++ Note: df102 -0.27852 C++ Note: df103 -39.141 C++ Note: df104 -0.0987146 C++ Note: df105 0.00711582 C++ Note: df106 1605.64 C++ Note: Exiting Regression C++ Note: df501 -447.2035 C++ Note: df504 -0.09871455 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 1008 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Term checked 0 C++ Note: df99,51,Starting C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 1063 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: Starting Halves C++ Note: df501 -525.8191 C++ Note: df504 0.01 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: df100 2624 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: ending guess 0 C++ Note: df501 -525.8191 C++ Note: df504 0.01 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.01, -525.8191<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: Starting Halves C++ Note: df501 -525.8191 C++ Note: df504 0.01 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: df100 4716 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: Exiting Regression C++ Note: df501 -525.8191 C++ Note: df504 0.01 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 1005 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Term checked 0 C++ Note: df99,54,Starting C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 1062 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12309.1 C++ Note: risk1r checked 19240.9 C++ Note: risk2r checked 46924.9 C++ Note: riskl checked 116.159 C++ Note: risk1l checked 218.829 C++ Note: risk2l checked 595.535 C++ Note: df101 -525.819 C++ Note: df102 -4.47019 C++ Note: df103 -39.2834 C++ Note: df104 0.01 C++ Note: df105 0.113793 C++ Note: df106 117.628 C++ Note: Starting Halves C++ Note: df501 -525.8191 C++ Note: df504 0.01 C++ Note: values checked -0.0753449 C++ Note: sums checked 889.415 C++ Note: risk checked 889.415 C++ Note: risk1 checked 1321.38 C++ Note: risk2 checked 3565.92 C++ Note: riskr checked 10823.9 C++ Note: risk1r checked 15714.3 C++ Note: risk2r checked 36253.4 C++ Note: riskl checked 99.4622 C++ Note: risk1l checked 174.499 C++ Note: risk2l checked 450.907 C++ Note: df101 -525.581 C++ Note: df102 -1.10144 C++ Note: df103 -39.6548 C++ Note: df104 -0.0753449 C++ Note: df105 0.0277758 C++ Note: df106 477.175 C++ Note: df100 4429 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 10823.9 C++ Note: risk1r checked 15714.3 C++ Note: risk2r checked 36253.4 C++ Note: riskl checked 99.4622 C++ Note: risk1l checked 174.499 C++ Note: risk2l checked 450.907 C++ Note: df101 -525.581 C++ Note: df102 -1.10144 C++ Note: df103 -39.6548 C++ Note: df104 -0.0753449 C++ Note: df105 0.0277758 C++ Note: df106 477.175 C++ Note: ending guess 0 C++ Note: df501 -525.5812 C++ Note: df504 -0.07534494 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.07534494, -525.5812<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.0753449 C++ Note: sums checked 889.415 C++ Note: risk checked 889.415 C++ Note: risk1 checked 1321.38 C++ Note: risk2 checked 3565.92 C++ Note: Made Risk Side Lists C++ Note: riskr checked 10823.9 C++ Note: risk1r checked 15714.3 C++ Note: risk2r checked 36253.4 C++ Note: riskl checked 99.4622 C++ Note: risk1l checked 174.499 C++ Note: risk2l checked 450.907 C++ Note: df101 -525.581 C++ Note: df102 -1.10144 C++ Note: df103 -39.6548 C++ Note: df104 -0.0753449 C++ Note: df105 0.0277758 C++ Note: df106 477.175 C++ Note: Starting Halves C++ Note: df501 -525.5812 C++ Note: df504 -0.07534494 C++ Note: values checked -0.0961768 C++ Note: sums checked 862.645 C++ Note: risk checked 862.645 C++ Note: risk1 checked 1249.59 C++ Note: risk2 checked 3329.49 C++ Note: riskr checked 10504.3 C++ Note: risk1r checked 14981.8 C++ Note: risk2r checked 34097.7 C++ Note: riskl checked 95.9227 C++ Note: risk1l checked 165.411 C++ Note: risk2l checked 421.981 C++ Note: df101 -525.567 C++ Note: df102 -0.274471 C++ Note: df103 -39.7399 C++ Note: df104 -0.0961768 C++ Note: df105 0.00690668 C++ Note: df106 1914.84 C++ Note: df100 9236 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 10504.3 C++ Note: risk1r checked 14981.8 C++ Note: risk2r checked 34097.7 C++ Note: riskl checked 95.9227 C++ Note: risk1l checked 165.411 C++ Note: risk2l checked 421.981 C++ Note: df101 -525.567 C++ Note: df102 -0.274471 C++ Note: df103 -39.7399 C++ Note: df104 -0.0961768 C++ Note: df105 0.00690668 C++ Note: df106 1914.84 C++ Note: riskr checked 10504.3 C++ Note: risk1r checked 14981.8 C++ Note: risk2r checked 34097.7 C++ Note: riskl checked 95.9227 C++ Note: risk1l checked 165.411 C++ Note: risk2l checked 421.981 C++ Note: df101 -525.567 C++ Note: df102 -0.274471 C++ Note: df103 -39.7399 C++ Note: df104 -0.0961768 C++ Note: df105 0.00690668 C++ Note: df106 1914.84 C++ Note: Exiting Regression C++ Note: df501 -525.5668 C++ Note: df504 -0.09617677 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 996 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Term checked 0 C++ Note: df99,50,Starting C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 1065 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: dose checked 1000 C++ Note: non-dose checked 1016.5 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: Starting Halves C++ Note: df501 -525.8191 C++ Note: df504 0.01 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: dose checked 1000 C++ Note: non-dose checked 1016.5 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: df100 2386 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: ending guess 0 C++ Note: df501 -525.8191 C++ Note: df504 0.01 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.01, -525.8191<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: dose checked 1000 C++ Note: non-dose checked 1016.5 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: Starting Halves C++ Note: df501 -525.8191 C++ Note: df504 0.01 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: dose checked 1000 C++ Note: non-dose checked 1016.5 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: df100 3909 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: Exiting Regression C++ Note: df501 -525.8191 C++ Note: df504 0.01 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 636 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Term checked 0 C++ Note: df99,31,Starting C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 676 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: derivs checked 1673.67 C++ Note: second derivs checked 4753.83 C++ Note: dose checked 1000 C++ Note: non-dose checked 1016.5 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12309.1 C++ Note: risk1r checked 19240.9 C++ Note: risk2r checked 46924.9 C++ Note: riskl checked 116.159 C++ Note: risk1l checked 218.829 C++ Note: risk2l checked 595.535 C++ Note: df101 -525.819 C++ Note: df102 -4.47019 C++ Note: df103 -39.2834 C++ Note: df104 0.01 C++ Note: df105 0.113793 C++ Note: df106 117.628 C++ Note: Starting Halves C++ Note: df501 -525.8191 C++ Note: df504 0.01 C++ Note: values checked -0.0753449 C++ Note: sums checked 889.415 C++ Note: derivs checked 1321.38 C++ Note: second derivs checked 3565.92 C++ Note: dose checked 1000 C++ Note: non-dose checked 889.415 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 889.415 C++ Note: risk checked 889.415 C++ Note: risk1 checked 1321.38 C++ Note: risk2 checked 3565.92 C++ Note: riskr checked 10823.9 C++ Note: risk1r checked 15714.3 C++ Note: risk2r checked 36253.4 C++ Note: riskl checked 99.4622 C++ Note: risk1l checked 174.499 C++ Note: risk2l checked 450.907 C++ Note: df101 -525.581 C++ Note: df102 -1.10144 C++ Note: df103 -39.6548 C++ Note: df104 -0.0753449 C++ Note: df105 0.0277758 C++ Note: df106 477.175 C++ Note: df100 3055 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 10823.9 C++ Note: risk1r checked 15714.3 C++ Note: risk2r checked 36253.4 C++ Note: riskl checked 99.4622 C++ Note: risk1l checked 174.499 C++ Note: risk2l checked 450.907 C++ Note: df101 -525.581 C++ Note: df102 -1.10144 C++ Note: df103 -39.6548 C++ Note: df104 -0.0753449 C++ Note: df105 0.0277758 C++ Note: df106 477.175 C++ Note: ending guess 0 C++ Note: df501 -525.5812 C++ Note: df504 -0.07534494 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.07534494, -525.5812<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.0753449 C++ Note: sums checked 889.415 C++ Note: derivs checked 1321.38 C++ Note: second derivs checked 3565.92 C++ Note: dose checked 1000 C++ Note: non-dose checked 889.415 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 889.415 C++ Note: risk checked 889.415 C++ Note: risk1 checked 1321.38 C++ Note: risk2 checked 3565.92 C++ Note: Made Risk Side Lists C++ Note: riskr checked 10823.9 C++ Note: risk1r checked 15714.3 C++ Note: risk2r checked 36253.4 C++ Note: riskl checked 99.4622 C++ Note: risk1l checked 174.499 C++ Note: risk2l checked 450.907 C++ Note: df101 -525.581 C++ Note: df102 -1.10144 C++ Note: df103 -39.6548 C++ Note: df104 -0.0753449 C++ Note: df105 0.0277758 C++ Note: df106 477.175 C++ Note: Starting Halves C++ Note: df501 -525.5812 C++ Note: df504 -0.07534494 C++ Note: values checked -0.0961768 C++ Note: sums checked 862.645 C++ Note: derivs checked 1249.59 C++ Note: second derivs checked 3329.49 C++ Note: dose checked 1000 C++ Note: non-dose checked 862.645 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 862.645 C++ Note: risk checked 862.645 C++ Note: risk1 checked 1249.59 C++ Note: risk2 checked 3329.49 C++ Note: riskr checked 10504.3 C++ Note: risk1r checked 14981.8 C++ Note: risk2r checked 34097.7 C++ Note: riskl checked 95.9227 C++ Note: risk1l checked 165.411 C++ Note: risk2l checked 421.981 C++ Note: df101 -525.567 C++ Note: df102 -0.274471 C++ Note: df103 -39.7399 C++ Note: df104 -0.0961768 C++ Note: df105 0.00690668 C++ Note: df106 1914.84 C++ Note: df100 6283 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 10504.3 C++ Note: risk1r checked 14981.8 C++ Note: risk2r checked 34097.7 C++ Note: riskl checked 95.9227 C++ Note: risk1l checked 165.411 C++ Note: risk2l checked 421.981 C++ Note: df101 -525.567 C++ Note: df102 -0.274471 C++ Note: df103 -39.7399 C++ Note: df104 -0.0961768 C++ Note: df105 0.00690668 C++ Note: df106 1914.84 C++ Note: riskr checked 10504.3 C++ Note: risk1r checked 14981.8 C++ Note: risk2r checked 34097.7 C++ Note: riskl checked 95.9227 C++ Note: risk1l checked 165.411 C++ Note: risk2l checked 421.981 C++ Note: df101 -525.567 C++ Note: df102 -0.274471 C++ Note: df103 -39.7399 C++ Note: df104 -0.0961768 C++ Note: df105 0.00690668 C++ Note: df106 1914.84 C++ Note: Exiting Regression C++ Note: df501 -525.5668 C++ Note: df504 -0.09617677 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Term checked 0 C++ Note: df99,29,Starting C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 694 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0 C++ Note: sums checked 1000 C++ Note: derivs checked 1626.94 C++ Note: second derivs checked 4593.87 C++ Note: dose checked 1000 C++ Note: non-dose checked 1000 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 1626.94 C++ Note: risk2 checked 4593.87 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: ending guess 0 C++ Note: df501 -525.7764 C++ Note: df504 0 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0, -525.7764<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0 C++ Note: sums checked 1000 C++ Note: derivs checked 1626.94 C++ Note: second derivs checked 4593.87 C++ Note: dose checked 1000 C++ Note: non-dose checked 1000 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 1626.94 C++ Note: risk2 checked 4593.87 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: Exiting Regression C++ Note: df501 -525.7764 C++ Note: df504 0 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 647 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Term checked 0 C++ Note: df99,29,Starting C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 675 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0 C++ Note: sums checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 1626.94 C++ Note: risk2 checked 4593.87 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12119 C++ Note: riskl checked 114 C++ Note: df101 -525.776 C++ Note: df104 0 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 C++ Note: df101 -525.776 C++ Note: df104 0 C++ Note: ending guess 0 C++ Note: df501 -525.7764 C++ Note: df504 0 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0, -525.7764<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0 C++ Note: sums checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 1626.94 C++ Note: risk2 checked 4593.87 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12119 C++ Note: riskl checked 114 C++ Note: df101 -525.776 C++ Note: df104 0 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 C++ Note: df101 -525.776 C++ Note: df104 0 C++ Note: Exiting Regression C++ Note: df501 -525.7764 C++ Note: df504 0 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 1122 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Term checked 0 C++ Note: df99,47,Starting C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 1214 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0 C++ Note: sums checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 1626.94 C++ Note: risk2 checked 4593.87 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: ending guess 0 C++ Note: df501 -525.7764 C++ Note: df504 0 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0, -525.7764<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0 C++ Note: sums checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 1626.94 C++ Note: risk2 checked 4593.87 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: Exiting Regression C++ Note: df501 -525.7764 C++ Note: df504 0 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 1124 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Term checked 0 C++ Note: df99,44,Starting C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 1221 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0 C++ Note: sums checked 1000 C++ Note: dose checked 1000 C++ Note: non-dose checked 1000 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1000 C++ Note: risk checked 1000 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12119 C++ Note: riskl checked 114 C++ Note: df101 -525.776 C++ Note: df104 0 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 C++ Note: df101 -525.776 C++ Note: df104 0 C++ Note: ending guess 0 C++ Note: df501 -525.7764 C++ Note: df504 0 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0, -525.7764<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0 C++ Note: sums checked 1000 C++ Note: dose checked 1000 C++ Note: non-dose checked 1000 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1000 C++ Note: risk checked 1000 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12119 C++ Note: riskl checked 114 C++ Note: df101 -525.776 C++ Note: df104 0 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 C++ Note: df101 -525.776 C++ Note: df104 0 C++ Note: Exiting Regression C++ Note: df501 -525.7764 C++ Note: df504 0 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 1143 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Term checked 0 C++ Note: df99,41,Starting C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 1194 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0 C++ Note: sums checked 1000 C++ Note: derivs checked 1626.94 C++ Note: second derivs checked 4593.87 C++ Note: dose checked 1000 C++ Note: non-dose checked 1000 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 1626.94 C++ Note: risk2 checked 4593.87 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: ending guess 0 C++ Note: df501 -525.7764 C++ Note: df504 0 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0, -525.7764<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0 C++ Note: sums checked 1000 C++ Note: derivs checked 1626.94 C++ Note: second derivs checked 4593.87 C++ Note: dose checked 1000 C++ Note: non-dose checked 1000 