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Type 'q()' to quit R. > # This file is part of the standard setup for testthat. > # It is recommended that you do not modify it. > # > # Where should you do additional test configuration? > # Learn more about the roles of various files in: > # * https://r-pkgs.org/tests.html > # * https://testthat.r-lib.org/reference/test_package.html#special-files > > library(testthat) > library(Colossus) > > test_check("Colossus") Note: Starting Censoring weight Plot Function Note: 901 risk groups Saving 7 x 7 in image 153.499294651964 Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Note: 2 risk groups Note: Starting Plot Function Note: Getting Plot Info Error: no events Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Error: Plot type not given Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Error: Stratification Column not in dataframe Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Error: Stratification Column not given Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Error: dose column not given Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Error: dose column not given Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Error: ID column is not in the dataframe Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Error: ID column not given Note: Starting Plot Function Note: Getting Plot Info Note: 3 risk groups Note: 3 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:17:57 2024 C++ Note: Term checked 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:17:57 2024 C++ Note: Grouping Start C++ Note: df100 100 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:17:57 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: ending guess 0 C++ Note: df501 0 C++ Note: df504 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1, 0<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: Exiting Regression C++ Note: df501 0 C++ Note: df504 -0.1 Note: starting ph_plot Note: nonStratified survival curve calculation C++ Note: START_PLOT C++ Note: Current Time, Tue Feb 13 19:17:57 2024 C++ Note: Term checked 0 C++ Note: df99,21,Starting C++ Note: Current Time, Tue Feb 13 19:17:57 2024 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Grouping Start C++ Note: df100 321 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:17:57 2024 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan Note: writing survival data Note: Plotting Survival Curves Saving 7 x 7 in image Saving 7 x 7 in image Saving 7 x 7 in image Saving 7 x 7 in image Note: Starting Plot Function Note: Getting Plot Info Note: 3 risk groups Note: 3 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:17:58 2024 C++ Note: Term checked 0 C++ Note: df99,23,Starting C++ Note: Current Time, Tue Feb 13 19:17:58 2024 C++ Note: Grouping Start C++ Note: df100 98 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:17:58 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 7.11207 C++ Note: risk1r checked 41.5001 C++ Note: risk2r checked 269.583 C++ Note: riskl checked 2.29326 C++ Note: risk1l checked 12.3258 C++ Note: risk2l checked 74.9204 C++ Note: df101 -5.824 C++ Note: df102 -0.705933 C++ Note: df103 -15.0512 C++ Note: df104 -0.1 C++ Note: df105 0.046902 C++ Note: df106 8.25007 C++ Note: riskr checked 7.11207 C++ Note: risk1r checked 41.5001 C++ Note: risk2r checked 269.583 C++ Note: riskl checked 2.29326 C++ Note: risk1l checked 12.3258 C++ Note: risk2l checked 74.9204 C++ Note: df101 -5.824 C++ Note: df102 -0.705933 C++ Note: df103 -15.0512 C++ Note: df104 -0.1 C++ Note: df105 0.046902 C++ Note: df106 8.25007 C++ Note: ending guess 0 C++ Note: df501 -5.823998 C++ Note: df504 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1, -5.823998<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 7.11207 C++ Note: risk1r checked 41.5001 C++ Note: risk2r checked 269.583 C++ Note: riskl checked 2.29326 C++ Note: risk1l checked 12.3258 C++ Note: risk2l checked 74.9204 C++ Note: df101 -5.824 C++ Note: df102 -0.705933 C++ Note: df103 -15.0512 C++ Note: df104 -0.1 C++ Note: df105 0.046902 C++ Note: df106 8.25007 C++ Note: riskr checked 7.11207 C++ Note: risk1r checked 41.5001 C++ Note: risk2r checked 269.583 C++ Note: riskl checked 2.29326 C++ Note: risk1l checked 12.3258 C++ Note: risk2l checked 74.9204 C++ Note: df101 -5.824 C++ Note: df102 -0.705933 C++ Note: df103 -15.0512 C++ Note: df104 -0.1 C++ Note: df105 0.046902 C++ Note: df106 8.25007 C++ Note: Exiting Regression C++ Note: df501 -5.823998 C++ Note: df504 -0.1 Note: starting ph_plot Note: Stratified survival curve calculation Note: 2 strata used Note: 2 strata used Note: 3 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:17:58 2024 C++ Note: Term checked 0 C++ Note: df99,22,Starting C++ Note: Current Time, Tue Feb 13 19:17:58 2024 C++ Note: Grouping Start C++ Note: df100 82 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:17:58 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2.2112 3.88777 C++ Note: riskl checked 1.05586 1.2374 C++ Note: df101 -3.56531 C++ Note: df102 0.377208 C++ Note: df103 -10.9514 C++ Note: df104 -0.1 C++ Note: df105 -0.0344437 C++ Note: df106 -9.45185 C++ Note: riskr checked 2.2112 3.88777 C++ Note: riskl checked 1.05586 1.2374 C++ Note: df101 -3.56531 C++ Note: df102 0.377208 C++ Note: df103 -10.9514 C++ Note: df104 -0.1 C++ Note: df105 -0.0344437 C++ Note: df106 -9.45185 C++ Note: ending guess 0 C++ Note: df501 -3.56531 C++ Note: df504 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1, -3.56531<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2.2112 3.88777 C++ Note: riskl checked 1.05586 1.2374 C++ Note: df101 -3.56531 C++ Note: df102 0.377208 C++ Note: df103 -10.9514 C++ Note: df104 -0.1 C++ Note: df105 -0.0344437 C++ Note: df106 -9.45185 C++ Note: riskr checked 2.2112 3.88777 C++ Note: riskl checked 1.05586 1.2374 C++ Note: df101 -3.56531 C++ Note: df102 0.377208 C++ Note: df103 -10.9514 C++ Note: df104 -0.1 C++ Note: df105 -0.0344437 C++ Note: df106 -9.45185 C++ Note: Exiting Regression C++ Note: df501 -3.56531 C++ Note: df504 -0.1 Note: Starting Stratification: Calculation C++ Note: START_PLOT C++ Note: Current Time, Tue Feb 13 19:17:58 2024 C++ Note: Term checked 0 C++ Note: df99,21,Starting C++ Note: Current Time, Tue Feb 13 19:17:58 2024 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Grouping Start C++ Note: df100 322 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:17:58 2024 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2.2112 3.88777 C++ Note: riskl checked 1.05586 1.2374 C++ Note: df101 -3.56531 C++ Note: df102 0.377208 C++ Note: df103 -10.9514 C++ Note: df104 -0.1 C++ Note: df105 -0.0344437 C++ Note: df106 -9.45185 Note: Starting Stratification calculation 1 Note: Starting Stratification calculation 2 Saving 7 x 7 in image Note: Starting Plot Function Note: Getting Plot Info Note: 3 risk groups Note: 3 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:17:59 2024 C++ Note: Term checked 0 C++ Note: df99,24,Starting C++ Note: Current Time, Tue Feb 13 19:17:59 2024 C++ Note: Grouping Start C++ Note: df100 99 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:17:59 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: ending guess 0 C++ Note: df501 0 C++ Note: df504 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1, 0<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: Exiting Regression C++ Note: df501 0 C++ Note: df504 -0.1 C++ Note: START_PLOT C++ Note: Current Time, Tue Feb 13 19:17:59 2024 C++ Note: Term checked 0 C++ Note: df99,82,Starting C++ Note: Current Time, Tue Feb 13 19:17:59 2024 C++ Note: values checked -0.1 C++ Note: sums checked 5.29005 C++ Note: dose checked 7 C++ Note: non-dose checked 5.29005 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 5.29005 C++ Note: risk checked 5.29005 Saving 7 x 7 in image Note: Starting Plot Function Note: Getting Plot Info Note: 86 risk groups Note: 86 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:17:59 2024 C++ Note: Term checked 0 1 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:17:59 2024 C++ Note: Grouping Start C++ Note: df100 1489 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:17:59 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.95 3328 C++ Note: derivs checked 3813.95 0.000939732 C++ Note: second derivs checked 3813.95 0.000939732 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.95 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.95 3328 C++ Note: risk checked 9787.82 C++ Note: risk1 checked 6011.82 0.000944651 C++ Note: risk2 checked 6011.82 0.000944651 C++ Note: Made Risk Side Lists C++ Note: riskr checked 6489.99 C++ Note: risk1r checked 4018.99 0.000575324 C++ Note: risk2r checked 4018.99 0.000575324 C++ Note: riskl checked 119.492 C++ Note: risk1l checked 49.4925 1.62651e-05 C++ Note: risk2l checked 49.4925 1.62651e-05 C++ Note: df101 -329.891 -329.891 C++ Note: df102 -21.7852 9.27193e-06 C++ Note: df103 -19.521 9.27193e-06 C++ Note: df104 0.01 -15 C++ Note: df105 1.11599 1 C++ Note: df106 15.1429 -3.55796e+07 C++ Note: riskr checked 6489.99 C++ Note: risk1r checked 4018.99 0.000575324 C++ Note: risk2r checked 4018.99 0.000575324 C++ Note: riskl checked 119.492 C++ Note: risk1l checked 49.4925 1.62651e-05 C++ Note: risk2l checked 49.4925 1.62651e-05 C++ Note: df101 -329.891 -329.891 C++ Note: df102 -21.7852 9.27193e-06 C++ Note: df103 -19.521 9.27193e-06 C++ Note: df104 0.01 -15 C++ Note: df105 1.11599 1 C++ Note: df106 15.1429 -3.55796e+07 C++ Note: ending guess 0 C++ Note: df501 -329.8914 C++ Note: df504 0.01 -15 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.01 -15, -329.8914<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.95 3328 C++ Note: derivs checked 3813.95 0.000939732 C++ Note: second derivs checked 3813.95 0.000939732 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.95 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.95 3328 C++ Note: risk checked 9787.82 C++ Note: risk1 checked 6011.82 0.000944651 C++ Note: risk2 checked 6011.82 0.000944651 C++ Note: Made Risk Side Lists C++ Note: riskr checked 6489.99 C++ Note: risk1r checked 4018.99 0.000575324 C++ Note: risk2r checked 4018.99 0.000575324 C++ Note: riskl checked 119.492 C++ Note: risk1l checked 49.4925 1.62651e-05 C++ Note: risk2l checked 49.4925 1.62651e-05 C++ Note: df101 -329.891 -329.891 C++ Note: df102 -21.7852 9.27193e-06 C++ Note: df103 -19.521 9.27193e-06 C++ Note: df104 0.01 -15 C++ Note: df105 1.11599 1 C++ Note: df106 15.1429 -3.55796e+07 C++ Note: riskr checked 6489.99 C++ Note: risk1r checked 4018.99 0.000575324 C++ Note: risk2r checked 4018.99 0.000575324 C++ Note: riskl checked 119.492 C++ Note: risk1l checked 49.4925 1.62651e-05 C++ Note: risk2l checked 49.4925 1.62651e-05 C++ Note: df101 -329.891 -329.891 C++ Note: df102 -21.7852 9.27193e-06 C++ Note: df103 -19.521 9.27193e-06 C++ Note: df104 0.01 -15 C++ Note: df105 1.11599 1 C++ Note: df106 15.1429 -3.55796e+07 C++ Note: Exiting Regression C++ Note: df501 -329.8914 C++ Note: df504 0.01 -15 Note: 86 risk groups C++ Note: START_PLOT C++ Note: Current Time, Tue Feb 13 19:17:59 2024 C++ Note: Term checked 0 1 C++ Note: df99,34,Starting C++ Note: Current Time, Tue Feb 13 19:17:59 2024 C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.95 3328 C++ Note: derivs checked 3813.95 0.000939732 C++ Note: second derivs checked 3813.95 0.000939732 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.95 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.95 3328 C++ Note: risk checked 9787.82 C++ Note: risk1 checked 6011.82 0.000944651 C++ Note: risk2 checked 6011.82 0.000944651 C++ Note: Grouping Start C++ Note: df100 2563 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:17:59 2024 C++ Note: Made Risk Side Lists C++ Note: riskr checked 6489.99 C++ Note: risk1r checked 4018.99 0.000575324 C++ Note: risk2r checked 4018.99 0.000575324 C++ Note: riskl checked 119.492 C++ Note: risk1l checked 49.4925 1.62651e-05 C++ Note: risk2l checked 49.4925 1.62651e-05 C++ Note: df101 -329.891 -329.891 C++ Note: df102 -21.7852 9.27193e-06 C++ Note: df103 -19.521 9.27193e-06 C++ Note: df104 0.01 -15 C++ Note: df105 1.11599 1 C++ Note: df106 15.1429 -3.55796e+07 C++ Note: starting plot data Saving 7 x 7 in image Saving 7 x 7 in image Saving 7 x 7 in image Saving 7 x 7 in image Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Note: 2 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:00 2024 C++ Note: Term checked 0 C++ Note: df99,23,Starting C++ Note: Current Time, Tue Feb 13 19:18:00 2024 C++ Note: Grouping Start C++ Note: df100 100 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:00 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.11965 C++ Note: risk1r checked 6.27591 C++ Note: risk2r checked 39.4822 C++ Note: riskl checked 1.11965 C++ Note: risk1l checked 6.27591 C++ Note: risk2l checked 39.4822 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: riskr checked 1.11965 C++ Note: risk1r checked 6.27591 C++ Note: risk2r checked 39.4822 C++ Note: riskl checked 1.11965 C++ Note: risk1l checked 6.27591 C++ Note: risk2l checked 39.4822 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: ending guess 0 C++ Note: df501 0 C++ Note: df504 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1, 0<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.11965 C++ Note: risk1r checked 6.27591 C++ Note: risk2r checked 39.4822 C++ Note: riskl checked 1.11965 C++ Note: risk1l checked 6.27591 C++ Note: risk2l checked 39.4822 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: riskr checked 1.11965 C++ Note: risk1r checked 6.27591 C++ Note: risk2r checked 39.4822 C++ Note: riskl checked 1.11965 C++ Note: risk1l checked 6.27591 C++ Note: risk2l checked 39.4822 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: Exiting Regression C++ Note: df501 0 C++ Note: df504 -0.1 Note: starting ph_plot Note: nonStratified survival curve calculation C++ Note: START_PLOT C++ Note: Current Time, Tue Feb 13 19:18:00 2024 C++ Note: Term checked 0 C++ Note: df99,21,Starting C++ Note: Current Time, Tue Feb 13 19:18:00 2024 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Grouping Start C++ Note: df100 316 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:00 2024 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.11965 C++ Note: risk1r checked 6.27591 C++ Note: risk2r checked 39.4822 C++ Note: riskl checked 1.11965 C++ Note: risk1l checked 6.27591 C++ Note: risk2l checked 39.4822 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan Note: writing survival data Note: Plotting Martingale Residuals Note: Martingale Plot: d Saving 7 x 7 in image Saving 7 x 7 in image Note: Starting Plot Function Note: Getting Plot Info Note: 3 risk groups Note: 3 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:00 2024 C++ Note: Term checked 0 C++ Note: df99,24,Starting C++ Note: Current Time, Tue Feb 13 19:18:00 2024 C++ Note: Grouping Start C++ Note: df100 101 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:00 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: ending guess 0 C++ Note: df501 0 C++ Note: df504 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1, 0<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: Exiting Regression C++ Note: df501 0 C++ Note: df504 -0.1 Note: starting ph_plot Note: nonStratified survival curve calculation C++ Note: START_PLOT C++ Note: Current Time, Tue Feb 13 19:18:00 2024 C++ Note: Term checked 0 C++ Note: df99,20,Starting C++ Note: Current Time, Tue Feb 13 19:18:00 2024 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Grouping Start C++ Note: df100 322 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:00 2024 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.84393 C++ Note: risk1r checked 8.73121 C++ Note: risk2r checked 46.1633 C++ Note: riskl checked 1.84393 C++ Note: risk1l checked 8.73121 C++ Note: risk2l checked 46.1633 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan Note: writing survival data Note: Plotting Survival Curves Saving 7 x 7 in image Saving 7 x 7 in image Saving 7 x 7 in image Saving 7 x 7 in image Note: Plotting Kaplan-Meier Curve Saving 7 x 7 in image Saving 7 x 7 in image Saving 7 x 7 in image Error: Cores Requested: 196 , Cores Available: 2 Warning: a and e are equal Warning: a and e are equal Warning: b and f are equal Warning: a and d are equal Warning: a and f are equal Warning: a and b are equal Warning: a and c are equal Warning: a and b are equal Warning: a and c are equal Warning: a and b are equal Warning: a and c are equal Error: e not in data.table Error: e not in data.table Error: Iteration: a?+?b?+c has incorrect length of 4 but should be 3. Error: Incorrect operation of ++ Error: Terms used: 2 , Terms with gmix types available: 1 Error: Model formula FAILING_CHOICE not in acceptable list Error: Model formula MA not in acceptable list Error: Model formula EA not in acceptable list Note: Number of factors:1 Note: Number of factors:7 Error: a0 arguement was negative Error: a0 arguement was not a number Error: a0 arguement was not a number Error: a0 arguement was negative Error: a0 arguement was not a number Error: a0 arguement was not a number Error: a0 arguement was not a number Error: goal is too low Error: a0 arguement was negative Error: e missing from column names Error: The missing-value replacement is also NA Note: Column b had replaced values Note: Column b had replaced values Warning: Parameters used: 4, Covariates used: 5, Remaining filled with 0.01 Error: Atleast one parameter must be free Error: Parameters used: 6, Covariates used: 5 Error: Terms used: 4, Covariates used: 5 Error: Terms used: 6, Covariates used: 5 Error: Term types used: 4, Covariates used: 5 Error: Term types used: 6, Covariates used: 5 Error: lin_int missing Error: step_int missing Error: loglin_top missing Error: lin_quad_int missing Error: lin_exp_int missing Error: lin_exp_exp_slope missing Error: step_slope missing Error: lin_slope missing Error: lin_quad_slope missing Error: lin_exp_slope missing Error: lin_exp_int missing Error: Parameters used in first option: 5, Parameters used in different option: 4, please fix parameter length Warning: Parameters used: 4, Covariates used: 5, Remaining filled with 0.01 Error: Parameters used: 6, Covariates used: 5 Error: Terms used: 4, Covariates used: 5 Error: Terms used: 6, Covariates used: 5 Error: Term types used: 4, Covariates used: 5 Error: Term types used: 6, Covariates used: 5 Error: verbosity arguement not valid Error: verbosity arguement not valid Error: verbosity arguement not valid C++ Error: A non-positive risk was detected: -0.3510469 C++ Warning: final failing values -0.1 -0.1 6 0.1 C++ Warning: final failing terms loglin lin_exp_slope lin_exp_int lin_exp_exp_slope C++ Error: A non-positive risk was detected: -405.3309 C++ Warning: final failing values 0.6015392 6.865976 -0.7707766 1.969241 C++ Warning: final failing terms loglin lin_exp_slope lin_exp_int lin_exp_exp_slope C++ Error: A non-positive risk was detected: -0.0308254 C++ Warning: final failing values -0.3106292 6.580508 -0.6910757 1.46578 C++ Warning: final failing terms loglin lin_exp_slope lin_exp_int lin_exp_exp_slope C++ Error: A non-positive risk was detected: -42.86911 C++ Warning: final failing values 0.3351325 6.487189 -0.8399744 1.937037 C++ Warning: final failing terms loglin lin_exp_slope lin_exp_int lin_exp_exp_slope C++ Error: A non-positive risk was detected: -0.3510469 C++ Warning: final failing values -0.1 -0.1 6 0.1 C++ Warning: final failing terms loglin lin_exp_slope lin_exp_int lin_exp_exp_slope Error: Default Parameters used: 7, Covariates used: 4 Error: Terms used: 1, Covariates used: 4 Error: Terms used: 8, Covariates used: 4 Error: Term types used: 1, Covariates used: 4 Error: Term types used: 5, Covariates used: 4 C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 1 1 2 C++ Note: df99,39,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 3 C++ Note: values checked -0.75 0.1 -0.05 -1.5 C++ Note: sums checked 4.889466 -2.95 -2.95 1 C++ Note: dose checked 7 7 7 C++ Note: non-dose checked 4.889466 -2.95 1 C++ Note: LIN_non-dose checked 7 -2.95 7 C++ Note: PLIN_non-dose checked 7 7 1 C++ Note: LOGLIN_non-dose checked 4.889466 7 7 C++ Note: df99,289,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Note: 2 risk groups C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 1 1 2 C++ Note: df99,32,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 3 C++ Note: values checked 0.1 0.1 0.1 0.1 C++ Note: sums checked 7.420684 8.15 8.15 7.4 C++ Note: dose checked 7 7 7 C++ Note: non-dose checked 7.420684 8.15 7.4 C++ Note: LIN_non-dose checked 7 8.15 7 C++ Note: PLIN_non-dose checked 7 7 7.4 C++ Note: LOGLIN_non-dose checked 7.420684 7 7 C++ Note: df99,294,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,32,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.1 6 0.1 0.1 C++ Note: sums checked 6.978181e+23 6.978181e+23 6.978181e+23 6.978181e+23 C++ Note: dose checked 7 C++ Note: non-dose checked 6.978181e+23 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 6.978181e+23 C++ Note: df99,244,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Note: 1 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.2851498 6.742355 -0.5350491 0.01638199 C++ Note: sums checked 2.763243e+25 2.763243e+25 2.763243e+25 2.763243e+25 C++ Note: dose checked 7 C++ Note: non-dose checked 2.763243e+25 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 2.763243e+25 C++ Note: df99,239,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Note: 2 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.3603669 6.650031 -0.2246941 -0.1425659 C++ Note: sums checked 1.411792e+23 1.411792e+23 1.411792e+23 1.411792e+23 C++ Note: dose checked 7 C++ Note: non-dose checked 1.411792e+23 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 1.411792e+23 C++ Note: df99,231,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Note: 3 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,37,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.5884538 6.048723 0.4087646 -0.8690517 C++ Note: sums checked 3.516547e+19 3.516547e+19 3.516547e+19 3.516547e+19 C++ Note: dose checked 7 C++ Note: non-dose checked 3.516547e+19 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.516547e+19 C++ Note: df99,524,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Note: 4 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.2152961 6.113972 0.3317212 -0.01014412 C++ Note: sums checked 2.059003e+24 2.059003e+24 2.059003e+24 2.059003e+24 C++ Note: dose checked 7 C++ Note: non-dose checked 2.059003e+24 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 2.059003e+24 C++ Note: df99,222,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Note: 5 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.4806577 6.881774 0.1278675 -0.7194356 C++ Note: sums checked 2.920361e+26 2.920361e+26 2.920361e+26 2.920361e+26 C++ Note: dose checked 7 C++ Note: non-dose checked 2.920361e+26 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 2.920361e+26 C++ Note: df99,223,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Note: 6 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.2420836 5.577486 -0.1438468 0.365162 C++ Note: sums checked 4.099603e+23 4.099603e+23 4.099603e+23 4.099603e+23 C++ Note: dose checked 7 C++ Note: non-dose checked 4.099603e+23 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 4.099603e+23 C++ Note: df99,225,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Note: 7 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,31,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -1.014784 5.988445 0.5727192 0.5814375 C++ Note: sums checked 8.962835e+23 8.962835e+23 8.962835e+23 8.962835e+23 C++ Note: dose checked 7 C++ Note: non-dose checked 8.962835e+23 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 8.962835e+23 C++ Note: df99,219,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Note: 8 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.7509835 5.915122 0.2257871 1.039219 C++ Note: sums checked 1.000227e+31 1.000227e+31 1.000227e+31 1.000227e+31 C++ Note: dose checked 7 C++ Note: non-dose checked 1.000227e+31 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 1.000227e+31 C++ Note: df99,216,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Note: 9 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.48869 6.64484 -0.6500637 -0.7960909 C++ Note: sums checked 1.703871e+22 1.703871e+22 1.703871e+22 1.703871e+22 C++ Note: dose checked 7 C++ Note: non-dose checked 1.703871e+22 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 1.703871e+22 C++ Note: df99,219,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,31,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.1 6 0.1 0.1 C++ Note: sums checked 6.978181e+23 6.978181e+23 6.978181e+23 6.978181e+23 C++ Note: dose checked 7 C++ Note: non-dose checked 6.978181e+23 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 6.978181e+23 C++ Note: df99,223,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Note: 1 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.0729831 6.289349 0.1710639 0.13766 C++ Note: sums checked 3.198377e+25 3.198377e+25 3.198377e+25 3.198377e+25 C++ Note: dose checked 7 C++ Note: non-dose checked 3.198377e+25 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.198377e+25 C++ Note: df99,217,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Note: 2 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.07120566 6.382836 0.05830978 0.1789169 C++ Note: sums checked 3.961074e+25 3.961074e+25 3.961074e+25 3.961074e+25 C++ Note: dose checked 7 C++ Note: non-dose checked 3.961074e+25 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.961074e+25 C++ Note: df99,223,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Note: 3 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.1081154 6.427015 0.1120606 0.1522575 C++ Note: sums checked 5.396333e+25 5.396333e+25 5.396333e+25 5.396333e+25 C++ Note: dose checked 7 C++ Note: non-dose checked 5.396333e+25 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 5.396333e+25 C++ Note: df99,216,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Note: 4 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,31,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.0151819 5.873729 0.04800939 0.1864154 C++ Note: sums checked 6.550549e+23 6.550549e+23 6.550549e+23 6.550549e+23 C++ Note: dose checked 7 C++ Note: non-dose checked 6.550549e+23 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 6.550549e+23 C++ Note: df99,220,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Note: 5 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.03751009 6.002182 0.1492348 0.1670254 C++ Note: sums checked 3.554528e+24 3.554528e+24 3.554528e+24 3.554528e+24 C++ Note: dose checked 7 C++ Note: non-dose checked 3.554528e+24 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.554528e+24 C++ Note: df99,215,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Note: 6 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.1635192 6.381179 0.03173972 0.1701593 C++ Note: sums checked 1.237426e+25 1.237426e+25 1.237426e+25 1.237426e+25 C++ Note: dose checked 7 C++ Note: non-dose checked 1.237426e+25 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 1.237426e+25 C++ Note: df99,217,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Note: 7 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.02370032 6.026411 0.1877047 0.1079035 C++ Note: sums checked 4.15648e+24 4.15648e+24 4.15648e+24 4.15648e+24 C++ Note: dose checked 7 C++ Note: non-dose checked 4.15648e+24 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 4.15648e+24 C++ Note: df99,218,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Note: 8 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.01075673 6.822994 0.0871287 0.1399378 C++ Note: sums checked 3.270069e+27 3.270069e+27 3.270069e+27 3.270069e+27 C++ Note: dose checked 7 C++ Note: non-dose checked 3.270069e+27 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.270069e+27 C++ Note: df99,218,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Note: 9 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.1839457 6.505287 0.1557788 0.1287812 C++ Note: sums checked 6.618297e+25 6.618297e+25 6.618297e+25 6.618297e+25 C++ Note: dose checked 7 C++ Note: non-dose checked 6.618297e+25 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 6.618297e+25 C++ Note: df99,218,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Error: tform not implemented bad_bad Error: der_iden should be within 0:(length(Term_n)-1) Error: der_iden should be within 0:(length(Term_n)-1) Error: Constraint matrix has incorrect number of columns Error: Constraint rows and constant lengths do not match Error: verbosity arguement not valid Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 1 2 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 3 in guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1230.97 1230.97 1016.5 C++ Note: derivs checked 2679.31 2679.31 1673.67 C++ Note: second derivs checked 8240.29 8240.29 4753.83 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1230.97 1230.97 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1230.97 1230.97 1016.5 C++ Note: risk checked 4027.44 C++ Note: risk1 checked 9063.19 3660.12 2061.97 C++ Note: risk2 checked 28192.2 11574 5852.76 C++ Note: df101 -4488.9 -4488.9 -4488.9 C++ Note: df102 -10062.4 -4065.51 -2249.7 C++ Note: df103 -32027.2 -12992.7 -6467.05 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8749.79 C++ Note: df105 0.314183 0.312906 0.347871 C++ Note: df106 0.446106 1.10414 1.99533 C++ Note: Starting Halves C++ Note: df501 -4488.897 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked -0.135637 -0.13468 -0.250903 C++ Note: sums checked 778.641 779.918 703.276 C++ Note: derivs checked 1332.45 1336.09 843.492 C++ Note: second derivs checked 3795.37 3807.04 2039.6 