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 1626.94 C++ Note: risk2 checked 4593.87 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: Exiting Regression C++ Note: df501 -525.7764 C++ Note: df504 0 Note: 901 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Term checked 0 0 C++ Note: df99,53,Starting C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Grouping Start C++ Note: df100 8787 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0 0 C++ Note: sums checked 1000 1000 C++ Note: derivs checked 531 C++ Note: second derivs checked 531 C++ Note: dose checked 1000 C++ Note: non-dose checked 1000 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 531 C++ Note: risk2 checked 531 C++ Note: Made Risk Side Lists C++ Note: riskr checked 94828 C++ Note: risk1r checked 50387 C++ Note: risk2r checked 50387 C++ Note: riskl checked 901 C++ Note: risk1l checked 479 C++ Note: risk2l checked 479 C++ Note: df101 -4115.03 C++ Note: df102 1.62 C++ Note: df103 -222.912 C++ Note: df104 0 0 C++ Note: df105 -0.00726744 C++ Note: df106 -2540.14 C++ Note: Starting Halves C++ Note: df501 -4115.028 C++ Note: df504 0 0 C++ Note: values checked 0 0.00545058 C++ Note: sums checked 1000 1002.9 C++ Note: derivs checked 533.902 C++ Note: second derivs checked 533.902 C++ Note: dose checked 1000 C++ Note: non-dose checked 1002.9 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1002.9 C++ Note: risk checked 1002.9 C++ Note: risk1 checked 533.902 C++ Note: risk2 checked 533.902 C++ Note: riskr checked 95103.4 C++ Note: risk1r checked 50662.4 C++ Note: risk2r checked 50662.4 C++ Note: riskl checked 903.618 C++ Note: risk1l checked 481.618 C++ Note: risk2l checked 481.618 C++ Note: df101 -4115.02 C++ Note: df102 0.405212 C++ Note: df103 -222.834 C++ Note: df104 0 0.00545058 C++ Note: df105 -0.00181845 C++ Note: df106 -10155.2 C++ Note: df100 26949 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: riskr checked 95103.4 C++ Note: risk1r checked 50662.4 C++ Note: risk2r checked 50662.4 C++ Note: riskl checked 903.618 C++ Note: risk1l checked 481.618 C++ Note: risk2l checked 481.618 C++ Note: df101 -4115.02 C++ Note: df102 0.405212 C++ Note: df103 -222.834 C++ Note: df104 0 0.00545058 C++ Note: df105 -0.00181845 C++ Note: df106 -10155.2 C++ Note: ending guess 0 C++ Note: df501 -4115.022 C++ Note: df504 0 0.005450583 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0 0.005450583, -4115.022<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0 0.00545058 C++ Note: sums checked 1000 1002.9 C++ Note: derivs checked 533.902 C++ Note: second derivs checked 533.902 C++ Note: dose checked 1000 C++ Note: non-dose checked 1002.9 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1002.9 C++ Note: risk checked 1002.9 C++ Note: risk1 checked 533.902 C++ Note: risk2 checked 533.902 C++ Note: Made Risk Side Lists C++ Note: riskr checked 95103.4 C++ Note: risk1r checked 50662.4 C++ Note: risk2r checked 50662.4 C++ Note: riskl checked 903.618 C++ Note: risk1l checked 481.618 C++ Note: risk2l checked 481.618 C++ Note: df101 -4115.02 C++ Note: df102 0.405212 C++ Note: df103 -222.834 C++ Note: df104 0 0.00545058 C++ Note: df105 -0.00181845 C++ Note: df106 -10155.2 C++ Note: riskr checked 95103.4 C++ Note: risk1r checked 50662.4 C++ Note: risk2r checked 50662.4 C++ Note: riskl checked 903.618 C++ Note: risk1l checked 481.618 C++ Note: risk2l checked 481.618 C++ Note: df101 -4115.02 C++ Note: df102 0.405212 C++ Note: df103 -222.834 C++ Note: df104 0 0.00545058 C++ Note: df105 -0.00181845 C++ Note: df106 -10155.2 C++ Note: Exiting Regression C++ Note: df501 -4115.022 C++ Note: df504 0 0.005450583 C++ Note: START_PLOT C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Term checked 0 0 C++ Note: df99,51,Starting C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: values checked 0 0 C++ Note: sums checked 1000 1000 C++ Note: derivs checked 531 C++ Note: second derivs checked 531 C++ Note: dose checked 1000 C++ Note: non-dose checked 1000 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 531 C++ Note: risk2 checked 531 C++ Note: Grouping Start C++ Note: df100 8180 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:12 2024 C++ Note: Made Risk Side Lists C++ Note: riskr checked 94828 C++ Note: risk1r checked 50387 C++ Note: risk2r checked 50387 C++ Note: riskl checked 901 C++ Note: risk1l checked 479 C++ Note: risk2l checked 479 C++ Note: df101 -4115.03 C++ Note: df102 1.62 C++ Note: df103 -222.912 C++ Note: df104 0 0 C++ Note: df105 -0.00726744 C++ Note: df106 -2540.14 Saving 7 x 7 in image Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,40,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 527 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -70.83362 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1796 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2580 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -70.83362 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -70.83362<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -70.83362 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: df100 4397 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: df100 4995 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -70.83362 C++ Note: df504 -0.1 -0.1 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,32,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 498 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -70.83362 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1733 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2330 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -70.83362 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -70.83362<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -70.83362 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3994 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: df100 4570 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -70.83362 C++ Note: df504 -0.1 -0.1 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,69,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 766 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2637 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3518 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -79.58847<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 5796 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 6459 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,63,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 868 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2716 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3610 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -79.58847<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 5960 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 6812 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,33,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 519 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df102 16.5074 3.30325 C++ Note: df103 -18.3093 -6.12901 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.901584 -0.538953 C++ Note: df106 -4.29102 -21.4436 C++ Note: Starting Halves C++ Note: df501 -70.83362 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.619883 0.469278 C++ Note: sums checked 4417.35 1317.98 C++ Note: risk checked 5772.73 C++ Note: risk1 checked 17938.5 3618.7 C++ Note: risk2 checked 69199.8 3618.7 C++ Note: riskr checked 514.821 505.603 303.554 486.147 193.756 C++ Note: riskl checked 63.54 32.6275 33.8238 33.2801 27.4927 C++ Note: df101 -62.0935 -62.0935 C++ Note: df102 5.22908 0.548145 C++ Note: df103 -13.5197 -5.96742 C++ Note: df104 0.619883 0.469278 C++ Note: df105 -0.386774 -0.0918563 C++ Note: df106 -11.8747 -113.279 C++ Note: df100 4650 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 514.821 505.603 303.554 486.147 193.756 C++ Note: riskl checked 63.54 32.6275 33.8238 33.2801 27.4927 C++ Note: df101 -62.0935 -62.0935 C++ Note: df102 5.22908 0.548145 C++ Note: df103 -13.5197 -5.96742 C++ Note: df104 0.619883 0.469278 C++ Note: df105 -0.386774 -0.0918563 C++ Note: df106 -11.8747 -113.279 C++ Note: ending guess 0 C++ Note: df501 -62.09354 C++ Note: df504 0.6198828 0.4692784 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.6198828 0.4692784, -62.09354<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.619883 0.469278 C++ Note: sums checked 4417.35 1317.98 C++ Note: risk checked 5772.73 C++ Note: risk1 checked 17938.5 3618.7 C++ Note: risk2 checked 69199.8 3618.7 C++ Note: Made Risk Side Lists C++ Note: riskr checked 514.821 505.603 303.554 486.147 193.756 C++ Note: riskl checked 63.54 32.6275 33.8238 33.2801 27.4927 C++ Note: df101 -62.0935 -62.0935 C++ Note: df102 5.22908 0.548145 C++ Note: df103 -13.5197 -5.96742 C++ Note: df104 0.619883 0.469278 C++ Note: df105 -0.386774 -0.0918563 C++ Note: df106 -11.8747 -113.279 C++ Note: Starting Halves C++ Note: df501 -62.09354 C++ Note: df504 0.6198828 0.4692784 C++ Note: values checked 0.91652 0.578509 C++ Note: sums checked 12306.6 1415.97 C++ Note: risk checked 17152.3 C++ Note: risk1 checked 64328.2 11031.4 C++ Note: risk2 checked 275417 11031.4 C++ Note: riskr checked 1462.23 1165.04 646.347 1186.85 500.957 C++ Note: riskl checked 217.79 86.9718 83.1523 75.8908 78.6265 C++ Note: df101 -61.0456 -61.0456 C++ Note: df102 1.71587 0.145675 C++ Note: df103 -10.8383 -5.83821 C++ Note: df104 0.91652 0.578509 C++ Note: df105 -0.158315 -0.0249519 C++ Note: df106 -35.577 -419.054 C++ Note: df100 10675 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 1462.23 1165.04 646.347 1186.85 500.957 C++ Note: riskl checked 217.79 86.9718 83.1523 75.8908 78.6265 C++ Note: df101 -61.0456 -61.0456 C++ Note: df102 1.71587 0.145675 C++ Note: df103 -10.8383 -5.83821 C++ Note: df104 0.91652 0.578509 C++ Note: df105 -0.158315 -0.0249519 C++ Note: df106 -35.577 -419.054 C++ Note: riskr checked 1462.23 1165.04 646.347 1186.85 500.957 C++ Note: riskl checked 217.79 86.9718 83.1523 75.8908 78.6265 C++ Note: df101 -61.0456 -61.0456 C++ Note: df102 1.71587 0.145675 C++ Note: df103 -10.8383 -5.83821 C++ Note: df104 0.91652 0.578509 C++ Note: df105 -0.158315 -0.0249519 C++ Note: df106 -35.577 -419.054 C++ Note: Exiting Regression C++ Note: df501 -61.04555 C++ Note: df504 0.9165196 0.5785091 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,54,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 901 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df102 16.5074 3.30325 C++ Note: df103 -18.3093 -6.12901 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.901584 -0.538953 C++ Note: df106 -4.29102 -21.4436 C++ Note: Starting Halves C++ Note: df501 -70.83362 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.576188 0.304215 C++ Note: sums checked 3862.31 1188.8 C++ Note: risk checked 4568.13 C++ Note: risk1 checked 13753.3 2690.9 C++ Note: risk2 checked 52183.5 2690.9 C++ Note: riskr checked 414.363 413.933 244.68 398.005 156.588 C++ Note: riskl checked 48.1685 26.6528 25.8366 27.4467 21.1353 C++ Note: df101 -62.5017 -62.5017 C++ Note: df102 5.6944 1.50957 C++ Note: df103 -13.9239 -6.102 C++ Note: df104 0.576188 0.304215 C++ Note: df105 -0.408965 -0.247389 C++ Note: df106 -10.976 -41.4037 C++ Note: df100 5192 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 414.363 413.933 244.68 398.005 156.588 C++ Note: riskl checked 48.1685 26.6528 25.8366 27.4467 21.1353 C++ Note: df101 -62.5017 -62.5017 C++ Note: df102 5.6944 1.50957 C++ Note: df103 -13.9239 -6.102 C++ Note: df104 0.576188 0.304215 C++ Note: df105 -0.408965 -0.247389 C++ Note: df106 -10.976 -41.4037 C++ Note: ending guess 0 C++ Note: df501 -62.50166 C++ Note: df504 0.5761878 0.304215 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.5761878 0.304215, -62.50166<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.576188 0.304215 C++ Note: sums checked 3862.31 1188.8 C++ Note: risk checked 4568.13 C++ Note: risk1 checked 13753.3 2690.9 C++ Note: risk2 checked 52183.5 2690.9 C++ Note: Made Risk Side Lists C++ Note: riskr checked 414.363 413.933 244.68 398.005 156.588 C++ Note: riskl checked 48.1685 26.6528 25.8366 27.4467 21.1353 C++ Note: df101 -62.5017 -62.5017 C++ Note: df102 5.6944 1.50957 C++ Note: df103 -13.9239 -6.102 C++ Note: df104 0.576188 0.304215 C++ Note: df105 -0.408965 -0.247389 C++ Note: df106 -10.976 -41.4037 C++ Note: Starting Halves C++ Note: df501 -62.50166 C++ Note: df504 0.5761878 0.304215 C++ Note: values checked 0.882912 0.489757 C++ Note: sums checked 10855.8 1335.55 C++ Note: risk checked 14310.2 C++ Note: risk1 checked 52733.9 8921.09 C++ Note: risk2 checked 223453 8921.09 C++ Note: riskr checked 1234.55 1011.75 557.458 1025.04 421.979 C++ Note: riskl checked 179.683 75.2975 69.5878 66.5242 64.9931 C++ Note: df101 -61.143 -61.143 C++ Note: df102 2.01148 0.640444 C++ Note: df103 -11.1257 -5.93546 C++ Note: df104 0.882912 0.489757 C++ Note: df105 -0.180796 -0.107901 C++ Note: df106 -30.3971 -95.4697 C++ Note: df100 11239 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 1234.55 1011.75 557.458 1025.04 421.979 C++ Note: riskl checked 179.683 75.2975 69.5878 66.5242 64.9931 C++ Note: df101 -61.143 -61.143 C++ Note: df102 2.01148 0.640444 C++ Note: df103 -11.1257 -5.93546 C++ Note: df104 0.882912 0.489757 C++ Note: df105 -0.180796 -0.107901 C++ Note: df106 -30.3971 -95.4697 C++ Note: riskr checked 1234.55 1011.75 557.458 1025.04 421.979 C++ Note: riskl checked 179.683 75.2975 69.5878 66.5242 64.9931 C++ Note: df101 -61.143 -61.143 C++ Note: df102 2.01148 0.640444 C++ Note: df103 -11.1257 -5.93546 C++ Note: df104 0.882912 0.489757 C++ Note: df105 -0.180796 -0.107901 C++ Note: df106 -30.3971 -95.4697 C++ Note: Exiting Regression C++ Note: df501 -61.14297 C++ Note: df504 0.8829119 0.4897568 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,73,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 1042 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df102 5.42704 2.14202 C++ Note: df103 -7.11684 -6.21271 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.762564 -0.34478 C++ Note: df106 -14.6652 -37.1559 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.550424 0.30353 C++ Note: sums checked 3575.85 1188.31 C++ Note: risk checked 4228.8 C++ Note: risk1 checked 12473.9 2494.15 C++ Note: risk2 checked 46827.4 2494.15 C++ Note: riskr checked 616.483 485.721 374.917 603.993 261.606 C++ Note: riskl checked 43.76 24.6658 24.1668 25.7075 19.5703 C++ Note: df101 -76.8654 -76.8654 C++ Note: df102 1.27777 0.508497 C++ Note: df103 -7.18963 -6.04474 C++ Note: df104 0.550424 0.30353 C++ Note: df105 -0.177724 -0.0841223 C++ Note: df106 -60.1559 -151.162 C++ Note: df100 4790 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 616.483 485.721 374.917 603.993 261.606 C++ Note: riskl checked 43.76 24.6658 24.1668 25.7075 19.5703 C++ Note: df101 -76.8654 -76.8654 C++ Note: df102 1.27777 0.508497 C++ Note: df103 -7.18963 -6.04474 C++ Note: df104 0.550424 0.30353 C++ Note: df105 -0.177724 -0.0841223 C++ Note: df106 -60.1559 -151.162 C++ Note: ending guess 0 C++ Note: df501 -76.86543 C++ Note: df504 0.5504238 0.3035295 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.5504238 0.3035295, -76.86543<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.550424 0.30353 C++ Note: sums checked 3575.85 1188.31 C++ Note: risk checked 4228.8 C++ Note: risk1 checked 12473.9 2494.15 C++ Note: risk2 checked 46827.4 2494.15 C++ Note: Made Risk Side Lists C++ Note: riskr checked 616.483 485.721 374.917 603.993 261.606 C++ Note: riskl checked 43.76 24.6658 24.1668 25.7075 19.5703 C++ Note: df101 -76.8654 -76.8654 C++ Note: df102 1.27777 0.508497 C++ Note: df103 -7.18963 -6.04474 C++ Note: df104 0.550424 0.30353 C++ Note: df105 -0.177724 -0.0841223 C++ Note: df106 -60.1559 -151.162 C++ Note: Starting Halves C++ Note: df501 -76.86543 C++ Note: df504 0.5504238 0.3035295 C++ Note: values checked 0.699516 0.396693 C++ Note: sums checked 5706.63 1258.54 C++ Note: risk checked 7122.36 C++ Note: risk1 checked 23453.2 4323.35 C++ Note: risk2 checked 93329.8 4323.35 C++ Note: riskr checked 1103.97 748.255 549.423 973.678 397.318 C++ Note: riskl checked 81.8797 40.3981 38.9034 39.35 33.1873 C++ Note: df101 -76.7167 -76.7167 C++ Note: df102 0.321463 0.127669 C++ Note: df103 -7.13078 -5.96512 C++ Note: df104 0.699516 0.396693 C++ Note: df105 -0.045081 -0.0214027 C++ Note: df106 -238.649 -600.901 C++ Note: df100 10030 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 1103.97 748.255 549.423 973.678 397.318 C++ Note: riskl checked 81.8797 40.3981 38.9034 39.35 33.1873 C++ Note: df101 -76.7167 -76.7167 C++ Note: df102 0.321463 0.127669 C++ Note: df103 -7.13078 -5.96512 C++ Note: df104 0.699516 0.396693 C++ Note: df105 -0.045081 -0.0214027 C++ Note: df106 -238.649 -600.901 C++ Note: riskr checked 1103.97 748.255 549.423 973.678 397.318 C++ Note: riskl checked 81.8797 40.3981 38.9034 39.35 33.1873 C++ Note: df101 -76.7167 -76.7167 C++ Note: df102 0.321463 0.127669 C++ Note: df103 -7.13078 -5.96512 C++ Note: df104 0.699516 0.396693 C++ Note: df105 -0.045081 -0.0214027 C++ Note: df106 -238.649 -600.901 C++ Note: Exiting Regression C++ Note: df501 -76.71665 C++ Note: df504 0.6995155 0.3966929 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,55,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 903 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df102 5.42704 2.14202 C++ Note: df103 -7.11684 -6.21271 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.762564 -0.34478 C++ Note: df106 -14.6652 -37.1559 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.471923 0.158585 C++ Note: sums checked 2855.18 1091.25 C++ Note: risk checked 3109.21 C++ Note: risk1 checked 8604.8 1732.23 C++ Note: risk2 checked 31265.5 1732.23 C++ Note: riskr checked 437.598 369.44 288.407 451.269 203.987 C++ Note: riskl checked 29.7555 18.4415 17.3204 19.7081 14.0257 C++ Note: df101 -77.1115 -77.1115 C++ Note: df102 1.6628 1.2965 C++ Note: df103 -7.18852 -6.1617 C++ Note: df104 0.471923 0.158585 C++ Note: df105 -0.231313 -0.210412 C++ Note: df106 -46.3745 -59.4767 C++ Note: df100 4113 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 437.598 369.44 288.407 451.269 203.987 C++ Note: riskl checked 29.7555 18.4415 17.3204 19.7081 14.0257 C++ Note: df101 -77.1115 -77.1115 C++ Note: df102 1.6628 1.2965 C++ Note: df103 -7.18852 -6.1617 C++ Note: df104 0.471923 0.158585 C++ Note: df105 -0.231313 -0.210412 C++ Note: df106 -46.3745 -59.4767 C++ Note: ending guess 0 C++ Note: df501 -77.11153 C++ Note: df504 0.4719227 0.1585847 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.4719227 0.1585847, -77.11153<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.471923 0.158585 C++ Note: sums checked 2855.18 1091.25 C++ Note: risk checked 3109.21 C++ Note: risk1 checked 8604.8 1732.23 C++ Note: risk2 checked 31265.5 1732.23 C++ Note: Made Risk Side Lists C++ Note: riskr checked 437.598 369.44 288.407 451.269 203.987 C++ Note: riskl checked 29.7555 18.4415 17.3204 19.7081 14.0257 C++ Note: df101 -77.1115 -77.1115 C++ Note: df102 1.6628 1.2965 C++ Note: df103 -7.18852 -6.1617 C++ Note: df104 0.471923 0.158585 C++ Note: df105 -0.231313 -0.210412 C++ Note: df106 -46.3745 -59.4767 C++ Note: Starting Halves C++ Note: df501 -77.11153 C++ Note: df504 0.4719227 0.1585847 C++ Note: values checked 0.645408 0.316394 C++ Note: sums checked 4787.64 1197.62 C++ Note: risk checked 5698.95 C++ Note: risk1 checked 18076.9 3359.94 C++ Note: risk2 checked 70503.7 3359.94 C++ Note: riskr checked 866.381 621.431 461.192 794.093 330.167 C++ Note: riskl checked 63.0668 33.0727 31.2711 32.9428 26.3017 C++ Note: df101 -76.7689 -76.7689 C++ Note: df102 0.612277 0.54564 C++ Note: df103 -7.1484 -6.0464 C++ Note: df104 0.645408 0.316394 C++ Note: df105 -0.0856523 -0.0902421 C++ Note: df106 -125.383 -140.695 C++ Note: df100 8730 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 866.381 621.431 461.192 794.093 330.167 C++ Note: riskl checked 63.0668 33.0727 31.2711 32.9428 26.3017 C++ Note: df101 -76.7689 -76.7689 C++ Note: df102 0.612277 0.54564 C++ Note: df103 -7.1484 -6.0464 C++ Note: df104 0.645408 0.316394 C++ Note: df105 -0.0856523 -0.0902421 C++ Note: df106 -125.383 -140.695 C++ Note: riskr checked 866.381 621.431 461.192 794.093 330.167 C++ Note: riskl checked 63.0668 33.0727 31.2711 32.9428 26.3017 C++ Note: df101 -76.7689 -76.7689 C++ Note: df102 0.612277 0.54564 C++ Note: df103 -7.1484 -6.0464 C++ Note: df104 0.645408 0.316394 C++ Note: df105 -0.0856523 -0.0902421 C++ Note: df106 -125.383 -140.695 C++ Note: Exiting Regression C++ Note: df501 -76.76892 C++ Note: df504 0.6454076 0.316394 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,61,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 990 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -70.83362 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3414 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: df100 4597 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -70.83362 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -70.83362<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -70.83362 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: df100 7876 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: df100 9015 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -70.83362 C++ Note: df504 -0.1 -0.1 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,71,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 958 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -70.83362 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3387 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: df100 4518 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -70.83362 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -70.83362<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -70.83362 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: df100 7736 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: df100 8746 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -70.83362 C++ Note: df504 -0.1 -0.1 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,65,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 963 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2898 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3781 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -79.58847<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 6308 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 7180 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,59,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 936 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2818 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3699 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -79.58847<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 6191 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 7082 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,58,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 895 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: derivs checked 1229.85 410.233 C++ Note: second derivs checked 3319.14 410.233 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df102 16.5074 3.30325 C++ Note: df103 -18.3093 -6.12901 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.901584 -0.538953 C++ Note: df106 -4.29102 -21.4436 C++ Note: Starting Halves C++ Note: df501 -70.83362 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.619883 0.469278 C++ Note: sums checked 5772.73 5772.73 C++ Note: derivs checked 17938.5 3618.7 C++ Note: second derivs checked 69199.8 3618.7 C++ Note: dose checked 1000 C++ Note: non-dose checked 5772.73 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 5772.73 C++ Note: risk checked 5772.73 C++ Note: risk1 checked 17938.5 3618.7 C++ Note: risk2 checked 69199.8 3618.7 C++ Note: riskr checked 514.821 505.603 303.554 486.147 193.756 C++ Note: riskl checked 63.54 32.6275 33.8238 33.2801 27.4927 C++ Note: df101 -62.0935 -62.0935 C++ Note: df102 5.22908 0.548145 C++ Note: df103 -13.5197 -5.96742 C++ Note: df104 0.619883 0.469278 C++ Note: df105 -0.386774 -0.0918563 C++ Note: df106 -11.8747 -113.279 C++ Note: df100 6299 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 514.821 505.603 303.554 486.147 193.756 C++ Note: riskl checked 63.54 32.6275 33.8238 33.2801 27.4927 C++ Note: df101 -62.0935 -62.0935 C++ Note: df102 5.22908 0.548145 C++ Note: df103 -13.5197 -5.96742 C++ Note: df104 0.619883 0.469278 C++ Note: df105 -0.386774 -0.0918563 C++ Note: df106 -11.8747 -113.279 C++ Note: ending guess 0 C++ Note: df501 -62.09354 C++ Note: df504 0.6198828 0.4692784 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.6198828 0.4692784, -62.09354<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.619883 0.469278 C++ Note: sums checked 5772.73 5772.73 C++ Note: derivs checked 17938.5 3618.7 C++ Note: second derivs checked 69199.8 3618.7 C++ Note: dose checked 1000 C++ Note: non-dose checked 5772.73 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 5772.73 C++ Note: risk checked 5772.73 C++ Note: risk1 checked 17938.5 3618.7 C++ Note: risk2 checked 69199.8 3618.7 C++ Note: Made Risk Side Lists C++ Note: riskr checked 514.821 505.603 303.554 486.147 193.756 C++ Note: riskl checked 63.54 32.6275 33.8238 33.2801 27.4927 C++ Note: df101 -62.0935 -62.0935 C++ Note: df102 5.22908 0.548145 C++ Note: df103 -13.5197 -5.96742 C++ Note: df104 0.619883 0.469278 C++ Note: df105 -0.386774 -0.0918563 C++ Note: df106 -11.8747 -113.279 C++ Note: Starting Halves C++ Note: df501 -62.09354 C++ Note: df504 0.6198828 0.4692784 C++ Note: values checked 0.91652 0.578509 C++ Note: sums checked 17152.3 17152.3 C++ Note: derivs checked 64328.2 11031.4 C++ Note: second derivs checked 275417 11031.4 C++ Note: dose checked 1000 C++ Note: non-dose checked 17152.3 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 17152.3 C++ Note: risk checked 17152.3 C++ Note: risk1 checked 64328.2 11031.4 C++ Note: risk2 checked 275417 11031.4 C++ Note: riskr checked 1462.23 1165.04 646.347 1186.85 500.957 C++ Note: riskl checked 217.79 86.9718 83.1523 75.8908 78.6265 C++ Note: df101 -61.0456 -61.0456 C++ Note: df102 1.71587 0.145675 C++ Note: df103 -10.8383 -5.83821 C++ Note: df104 0.91652 0.578509 C++ Note: df105 -0.158315 -0.0249519 C++ Note: df106 -35.577 -419.054 C++ Note: df100 13501 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 1462.23 1165.04 646.347 1186.85 500.957 C++ Note: riskl checked 217.79 86.9718 83.1523 75.8908 78.6265 C++ Note: df101 -61.0456 -61.0456 C++ Note: df102 1.71587 0.145675 C++ Note: df103 -10.8383 -5.83821 C++ Note: df104 0.91652 0.578509 C++ Note: df105 -0.158315 -0.0249519 C++ Note: df106 -35.577 -419.054 C++ Note: riskr checked 1462.23 1165.04 646.347 1186.85 500.957 C++ Note: riskl checked 217.79 86.9718 83.1523 75.8908 78.6265 C++ Note: df101 -61.0456 -61.0456 C++ Note: df102 1.71587 0.145675 C++ Note: df103 -10.8383 -5.83821 C++ Note: df104 0.91652 0.578509 C++ Note: df105 -0.158315 -0.0249519 C++ Note: df106 -35.577 -419.054 C++ Note: Exiting Regression C++ Note: df501 -61.04555 C++ Note: df504 0.9165196 0.5785091 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,64,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 954 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: derivs checked 1229.85 410.233 C++ Note: second derivs checked 3319.14 410.233 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 82.896 79.114 52.5526 70.4917 37.8165 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -70.8336 -70.8336 C++ Note: df102 16.5074 3.30325 C++ Note: df103 -18.3093 -6.12901 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.901584 -0.538953 C++ Note: df106 -4.29102 -21.4436 C++ Note: Starting Halves C++ Note: df501 -70.83362 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.576188 0.304215 C++ Note: sums checked 4568.13 4568.13 C++ Note: derivs checked 13753.3 2690.9 C++ Note: second derivs checked 52183.5 2690.9 C++ Note: dose checked 1000 C++ Note: non-dose checked 4568.13 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 4568.13 C++ Note: risk checked 4568.13 C++ Note: risk1 checked 13753.3 2690.9 C++ Note: risk2 checked 52183.5 2690.9 C++ Note: riskr checked 414.363 413.933 244.68 398.005 156.588 C++ Note: riskl checked 48.1685 26.6528 25.8366 27.4467 21.1353 C++ Note: df101 -62.5017 -62.5017 C++ Note: df102 5.6944 1.50957 C++ Note: df103 -13.9239 -6.102 C++ Note: df104 0.576188 0.304215 C++ Note: df105 -0.408965 -0.247389 C++ Note: df106 -10.976 -41.4037 C++ Note: df100 6222 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 414.363 413.933 244.68 398.005 156.588 C++ Note: riskl checked 48.1685 26.6528 25.8366 27.4467 21.1353 C++ Note: df101 -62.5017 -62.5017 C++ Note: df102 5.6944 1.50957 C++ Note: df103 -13.9239 -6.102 C++ Note: df104 0.576188 0.304215 C++ Note: df105 -0.408965 -0.247389 C++ Note: df106 -10.976 -41.4037 C++ Note: ending guess 0 C++ Note: df501 -62.50166 C++ Note: df504 0.5761878 0.304215 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.5761878 0.304215, -62.50166<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.576188 0.304215 C++ Note: sums checked 4568.13 4568.13 C++ Note: derivs checked 13753.3 2690.9 C++ Note: second derivs checked 52183.5 2690.9 C++ Note: dose checked 1000 C++ Note: non-dose checked 4568.13 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 4568.13 C++ Note: risk checked 4568.13 C++ Note: risk1 checked 13753.3 2690.9 C++ Note: risk2 checked 52183.5 2690.9 C++ Note: Made Risk Side Lists C++ Note: riskr checked 414.363 413.933 244.68 398.005 156.588 C++ Note: riskl checked 48.1685 26.6528 25.8366 27.4467 21.1353 C++ Note: df101 -62.5017 -62.5017 C++ Note: df102 5.6944 1.50957 C++ Note: df103 -13.9239 -6.102 C++ Note: df104 0.576188 0.304215 C++ Note: df105 -0.408965 -0.247389 C++ Note: df106 -10.976 -41.4037 C++ Note: Starting Halves C++ Note: df501 -62.50166 C++ Note: df504 0.5761878 0.304215 C++ Note: values checked 0.882912 0.489757 C++ Note: sums checked 14310.2 14310.2 C++ Note: derivs checked 52733.9 8921.09 C++ Note: second derivs checked 223453 8921.09 C++ Note: dose checked 1000 C++ Note: non-dose checked 14310.2 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 14310.2 C++ Note: risk checked 14310.2 C++ Note: risk1 checked 52733.9 8921.09 C++ Note: risk2 checked 223453 8921.09 C++ Note: riskr checked 1234.55 1011.75 557.458 1025.04 421.979 C++ Note: riskl checked 179.683 75.2975 69.5878 66.5242 64.9931 C++ Note: df101 -61.143 -61.143 C++ Note: df102 2.01148 0.640444 C++ Note: df103 -11.1257 -5.93546 C++ Note: df104 0.882912 0.489757 C++ Note: df105 -0.180796 -0.107901 C++ Note: df106 -30.3971 -95.4697 C++ Note: df100 13145 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 1234.55 1011.75 557.458 1025.04 421.979 C++ Note: riskl checked 179.683 75.2975 69.5878 66.5242 64.9931 C++ Note: df101 -61.143 -61.143 C++ Note: df102 2.01148 0.640444 C++ Note: df103 -11.1257 -5.93546 C++ Note: df104 0.882912 0.489757 C++ Note: df105 -0.180796 -0.107901 C++ Note: df106 -30.3971 -95.4697 C++ Note: riskr checked 1234.55 1011.75 557.458 1025.04 421.979 C++ Note: riskl checked 179.683 75.2975 69.5878 66.5242 64.9931 C++ Note: df101 -61.143 -61.143 C++ Note: df102 2.01148 0.640444 C++ Note: df103 -11.1257 -5.93546 C++ Note: df104 0.882912 0.489757 C++ Note: df105 -0.180796 -0.107901 C++ Note: df106 -30.3971 -95.4697 C++ Note: Exiting Regression C++ Note: df501 -61.14297 C++ Note: df504 0.8829119 0.4897568 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,71,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 963 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: derivs checked 1229.85 410.233 C++ Note: second derivs checked 3319.14 410.233 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df102 5.42704 2.14202 C++ Note: df103 -7.11684 -6.21271 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.762564 -0.34478 C++ Note: df106 -14.6652 -37.1559 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.550424 0.30353 C++ Note: sums checked 4228.8 4228.8 C++ Note: derivs