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 778.641 779.918 703.276 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 778.641 779.918 703.276 C++ Note: risk checked 1955.66 C++ Note: risk1 checked 3185.07 916.539 655.763 C++ Note: risk2 checked 8936.16 2481.04 1587.72 C++ Note: df101 -2228.32 -2228.32 -2228.32 C++ Note: df102 -3388.98 -973.792 -684.894 C++ Note: df103 -10146.5 -2686.07 -1687.25 C++ Note: df104 -0.135637 -0.13468 -0.250903 C++ Note: Checking Deviance 4228.65 C++ Note: df105 0.334004 0.362534 0.405923 C++ Note: df106 0.657521 2.2883 3.25353 C++ Note: df100 2418 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df100 2466 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -2228.325 -2228.325 -2228.325 C++ Note: df102 -3388.981 -973.7925 -684.8944 C++ Note: df103 -10146.53 -2686.074 -1687.253 C++ Note: df104 -0.1356371 -0.1346796 -0.2509035 C++ Note: Checking Deviance 4228.65 C++ Note: df105 0.3340041 0.3625337 0.4059227 C++ Note: df106 0.6575206 2.288295 3.253531 C++ Note: df101 -2228.32 -2228.32 -2228.32 C++ Note: df102 -3388.98 -973.792 -684.894 C++ Note: df103 -10146.5 -2686.07 -1687.25 C++ Note: df104 -0.135637 -0.13468 -0.250903 C++ Note: Checking Deviance 4228.65 C++ Note: df105 0.334004 0.362534 0.405923 C++ Note: df106 0.657521 2.2883 3.25353 C++ Note: ending guess 0 C++ Note: df501 -2228.325 C++ Note: df504 -0.1356371 -0.1346796 -0.2509035 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1356371 -0.1346796 -0.2509035, -2228.325<-- Best Guess C++ Note: starting subterms 3 in best guess 0 C++ Note: values checked -0.135637 -0.13468 -0.250903 C++ Note: sums checked 778.641 779.918 703.276 C++ Note: derivs checked 1332.45 1336.09 843.492 C++ Note: second derivs checked 3795.37 3807.04 2039.6 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 778.641 779.918 703.276 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 778.641 779.918 703.276 C++ Note: risk checked 1955.66 C++ Note: risk1 checked 3185.07 916.539 655.763 C++ Note: risk2 checked 8936.16 2481.04 1587.72 C++ Note: Made Risk Side Lists C++ Note: df101 -2228.32 -2228.32 -2228.32 C++ Note: df102 -3388.98 -973.792 -684.894 C++ Note: df103 -10146.5 -2686.07 -1687.25 C++ Note: df104 -0.135637 -0.13468 -0.250903 C++ Note: Checking Deviance 4228.65 C++ Note: df105 0.334004 0.362534 0.405923 C++ Note: df106 0.657521 2.2883 3.25353 C++ Note: Starting Halves C++ Note: df501 -2228.325 C++ Note: df504 -0.1356371 -0.1346796 -0.2509035 C++ Note: values checked -0.38614 -0.40658 -0.555345 C++ Note: sums checked 537.844 524.409 518.019 C++ Note: derivs checked 674.748 640.22 432.336 C++ Note: second derivs checked 1741.56 1638.06 858.586 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 537.844 524.409 518.019 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 537.844 524.409 518.019 C++ Note: risk checked 1181.24 C++ Note: risk1 checked 1282.77 258.659 231.082 C++ Note: risk2 checked 3193.16 553.491 460.337 C++ Note: df101 -1434.63 -1434.63 -1434.63 C++ Note: df102 -1232.02 -251.244 -225.825 C++ Note: df103 -3624.77 -541.316 -459.331 C++ Note: df104 -0.38614 -0.40658 -0.555345 C++ Note: Checking Deviance 2641.26 C++ Note: df105 0.339889 0.464135 0.49164 C++ Note: df106 1.16445 5.7101 6.35282 C++ Note: df100 5082 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df100 5130 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -1434.628 -1434.628 -1434.628 C++ Note: df102 -1232.021 -251.2437 -225.8252 C++ Note: df103 -3624.772 -541.3157 -459.3305 C++ Note: df104 -0.3861401 -0.4065798 -0.5553454 C++ Note: Checking Deviance 2641.255 C++ Note: df105 0.3398893 0.4641353 0.4916399 C++ Note: df106 1.16445 5.710103 6.352823 C++ Note: df101 -1434.63 -1434.63 -1434.63 C++ Note: df102 -1232.02 -251.244 -225.825 C++ Note: df103 -3624.77 -541.316 -459.331 C++ Note: df104 -0.38614 -0.40658 -0.555345 C++ Note: Checking Deviance 2641.26 C++ Note: df105 0.339889 0.464135 0.49164 C++ Note: df106 1.16445 5.7101 6.35282 C++ Note: df501 -1434.628 C++ Note: df504 -0.3861401 -0.4065798 -0.5553454 Error: Atleast one parameter must be free Warning: model covariate order changed Error: no events Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 0 1 2 C++ Note: df99,31,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 3 in guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1105.17 1230.97 1016.5 C++ Note: derivs checked 1105.17 2679.31 1673.67 C++ Note: second derivs checked 1105.17 8240.29 4753.83 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1105.17 1230.97 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1105.17 1230.97 1016.5 C++ Note: risk checked 3589.01 C++ Note: risk1 checked 3589.01 2961.09 1849.69 C++ Note: risk2 checked 3589.01 9106.92 5253.79 C++ Note: df101 -4001.02 -4001.02 -4001.02 C++ Note: df102 -3944.69 -3270.87 -2006.84 C++ Note: df103 -4058.69 -10188.6 -5775.27 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7774.04 C++ Note: df105 0.971912 0.321033 0.347488 C++ Note: df106 1.01428 1.22323 1.99369 C++ Note: Starting Halves C++ Note: df501 -4001.019 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked -0.628934 -0.140775 -0.250616 C++ Note: sums checked 533.16 771.845 703.518 C++ Note: derivs checked 533.16 1313.11 844.078 C++ Note: second derivs checked 533.16 3733.37 2041.39 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 533.16 771.845 703.518 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 533.16 771.845 703.518 C++ Note: risk checked 1319.76 C++ Note: risk1 checked 1319.76 700.1 450.028 C++ Note: risk2 checked 1319.76 1990.48 1088.39 C++ Note: df101 -1551.97 -1551.97 -1551.97 C++ Note: df102 -1379.46 -730.447 -455.704 C++ Note: df103 -1493.46 -2131.49 -1131.54 C++ Note: df104 -0.628934 -0.140775 -0.250616 C++ Note: Checking Deviance 2875.93 C++ Note: df105 0.923667 0.342693 0.402729 C++ Note: df106 1.12505 2.12468 3.40565 C++ Note: df100 2146 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df100 2193 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -1551.967 -1551.967 -1551.967 C++ Note: df102 -1379.465 -730.4472 -455.7038 C++ Note: df103 -1493.465 -2131.492 -1131.539 C++ Note: df104 -0.6289341 -0.1407748 -0.2506163 C++ Note: Checking Deviance 2875.934 C++ Note: df105 0.9236674 0.3426929 0.4027293 C++ Note: df106 1.12505 2.124681 3.405648 C++ Note: df101 -1551.97 -1551.97 -1551.97 C++ Note: df102 -1379.46 -730.447 -455.704 C++ Note: df103 -1493.46 -2131.49 -1131.54 C++ Note: df104 -0.628934 -0.140775 -0.250616 C++ Note: Checking Deviance 2875.93 C++ Note: df105 0.923667 0.342693 0.402729 C++ Note: df106 1.12505 2.12468 3.40565 C++ Note: ending guess 0 C++ Note: df501 -1551.967 C++ Note: df504 -0.6289341 -0.1407748 -0.2506163 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.6289341 -0.1407748 -0.2506163, -1551.967<-- Best Guess C++ Note: starting subterms 3 in best guess 0 C++ Note: values checked -0.628934 -0.140775 -0.250616 C++ Note: sums checked 533.16 771.845 703.518 C++ Note: derivs checked 533.16 1313.11 844.078 C++ Note: second derivs checked 533.16 3733.37 2041.39 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 533.16 771.845 703.518 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 533.16 771.845 703.518 C++ Note: risk checked 1319.76 C++ Note: risk1 checked 1319.76 700.1 450.028 C++ Note: risk2 checked 1319.76 1990.48 1088.39 C++ Note: Made Risk Side Lists C++ Note: df101 -1551.97 -1551.97 -1551.97 C++ Note: df102 -1379.46 -730.447 -455.704 C++ Note: df103 -1493.46 -2131.49 -1131.54 C++ Note: df104 -0.628934 -0.140775 -0.250616 C++ Note: Checking Deviance 2875.93 C++ Note: df105 0.923667 0.342693 0.402729 C++ Note: df106 1.12505 2.12468 3.40565 C++ Note: Starting Halves C++ Note: df501 -1551.967 C++ Note: df504 -0.6289341 -0.1407748 -0.2506163 C++ Note: values checked -1.32168 -0.397794 -0.552663 C++ Note: sums checked 266.686 530.097 519.182 C++ Note: derivs checked 266.686 654.802 434.647 C++ Note: second derivs checked 266.686 1681.7 864.673 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 266.686 530.097 519.182 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 266.686 530.097 519.182 C++ Note: risk checked 546.513 C++ Note: risk1 checked 546.513 174.626 115.914 C++ Note: risk2 checked 546.513 448.485 230.596 C++ Note: df101 -781.571 -781.571 -781.571 C++ Note: df102 -505.067 -156.705 -97.8291 C++ Note: df103 -619.067 -422.24 -204.505 C++ Note: df104 -1.32168 -0.397794 -0.552663 C++ Note: Checking Deviance 1335.14 C++ Note: df105 0.815852 0.371129 0.47837 C++ Note: df106 1.54746 4.98752 7.98915 C++ Note: df100 4770 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df100 4817 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -781.5713 -781.5713 -781.5713 C++ Note: df102 -505.0671 -156.7052 -97.82908 C++ Note: df103 -619.0671 -422.2398 -204.5049 C++ Note: df104 -1.321685 -0.3977945 -0.5526633 C++ Note: Checking Deviance 1335.143 C++ Note: df105 0.8158519 0.3711285 0.4783703 C++ Note: df106 1.54746 4.987525 7.989151 C++ Note: df101 -781.571 -781.571 -781.571 C++ Note: df102 -505.067 -156.705 -97.8291 C++ Note: df103 -619.067 -422.24 -204.505 C++ Note: df104 -1.32168 -0.397794 -0.552663 C++ Note: Checking Deviance 1335.14 C++ Note: df105 0.815852 0.371129 0.47837 C++ Note: df106 1.54746 4.98752 7.98915 C++ Note: df501 -781.5713 C++ Note: df504 -1.321685 -0.3977945 -0.5526633 Warning: model covariate order changed Error: guesses: 100 , iterations per guess: c(1, 1) Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 1 C++ Note: df99,20,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 2 C++ Note: values checked 0.01 C++ Note: sums checked 10679.25 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 10679.25 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 10679.25 C++ Note: df99,616,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Note: 1 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 1 C++ Note: df99,19,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 2 C++ Note: values checked -0.1760066 C++ Note: sums checked 26.07522 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 26.07522 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 26.07522 C++ Note: df99,383,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: START_POIS_GUESS C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 1 C++ Note: df99,21,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 10679.3 C++ Note: derivs checked 564819 C++ Note: second derivs checked 3.34438e+07 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 10679.3 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 10679.3 C++ Note: risk checked 121.53 C++ Note: risk1 checked 4019.07 C++ Note: risk2 checked 237975 C++ Note: df101 -455.955 C++ Note: df102 -880.754 C++ Note: df103 -164749 C++ Note: df104 0.01 C++ Note: Checking Deviance 739.91 C++ Note: df105 0.00534604 C++ Note: df106 0.517687 C++ Note: Starting Halves C++ Note: df501 -455.9548 C++ Note: df504 0.01 C++ Note: values checked 0.00599047 C++ Note: sums checked 8661.97 C++ Note: derivs checked 446431 C++ Note: second derivs checked 2.5943e+07 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 8661.97 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 8661.97 C++ Note: risk checked 107.176 C++ Note: risk1 checked 3176.66 C++ Note: risk2 checked 184602 C++ Note: df101 -453.592 C++ Note: df102 -334.069 C++ Note: df103 -110449 C++ Note: df104 0.00599047 C++ Note: Checking Deviance 735.184 C++ Note: df105 0.00302466 C++ Note: df106 1.35778 C++ Note: df100 4886 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df100 4934 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -453.5921 C++ Note: df102 -334.0694 C++ Note: df103 -110448.7 C++ Note: df104 0.005990473 C++ Note: Checking Deviance 735.1842 C++ Note: df105 0.003024657 C++ Note: df106 1.357778 C++ Note: Starting Halves C++ Note: df501 -453.5921 C++ Note: df504 0.005990473 C++ Note: values checked 0.00372198 C++ Note: sums checked 7712.93 C++ Note: derivs checked 391577 C++ Note: second derivs checked 2.25045e+07 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 7712.93 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7712.93 C++ Note: risk checked 100.423 C++ Note: risk1 checked 2786.34 C++ Note: risk2 checked 160135 C++ Note: df101 -453.097 C++ Note: df102 -112.117 C++ Note: df103 -85914.4 C++ Note: df104 0.00372198 C++ Note: Checking Deviance 734.193 C++ Note: df105 0.00130499 C++ Note: df106 4.04127 C++ Note: df100 7225 1 2 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df100 7271 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -453.0965 C++ Note: df102 -112.1175 C++ Note: df103 -85914.38 C++ Note: df104 0.00372198 C++ Note: Checking Deviance 734.193 C++ Note: df105 0.001304991 C++ Note: df106 4.041266 C++ Note: Starting Halves C++ Note: df501 -453.0965 C++ Note: df504 0.00372198 C++ Note: values checked 0.00274324 C++ Note: sums checked 7340.24 C++ Note: derivs checked 370210 C++ Note: second derivs checked 2.11728e+07 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 7340.24 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7340.24 C++ Note: risk checked 97.771 C++ Note: risk1 checked 2634.29 C++ Note: risk2 checked 150659 C++ Note: df101 -453.026 C++ Note: df102 -32.671 C++ Note: df103 -76546.2 C++ Note: df104 0.00274324 C++ Note: Checking Deviance 734.053 C++ Note: df105 0.000426814 C++ Note: df106 13.8663 C++ Note: df100 9566 1 3 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df100 9612 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -453.0264 C++ Note: df102 -32.67097 C++ Note: df103 -76546.19 C++ Note: df104 0.002743237 C++ Note: Checking Deviance 734.0528 C++ Note: df105 0.0004268137 C++ Note: df106 13.86633 C++ Note: Starting Halves C++ Note: df501 -453.0264 C++ Note: df504 0.002743237 C++ Note: values checked 0.00242313 C++ Note: sums checked 7222.81 C++ Note: derivs checked 363499 C++ Note: second derivs checked 2.07555e+07 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 7222.81 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7222.81 C++ Note: risk checked 96.9354 C++ Note: risk1 checked 2586.54 C++ Note: risk2 checked 147689 C++ Note: df101 -453.02 C++ Note: df102 -8.6361 C++ Note: df103 -73632 C++ Note: df104 0.00242313 C++ Note: Checking Deviance 734.04 C++ Note: df105 0.000117287 C++ Note: df106 52.4565 C++ Note: df100 11905 1 4 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df100 11952 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -453.0198 C++ Note: df102 -8.636103 C++ Note: df103 -73632.01 C++ Note: df104 0.002423127 C++ Note: Checking Deviance 734.0397 C++ Note: df105 0.0001172873 C++ Note: df106 52.45651 C++ Note: Starting Halves C++ Note: df501 -453.0198 C++ Note: df504 0.002423127 C++ Note: values checked 0.00233516 C++ Note: sums checked 7190.92 C++ Note: derivs checked 361679 C++ Note: second derivs checked 2.06424e+07 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 7190.92 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7190.92 C++ Note: risk checked 96.7085 C++ Note: risk1 checked 2573.58 C++ Note: risk2 checked 146884 C++ Note: df101 -453.019 C++ Note: df102 -2.19373 C++ Note: df103 -72843.8 C++ Note: df104 0.00233516 C++ Note: Checking Deviance 734.039 C++ Note: df105 3.01155e-05 C++ Note: df106 206.506 C++ Note: df100 14265 1 5 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df100 14312 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -453.0194 C++ Note: df102 -2.193732 C++ Note: df103 -72843.83 C++ Note: df104 0.002335161 C++ Note: Checking Deviance 734.0387 C++ Note: df105 3.011555e-05 C++ Note: df106 206.5063 C++ Note: df101 -453.019 C++ Note: df102 -2.19373 C++ Note: df103 -72843.8 C++ Note: df104 0.00233516 C++ Note: Checking Deviance 734.039 C++ Note: df105 3.01155e-05 C++ Note: df106 206.506 C++ Note: ending guess 0 C++ Note: df501 -453.0194 C++ Note: df504 0.002335161 C++ Note: starting subterms 2 in guess 1 C++ Note: values checked -0.176007 C++ Note: sums checked 26.0752 C++ Note: derivs checked 604.826 C++ Note: second derivs checked 14867.4 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 26.0752 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 26.0752 C++ Note: risk checked 45.7258 C++ Note: risk1 checked 4.30374 C++ Note: risk2 checked 105.792 C++ Note: df101 -469.813 C++ Note: df102 0.372681 C++ Note: df103 23.9158 C++ Note: df104 -0.176007 C++ Note: Checking Deviance 767.625 C++ Note: df105 0.015583 C++ Note: df106 -1260.63 C++ Note: Starting Halves C++ Note: df501 -453.0194 C++ Note: df504 0.002335161 C++ Note: values checked -0.187694 C++ Note: sums checked 19.9254 C++ Note: derivs checked 455.158 C++ Note: second derivs checked 10960.6 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 19.9254 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 19.9254 C++ Note: risk checked 45.6821 C++ Note: risk1 checked 3.23875 C++ Note: risk2 checked 77.9924 C++ Note: df101 -469.816 C++ Note: df102 0.154206 C++ Note: df103 14.2169 C++ Note: df104 -0.187694 C++ Note: Checking Deviance 767.631 C++ Note: df105 0.0108467 C++ Note: df106 -3046.67 C++ Note: df100 19677 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked -0.18185 C++ Note: sums checked 22.7821 C++ Note: derivs checked 524.299 C++ Note: second derivs checked 12752.2 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 22.7821 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 22.7821 C++ Note: risk checked 45.7024 C++ Note: risk1 checked 3.73074 C++ Note: risk2 checked 90.7406 C++ Note: df101 -469.814 C++ Note: df102 0.249336 C++ Note: df103 18.5074 C++ Note: df104 -0.18185 C++ Note: Checking Deviance 767.629 C++ Note: df105 0.0134723 C++ Note: df106 -1884.26 C++ Note: df100 21831 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked -0.178928 C++ Note: sums checked 24.3699 C++ Note: derivs checked 563.019 C++ Note: second derivs checked 13765.6 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 24.3699 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 24.3699 C++ Note: risk checked 45.7137 C++ Note: risk1 checked 4.00626 C++ Note: risk2 checked 97.9511 C++ Note: df101 -469.814 C++ Note: df102 0.307063 C++ Note: df103 21.0555 C++ Note: df104 -0.178928 C++ Note: Checking Deviance 767.627 C++ Note: df105 0.0145835 C++ Note: df106 -1530.03 C++ Note: df100 23990 3 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked -0.177468 C++ Note: sums checked 25.2073 C++ Note: derivs checked 583.52 C++ Note: second derivs checked 14304.9 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 25.2073 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 25.2073 C++ Note: risk checked 45.7197 C++ Note: risk1 checked 4.15214 C++ Note: risk2 checked 101.789 C++ Note: df101 -469.813 C++ Note: df102 0.338827 C++ Note: df103 22.4444 C++ Note: df104 -0.177468 C++ Note: Checking Deviance 767.626 C++ Note: df105 0.0150963 C++ Note: df106 -1386.58 C++ Note: df100 26142 4 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked -0.176737 C++ Note: sums checked 25.6374 C++ Note: derivs checked 594.071 C++ Note: second derivs checked 14583.2 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 25.6374 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 25.6374 C++ Note: risk checked 45.7227 C++ Note: risk1 checked 4.22721 C++ Note: risk2 checked 103.769 C++ Note: df101 -469.813 C++ Note: df102 0.355486 C++ Note: df103 23.1695 C++ Note: df104 -0.176737 C++ Note: Checking Deviance 767.626 C++ Note: df105 0.0153428 C++ Note: df106 -1321.61 C++ Note: df100 28297 5 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Changing back to best C++ Note: values checked -0.176007 C++ Note: sums checked 26.0752 C++ Note: derivs checked 604.826 C++ Note: second derivs checked 14867.4 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 26.0752 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 26.0752 C++ Note: risk checked 45.7258 C++ Note: risk1 checked 4.30374 C++ Note: risk2 checked 105.792 C++ Note: df101 -469.813 C++ Note: df102 