checked 12473.9 2494.15 C++ Note: second derivs checked 46827.4 2494.15 C++ Note: dose checked 1000 C++ Note: non-dose checked 4228.8 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 4228.8 C++ Note: risk checked 4228.8 C++ Note: risk1 checked 12473.9 2494.15 C++ Note: risk2 checked 46827.4 2494.15 C++ Note: riskr checked 616.483 485.721 374.917 603.993 261.606 C++ Note: riskl checked 43.76 24.6658 24.1668 25.7075 19.5703 C++ Note: df101 -76.8654 -76.8654 C++ Note: df102 1.27777 0.508497 C++ Note: df103 -7.18963 -6.04474 C++ Note: df104 0.550424 0.30353 C++ Note: df105 -0.177724 -0.0841223 C++ Note: df106 -60.1559 -151.162 C++ Note: df100 5340 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 616.483 485.721 374.917 603.993 261.606 C++ Note: riskl checked 43.76 24.6658 24.1668 25.7075 19.5703 C++ Note: df101 -76.8654 -76.8654 C++ Note: df102 1.27777 0.508497 C++ Note: df103 -7.18963 -6.04474 C++ Note: df104 0.550424 0.30353 C++ Note: df105 -0.177724 -0.0841223 C++ Note: df106 -60.1559 -151.162 C++ Note: ending guess 0 C++ Note: df501 -76.86543 C++ Note: df504 0.5504238 0.3035295 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.5504238 0.3035295, -76.86543<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.550424 0.30353 C++ Note: sums checked 4228.8 4228.8 C++ Note: derivs checked 12473.9 2494.15 C++ Note: second derivs checked 46827.4 2494.15 C++ Note: dose checked 1000 C++ Note: non-dose checked 4228.8 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 4228.8 C++ Note: risk checked 4228.8 C++ Note: risk1 checked 12473.9 2494.15 C++ Note: risk2 checked 46827.4 2494.15 C++ Note: Made Risk Side Lists C++ Note: riskr checked 616.483 485.721 374.917 603.993 261.606 C++ Note: riskl checked 43.76 24.6658 24.1668 25.7075 19.5703 C++ Note: df101 -76.8654 -76.8654 C++ Note: df102 1.27777 0.508497 C++ Note: df103 -7.18963 -6.04474 C++ Note: df104 0.550424 0.30353 C++ Note: df105 -0.177724 -0.0841223 C++ Note: df106 -60.1559 -151.162 C++ Note: Starting Halves C++ Note: df501 -76.86543 C++ Note: df504 0.5504238 0.3035295 C++ Note: values checked 0.699516 0.396693 C++ Note: sums checked 7122.36 7122.36 C++ Note: derivs checked 23453.2 4323.35 C++ Note: second derivs checked 93329.8 4323.35 C++ Note: dose checked 1000 C++ Note: non-dose checked 7122.36 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 7122.36 C++ Note: risk checked 7122.36 C++ Note: risk1 checked 23453.2 4323.35 C++ Note: risk2 checked 93329.8 4323.35 C++ Note: riskr checked 1103.97 748.255 549.423 973.678 397.318 C++ Note: riskl checked 81.8797 40.3981 38.9034 39.35 33.1873 C++ Note: df101 -76.7167 -76.7167 C++ Note: df102 0.321463 0.127669 C++ Note: df103 -7.13078 -5.96512 C++ Note: df104 0.699516 0.396693 C++ Note: df105 -0.045081 -0.0214027 C++ Note: df106 -238.649 -600.901 C++ Note: df100 10926 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 1103.97 748.255 549.423 973.678 397.318 C++ Note: riskl checked 81.8797 40.3981 38.9034 39.35 33.1873 C++ Note: df101 -76.7167 -76.7167 C++ Note: df102 0.321463 0.127669 C++ Note: df103 -7.13078 -5.96512 C++ Note: df104 0.699516 0.396693 C++ Note: df105 -0.045081 -0.0214027 C++ Note: df106 -238.649 -600.901 C++ Note: riskr checked 1103.97 748.255 549.423 973.678 397.318 C++ Note: riskl checked 81.8797 40.3981 38.9034 39.35 33.1873 C++ Note: df101 -76.7167 -76.7167 C++ Note: df102 0.321463 0.127669 C++ Note: df103 -7.13078 -5.96512 C++ Note: df104 0.699516 0.396693 C++ Note: df105 -0.045081 -0.0214027 C++ Note: df106 -238.649 -600.901 C++ Note: Exiting Regression C++ Note: df501 -76.71665 C++ Note: df504 0.6995155 0.3966929 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,59,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 1022 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: derivs checked 1229.85 410.233 C++ Note: second derivs checked 3319.14 410.233 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df102 5.42704 2.14202 C++ Note: df103 -7.11684 -6.21271 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.762564 -0.34478 C++ Note: df106 -14.6652 -37.1559 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.471923 0.158585 C++ Note: sums checked 3109.21 3109.21 C++ Note: derivs checked 8604.8 1732.23 C++ Note: second derivs checked 31265.5 1732.23 C++ Note: dose checked 1000 C++ Note: non-dose checked 3109.21 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 3109.21 C++ Note: risk checked 3109.21 C++ Note: risk1 checked 8604.8 1732.23 C++ Note: risk2 checked 31265.5 1732.23 C++ Note: riskr checked 437.598 369.44 288.407 451.269 203.987 C++ Note: riskl checked 29.7555 18.4415 17.3204 19.7081 14.0257 C++ Note: df101 -77.1115 -77.1115 C++ Note: df102 1.6628 1.2965 C++ Note: df103 -7.18852 -6.1617 C++ Note: df104 0.471923 0.158585 C++ Note: df105 -0.231313 -0.210412 C++ Note: df106 -46.3745 -59.4767 C++ Note: df100 5340 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 437.598 369.44 288.407 451.269 203.987 C++ Note: riskl checked 29.7555 18.4415 17.3204 19.7081 14.0257 C++ Note: df101 -77.1115 -77.1115 C++ Note: df102 1.6628 1.2965 C++ Note: df103 -7.18852 -6.1617 C++ Note: df104 0.471923 0.158585 C++ Note: df105 -0.231313 -0.210412 C++ Note: df106 -46.3745 -59.4767 C++ Note: ending guess 0 C++ Note: df501 -77.11153 C++ Note: df504 0.4719227 0.1585847 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.4719227 0.1585847, -77.11153<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.471923 0.158585 C++ Note: sums checked 3109.21 3109.21 C++ Note: derivs checked 8604.8 1732.23 C++ Note: second derivs checked 31265.5 1732.23 C++ Note: dose checked 1000 C++ Note: non-dose checked 3109.21 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 3109.21 C++ Note: risk checked 3109.21 C++ Note: risk1 checked 8604.8 1732.23 C++ Note: risk2 checked 31265.5 1732.23 C++ Note: Made Risk Side Lists C++ Note: riskr checked 437.598 369.44 288.407 451.269 203.987 C++ Note: riskl checked 29.7555 18.4415 17.3204 19.7081 14.0257 C++ Note: df101 -77.1115 -77.1115 C++ Note: df102 1.6628 1.2965 C++ Note: df103 -7.18852 -6.1617 C++ Note: df104 0.471923 0.158585 C++ Note: df105 -0.231313 -0.210412 C++ Note: df106 -46.3745 -59.4767 C++ Note: Starting Halves C++ Note: df501 -77.11153 C++ Note: df504 0.4719227 0.1585847 C++ Note: values checked 0.645408 0.316394 C++ Note: sums checked 5698.95 5698.95 C++ Note: derivs checked 18076.9 3359.94 C++ Note: second derivs checked 70503.7 3359.94 C++ Note: dose checked 1000 C++ Note: non-dose checked 5698.95 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 5698.95 C++ Note: risk checked 5698.95 C++ Note: risk1 checked 18076.9 3359.94 C++ Note: risk2 checked 70503.7 3359.94 C++ Note: riskr checked 866.381 621.431 461.192 794.093 330.167 C++ Note: riskl checked 63.0668 33.0727 31.2711 32.9428 26.3017 C++ Note: df101 -76.7689 -76.7689 C++ Note: df102 0.612277 0.54564 C++ Note: df103 -7.1484 -6.0464 C++ Note: df104 0.645408 0.316394 C++ Note: df105 -0.0856523 -0.0902421 C++ Note: df106 -125.383 -140.695 C++ Note: df100 10878 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 866.381 621.431 461.192 794.093 330.167 C++ Note: riskl checked 63.0668 33.0727 31.2711 32.9428 26.3017 C++ Note: df101 -76.7689 -76.7689 C++ Note: df102 0.612277 0.54564 C++ Note: df103 -7.1484 -6.0464 C++ Note: df104 0.645408 0.316394 C++ Note: df105 -0.0856523 -0.0902421 C++ Note: df106 -125.383 -140.695 C++ Note: riskr checked 866.381 621.431 461.192 794.093 330.167 C++ Note: riskl checked 63.0668 33.0727 31.2711 32.9428 26.3017 C++ Note: df101 -76.7689 -76.7689 C++ Note: df102 0.612277 0.54564 C++ Note: df103 -7.1484 -6.0464 C++ Note: df104 0.645408 0.316394 C++ Note: df105 -0.0856523 -0.0902421 C++ Note: df106 -125.383 -140.695 C++ Note: Exiting Regression C++ Note: df501 -76.76892 C++ Note: df504 0.6454076 0.316394 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,69,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 784 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 -111.301 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -111.3009 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 -111.301 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2951 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 -111.301 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3739 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 -111.301 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -111.3009 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -111.3009<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 -111.301 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -111.3009 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 -111.301 C++ Note: df104 -0.1 -0.1 C++ Note: df100 6102 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 -111.301 C++ Note: df104 -0.1 -0.1 C++ Note: df100 7016 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 -111.301 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 -111.301 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -111.3009 C++ Note: df504 -0.1 -0.1 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,65,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 740 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 -111.301 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -111.3009 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 -111.301 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2687 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 -111.301 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3610 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 -111.301 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -111.3009 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -111.3009<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 -111.301 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -111.3009 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 -111.301 C++ Note: df104 -0.1 -0.1 C++ Note: df100 6263 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 -111.301 C++ Note: df104 -0.1 -0.1 C++ Note: df100 7180 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 -111.301 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 -111.301 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -111.3009 C++ Note: df504 -0.1 -0.1 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,66,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 494 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1760 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2335 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -119.9814<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3986 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: df100 4562 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,70,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 447 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1720 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2334 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -119.9814<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: df100 4003 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: df100 4607 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,56,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 615 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1523.45 C++ Note: risk1r checked 2375.29 768.455 C++ Note: risk2r checked 5718.38 768.455 C++ Note: riskl checked 19.6098 C++ Note: risk1l checked 42.0717 11.5472 C++ Note: risk2l checked 118.124 11.5472 C++ Note: df101 -111.301 -111.301 C++ Note: df102 18.2432 2.83837 C++ Note: df103 -20.4205 -6.48157 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.893375 -0.437914 C++ Note: df106 -6.10097 -39.213 C++ Note: Starting Halves C++ Note: df501 -111.3009 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.627958 0.463993 C++ Note: sums checked 4530.56 1313.51 C++ Note: risk checked 5900.31 C++ Note: risk1 checked 18447 3689.76 C++ Note: risk2 checked 71392 3689.76 C++ Note: riskr checked 9484.43 C++ Note: risk1r checked 25238.6 5651.52 C++ Note: risk2r checked 83139.2 5651.52 C++ Note: riskl checked 194.918 C++ Note: risk1l checked 608.095 132.941 C++ Note: risk2l checked 2134.11 132.941 C++ Note: df101 -101.86 -101.86 C++ Note: df102 5.56885 0.544858 C++ Note: df103 -15.9846 -6.24361 C++ Note: df104 0.627958 0.463993 C++ Note: df105 -0.348388 -0.0872665 C++ Note: df106 -18.291 -186.947 C++ Note: df100 6389 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 9484.43 C++ Note: risk1r checked 25238.6 5651.52 C++ Note: risk2r checked 83139.2 5651.52 C++ Note: riskl checked 194.918 C++ Note: risk1l checked 608.095 132.941 C++ Note: risk2l checked 2134.11 132.941 C++ Note: df101 -101.86 -101.86 C++ Note: df102 5.56885 0.544858 C++ Note: df103 -15.9846 -6.24361 C++ Note: df104 0.627958 0.463993 C++ Note: df105 -0.348388 -0.0872665 C++ Note: df106 -18.291 -186.947 C++ Note: ending guess 0 C++ Note: df501 -101.8596 C++ Note: df504 0.6279581 0.4639928 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.6279581 0.4639928, -101.8596<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.627958 0.463993 C++ Note: sums checked 4530.56 1313.51 C++ Note: risk checked 5900.31 C++ Note: risk1 checked 18447 3689.76 C++ Note: risk2 checked 71392 3689.76 C++ Note: Made Risk Side Lists C++ Note: riskr checked 9484.43 C++ Note: risk1r checked 25238.6 5651.52 C++ Note: risk2r checked 83139.2 5651.52 C++ Note: riskl checked 194.918 C++ Note: risk1l checked 608.095 132.941 C++ Note: risk2l checked 2134.11 132.941 C++ Note: df101 -101.86 -101.86 C++ Note: df102 5.56885 0.544858 C++ Note: df103 -15.9846 -6.24361 C++ Note: df104 0.627958 0.463993 C++ Note: df105 -0.348388 -0.0872665 C++ Note: df106 -18.291 -186.947 C++ Note: Starting Halves C++ Note: df501 -101.8596 C++ Note: df504 0.6279581 0.4639928 C++ Note: values checked 0.902099 0.597165 C++ Note: sums checked 11658.5 1433.81 C++ Note: risk checked 16449.6 C++ Note: risk1 checked 61210.2 10655.6 C++ Note: risk2 checked 260882 10655.6 C++ Note: riskr checked 22682.7 C++ Note: risk1r checked 70542.6 13934 C++ Note: risk2r checked 256218 13934 C++ Note: riskl checked 522.822 C++ Note: risk1l checked 1783.26 351.796 C++ Note: risk2l checked 6625.89 351.796 C++ Note: df101 -100.833 -100.833 C++ Note: df102 1.69373 0.116238 C++ Note: df103 -13.7767 -6.14867 C++ Note: df104 0.902099 0.597165 C++ Note: df105 -0.122942 -0.0189046 C++ Note: df106 -59.5329 -867.469 C++ Note: df100 14734 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 22682.7 C++ Note: risk1r checked 70542.6 13934 C++ Note: risk2r checked 256218 13934 C++ Note: riskl checked 522.822 C++ Note: risk1l checked 1783.26 351.796 C++ Note: risk2l checked 6625.89 351.796 C++ Note: df101 -100.833 -100.833 C++ Note: df102 1.69373 0.116238 C++ Note: df103 -13.7767 -6.14867 C++ Note: df104 0.902099 0.597165 C++ Note: df105 -0.122942 -0.0189046 C++ Note: df106 -59.5329 -867.469 C++ Note: riskr checked 22682.7 C++ Note: risk1r checked 70542.6 13934 C++ Note: risk2r checked 256218 13934 C++ Note: riskl checked 522.822 C++ Note: risk1l checked 1783.26 351.796 C++ Note: risk2l checked 6625.89 351.796 C++ Note: df101 -100.833 -100.833 C++ Note: df102 1.69373 0.116238 C++ Note: df103 -13.7767 -6.14867 C++ Note: df104 0.902099 0.597165 C++ Note: df105 -0.122942 -0.0189046 C++ Note: df106 -59.5329 -867.469 C++ Note: Exiting Regression C++ Note: df501 -100.8329 C++ Note: df504 0.9020989 0.5971652 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,55,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 602 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1523.45 C++ Note: risk1r checked 2375.29 768.455 C++ Note: risk2r checked 5718.38 768.455 C++ Note: riskl checked 19.6098 C++ Note: risk1l checked 42.0717 11.5472 C++ Note: risk2l checked 118.124 11.5472 C++ Note: df101 -111.301 -111.301 C++ Note: df102 18.2432 2.83837 C++ Note: df103 -20.4205 -6.48157 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.893375 -0.437914 C++ Note: df106 -6.10097 -39.213 C++ Note: Starting Halves C++ Note: df501 -111.3009 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.570032 0.228436 C++ Note: sums checked 3791.3 1136.27 C++ Note: risk checked 4291.59 C++ Note: risk1 checked 12869.9 2449.73 C++ Note: risk2 checked 48734.6 2449.73 C++ Note: riskr checked 7127.66 C++ Note: risk1r checked 18365.6 3858.67 C++ Note: risk2r checked 59288.1 3858.67 C++ Note: riskl checked 139.46 C++ Note: risk1l checked 428.96 88.7267 C++ Note: risk2l checked 1499.2 88.7267 C++ Note: df101 -102.491 -102.491 C++ Note: df102 6.13357 1.94898 C++ Note: df103 -16.3931 -6.43279 C++ Note: df104 0.570032 0.228436 C++ Note: df105 -0.374157 -0.302977 C++ Note: df106 -16.7099 -52.5871 C++ Note: df100 6434 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 7127.66 C++ Note: risk1r checked 18365.6 3858.67 C++ Note: risk2r checked 59288.1 3858.67 C++ Note: riskl checked 139.46 C++ Note: risk1l checked 428.96 88.7267 C++ Note: risk2l checked 1499.2 88.7267 C++ Note: df101 -102.491 -102.491 C++ Note: df102 6.13357 1.94898 C++ Note: df103 -16.3931 -6.43279 C++ Note: df104 0.570032 0.228436 C++ Note: df105 -0.374157 -0.302977 C++ Note: df106 -16.7099 -52.5871 C++ Note: ending guess 0 C++ Note: df501 -102.4914 C++ Note: df504 0.5700316 0.2284355 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.5700316 0.2284355, -102.4914<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.570032 0.228436 C++ Note: sums checked 3791.3 1136.27 C++ Note: risk checked 4291.59 C++ Note: risk1 checked 12869.9 2449.73 C++ Note: risk2 checked 48734.6 2449.73 C++ Note: Made Risk Side Lists C++ Note: riskr checked 7127.66 C++ Note: risk1r checked 18365.6 3858.67 C++ Note: risk2r checked 59288.1 3858.67 C++ Note: riskl checked 139.46 C++ Note: risk1l checked 428.96 88.7267 C++ Note: risk2l checked 1499.2 88.7267 C++ Note: df101 -102.491 -102.491 C++ Note: df102 6.13357 1.94898 C++ Note: df103 -16.3931 -6.43279 C++ Note: df104 0.570032 0.228436 C++ Note: df105 -0.374157 -0.302977 C++ Note: df106 -16.7099 -52.5871 C++ Note: Starting Halves C++ Note: df501 -102.4914 C++ Note: df504 0.5700316 0.2284355 C++ Note: values checked 0.850649 0.455668 C++ Note: sums checked 9644.79 1306.51 C++ Note: risk checked 12453.6 C++ Note: risk1 checked 45077.2 7674.77 C++ Note: risk2 checked 189052 7674.77 C++ Note: riskr checked 17794.6 C++ Note: risk1r checked 53962.4 10368.3 C++ Note: risk2r checked 192789 10368.3 C++ Note: riskl checked 399.833 C++ Note: risk1l checked 1350.62 259.541 C++ Note: risk2l checked 4997.2 259.541 C++ Note: df101 -101.007 -101.007 C++ Note: df102 2.21481 0.926728 C++ Note: df103 -14.0758 -6.30344 C++ Note: df104 0.850649 0.455668 C++ Note: df105 -0.157348 -0.147019 C++ Note: df106 -45.6053 -108.993 C++ Note: df100 14912 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 17794.6 C++ Note: risk1r checked 53962.4 10368.3 C++ Note: risk2r checked 192789 10368.3 C++ Note: riskl checked 399.833 C++ Note: risk1l checked 1350.62 259.541 C++ Note: risk2l checked 4997.2 259.541 C++ Note: df101 -101.007 -101.007 C++ Note: df102 2.21481 0.926728 C++ Note: df103 -14.0758 -6.30344 C++ Note: df104 0.850649 0.455668 C++ Note: df105 -0.157348 -0.147019 C++ Note: df106 -45.6053 -108.993 C++ Note: riskr checked 17794.6 C++ Note: risk1r checked 53962.4 10368.3 C++ Note: risk2r checked 192789 10368.3 C++ Note: riskl checked 399.833 C++ Note: risk1l checked 1350.62 259.541 C++ Note: risk2l checked 4997.2 259.541 C++ Note: df101 -101.007 -101.007 C++ Note: df102 2.21481 0.926728 C++ Note: df103 -14.0758 -6.30344 C++ Note: df104 0.850649 0.455668 C++ Note: df105 -0.157348 -0.147019 C++ Note: df106 -45.6053 -108.993 C++ Note: Exiting Regression C++ Note: df501 -101.007 C++ Note: df504 0.850649 0.4556681 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,58,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 384 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: risk1r checked 3418.73 1095.31 C++ Note: risk2r checked 8667.81 1095.31 C++ Note: riskl checked 19.6098 C++ Note: risk1l checked 42.0717 11.5472 C++ Note: risk2l checked 118.124 11.5472 C++ Note: df101 -119.981 -119.981 C++ Note: df102 6.06579 2.41134 C++ Note: df103 -8.60689 -6.47374 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.70476 -0.37248 C++ Note: df106 -19.78 -49.7572 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.497478 0.312164 C++ Note: sums checked 3067.26 1194.55 C++ Note: risk checked 3648.05 C++ Note: risk1 checked 10299.6 2165.99 C++ Note: risk2 checked 37798.4 2165.99 C++ Note: riskr checked 9367.5 C++ Note: risk1r checked 24562.6 5580.77 C++ Note: risk2r checked 81557.6 5580.77 C++ Note: riskl checked 118.249 C++ Note: risk1l checked 351.472 78.443 C++ Note: risk2l checked 1199.14 78.443 C++ Note: df101 -117.142 -117.142 C++ Note: df102 1.31609 0.547704 C++ Note: df103 -9.05233 -6.2666 C++ Note: df104 0.497478 0.312164 C++ Note: df105 -0.145387 -0.0874005 C++ Note: df106 -89.0079 -213.879 C++ Note: df100 2882 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 9367.5 C++ Note: risk1r checked 24562.6 5580.77 C++ Note: risk2r checked 81557.6 5580.77 C++ Note: riskl checked 118.249 C++ Note: risk1l checked 351.472 78.443 C++ Note: risk2l checked 1199.14 78.443 C++ Note: df101 -117.142 -117.142 C++ Note: df102 1.31609 0.547704 C++ Note: df103 -9.05233 -6.2666 C++ Note: df104 0.497478 0.312164 C++ Note: df105 -0.145387 -0.0874005 C++ Note: df106 -89.0079 -213.879 C++ Note: ending guess 0 C++ Note: df501 -117.1424 C++ Note: df504 0.4974778 0.3121644 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.4974778 0.3121644, -117.1424<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.497478 0.312164 C++ Note: sums checked 3067.26 1194.55 C++ Note: risk checked 3648.05 C++ Note: risk1 checked 10299.6 2165.99 C++ Note: risk2 checked 37798.4 2165.99 C++ Note: Made Risk Side Lists C++ Note: riskr checked 9367.5 C++ Note: risk1r checked 24562.6 5580.77 C++ Note: risk2r checked 81557.6 5580.77 C++ Note: riskl checked 118.249 C++ Note: risk1l checked 351.472 78.443 C++ Note: risk2l checked 1199.14 78.443 C++ Note: df101 -117.142 -117.142 C++ Note: df102 1.31609 0.547704 C++ Note: df103 -9.05233 -6.2666 C++ Note: df104 0.497478 0.312164 C++ Note: df105 -0.145387 -0.0874005 C++ Note: df106 -89.0079 -213.879 C++ Note: Starting Halves C++ Note: df501 -117.1424 C++ Note: df504 0.4974778 0.3121644 C++ Note: values checked 0.617144 0.398893 C++ Note: sums checked 4379.75 1260.28 C++ Note: risk checked 5479.95 C++ Note: risk1 checked 17006.9 3344.7 C++ Note: risk2 checked 65563.9 3344.7 C++ Note: riskr checked 13683.9 C++ Note: risk1r checked 38812.2 8366.11 C++ Note: risk2r checked 134810 8366.11 C++ Note: riskl checked 180.348 C++ Note: risk1l checked 561.69 120.669 C++ Note: risk2l checked 1971.73 120.669 C++ Note: df101 -117.015 -117.015 C++ Note: df102 0.320802 0.13496 C++ Note: df103 -9.12088 -6.18217 C++ Note: df104 0.617144 0.398893 C++ Note: df105 -0.0351723 -0.0218306 C++ Note: df106 -364.756 -867.031 C++ Note: df100 6433 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 13683.9 C++ Note: risk1r checked 38812.2 8366.11 C++ Note: risk2r checked 134810 8366.11 C++ Note: riskl checked 180.348 C++ Note: risk1l checked 561.69 120.669 C++ Note: risk2l checked 1971.73 120.669 C++ Note: df101 -117.015 -117.015 C++ Note: df102 0.320802 0.13496 C++ Note: df103 -9.12088 -6.18217 C++ Note: df104 0.617144 0.398893 C++ Note: df105 -0.0351723 -0.0218306 C++ Note: df106 -364.756 -867.031 C++ Note: riskr checked 13683.9 C++ Note: risk1r checked 38812.2 8366.11 C++ Note: risk2r checked 134810 8366.11 C++ Note: riskl checked 180.348 C++ Note: risk1l checked 561.69 120.669 C++ Note: risk2l checked 1971.73 120.669 C++ Note: df101 -117.015 -117.015 C++ Note: df102 0.320802 0.13496 C++ Note: df103 -9.12088 -6.18217 C++ Note: df104 0.617144 0.398893 C++ Note: df105 -0.0351723 -0.0218306 C++ Note: df106 -364.756 -867.031 C++ Note: Exiting Regression C++ Note: df501 -117.0147 C++ Note: df504 0.6171437 0.3988932 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,55,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 382 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: risk1r checked 3418.73 1095.31 C++ Note: risk2r checked 8667.81 1095.31 C++ Note: riskl checked 19.6098 C++ Note: risk1l checked 42.0717 11.5472 C++ Note: risk2l checked 118.124 11.5472 C++ Note: df101 -119.981 -119.981 C++ Note: df102 6.06579 2.41134 C++ Note: df103 -8.60689 -6.47374 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.70476 -0.37248 C++ Note: df106 -19.78 -49.7572 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.42857 0.17936 C++ Note: sums checked 2537.47 1104.32 C++ Note: risk checked 2796.31 C++ Note: risk1 checked 7446.21 1576.41 C++ Note: risk2 checked 26529.4 1576.41 C++ Note: riskr checked 7268.45 C++ Note: risk1r checked 18181.7 4116.59 C++ Note: risk2r checked 58803.1 4116.59 C++ Note: riskl checked 88.5975 C++ Note: risk1l checked 256.339 56.699 C++ Note: risk2l checked 862.409 56.699 C++ Note: df101 -117.373 -117.373 C++ Note: df102 1.78502 1.30975 C++ Note: df103 -8.96103 -6.38772 C++ Note: df104 0.42857 0.17936 C++ Note: df105 -0.199199 -0.205041 C++ Note: df106 -65.7541 -89.6148 C++ Note: df100 2825 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 7268.45 C++ Note: risk1r checked 18181.7 4116.59 C++ Note: risk2r checked 58803.1 4116.59 C++ Note: riskl checked 88.5975 C++ Note: risk1l checked 256.339 56.699 C++ Note: risk2l checked 862.409 56.699 C++ Note: df101 -117.373 -117.373 C++ Note: df102 1.78502 1.30975 C++ Note: df103 -8.96103 -6.38772 C++ Note: df104 0.42857 0.17936 C++ Note: df105 -0.199199 -0.205041 C++ Note: df106 -65.7541 -89.6148 C++ Note: ending guess 0 C++ Note: df501 -117.3726 C++ Note: df504 0.4285697 0.17936 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.4285697 0.17936, -117.3726<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.42857 0.17936 C++ Note: sums checked 2537.47 1104.32 C++ Note: risk checked 2796.31 C++ Note: risk1 checked 7446.21 1576.41 C++ Note: risk2 checked 26529.4 1576.41 C++ Note: Made Risk Side Lists C++ Note: riskr checked 7268.45 C++ Note: risk1r checked 18181.7 4116.59 C++ Note: risk2r checked 58803.1 4116.59 C++ Note: riskl checked 88.5975 C++ Note: risk1l checked 256.339 56.699 C++ Note: risk2l checked 862.409 56.699 C++ Note: df101 -117.373 -117.373 C++ Note: df102 1.78502 1.30975 C++ Note: df103 -8.96103 -6.38772 C++ Note: df104 0.42857 0.17936 C++ Note: df105 -0.199199 -0.205041 C++ Note: df106 -65.7541 -89.6148 C++ Note: Starting Halves C++ Note: df501 -117.3726 C++ Note: df504 0.4285697 0.17936 C++ Note: values checked 0.577969 0.333141 C++ Note: sums checked 3883.17 1209.93 C++ Note: risk checked 4672.1 C++ Note: risk1 checked 14081.1 2784.48 C++ Note: risk2 checked 53455.8 2784.48 C++ Note: riskr checked 11783.5 C++ Note: risk1r checked 32618.6 7038.87 C++ Note: risk2r checked 111717 7038.87 C++ Note: riskl checked 152.934 C++ Note: risk1l checked 470.041 100.807 C++ Note: risk2l checked 1638.11 100.807 C++ Note: df101 -117.054 -117.054 C++ Note: df102 0.609162 0.503449 C++ Note: df103 -9.07577 -6.25818 C++ Note: df104 0.577969 0.333141 C++ Note: df105 -0.0671196 -0.0804466 C++ Note: df106 -192.156 -232.504 C++ Note: df100 6280 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 11783.5 C++ Note: risk1r checked 32618.6 7038.87 C++ Note: risk2r checked 111717 7038.87 C++ Note: riskl checked 152.934 C++ Note: risk1l checked 470.041 100.807 C++ Note: risk2l checked 1638.11 100.807 C++ Note: df101 -117.054 -117.054 C++ Note: df102 0.609162 0.503449 C++ Note: df103 -9.07577 -6.25818 C++ Note: df104 0.577969 0.333141 C++ Note: df105 -0.0671196 -0.0804466 C++ Note: df106 -192.156 -232.504 C++ Note: riskr checked 11783.5 C++ Note: risk1r checked 32618.6 7038.87 C++ Note: risk2r checked 111717 7038.87 C++ Note: riskl checked 152.934 C++ Note: risk1l checked 470.041 100.807 C++ Note: risk2l checked 1638.11 100.807 C++ Note: df101 -117.054 -117.054 C++ Note: df102 0.609162 0.503449 C++ Note: df103 -9.07577 -6.25818 C++ Note: df104 0.577969 0.333141 C++ Note: df105 -0.0671196 -0.0804466 C++ Note: df106 -192.156 -232.504 C++ Note: Exiting Regression C++ Note: df501 -117.0539 C++ Note: df504 0.5779686 0.3331409 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,48,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 537 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 0 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -111.3009 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2150 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2911 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 0 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -111.3009 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -111.3009<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 0 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -111.3009 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 5025 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 5778 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 0 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 0 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -111.3009 C++ Note: df504 -0.1 -0.1 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,53,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 557 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 0 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -111.3009 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2156 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2927 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 0 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -111.3009 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -111.3009<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 0 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -111.3009 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 5099 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 5880 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 0 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 1523.45 C++ Note: riskl checked 19.6098 C++ Note: df101 -111.301 0 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -111.3009 C++ Note: df504 -0.1 -0.1 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,48,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 323 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1452 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1959 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -119.9814<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3362 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3858 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,50,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 333 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1401 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1906 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -119.9814<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3284 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3781 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,46,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 581 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: derivs checked 1229.85 410.233 C++ Note: second derivs checked 3319.14 410.233 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1523.45 C++ Note: risk1r checked 2375.29 768.455 C++ Note: risk2r checked 5718.38 768.455 C++ Note: riskl checked 19.6098 C++ Note: risk1l checked 42.0717 11.5472 C++ Note: risk2l checked 118.124 11.5472 C++ Note: df101 -111.301 -111.301 C++ Note: df102 18.2432 2.83837 C++ Note: df103 -20.4205 -6.48157 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.893375 -0.437914 C++ Note: df106 -6.10097 -39.213 C++ Note: Starting Halves C++ Note: df501 -111.3009 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.627958 0.463993 C++ Note: sums checked 5900.31 5900.31 C++ Note: derivs checked 18447 3689.76 C++ Note: second derivs checked 71392 3689.76 C++ Note: dose checked 1000 C++ Note: non-dose checked 5900.31 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 5900.31 C++ Note: risk checked 5900.31 C++ Note: risk1 checked 18447 3689.76 C++ Note: risk2 checked 71392 3689.76 C++ Note: riskr checked 9484.43 C++ Note: risk1r checked 25238.6 5651.52 C++ Note: risk2r checked 83139.2 5651.52 C++ Note: riskl checked 194.918 C++ Note: risk1l checked 608.095 132.941 C++ Note: risk2l checked 2134.11 132.941 C++ Note: df101 -101.86 -101.86 C++ Note: df102 5.56885 0.544858 C++ Note: df103 -15.9846 -6.24361 C++ Note: df104 0.627958 0.463993 C++ Note: df105 -0.348388 -0.0872665 C++ Note: df106 -18.291 -186.947 C++ Note: df100 6509 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 9484.43 C++ Note: risk1r checked 25238.6 5651.52 C++ Note: risk2r checked 83139.2 5651.52 C++ Note: riskl checked 194.918 C++ Note: risk1l checked 608.095 132.941 C++ Note: risk2l checked 2134.11 132.941 C++ Note: df101 -101.86 -101.86 C++ Note: df102 5.56885 0.544858 C++ Note: df103 -15.9846 -6.24361 C++ Note: df104 0.627958 0.463993 C++ Note: df105 -0.348388 -0.0872665 C++ Note: df106 -18.291 -186.947 C++ Note: ending guess 0 C++ Note: df501 -101.8596 C++ Note: df504 0.6279581 0.4639928 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.6279581 0.4639928, -101.8596<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.627958 0.463993 C++ Note: sums checked 5900.31 5900.31 C++ Note: derivs checked 18447 3689.76 C++ Note: second derivs checked 71392 3689.76 C++ Note: dose checked 1000 C++ Note: non-dose checked 5900.31 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 5900.31 C++ Note: risk checked 5900.31 C++ Note: risk1 checked 18447 3689.76 C++ Note: risk2 checked 71392 3689.76 C++ Note: Made Risk Side Lists C++ Note: riskr checked 9484.43 C++ Note: risk1r checked 25238.6 5651.52 C++ Note: risk2r checked 83139.2 5651.52 C++ Note: riskl checked 194.918 C++ Note: risk1l checked 608.095 132.941 C++ Note: risk2l checked 2134.11 132.941 C++ Note: df101 -101.86 -101.86 C++ Note: df102 5.56885 0.544858 C++ Note: df103 -15.9846 -6.24361 C++ Note: df104 0.627958 0.463993 C++ Note: df105 -0.348388 -0.0872665 C++ Note: df106 -18.291 -186.947 C++ Note: Starting Halves C++ Note: df501 -101.8596 C++ Note: df504 0.6279581 0.4639928 C++ Note: values checked 0.902099 0.597165 C++ Note: sums checked 16449.6 16449.6 C++ Note: derivs checked 61210.2 10655.6 C++ Note: second derivs checked 260882 10655.6 C++ Note: dose checked 1000 C++ Note: non-dose checked 16449.6 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 16449.6 C++ Note: risk checked 16449.6 C++ Note: risk1 checked 61210.2 10655.6 C++ Note: risk2 checked 260882 10655.6 C++ Note: riskr checked 22682.7 C++ Note: risk1r checked 70542.6 13934 C++ Note: risk2r checked 256218 13934 C++ Note: riskl checked 522.822 C++ Note: risk1l checked 1783.26 351.796 C++ Note: risk2l checked 6625.89 351.796 C++ Note: df101 -100.833 -100.833 C++ Note: df102 1.69373 0.116238 C++ Note: df103 -13.7767 -6.14867 C++ Note: df104 0.902099 0.597165 C++ Note: df105 -0.122942 -0.0189046 C++ Note: df106 -59.5329 -867.469 C++ Note: df100 14841 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 22682.7 C++ Note: risk1r checked 70542.6 13934 C++ Note: risk2r checked 256218 13934 C++ Note: riskl checked 522.822 C++ Note: risk1l checked 1783.26 351.796 C++ Note: risk2l checked 6625.89 351.796 C++ Note: df101 -100.833 -100.833 C++ Note: df102 1.69373 0.116238 C++ Note: df103 -13.7767 -6.14867 C++ Note: df104 0.902099 0.597165 C++ Note: df105 -0.122942 -0.0189046 C++ Note: df106 -59.5329 -867.469 C++ Note: riskr checked 22682.7 C++ Note: risk1r checked 70542.6 13934 C++ Note: risk2r checked 256218 13934 C++ Note: riskl checked 522.822 C++ Note: risk1l checked 1783.26 351.796 C++ Note: risk2l checked 6625.89 351.796 C++ Note: df101 -100.833 -100.833 C++ Note: df102 1.69373 0.116238 C++ Note: df103 -13.7767 -6.14867 C++ Note: df104 0.902099 0.597165 C++ Note: df105 -0.122942 -0.0189046 C++ Note: df106 -59.5329 -867.469 C++ Note: Exiting Regression C++ Note: df501 -100.8329 C++ Note: df504 0.9020989 0.5971652 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,53,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 537 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: derivs checked 1229.85 410.233 C++ Note: second derivs checked 3319.14 410.233 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1523.45 C++ Note: risk1r checked 2375.29 768.455 C++ Note: risk2r checked 5718.38 768.455 C++ Note: riskl checked 19.6098 C++ Note: risk1l checked 42.0717 11.5472 C++ Note: risk2l checked 118.124 11.5472 C++ Note: df101 -111.301 -111.301 C++ Note: df102 18.2432 2.83837 C++ Note: df103 -20.4205 -6.48157 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.893375 -0.437914 C++ Note: df106 -6.10097 -39.213 C++ Note: Starting Halves C++ Note: df501 -111.3009 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.570032 0.228436 C++ Note: sums checked 4291.59 4291.59 C++ Note: derivs checked 12869.9 2449.73 C++ Note: second derivs checked 48734.6 2449.73 C++ Note: dose checked 1000 C++ Note: non-dose checked 4291.59 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 4291.59 C++ Note: risk checked 4291.59 C++ Note: risk1 checked 12869.9 2449.73 C++ Note: risk2 checked 48734.6 2449.73 C++ Note: riskr checked 7127.66 C++ Note: risk1r checked 18365.6 3858.67 C++ Note: risk2r checked 59288.1 3858.67 C++ Note: riskl checked 139.46 C++ Note: risk1l checked 428.96 88.7267 C++ Note: risk2l checked 1499.2 88.7267 C++ Note: df101 -102.491 -102.491 C++ Note: df102 6.13357 1.94898 C++ Note: df103 -16.3931 -6.43279 C++ Note: df104 0.570032 0.228436 C++ Note: df105 -0.374157 -0.302977 C++ Note: df106 -16.7099 -52.5871 C++ Note: df100 6543 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 7127.66 C++ Note: risk1r checked 18365.6 3858.67 C++ Note: risk2r checked 59288.1 3858.67 C++ Note: riskl checked 139.46 C++ Note: risk1l checked 428.96 88.7267 C++ Note: risk2l checked 1499.2 88.7267 C++ Note: df101 -102.491 -102.491 C++ Note: df102 6.13357 1.94898 C++ Note: df103 -16.3931 -6.43279 C++ Note: df104 0.570032 0.228436 C++ Note: df105 -0.374157 -0.302977 C++ Note: df106 -16.7099 -52.5871 C++ Note: ending guess 0 C++ Note: df501 -102.4914 C++ Note: df504 0.5700316 0.2284355 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.5700316 0.2284355, -102.4914<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.570032 0.228436 C++ Note: sums checked 4291.59 4291.59 C++ Note: derivs checked 12869.9 2449.73 C++ Note: second derivs checked 48734.6 2449.73 C++ Note: dose checked 1000 C++ Note: non-dose checked 4291.59 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 4291.59 C++ Note: risk checked 4291.59 C++ Note: risk1 checked 12869.9 2449.73 C++ Note: risk2 checked 48734.6 2449.73 C++ Note: Made Risk Side Lists C++ Note: riskr checked 7127.66 C++ Note: risk1r checked 18365.6 3858.67 C++ Note: risk2r checked 59288.1 3858.67 C++ Note: riskl checked 139.46 C++ Note: risk1l checked 428.96 88.7267 C++ Note: risk2l checked 1499.2 88.7267 C++ Note: df101 -102.491 -102.491 C++ Note: df102 6.13357 1.94898 C++ Note: df103 -16.3931 -6.43279 C++ Note: df104 0.570032 0.228436 C++ Note: df105 -0.374157 -0.302977 C++ Note: df106 -16.7099 -52.5871 C++ Note: Starting Halves C++ Note: df501 -102.4914 C++ Note: df504 0.5700316 0.2284355 C++ Note: values checked 0.850649 0.455668 C++ Note: sums checked 12453.6 12453.6 C++ Note: derivs checked 45077.2 7674.77 C++ Note: second derivs checked 189052 7674.77 C++ Note: dose checked 1000 C++ Note: non-dose checked 12453.6 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 12453.6 C++ Note: risk checked 12453.6 C++ Note: risk1 checked 45077.2 7674.77 C++ Note: risk2 checked 189052 7674.77 C++ Note: riskr checked 17794.6 C++ Note: risk1r checked 53962.4 10368.3 C++ Note: risk2r checked 192789 10368.3 C++ Note: riskl checked 399.833 C++ Note: risk1l checked 1350.62 259.541 C++ Note: risk2l checked 4997.2 259.541 C++ Note: df101 -101.007 -101.007 C++ Note: df102 2.21481 0.926728 C++ Note: df103 -14.0758 -6.30344 C++ Note: df104 0.850649 0.455668 C++ Note: df105 -0.157348 -0.147019 C++ Note: df106 -45.6053 -108.993 C++ Note: df100 14706 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 17794.6 C++ Note: risk1r checked 53962.4 10368.3 C++ Note: risk2r checked 192789 10368.3 C++ Note: riskl checked 399.833 C++ Note: risk1l checked 1350.62 259.541 C++ Note: risk2l checked 4997.2 259.541 C++ Note: df101 -101.007 -101.007 C++ Note: df102 2.21481 0.926728 C++ Note: df103 -14.0758 -6.30344 C++ Note: df104 0.850649 0.455668 C++ Note: df105 -0.157348 -0.147019 C++ Note: df106 -45.6053 -108.993 C++ Note: riskr checked 17794.6 C++ Note: risk1r checked 53962.4 10368.3 C++ Note: risk2r checked 192789 10368.3 C++ Note: riskl checked 399.833 C++ Note: risk1l checked 1350.62 259.541 C++ Note: risk2l checked 4997.2 259.541 C++ Note: df101 -101.007 -101.007 C++ Note: df102 2.21481 0.926728 C++ Note: df103 -14.0758 -6.30344 C++ Note: df104 0.850649 0.455668 C++ Note: df105 -0.157348 -0.147019 C++ Note: df106 -45.6053 -108.993 C++ Note: Exiting Regression C++ Note: df501 -101.007 C++ Note: df504 0.850649 0.4556681 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,48,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 372 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: derivs checked 1229.85 410.233 C++ Note: second derivs checked 3319.14 410.233 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: risk1r checked 3418.73 1095.31 C++ Note: risk2r checked 8667.81 1095.31 C++ Note: riskl checked 19.6098 C++ Note: risk1l checked 42.0717 11.5472 C++ Note: risk2l checked 118.124 11.5472 C++ Note: df101 -119.981 -119.981 C++ Note: df102 6.06579 2.41134 C++ Note: df103 -8.60689 -6.47374 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.70476 -0.37248 C++ Note: df106 -19.78 -49.7572 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.497478 0.312164 C++ Note: sums checked 3648.05 3648.05 C++ Note: derivs checked 10299.6 2165.99 C++ Note: second derivs checked 37798.4 2165.99 C++ Note: dose checked 1000 C++ Note: non-dose checked 3648.05 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 3648.05 C++ Note: risk checked 3648.05 C++ Note: risk1 checked 10299.6 2165.99 C++ Note: risk2 checked 37798.4 2165.99 C++ Note: riskr checked 9367.5 C++ Note: risk1r checked 24562.6 5580.77 C++ Note: risk2r checked 81557.6 5580.77 C++ Note: riskl checked 118.249 C++ Note: risk1l checked 351.472 78.443 C++ Note: risk2l checked 1199.14 78.443 C++ Note: df101 -117.142 -117.142 C++ Note: df102 1.31609 0.547704 C++ Note: df103 -9.05233 -6.2666 C++ Note: df104 0.497478 0.312164 C++ Note: df105 -0.145387 -0.0874005 C++ Note: df106 -89.0079 -213.879 C++ Note: df100 3253 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 9367.5 C++ Note: risk1r checked 24562.6 5580.77 C++ Note: risk2r checked 81557.6 5580.77 C++ Note: riskl checked 118.249 C++ Note: risk1l checked 351.472 78.443 C++ Note: risk2l checked 1199.14 78.443 C++ Note: df101 -117.142 -117.142 C++ Note: df102 1.31609 0.547704 C++ Note: df103 -9.05233 -6.2666 C++ Note: df104 0.497478 0.312164 C++ Note: df105 -0.145387 -0.0874005 C++ Note: df106 -89.0079 -213.879 C++ Note: ending guess 0 C++ Note: df501 -117.1424 C++ Note: df504 0.4974778 0.3121644 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.4974778 0.3121644, -117.1424<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.497478 0.312164 C++ Note: sums checked 3648.05 3648.05 C++ Note: derivs checked 10299.6 2165.99 C++ Note: second derivs checked 37798.4 2165.99 C++ Note: dose checked 1000 C++ Note: non-dose checked 3648.05 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 3648.05 C++ Note: risk checked 3648.05 C++ Note: risk1 checked 10299.6 2165.99 C++ Note: risk2 checked 37798.4 2165.99 C++ Note: Made Risk Side Lists C++ Note: riskr checked 9367.5 C++ Note: risk1r checked 24562.6 5580.77 C++ Note: risk2r checked 81557.6 5580.77 C++ Note: riskl checked 118.249 C++ Note: risk1l checked 351.472 78.443 C++ Note: risk2l checked 1199.14 78.443 C++ Note: df101 -117.142 -117.142 C++ Note: df102 1.31609 0.547704 C++ Note: df103 -9.05233 -6.2666 C++ Note: df104 0.497478 0.312164 C++ Note: df105 -0.145387 -0.0874005 C++ Note: df106 -89.0079 -213.879 C++ Note: Starting Halves C++ Note: df501 -117.1424 C++ Note: df504 0.4974778 0.3121644 C++ Note: values checked 0.617144 0.398893 C++ Note: sums checked 5479.95 5479.95 C++ Note: derivs checked 17006.9 3344.7 C++ Note: second derivs checked 65563.9 3344.7 C++ Note: dose checked 1000 C++ Note: non-dose checked 5479.95 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 5479.95 C++ Note: risk checked 5479.95 C++ Note: risk1 checked 17006.9 3344.7 C++ Note: risk2 checked 65563.9 3344.7 C++ Note: riskr checked 13683.9 C++ Note: risk1r checked 38812.2 8366.11 C++ Note: risk2r checked 134810 8366.11 C++ Note: riskl checked 180.348 C++ Note: risk1l checked 561.69 120.669 C++ Note: risk2l checked 1971.73 120.669 C++ Note: df101 -117.015 -117.015 C++ Note: df102 0.320802 0.13496 C++ Note: df103 -9.12088 -6.18217 C++ Note: df104 0.617144 0.398893 C++ Note: df105 -0.0351723 -0.0218306 C++ Note: df106 -364.756 -867.031 C++ Note: df100 6988 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 13683.9 C++ Note: risk1r checked 38812.2 8366.11 C++ Note: risk2r checked 134810 8366.11 C++ Note: riskl checked 180.348 C++ Note: risk1l checked 561.69 120.669 C++ Note: risk2l checked 1971.73 120.669 C++ Note: df101 -117.015 -117.015 C++ Note: df102 0.320802 0.13496 C++ Note: df103 -9.12088 -6.18217 C++ Note: df104 0.617144 0.398893 C++ Note: df105 -0.0351723 -0.0218306 C++ Note: df106 -364.756 -867.031 C++ Note: riskr checked 13683.9 C++ Note: risk1r checked 38812.2 8366.11 C++ Note: risk2r checked 134810 8366.11 C++ Note: riskl checked 180.348 C++ Note: risk1l checked 561.69 120.669 C++ Note: risk2l checked 1971.73 120.669 C++ Note: df101 -117.015 -117.015 C++ Note: df102 0.320802 0.13496 C++ Note: df103 -9.12088 -6.18217 C++ Note: df104 0.617144 0.398893 C++ Note: df105 -0.0351723 -0.0218306 C++ Note: df106 -364.756 -867.031 C++ Note: Exiting Regression C++ Note: df501 -117.0147 C++ Note: df504 0.6171437 0.3988932 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 0 C++ Note: df99,51,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Grouping Start C++ Note: df100 365 0 0 -1,Prep_List C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: derivs checked 1229.85 410.233 C++ Note: second derivs checked 3319.14 410.233 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: risk1r checked 3418.73 1095.31 C++ Note: risk2r checked 8667.81 1095.31 C++ Note: riskl checked 19.6098 C++ Note: risk1l checked 42.0717 11.5472 C++ Note: risk2l checked 118.124 11.5472 C++ Note: df101 -119.981 -119.981 C++ Note: df102 6.06579 2.41134 C++ Note: df103 -8.60689 -6.47374 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.70476 -0.37248 C++ Note: df106 -19.78 -49.7572 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.42857 0.17936 C++ Note: sums checked 2796.31 2796.31 C++ Note: derivs checked 7446.21 1576.41 C++ Note: second derivs checked 26529.4 1576.41 C++ Note: dose checked 1000 C++ Note: non-dose checked 2796.31 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 2796.31 C++ Note: risk checked 2796.31 C++ Note: risk1 checked 7446.21 1576.41 C++ Note: risk2 checked 26529.4 1576.41 C++ Note: riskr checked 7268.45 C++ Note: risk1r checked 18181.7 4116.59 C++ Note: risk2r checked 58803.1 4116.59 C++ Note: riskl checked 88.5975 C++ Note: risk1l checked 256.339 56.699 C++ Note: risk2l checked 862.409 56.699 C++ Note: df101 -117.373 -117.373 C++ Note: df102 1.78502 1.30975 C++ Note: df103 -8.96103 -6.38772 C++ Note: df104 0.42857 0.17936 C++ Note: df105 -0.199199 -0.205041 C++ Note: df106 -65.7541 -89.6148 C++ Note: df100 3370 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 7268.45 C++ Note: risk1r checked 18181.7 4116.59 C++ Note: risk2r checked 58803.1 4116.59 C++ Note: riskl checked 88.5975 C++ Note: risk1l checked 256.339 56.699 C++ Note: risk2l checked 862.409 56.699 C++ Note: df101 -117.373 -117.373 C++ Note: df102 1.78502 1.30975 C++ Note: df103 -8.96103 -6.38772 C++ Note: df104 0.42857 0.17936 C++ Note: df105 -0.199199 -0.205041 C++ Note: df106 -65.7541 -89.6148 C++ Note: ending guess 0 C++ Note: df501 -117.3726 C++ Note: df504 0.4285697 0.17936 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.4285697 0.17936, -117.3726<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.42857 0.17936 C++ Note: sums checked 2796.31 2796.31 C++ Note: derivs checked 7446.21 1576.41 C++ Note: second derivs checked 26529.4 1576.41 C++ Note: dose checked 1000 C++ Note: non-dose checked 2796.31 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 2796.31 C++ Note: risk checked 2796.31 C++ Note: risk1 checked 7446.21 1576.41 C++ Note: risk2 checked 26529.4 1576.41 C++ Note: Made Risk Side Lists C++ Note: riskr checked 7268.45 C++ Note: risk1r checked 18181.7 4116.59 C++ Note: risk2r checked 58803.1 4116.59 C++ Note: riskl checked 88.5975 C++ Note: risk1l checked 256.339 56.699 C++ Note: risk2l checked 862.409 56.699 C++ Note: df101 -117.373 -117.373 C++ Note: df102 1.78502 1.30975 C++ Note: df103 -8.96103 -6.38772 C++ Note: df104 0.42857 0.17936 C++ Note: df105 -0.199199 -0.205041 C++ Note: df106 -65.7541 -89.6148 C++ Note: Starting Halves C++ Note: df501 -117.3726 C++ Note: df504 0.4285697 0.17936 C++ Note: values checked 0.577969 0.333141 C++ Note: sums checked 4672.1 4672.1 C++ Note: derivs checked 14081.1 2784.48 C++ Note: second derivs checked 53455.8 2784.48 C++ Note: dose checked 1000 C++ Note: non-dose checked 4672.1 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 4672.1 C++ Note: risk checked 4672.1 C++ Note: risk1 checked 14081.1 2784.48 C++ Note: risk2 checked 53455.8 2784.48 C++ Note: riskr checked 11783.5 C++ Note: risk1r checked 32618.6 7038.87 C++ Note: risk2r checked 111717 7038.87 C++ Note: riskl checked 152.934 C++ Note: risk1l checked 470.041 100.807 C++ Note: risk2l checked 1638.11 100.807 C++ Note: df101 -117.054 -117.054 C++ Note: df102 0.609162 0.503449 C++ Note: df103 -9.07577 -6.25818 C++ Note: df104 0.577969 0.333141 C++ Note: df105 -0.0671196 -0.0804466 C++ Note: df106 -192.156 -232.504 C++ Note: df100 7116 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: riskr checked 11783.5 C++ Note: risk1r checked 32618.6 7038.87 C++ Note: risk2r checked 111717 7038.87 C++ Note: riskl checked 152.934 C++ Note: risk1l checked 470.041 100.807 C++ Note: risk2l checked 1638.11 100.807 C++ Note: df101 -117.054 -117.054 C++ Note: df102 0.609162 0.503449 C++ Note: df103 -9.07577 -6.25818 C++ Note: df104 0.577969 0.333141 C++ Note: df105 -0.0671196 -0.0804466 C++ Note: df106 -192.156 -232.504 C++ Note: riskr checked 11783.5 C++ Note: risk1r checked 32618.6 7038.87 C++ Note: risk2r checked 111717 7038.87 C++ Note: riskl checked 152.934 C++ Note: risk1l checked 470.041 100.807 C++ Note: risk2l checked 1638.11 100.807 C++ Note: df101 -117.054 -117.054 C++ Note: df102 0.609162 0.503449 C++ Note: df103 -9.07577 -6.25818 C++ Note: df104 0.577969 0.333141 C++ Note: df105 -0.0671196 -0.0804466 C++ Note: df106 -192.156 -232.504 C++ Note: Exiting Regression C++ Note: df501 -117.0539 C++ Note: df504 0.5779686 0.3331409 Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 1 2 C++ Note: df99,62,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 3 in guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: Starting Halves C++ Note: df501 -467.6607 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df100 1541 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df100 2214 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df100 2878 3 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df100 3543 4 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df100 4326 5 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: df100 4391 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: df101 -467.6607 -467.6607 -467.6607 C++ Note: df104 0.1 0.1 0.01 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: ending guess 0 C++ Note: df501 -467.6607 C++ Note: df504 0.1 0.1 0.01 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.1 0.1 0.01, -467.6607<-- Best Guess C++ Note: starting subterms 3 in best guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: Made Risk Side Lists C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: Starting Halves C++ Note: df501 -467.6607 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df100 6227 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df100 6907 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df100 7565 3 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df100 8232 4 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df100 8993 5 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: df100 9059 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: df101 -467.6607 -467.6607 -467.6607 C++ Note: df104 0.1 0.1 0.01 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df501 -467.6607 C++ Note: df504 0.1 0.1 0.01 Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: Term checked 0 1 2 C++ Note: df99,66,Starting C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: starting subterms 3 in guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: Starting Halves C++ Note: df501 -463.5098 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df100 1516 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df100 2206 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df100 2885 3 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df100 3541 4 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df100 4259 5 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: df100 4326 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: df101 -463.5098 -463.5098 -463.5098 C++ Note: df104 0.1 0.1 0.01 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: ending guess 0 C++ Note: df501 -463.5098 C++ Note: df504 0.1 0.1 0.01 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.1 0.1 0.01, -463.5098<-- Best Guess C++ Note: starting subterms 3 in best guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: Made Risk Side Lists C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: Starting Halves C++ Note: df501 -463.5098 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df100 6167 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df100 6831 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df100 7471 3 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df100 8112 4 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df100 9119 5 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: df100 9183 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:13 2024 C++ Note: df101 -463.5098 -463.5098 -463.5098 C++ Note: df104 0.1 0.1 0.01 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df501 -463.5098 C++ Note: df504 0.1 0.1 0.01 Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: Term checked 0 1 2 C++ Note: df99,62,Starting C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: starting subterms 3 in guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: derivs checked 2662.16 2662.16 1673.67 C++ Note: second derivs checked 8088.51 8088.51 4753.83 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: risk1 checked 302.14 121.78 68.7623 C++ Note: risk2 checked 928.77 380.955 194.839 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df102 -94.3101 -39.4194 -9.93487 C++ Note: df103 -1040.45 -259.573 -93.8514 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df105 0.0906437 0.151862 0.105857 C++ Note: df106 4.95875 11.8637 47.0727 C++ Note: Starting Halves C++ Note: df501 -467.6607 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked 0.0320172 -0.0138968 -0.0693931 C++ Note: sums checked 1066.29 973.12 897.344 C++ Note: derivs checked 2170.09 1895.1 1342.81 C++ Note: second derivs checked 6452.98 5549.74 3636.92 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1066.29 973.12 897.344 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1066.29 973.12 897.344 C++ Note: risk checked 102.86 C++ Note: risk1 checked 208.566 69.9862 48.0225 C++ Note: risk2 checked 619.655 207.132 129.963 C++ Note: df101 -463.451 -463.451 -463.451 C++ Note: df102 10.3802 4.17009 9.3252 C++ Note: df103 -694.198 -76.4056 -27.9422 C++ Note: df104 0.0320172 -0.0138968 -0.0693931 C++ Note: Checking Deviance 698.903 C++ Note: df105 -0.0149527 -0.0545783 -0.333732 C++ Note: df106 -44.6478 -111.137 -49.6988 C++ Note: df100 3458 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df100 3520 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df101 -463.4514 -463.4514 -463.4514 C++ Note: df102 10.38017 4.170085 9.325204 C++ Note: df103 -694.1983 -76.40556 -27.94216 C++ Note: df104 0.03201725 -0.01389683 -0.06939307 C++ Note: Checking Deviance 698.9028 C++ Note: df105 -0.01495275 -0.05457829 -0.3337324 C++ Note: df106 -44.64776 -111.1372 -49.69879 C++ Note: df101 -463.451 -463.451 -463.451 C++ Note: df102 10.3802 4.17009 9.3252 C++ Note: df103 -694.198 -76.4056 -27.9422 C++ Note: df104 0.0320172 -0.0138968 -0.0693931 C++ Note: Checking Deviance 698.903 C++ Note: df105 -0.0149527 -0.0545783 -0.333732 C++ Note: df106 -44.6478 -111.137 -49.6988 C++ Note: ending guess 0 C++ Note: df501 -463.4514 C++ Note: df504 0.03201725 -0.01389683 -0.06939307 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.03201725 -0.01389683 -0.06939307, -463.4514<-- Best Guess C++ Note: starting subterms 3 in best guess 0 C++ Note: values checked 0.0320172 -0.0138968 -0.0693931 C++ Note: sums checked 1066.29 973.12 897.344 C++ Note: derivs checked 2170.09 1895.1 1342.81 C++ Note: second derivs checked 6452.98 5549.74 3636.92 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1066.29 973.12 897.344 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1066.29 973.12 897.344 C++ Note: risk checked 102.86 C++ Note: risk1 checked 208.566 69.9862 48.0225 C++ Note: risk2 checked 619.655 207.132 129.963 C++ Note: Made Risk Side Lists C++ Note: df101 -463.451 -463.451 -463.451 C++ Note: df102 10.3802 4.17009 9.3252 C++ Note: df103 -694.198 -76.4056 -27.9422 C++ Note: df104 0.0320172 -0.0138968 -0.0693931 C++ Note: Checking Deviance 698.903 C++ Note: df105 -0.0149527 -0.0545783 -0.333732 C++ Note: df106 -44.6478 -111.137 -49.6988 C++ Note: Starting Halves C++ Note: df501 -463.4514 C++ Note: df504 0.03201725 -0.01389683 -0.06939307 C++ Note: values checked 0.0432318 0.0270369 0.180906 C++ Note: sums checked 1091.03 1055.56 1388.12 C++ Note: derivs checked 2243.81 2138.21 2787.22 C++ Note: second derivs checked 6696.56 6347.84 8719.98 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1091.03 1055.56 1388.12 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1091.03 1055.56 1388.12 C++ Note: risk checked 126.33 C++ Note: risk1 checked 260.899 81.7736 101.847 C++ Note: risk2 checked 778.474 246.131 318.199 C++ Note: df101 -464.18 -464.18 -464.18 C++ Note: df102 -47.7167 -15.934 -19.8545 C++ Note: df103 -870.336 -126.985 -214.851 C++ Note: df104 0.0432318 0.0270369 0.180906 C++ Note: Checking Deviance 700.36 C++ Note: df105 0.0548256 0.125479 0.0924107 C++ Note: df106 9.72783 29.1314 23.379 C++ Note: df100 6766 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: values checked 0.0376245 0.00657003 0.0557566 C++ Note: sums checked 1078.56 1013.1 1098.33 C++ Note: derivs checked 2206.61 2012.57 1909.31 C++ Note: second derivs checked 6573.57 5934.53 5569.82 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1078.56 1013.1 1098.33 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1078.56 1013.1 1098.33 C++ Note: risk checked 112.808 C++ Note: risk1 checked 231.02 75.6258 69.025 C++ Note: risk2 checked 688.083 225.739 201.15 C++ Note: df101 -462.759 -462.759 -462.759 C++ Note: df102 -14.5654 -5.21187 0.637868 C++ Note: df103 -770.184 -99.8931 -90.8891 C++ Note: df104 0.0376245 0.00657003 0.0557566 C++ Note: Checking Deviance 697.518 C++ Note: df105 0.0189115 0.0521745 -0.00701809 C++ Note: df106 31.7712 88.7894 -725.478 C++ Note: df100 7622 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df100 7656 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df101 -462.7591 -462.7591 -462.7591 C++ Note: df102 -14.56536 -5.211874 0.6378678 C++ Note: df103 -770.1842 -99.89313 -90.88914 C++ Note: df104 0.03762453 0.006570034 0.05575656 C++ Note: Checking Deviance 697.5182 C++ Note: df105 0.01891153 0.0521745 -0.007018085 C++ Note: df106 31.7712 88.78939 -725.4781 C++ Note: df101 -462.759 -462.759 -462.759 C++ Note: df102 -14.5654 -5.21187 0.637868 C++ Note: df103 -770.184 -99.8931 -90.8891 C++ Note: df104 0.0376245 0.00657003 0.0557566 C++ Note: Checking Deviance 697.518 C++ Note: df105 0.0189115 0.0521745 -0.00701809 C++ Note: df106 31.7712 88.7894 -725.478 C++ Note: df501 -462.7591 C++ Note: df504 0.03762453 0.006570034 0.05575656 Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: Term checked 0 1 2 C++ Note: df99,41,Starting C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: starting subterms 3 in guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: derivs checked 2662.16 2662.16 1673.67 C++ Note: second derivs checked 8088.51 8088.51 4753.83 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: risk1 checked 89.4661 89.4661 56.218 C++ Note: risk2 checked 271.789 271.789 159.656 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df102 -12.0037 -12.0037 -0.410377 C++ Note: df103 -143.316 -143.316 -59.8747 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df105 0.0837566 0.0837566 0.00685392 C++ Note: df106 38.614 38.614 1129.47 C++ Note: Starting Halves C++ Note: df501 -463.5098 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked 0.0371826 0.0371826 0.00485956 C++ Note: sums checked 1077.58 1077.58 1007.96 C++ Note: derivs checked 2203.71 2203.71 1649.45 C++ Note: second derivs checked 6563.98 6563.98 4670.84 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1077.58 1077.58 1007.96 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1077.58 1077.58 1007.96 C++ Note: risk checked 106.323 C++ Note: risk1 checked 74.0612 74.0612 55.4045 C++ Note: risk2 checked 220.567 220.567 156.868 C++ Note: df101 -462.873 -462.873 -462.873 C++ Note: df102 0.991755 0.991755 5.79074 C++ Note: df103 -89.711 -89.711 -50.9916 C++ Note: df104 0.0371826 0.0371826 0.00485956 C++ Note: Checking Deviance 697.746 C++ Note: df105 -0.011055 -0.011055 -0.113563 C++ Note: df106 -466.721 -466.721 -79.9334 C++ Note: df100 1888 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df100 1922 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df101 -462.873 -462.873 -462.873 C++ Note: df102 0.991755 0.991755 5.790736 C++ Note: df103 -89.71102 -89.71102 -50.99157 C++ Note: df104 0.03718258 0.03718258 0.004859558 C++ Note: Checking Deviance 697.7461 C++ Note: df105 -0.011055 -0.011055 -0.1135626 C++ Note: df106 -466.7211 -466.7211 -79.93336 C++ Note: df101 -462.873 -462.873 -462.873 C++ Note: df102 0.991755 0.991755 5.79074 C++ Note: df103 -89.711 -89.711 -50.9916 C++ Note: df104 0.0371826 0.0371826 0.00485956 C++ Note: Checking Deviance 697.746 C++ Note: df105 -0.011055 -0.011055 -0.113563 C++ Note: df106 -466.721 -466.721 -79.9334 C++ Note: ending guess 0 C++ Note: df501 -462.873 C++ Note: df504 0.03718258 0.03718258 0.004859558 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.03718258 0.03718258 0.004859558, -462.873<-- Best Guess C++ Note: starting subterms 3 in best guess 0 C++ Note: values checked 0.0371826 0.0371826 0.00485956 C++ Note: sums checked 1077.58 1077.58 1007.96 C++ Note: derivs checked 2203.71 2203.71 1649.45 C++ Note: second derivs checked 6563.98 6563.98 4670.84 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1077.58 1077.58 1007.96 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1077.58 1077.58 1007.96 C++ Note: risk checked 106.323 C++ Note: risk1 checked 74.0612 74.0612 55.4045 C++ Note: risk2 checked 220.567 220.567 156.868 C++ Note: Made Risk Side Lists C++ Note: df101 -462.873 -462.873 -462.873 C++ Note: df102 0.991755 0.991755 5.79074 C++ Note: df103 -89.711 -89.711 -50.9916 C++ Note: df104 0.0371826 0.0371826 0.00485956 C++ Note: Checking Deviance 697.746 C++ Note: df105 -0.011055 -0.011055 -0.113563 C++ Note: df106 -466.721 -466.721 -79.9334 C++ Note: Starting Halves C++ Note: df501 -462.873 C++ Note: df504 0.03718258 0.03718258 0.004859558 C++ Note: values checked 0.0454738 0.0454738 0.0900315 C++ Note: sums checked 1096.08 1096.08 1167.18 C++ Note: derivs checked 2258.88 2258.88 2112.17 C++ Note: second derivs checked 6746.42 6746.42 6283.7 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1096.08 1096.08 1167.18 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1096.08 1096.08 1167.18 C++ Note: risk checked 112.914 C++ Note: risk1 checked 75.9152 75.9152 70.9449 C++ Note: risk2 checked 226.697 226.697 211.036 C++ Note: df101 -462.685 -462.685 -462.685 C++ Note: df102 -4.74661 -4.74661 -1.37928 C++ Note: df103 -100.025 -100.025 -101.757 C++ Note: df104 0.0454738 0.0454738 0.0900315 C++ Note: Checking Deviance 697.37 C++ Note: df105 0.0474545 0.0474545 0.0135546 C++ Note: df106 97.4769 97.4769 335.454 C++ Note: df100 5611 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df100 5686 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df101 -462.6849 -462.6849 -462.6849 C++ Note: df102 -4.746612 -4.746612 -1.37928 C++ Note: df103 -100.0246 -100.0246 -101.757 C++ Note: df104 0.04547382 0.04547382 0.09003152 C++ Note: Checking Deviance 697.3697 C++ Note: df105 0.04745446 0.04745446 0.01355464 C++ Note: df106 97.47686 97.47686 335.4539 C++ Note: df101 -462.685 -462.685 -462.685 C++ Note: df102 -4.74661 -4.74661 -1.37928 C++ Note: df103 -100.025 -100.025 -101.757 C++ Note: df104 0.0454738 0.0454738 0.0900315 C++ Note: Checking Deviance 697.37 C++ Note: df105 0.0474545 0.0474545 0.0135546 C++ Note: df106 97.4769 97.4769 335.454 C++ Note: df501 -462.6849 C++ Note: df504 0.04547382 0.04547382 0.09003152 Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: Term checked 0 1 2 C++ Note: df99,63,Starting C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: starting subterms 3 in guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: Starting Halves C++ Note: df501 -4464.359 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df100 1486 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df100 1971 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df100 2362 3 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df100 2948 4 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df100 3630 5 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df100 3697 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df101 -4464.359 -4464.359 -4464.359 C++ Note: df104 0.1 0.1 0.01 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: ending guess 0 C++ Note: df501 -4464.359 C++ Note: df504 0.1 0.1 0.01 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.1 0.1 0.01, -4464.359<-- Best Guess C++ Note: starting subterms 3 in best guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: Made Risk Side Lists C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: Starting Halves C++ Note: df501 -4464.359 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df100 4930 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df100 5337 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df100 5785 3 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df100 6461 4 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df100 7111 5 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df100 7171 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df101 -4464.359 -4464.359 -4464.359 C++ Note: df104 0.1 0.1 0.01 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df501 -4464.359 C++ Note: df504 0.1 0.1 0.01 Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: Term checked 0 1 2 C++ Note: df99,36,Starting C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: starting subterms 3 in guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: Starting Halves C++ Note: df501 -3870.252 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df100 857 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df100 1233 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df100 1636 3 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df100 2012 4 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df100 2387 5 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df100 2420 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df101 -3870.252 -3870.252 -3870.252 C++ Note: df104 0.1 0.1 0.01 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: ending guess 0 C++ Note: df501 -3870.252 C++ Note: df504 0.1 0.1 0.01 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.1 0.1 0.01, -3870.252<-- Best Guess C++ Note: starting subterms 3 in best guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: Made Risk Side Lists C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: Starting Halves C++ Note: df501 -3870.252 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df100 3445 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df100 3833 2 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df100 4210 3 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df100 4633 4 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df100 5014 5 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df100 5048 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df101 -3870.252 -3870.252 -3870.252 C++ Note: df104 0.1 0.1 0.01 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df501 -3870.252 C++ Note: df504 0.1 0.1 0.01 Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: Term checked 0 1 2 C++ Note: df99,37,Starting C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: starting subterms 3 in guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: derivs checked 2662.16 2662.16 1673.67 C++ Note: second derivs checked 8088.51 8088.51 4753.83 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: risk1 checked 8990.66 3623.84 2047.21 C++ Note: risk2 checked 27640.9 11337.7 5801.4 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df102 -9823.7 -3961.6 -2223.36 C++ Note: df103 -30965.7 -12538.3 -6371.77 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df105 0.317244 0.315959 0.34894 C++ Note: df106 0.454448 1.12691 2.00793 C++ Note: Starting Halves C++ Note: df501 -4464.359 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked -0.137933 -0.136969 -0.251705 C++ Note: sums checked 775.553 776.836 702.601 C++ Note: derivs checked 1328.21 1331.8 841.86 C++ Note: second derivs checked 3721.09 3732.5 2034.61 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 775.553 776.836 702.601 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 775.553 776.836 702.601 C++ Note: risk checked 1943.25 C++ Note: risk1 checked 3180.78 914.006 655.882 C++ Note: risk2 checked 8802.59 2426.63 1587.74 C++ Note: df101 -2228.98 -2228.98 -2228.98 C++ Note: df102 -3323.52 -952.67 -688.275 C++ Note: df103 -9864.88 -2573.61 -1698.13 C++ Note: df104 -0.137933 -0.136969 -0.251705 C++ Note: Checking Deviance 4229.97 C++ Note: df105 0.336904 0.370169 0.405314 C++ Note: df106 0.67067 2.33972 3.23851 C++ Note: df100 1872 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df100 1924 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df101 -2228.983 -2228.983 -2228.983 C++ Note: df102 -3323.517 -952.6701 -688.2751 C++ Note: df103 -9864.881 -2573.61 -1698.127 C++ Note: df104 -0.1379333 -0.1369691 -0.2517047 C++ Note: Checking Deviance 4229.966 C++ Note: df105 0.336904 0.3701688 0.4053143 C++ Note: df106 0.6706698 2.339722 3.238506 C++ Note: df101 -2228.98 -2228.98 -2228.98 C++ Note: df102 -3323.52 -952.67 -688.275 C++ Note: df103 -9864.88 -2573.61 -1698.13 C++ Note: df104 -0.137933 -0.136969 -0.251705 C++ Note: Checking Deviance 4229.97 C++ Note: df105 0.336904 0.370169 0.405314 C++ Note: df106 0.67067 2.33972 3.23851 C++ Note: ending guess 0 C++ Note: df501 -2228.983 C++ Note: df504 -0.1379333 -0.1369691 -0.2517047 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1379333 -0.1369691 -0.2517047, -2228.983<-- Best Guess C++ Note: starting subterms 3 in best guess 0 C++ Note: values checked -0.137933 -0.136969 -0.251705 C++ Note: sums checked 775.553 776.836 702.601 C++ Note: derivs checked 1328.21 1331.8 841.86 C++ Note: second derivs checked 3721.09 3732.5 2034.61 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 775.553 776.836 702.601 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 775.553 776.836 702.601 C++ Note: risk checked 1943.25 C++ Note: risk1 checked 3180.78 914.006 655.882 C++ Note: risk2 checked 8802.59 2426.63 1587.74 C++ Note: Made Risk Side Lists C++ Note: df101 -2228.98 -2228.98 -2228.98 C++ Note: df102 -3323.52 -952.67 -688.275 C++ Note: df103 -9864.88 -2573.61 -1698.13 C++ Note: df104 -0.137933 -0.136969 -0.251705 C++ Note: Checking Deviance 4229.97 C++ Note: df105 0.336904 0.370169 0.405314 C++ Note: df106 0.67067 2.33972 3.23851 C++ Note: Starting Halves C++ Note: df501 -2228.983 C++ Note: df504 -0.1379333 -0.1369691 -0.2517047 C++ Note: values checked -0.390611 -0.414596 -0.55569 C++ Note: sums checked 532.749 516.988 517.87 C++ Note: derivs checked 677.199 637.561 432.04 C++ Note: second derivs checked 1711.97 1594.9 857.807 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 532.749 516.988 517.87 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 532.749 516.988 517.87 C++ Note: risk checked 1160.77 C++ Note: risk1 checked 1287.6 260.671 231.783 C++ Note: risk2 checked 3158.62 543.41 460.892 C++ Note: df101 -1440.04 -1440.04 -1440.04 C++ Note: df102 -1204.6 -248.036 -228.728 C++ Note: df103 -3543.56 -513.003 -465.909 C++ Note: df104 -0.390611 -0.414596 -0.55569 C++ Note: Checking Deviance 2652.09 C++ Note: df105 0.339942 0.483498 0.49093 C++ Note: df106 1.19545 5.80578 6.29587 C++ Note: df100 5615 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df100 5689 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df101 -1440.044 -1440.044 -1440.044 C++ Note: df102 -1204.604 -248.0364 -228.7284 C++ Note: df103 -3543.556 -513.0035 -465.9085 C++ Note: df104 -0.3906113 -0.4145957 -0.5556904 C++ Note: Checking Deviance 2652.088 C++ Note: df105 0.3399422 0.4834984 0.4909299 C++ Note: df106 1.19545 5.805777 6.295868 C++ Note: df101 -1440.04 -1440.04 -1440.04 C++ Note: df102 -1204.6 -248.036 -228.728 C++ Note: df103 -3543.56 -513.003 -465.909 C++ Note: df104 -0.390611 -0.414596 -0.55569 C++ Note: Checking Deviance 2652.09 C++ Note: df105 0.339942 0.483498 0.49093 C++ Note: df106 1.19545 5.80578 6.29587 C++ Note: df501 -1440.044 C++ Note: df504 -0.3906113 -0.4145957 -0.5556904 Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: Term checked 0 1 2 C++ Note: df99,74,Starting C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: starting subterms 3 in guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: derivs checked 2662.16 2662.16 1673.67 C++ Note: second derivs checked 8088.51 8088.51 4753.83 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: risk1 checked 2662.16 2662.16 1673.67 C++ Note: risk2 checked 8088.51 8088.51 4753.83 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df102 -2892.89 -2892.89 -1814.56 C++ Note: df103 -8899.28 -8899.28 -5219.6 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df105 0.32507 0.32507 0.347644 C++ Note: df106 1.33785 1.33785 2.13288 C++ Note: Starting Halves C++ Note: df501 -3870.252 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked -0.143803 -0.143803 -0.250733 C++ Note: sums checked 767.821 767.821 703.42 C++ Note: derivs checked 1306.57 1306.57 843.84 C++ Note: second derivs checked 3652.41 3652.41 2040.66 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 767.821 767.821 703.42 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 767.821 767.821 703.42 C++ Note: risk checked 2239.06 C++ Note: risk1 checked 1306.57 1306.57 843.84 C++ Note: risk2 checked 3652.41 3652.41 2040.66 C++ Note: df101 -2541.39 -2541.39 -2541.39 C++ Note: df102 -1381.02 -1381.02 -889.259 C++ Note: df103 -3933.71 -3933.71 -2190.79 C++ Note: df104 -0.143803 -0.143803 -0.250733 C++ Note: Checking Deviance 4854.78 C++ Note: df105 0.351073 0.351073 0.405908 C++ Note: df106 1.84023 1.84023 2.85787 C++ Note: df100 3389 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df100 3462 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df101 -2541.39 -2541.39 -2541.39 C++ Note: df102 -1381.017 -1381.017 -889.2586 C++ Note: df103 -3933.706 -3933.706 -2190.791 C++ Note: df104 -0.1438028 -0.1438028 -0.2507329 C++ Note: Checking Deviance 4854.78 C++ Note: df105 0.3510728 0.3510728 0.4059076 C++ Note: df106 1.84023 1.84023 2.857875 C++ Note: df101 -2541.39 -2541.39 -2541.39 C++ Note: df102 -1381.02 -1381.02 -889.259 C++ Note: df103 -3933.71 -3933.71 -2190.79 C++ Note: df104 -0.143803 -0.143803 -0.250733 C++ Note: Checking Deviance 4854.78 C++ Note: df105 0.351073 0.351073 0.405908 C++ Note: df106 1.84023 1.84023 2.85787 C++ Note: ending guess 0 C++ Note: df501 -2541.39 C++ Note: df504 -0.1438028 -0.1438028 -0.2507329 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1438028 -0.1438028 -0.2507329, -2541.39<-- Best Guess C++ Note: starting subterms 3 in best guess 0 C++ Note: values checked -0.143803 -0.143803 -0.250733 C++ Note: sums checked 767.821 767.821 703.42 C++ Note: derivs checked 1306.57 1306.57 843.84 C++ Note: second derivs checked 3652.41 3652.41 2040.66 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 767.821 767.821 703.42 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 767.821 767.821 703.42 C++ Note: risk checked 2239.06 C++ Note: risk1 checked 1306.57 1306.57 843.84 C++ Note: risk2 checked 3652.41 3652.41 2040.66 C++ Note: Made Risk Side Lists C++ Note: df101 -2541.39 -2541.39 -2541.39 C++ Note: df102 -1381.02 -1381.02 -889.259 C++ Note: df103 -3933.71 -3933.71 -2190.79 C++ Note: df104 -0.143803 -0.143803 -0.250733 C++ Note: Checking Deviance 4854.78 C++ Note: df105 0.351073 0.351073 0.405908 C++ Note: df106 1.84023 1.84023 2.85787 C++ Note: Starting Halves C++ Note: df501 -2541.39 C++ Note: df504 -0.1438028 -0.1438028 -0.2507329 C++ Note: values checked -0.407107 -0.407107 -0.555164 C++ Note: sums checked 521.807 521.807 518.098 C++ Note: derivs checked 649.637 649.637 432.492 C++ Note: second derivs checked 1630.48 1630.48 858.997 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 521.807 521.807 518.098 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 521.807 521.807 518.098 C++ Note: risk checked 1561.71 C++ Note: risk1 checked 649.637 649.637 432.492 C++ Note: risk2 checked 1630.48 1630.48 858.997 C++ Note: df101 -1840.51 -1840.51 -1840.51 C++ Note: df102 -652.83 -652.83 -432.167 C++ Note: df103 -1682.85 -1682.85 -882.861 C++ Note: df104 -0.407107 -0.407107 -0.555164 C++ Note: Checking Deviance 3453.02 C++ Note: df105 0.387933 0.387933 0.489507 C++ Note: df106 2.81927 2.81927 4.25879 C++ Note: df100 7771 1 1 0,Update_calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df100 7850 0 0 0,Update_Calc C++ Note: Current Time, Wed Apr 3 17:09:14 2024 C++ Note: df101 -1840.508 -1840.508 -1840.508 C++ Note: df102 -652.8304 -652.8304 -432.1668 C++ Note: df103 -1682.845 -1682.845 -882.8612 C++ Note: df104 -0.4071074 -0.4071074 -0.5551637 C++ Note: Checking Deviance 3453.016 C++ Note: df105 0.3879325 0.3879325 0.4895071 C++ Note: df106 2.819274 2.819274 4.258791 C++ Note: df101 -1840.51 -1840.51 -1840.51 C++ Note: df102 -652.83 -652.83 -432.167 C++ Note: df103 -1682.85 -1682.85 -882.861 C++ Note: df104 -0.407107 -0.407107 -0.555164 C++ Note: Checking Deviance 3453.02 C++ Note: df105 0.387933 0.387933 0.489507 C++ Note: df106 2.81927 2.81927 4.25879 C++ Note: df501 -1840.508 C++ Note: df504 -0.4071074 -0.4071074 -0.5551637 [ FAIL 0 | WARN 0 | SKIP 0 | PASS 1104 ] > > proc.time() user system elapsed 36.20 4.48 41.86