0.372681 C++ Note: df103 23.9158 C++ Note: df104 -0.176007 C++ Note: Checking Deviance 767.625 C++ Note: df105 0.015583 C++ Note: df106 -1260.63 C++ Note: df100 30439 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -469.8125 C++ Note: df102 0.3726812 C++ Note: df103 23.91581 C++ Note: df104 -0.1760066 C++ Note: Checking Deviance 767.6251 C++ Note: df105 0.01558304 C++ Note: df106 -1260.629 C++ Note: Starting Halves C++ Note: df501 -453.0194 C++ Note: df504 0.002335161 C++ Note: values checked -0.187694 C++ Note: sums checked 19.9254 C++ Note: derivs checked 455.158 C++ Note: second derivs checked 10960.6 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 19.9254 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 19.9254 C++ Note: risk checked 45.6821 C++ Note: risk1 checked 3.23875 C++ Note: risk2 checked 77.9924 C++ Note: df101 -469.816 C++ Note: df102 0.154206 C++ Note: df103 14.2169 C++ Note: df104 -0.187694 C++ Note: Checking Deviance 767.631 C++ Note: df105 0.0108467 C++ Note: df106 -3046.67 C++ Note: df100 32737 1 2 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked -0.18185 C++ Note: sums checked 22.7821 C++ Note: derivs checked 524.299 C++ Note: second derivs checked 12752.2 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 22.7821 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 22.7821 C++ Note: risk checked 45.7024 C++ Note: risk1 checked 3.73074 C++ Note: risk2 checked 90.7406 C++ Note: df101 -469.814 C++ Note: df102 0.249336 C++ Note: df103 18.5074 C++ Note: df104 -0.18185 C++ Note: Checking Deviance 767.629 C++ Note: df105 0.0134723 C++ Note: df106 -1884.26 C++ Note: df100 34893 2 2 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked -0.178928 C++ Note: sums checked 24.3699 C++ Note: derivs checked 563.019 C++ Note: second derivs checked 13765.6 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 24.3699 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 24.3699 C++ Note: risk checked 45.7137 C++ Note: risk1 checked 4.00626 C++ Note: risk2 checked 97.9511 C++ Note: df101 -469.814 C++ Note: df102 0.307063 C++ Note: df103 21.0555 C++ Note: df104 -0.178928 C++ Note: Checking Deviance 767.627 C++ Note: df105 0.0145835 C++ Note: df106 -1530.03 C++ Note: df100 37045 3 2 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked -0.177468 C++ Note: sums checked 25.2073 C++ Note: derivs checked 583.52 C++ Note: second derivs checked 14304.9 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 25.2073 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 25.2073 C++ Note: risk checked 45.7197 C++ Note: risk1 checked 4.15214 C++ Note: risk2 checked 101.789 C++ Note: df101 -469.813 C++ Note: df102 0.338827 C++ Note: df103 22.4444 C++ Note: df104 -0.177468 C++ Note: Checking Deviance 767.626 C++ Note: df105 0.0150963 C++ Note: df106 -1386.58 C++ Note: df100 39199 4 2 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked -0.176737 C++ Note: sums checked 25.6374 C++ Note: derivs checked 594.071 C++ Note: second derivs checked 14583.2 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 25.6374 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 25.6374 C++ Note: risk checked 45.7227 C++ Note: risk1 checked 4.22721 C++ Note: risk2 checked 103.769 C++ Note: df101 -469.813 C++ Note: df102 0.355486 C++ Note: df103 23.1695 C++ Note: df104 -0.176737 C++ Note: Checking Deviance 767.626 C++ Note: df105 0.0153428 C++ Note: df106 -1321.61 C++ Note: df100 41351 5 2 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Changing back to best C++ Note: values checked -0.176007 C++ Note: sums checked 26.0752 C++ Note: derivs checked 604.826 C++ Note: second derivs checked 14867.4 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 26.0752 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 26.0752 C++ Note: risk checked 45.7258 C++ Note: risk1 checked 4.30374 C++ Note: risk2 checked 105.792 C++ Note: df101 -469.813 C++ Note: df102 0.372681 C++ Note: df103 23.9158 C++ Note: df104 -0.176007 C++ Note: Checking Deviance 767.625 C++ Note: df105 0.015583 C++ Note: df106 -1260.63 C++ Note: df100 43491 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -469.8125 C++ Note: df102 0.3726812 C++ Note: df103 23.91581 C++ Note: df104 -0.1760066 C++ Note: Checking Deviance 767.6251 C++ Note: df105 0.01558304 C++ Note: df106 -1260.629 C++ Note: Starting Halves C++ Note: df501 -453.0194 C++ Note: df504 0.002335161 C++ Note: values checked -0.176983 C++ Note: sums checked 25.4916 C++ Note: derivs checked 590.493 C++ Note: second derivs checked 14488.8 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 25.4916 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 25.4916 C++ Note: risk checked 45.7217 C++ Note: risk1 checked 4.20175 C++ Note: risk2 checked 103.097 C++ Note: df101 -469.813 C++ Note: df102 0.349814 C++ Note: df103 22.9228 C++ Note: df104 -0.176983 C++ Note: Checking Deviance 767.626 C++ Note: df105 0.0152605 C++ Note: df106 -1343.04 C++ Note: df100 45816 1 3 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked -0.176495 C++ Note: sums checked 25.7817 C++ Note: derivs checked 597.614 C++ Note: second derivs checked 14676.7 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 25.7817 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 25.7817 C++ Note: risk checked 45.7237 C++ Note: risk1 checked 4.25242 C++ Note: risk2 checked 104.435 C++ Note: df101 -469.813 C++ Note: df102 0.361126 C++ Note: df103 23.4145 C++ Note: df104 -0.176495 C++ Note: Checking Deviance 767.625 C++ Note: df105 0.0154232 C++ Note: df106 -1300.97 C++ Note: df100 47968 2 3 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked -0.176251 C++ Note: sums checked 25.928 C++ Note: derivs checked 601.208 C++ Note: second derivs checked 14771.7 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 25.928 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 25.928 C++ Note: risk checked 45.7248 C++ Note: risk1 checked 4.278 C++ Note: risk2 checked 105.111 C++ Note: df101 -469.813 C++ Note: df102 0.366873 C++ Note: df103 23.664 C++ Note: df104 -0.176251 C++ Note: Checking Deviance 767.625 C++ Note: df105 0.0155035 C++ Note: df106 -1280.59 C++ Note: df100 50121 3 3 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked -0.176129 C++ Note: sums checked 26.0015 C++ Note: derivs checked 603.014 C++ Note: second derivs checked 14819.5 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 26.0015 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 26.0015 C++ Note: risk checked 45.7253 C++ Note: risk1 checked 4.29085 C++ Note: risk2 checked 105.451 C++ Note: df101 -469.813 C++ Note: df102 0.369769 C++ Note: df103 23.7896 C++ Note: df104 -0.176129 C++ Note: Checking Deviance 767.625 C++ Note: df105 0.0155433 C++ Note: df106 -1270.56 C++ Note: df100 52275 4 3 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked -0.176068 C++ Note: sums checked 26.0383 C++ Note: derivs checked 603.92 C++ Note: second derivs checked 14843.4 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 26.0383 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 26.0383 C++ Note: risk checked 45.7256 C++ Note: risk1 checked 4.29729 C++ Note: risk2 checked 105.621 C++ Note: df101 -469.813 C++ Note: df102 0.371223 C++ Note: df103 23.8526 C++ Note: df104 -0.176068 C++ Note: Checking Deviance 767.625 C++ Note: df105 0.0155632 C++ Note: df106 -1265.58 C++ Note: df100 54427 5 3 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Changing back to best C++ Note: values checked -0.176007 C++ Note: sums checked 26.0752 C++ Note: derivs checked 604.826 C++ Note: second derivs checked 14867.4 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 26.0752 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 26.0752 C++ Note: risk checked 45.7258 C++ Note: risk1 checked 4.30374 C++ Note: risk2 checked 105.792 C++ Note: df101 -469.813 C++ Note: df102 0.372681 C++ Note: df103 23.9158 C++ Note: df104 -0.176007 C++ Note: Checking Deviance 767.625 C++ Note: df105 0.015583 C++ Note: df106 -1260.63 C++ Note: df100 56573 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -469.8125 C++ Note: df102 0.3726812 C++ Note: df103 23.91581 C++ Note: df104 -0.1760066 C++ Note: Checking Deviance 767.6251 C++ Note: df105 0.01558304 C++ Note: df106 -1260.629 C++ Note: Starting Halves C++ Note: df501 -453.0194 C++ Note: df504 0.002335161 C++ Note: values checked -0.176037 C++ Note: sums checked 26.0568 C++ Note: derivs checked 604.373 C++ Note: second derivs checked 14855.4 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 26.0568 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 26.0568 C++ Note: risk checked 45.7257 C++ Note: risk1 checked 4.30052 C++ Note: risk2 checked 105.706 C++ Note: df101 -469.813 C++ Note: df102 0.371952 C++ Note: df103 23.8842 C++ Note: df104 -0.176037 C++ Note: Checking Deviance 767.625 C++ Note: df105 0.0155731 C++ Note: df106 -1263.1 C++ Note: df100 58869 1 4 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked -0.176022 C++ Note: sums checked 26.066 C++ Note: derivs checked 604.6 C++ Note: second derivs checked 14861.4 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 26.066 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 26.066 C++ Note: risk checked 45.7258 C++ Note: risk1 checked 4.30213 C++ Note: risk2 checked 105.749 C++ Note: df101 -469.813 C++ Note: df102 0.372316 C++ Note: df103 23.9 C++ Note: df104 -0.176022 C++ Note: Checking Deviance 767.625 C++ Note: df105 0.0155781 C++ Note: df106 -1261.86 C++ Note: df100 61104 2 4 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked -0.176014 C++ Note: sums checked 26.0706 C++ Note: derivs checked 604.713 C++ Note: second derivs checked 14864.4 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 26.0706 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 26.0706 C++ Note: risk checked 45.7258 C++ Note: risk1 checked 4.30294 C++ Note: risk2 checked 105.77 C++ Note: df101 -469.813 C++ Note: df102 0.372499 C++ Note: df103 23.9079 C++ Note: df104 -0.176014 C++ Note: Checking Deviance 767.625 C++ Note: df105 0.0155806 C++ Note: df106 -1261.25 C++ Note: df100 63257 3 4 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked -0.17601 C++ Note: sums checked 26.0729 C++ Note: derivs checked 604.77 C++ Note: second derivs checked 14865.9 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 26.0729 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 26.0729 C++ Note: risk checked 45.7258 C++ Note: risk1 checked 4.30334 C++ Note: risk2 checked 105.781 C++ Note: df101 -469.813 C++ Note: df102 0.37259 C++ Note: df103 23.9119 C++ Note: df104 -0.17601 C++ Note: Checking Deviance 767.625 C++ Note: df105 0.0155818 C++ Note: df106 -1260.94 C++ Note: df100 65411 4 4 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked -0.176008 C++ Note: sums checked 26.0741 C++ Note: derivs checked 604.798 C++ Note: second derivs checked 14866.7 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 26.0741 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 26.0741 C++ Note: risk checked 45.7258 C++ Note: risk1 checked 4.30354 C++ Note: risk2 checked 105.786 C++ Note: df101 -469.813 C++ Note: df102 0.372636 C++ Note: df103 23.9138 C++ Note: df104 -0.176008 C++ Note: Checking Deviance 767.625 C++ Note: df105 0.0155824 C++ Note: df106 -1260.78 C++ Note: df100 67569 5 4 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Changing back to best C++ Note: values checked -0.176007 C++ Note: sums checked 26.0752 C++ Note: derivs checked 604.826 C++ Note: second derivs checked 14867.4 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 26.0752 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 26.0752 C++ Note: risk checked 45.7258 C++ Note: risk1 checked 4.30374 C++ Note: risk2 checked 105.792 C++ Note: df101 -469.813 C++ Note: df102 0.372681 C++ Note: df103 23.9158 C++ Note: df104 -0.176007 C++ Note: Checking Deviance 767.625 C++ Note: df105 0.015583 C++ Note: df106 -1260.63 C++ Note: df100 69706 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -469.8125 C++ Note: df102 0.3726812 C++ Note: df103 23.91581 C++ Note: df104 -0.1760066 C++ Note: Checking Deviance 767.6251 C++ Note: df105 0.01558304 C++ Note: df106 -1260.629 C++ Note: Starting Halves C++ Note: df501 -453.0194 C++ Note: df504 0.002335161 C++ Note: values checked -0.176008 C++ Note: sums checked 26.0746 C++ Note: derivs checked 604.812 C++ Note: second derivs checked 14867 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 26.0746 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 26.0746 C++ Note: risk checked 45.7258 C++ Note: risk1 checked 4.30364 C++ Note: risk2 checked 105.789 C++ Note: df101 -469.813 C++ Note: df102 0.372658 C++ Note: df103 23.9148 C++ Note: df104 -0.176008 C++ Note: Checking Deviance 767.625 C++ Note: df105 0.0155827 C++ Note: df106 -1260.71 C++ Note: df100 72004 1 5 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked -0.176007 C++ Note: sums checked 26.0749 C++ Note: derivs checked 604.819 C++ Note: second derivs checked 14867.2 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 26.0749 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 26.0749 C++ Note: risk checked 45.7258 C++ Note: risk1 checked 4.30369 C++ Note: risk2 checked 105.79 C++ Note: df101 -469.813 C++ Note: df102 0.37267 C++ Note: df103 23.9153 C++ Note: df104 -0.176007 C++ Note: Checking Deviance 767.625 C++ Note: df105 0.0155829 C++ Note: df106 -1260.67 C++ Note: df100 74155 2 5 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked -0.176007 C++ Note: sums checked 26.0751 C++ Note: derivs checked 604.823 C++ Note: second derivs checked 14867.3 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 26.0751 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 26.0751 C++ Note: risk checked 45.7258 C++ Note: risk1 checked 4.30372 C++ Note: risk2 checked 105.791 C++ Note: df101 -469.813 C++ Note: df102 0.372675 C++ Note: df103 23.9156 C++ Note: df104 -0.176007 C++ Note: Checking Deviance 767.625 C++ Note: df105 0.015583 C++ Note: df106 -1260.65 C++ Note: df100 76313 3 5 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked -0.176007 C++ Note: sums checked 26.0751 C++ Note: derivs checked 604.825 C++ Note: second derivs checked 14867.4 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 26.0751 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 26.0751 C++ Note: risk checked 45.7258 C++ Note: risk1 checked 4.30373 C++ Note: risk2 checked 105.791 C++ Note: df101 -469.813 C++ Note: df102 0.372678 C++ Note: df103 23.9157 C++ Note: df104 -0.176007 C++ Note: Checking Deviance 767.625 C++ Note: df105 0.015583 C++ Note: df106 -1260.64 C++ Note: df100 78471 4 5 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked -0.176007 C++ Note: sums checked 26.0752 C++ Note: derivs checked 604.825 C++ Note: second derivs checked 14867.4 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 26.0752 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 26.0752 C++ Note: risk checked 45.7258 C++ Note: risk1 checked 4.30374 C++ Note: risk2 checked 105.791 C++ Note: df101 -469.813 C++ Note: df102 0.37268 C++ Note: df103 23.9158 C++ Note: df104 -0.176007 C++ Note: Checking Deviance 767.625 C++ Note: df105 0.015583 C++ Note: df106 -1260.63 C++ Note: df100 80621 5 5 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Changing back to best C++ Note: values checked -0.176007 C++ Note: sums checked 26.0752 C++ Note: derivs checked 604.826 C++ Note: second derivs checked 14867.4 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 26.0752 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 26.0752 C++ Note: risk checked 45.7258 C++ Note: risk1 checked 4.30374 C++ Note: risk2 checked 105.792 C++ Note: df101 -469.813 C++ Note: df102 0.372681 C++ Note: df103 23.9158 C++ Note: df104 -0.176007 C++ Note: Checking Deviance 767.625 C++ Note: df105 0.015583 C++ Note: df106 -1260.63 C++ Note: df100 82763 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -469.8125 C++ Note: df102 0.3726812 C++ Note: df103 23.91581 C++ Note: df104 -0.1760066 C++ Note: Checking Deviance 767.6251 C++ Note: df105 0.01558304 C++ Note: df106 -1260.629 C++ Note: df101 -469.813 C++ Note: df102 0.372681 C++ Note: df103 23.9158 C++ Note: df104 -0.176007 C++ Note: Checking Deviance 767.625 C++ Note: df105 0.015583 C++ Note: df106 -1260.63 C++ Note: ending guess 1 C++ Note: df501 -453.0194 C++ Note: df504 0.002335161 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.002335161, -453.0194<-- Best Guess 1, -0.1760066, -469.8125 C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.00233516 C++ Note: sums checked 7190.92 C++ Note: derivs checked 361679 C++ Note: second derivs checked 2.06424e+07 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 7190.92 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7190.92 C++ Note: risk checked 96.7085 C++ Note: risk1 checked 2573.58 C++ Note: risk2 checked 146884 C++ Note: Made Risk Side Lists C++ Note: df101 -453.019 C++ Note: df102 -2.19373 C++ Note: df103 -72843.8 C++ Note: df104 0.00233516 C++ Note: Checking Deviance 734.039 C++ Note: df105 3.01155e-05 C++ Note: df106 206.506 C++ Note: Starting Halves C++ Note: df501 -453.0194 C++ Note: df504 0.002335161 C++ Note: values checked 0.00231257 C++ Note: sums checked 7182.75 C++ Note: derivs checked 361213 C++ Note: second derivs checked 2.06134e+07 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6400 7182.75 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7182.75 C++ Note: risk checked 96.6504 C++ Note: risk1 checked 2570.27 C++ Note: risk2 checked 146678 C++ Note: df101 -453.019 C++ Note: df102 -0.550709 C++ Note: df103 -72642.3 C++ Note: df104 0.00231257 C++ Note: Checking Deviance 734.039 C++ Note: df105 7.58111e-06 C++ Note: df106 822.611 C++ Note: df100 88164 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df100 88211 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -453.0193 C++ Note: df102 -0.5507093 C++ Note: df103 -72642.32 C++ Note: df104 0.002312575 C++ Note: Checking Deviance 734.0386 C++ Note: df105 7.581108e-06 C++ Note: df106 822.6106 C++ Note: df101 -453.019 C++ Note: df102 -0.550709 C++ Note: df103 -72642.3 C++ Note: df104 0.00231257 C++ Note: Checking Deviance 734.039 C++ Note: df105 7.58111e-06 C++ Note: df106 822.611 C++ Note: df501 -453.0193 C++ Note: df504 0.002312575 Note: INITIAL TERM COMPLETE -453.019321355954-0.550709301883533-72642.32341779490.002312574716865620.00371026677080554736.038642711906914.802695981256734.038642711906list(Term_n = 1, tforms = "loglin", names = "t0")list(Iteration = 1, `Maximum Step` = 1, `Derivative Limiting` = 0.550709301883533)FALSE Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 1 2 C++ Note: df99,24,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 3 C++ Note: values checked 0.002312575 -15 C++ Note: sums checked 7182.753 2624.001 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7182.753 2624.001 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7182.753 2624.001 C++ Note: df99,948,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 Note: 1 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 1 2 C++ Note: df99,22,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 3 C++ Note: values checked 0.002312575 -15.35651 C++ Note: sums checked 7182.753 2624.001 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7182.753 2624.001 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7182.753 2624.001 C++ Note: df99,481,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: START_POIS_GUESS C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Term checked 1 2 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: starting subterms 3 in guess 0 C++ Note: values checked 0.00231257 -15 C++ Note: sums checked 7182.75 2624 C++ Note: derivs checked 361213 0.00115509 C++ Note: second derivs checked 2.06134e+07 0.00115509 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7182.75 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7182.75 2624 C++ Note: risk checked 69.0234 C++ Note: risk1 checked 1835.57 8.45116e-06 C++ Note: risk2 checked 104751 8.45116e-06 C++ Note: df101 -449.751 -449.751 C++ Note: df102 694.655 2.09788e-06 C++ Note: df103 -32968.8 2.09788e-06 C++ Note: df104 0.00231257 -15 C++ Note: Checking Deviance 727.502 C++ Note: df105 -0.02107 1 C++ Note: df106 -0.647445 -2.14383e+08 C++ Note: Starting Halves C++ Note: df501 -449.7512 C++ Note: df504 0.002312575 -15 C++ Note: values checked 0.0181151 -14.1481 C++ Note: sums checked 16582.9 2624 C++ Note: derivs checked 921141 0.0027077 C++ Note: second derivs checked 5.6465e+07 0.0027077 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 16582.9 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 16582.9 2624 C++ Note: risk checked 116.792 C++ Note: risk1 checked 4680.95 3.35213e-05 C++ Note: risk2 checked 286938 3.35213e-05 C++ Note: df101 -448.753 -448.753 C++ Note: df102 -1059.27 -8.05569e-06 C++ Note: df103 -222055 -8.05571e-06 C++ Note: df104 0.0181151 -14.1481 C++ Note: Checking Deviance 725.506 C++ Note: df105 0.00477029 0.999998 C++ Note: df106 0.423645 5.57063e+07 C++ Note: df100 6673 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df100 6720 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -448.753 -448.753 C++ Note: df102 -1059.267 -8.055693e-06 C++ Note: df103 -222055 -8.05571e-06 C++ Note: df104 0.0181151 -14.14807 C++ Note: Checking Deviance 725.506 C++ Note: df105 0.004770292 0.9999979 C++ Note: df106 0.4236448 5.570632e+07 C++ Note: Starting Halves C++ Note: df501 -448.753 C++ Note: df504 0.0181151 -14.14807 C++ Note: values checked 0.0145374 -14.3335 C++ Note: sums checked 13622.2 2624 C++ Note: derivs checked 740922 0.00224951 C++ Note: second derivs checked 4.47533e+07 0.00224951 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 13622.2 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 13622.2 2624 C++ Note: risk checked 101.747 C++ Note: risk1 checked 3765.14 2.42613e-05 C++ Note: risk2 checked 227423 2.42613e-05 C++ Note: df101 -446.246 -446.246 C++ Note: df102 -378.967 -3.2978e-06 C++ Note: df103 -160567 -3.29781e-06 C++ Note: df104 0.0145374 -14.3335 C++ Note: Checking Deviance 720.492 C++ Note: df105 0.00236018 0.999996 C++ Note: df106 1.17753 1.35316e+08 C++ Note: df100 10021 1 2 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df100 10069 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -446.2458 -446.2458 C++ Note: df102 -378.9665 -3.297802e-06 C++ Note: df103 -160566.9 -3.297813e-06 C++ Note: df104 0.01453739 -14.33346 C++ Note: Checking Deviance 720.4915 C++ Note: df105 0.002360179 0.9999964 C++ Note: df106 1.177533 1.353161e+08 C++ Note: Starting Halves C++ Note: df501 -446.2458 C++ Note: df504 0.01453739 -14.33346 C++ Note: values checked 0.0127673 -14.6275 C++ Note: sums checked 12378.2 2624 C++ Note: derivs checked 666059 0.0016765 C++ Note: second derivs checked 3.99267e+07 0.0016765 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 12378.2 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 12378.2 2624 C++ Note: risk checked 95.425 C++ Note: risk1 checked 3384.71 1.69579e-05 C++ Note: risk2 checked 202895 1.69579e-05 C++ Note: df101 -445.813 -445.813 C++ Note: df102 -117.841 -1.39473e-06 C++ Note: df103 -134954 -1.39474e-06 C++ Note: df104 0.0127673 -14.6275 C++ Note: Checking Deviance 719.625 C++ Note: df105 0.000873194 0.999995 C++ Note: df106 3.78318 3.19641e+08 C++ Note: df100 13239 1 3 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df100 13287 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -445.8127 -445.8127 C++ Note: df102 -117.8408 -1.39473e-06 C++ Note: df103 -134953.8 -1.394736e-06 C++ Note: df104 0.01276725 -14.62747 C++ Note: Checking Deviance 719.6255 C++ Note: df105 0.0008731937 0.9999953 C++ Note: df106 3.783177 3.19641e+08 C++ Note: Starting Halves C++ Note: df501 -445.8127 C++ Note: df504 0.01276725 -14.62747 C++ Note: values checked 0.0121124 -15.1102 C++ Note: sums checked 11950.4 2624 C++ Note: derivs checked 640454 0.00103454 C++ Note: second derivs checked 3.82819e+07 0.00103454 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 11950.4 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 11950.4 2624 C++ Note: risk checked 93.2513 C++ Note: risk1 checked 3254.59 1.02261e-05 C++ Note: risk2 checked 194537 1.02261e-05 C++ Note: df101 -445.764 -445.764 C++ Note: df102 -32.3484 -6.35105e-07 C++ Note: df103 -126196 -6.35107e-07 C++ Note: df104 0.0121124 -15.1102 C++ Note: Checking Deviance 719.528 C++ Note: df105 0.000256336 0.999996 C++ Note: df106 13.7801 7.01874e+08 C++ Note: df100 16429 1 4 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df100 16476 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -445.7639 -445.7639 C++ Note: df102 -32.34844 -6.35105e-07 C++ Note: df103 -126195.7 -6.351075e-07 C++ Note: df104 0.01211236 -15.11022 C++ Note: Checking Deviance 719.5277 C++ Note: df105 0.0002563356 0.9999961 C++ Note: df106 13.78007 7.018743e+08 C++ Note: Starting Halves C++ Note: df501 -445.7639 C++ Note: df504 0.01211236 -15.11022 C++ Note: values checked 0.0119201 -15.758 C++ Note: sums checked 11828 2624 C++ Note: derivs checked 633140 0.000541285 C++ Note: second derivs checked 3.78127e+07 0.000541285 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 11828 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 11828 2624 C++ Note: risk checked 92.6292 C++ Note: risk1 checked 3217.42 5.3147e-06 C++ Note: risk2 checked 192153 5.3147e-06 C++ Note: df101 -445.76 -445.76 C++ Note: df102 -8.32807 -2.98518e-07 C++ Note: df103 -123695 -2.98519e-07 C++ Note: df104 0.0119201 -15.758 C++ Note: Checking Deviance 719.52 C++ Note: df105 6.73276e-05 0.999998 C++ Note: df106 53.525 1.49324e+09 C++ Note: df100 19636 1 5 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df100 19683 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -445.76 -445.76 C++ Note: df102 -8.328071 -2.985182e-07 C++ Note: df103 -123694.8 -2.985189e-07 C++ Note: df104 0.01192011 -15.75799 C++ Note: Checking Deviance 719.5199 C++ Note: df105 6.732758e-05 0.9999977 C++ Note: df106 53.525 1.493242e+09 C++ Note: df101 -445.76 -445.76 C++ Note: df102 -8.32807 -2.98518e-07 C++ Note: df103 -123695 -2.98519e-07 C++ Note: df104 0.0119201 -15.758 C++ Note: Checking Deviance 719.52 C++ Note: df105 6.73276e-05 0.999998 C++ Note: df106 53.525 1.49324e+09 C++ Note: ending guess 0 C++ Note: df501 -445.76 C++ Note: df504 0.01192011 -15.75799 C++ Note: starting subterms 3 in guess 1 C++ Note: values checked 0.00231257 -15.3565 C++ Note: sums checked 7182.75 2624 C++ Note: derivs checked 361213 0.000808696 C++ Note: second derivs checked 2.06134e+07 0.000808696 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7182.75 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7182.75 2624 C++ Note: risk checked 69.0234 C++ Note: risk1 checked 1835.57 5.9168e-06 C++ Note: risk2 checked 104751 5.9168e-06 C++ Note: df101 -449.751 -449.751 C++ Note: df102 694.655 1.46876e-06 C++ Note: df103 -32968.8 1.46876e-06 C++ Note: df104 0.00231257 -15.3565 C++ Note: Checking Deviance 727.502 C++ Note: df105 -0.0210701 1 C++ Note: df106 -0.647445 -3.06211e+08 C++ Note: Starting Halves C++ Note: df501 -445.76 C++ Note: df504 0.01192011 -15.75799 C++ Note: values checked 0.0181151 -14.5046 C++ Note: sums checked 16582.9 2624 C++ Note: derivs checked 921141 0.00189571 C++ Note: second derivs checked 5.6465e+07 0.00189571 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 16582.9 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 16582.9 2624 C++ Note: risk checked 116.792 C++ Note: risk1 checked 4680.96 2.34688e-05 C++ Note: risk2 checked 286938 2.34688e-05 C++ Note: df101 -448.753 -448.753 C++ Note: df102 -1059.27 -5.63992e-06 C++ Note: df103 -222055 -5.63993e-06 C++ Note: df104 0.0181151 -14.5046 C++ Note: Checking Deviance 725.506 C++ Note: df105 0.00477029 0.999999 C++ Note: df106 0.423644 7.95672e+07 C++ Note: df100 26865 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked 0.0102138 -14.9305 C++ Note: sums checked 10800.8 2624 C++ Note: derivs checked 572020 0.00123816 C++ Note: second derivs checked 3.3903e+07 0.00123816 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 10800.8 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 10800.8 2624 C++ Note: risk checked 87.4092 C++ Note: risk1 checked 2906.83 1.1472e-05 C++ Note: risk2 checked 172285 1.1472e-05 C++ Note: df101 -445.915 -445.915 C++ Note: df102 184.596 -3.45756e-08 C++ Note: df103 -102833 -3.45792e-08 C++ Note: df104 0.0102138 -14.9305 C++ Note: Checking Deviance 719.831 C++ Note: df105 -0.0017951 0.999897 C++ Note: df106 -2.41564 1.28968e+10 C++ Note: df100 29812 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked 0.00626321 -15.1435 C++ Note: sums checked 8784.7 2624 C++ Note: derivs checked 453568 0.00100065 C++ Note: second derivs checked 2.63923e+07 0.00100065 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 8784.7 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 8784.7 2624 C++ Note: risk checked 77.164 C++ Note: risk1 checked 2304.89 8.18468e-06 C++ Note: risk2 checked 134118 8.18468e-06 C++ Note: df101 -447.336 -447.336 C++ Note: df102 508.325 1.00034e-06 C++ Note: df103 -62884.4 1.00034e-06 C++ Note: df104 0.00626321 -15.1435 C++ Note: Checking Deviance 722.672 C++ Note: df105 -0.00808349 1 C++ Note: df106 -0.880019 -4.47183e+08 C++ Note: df100 32776 3 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked 0.00428789 -15.25 C++ Note: sums checked 7938.18 2624 C++ Note: derivs checked 404541 0.000899567 C++ Note: second derivs checked 2.33147e+07 0.000899567 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7938.18 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7938.18 2624 C++ Note: risk checked 72.8622 C++ Note: risk1 checked 2055.75 6.9477e-06 C++ Note: risk2 checked 118478 6.9477e-06 C++ Note: df101 -448.452 -448.452 C++ Note: df102 616.247 1.28743e-06 C++ Note: df103 -46783.7 1.28743e-06 C++ Note: df104 0.00428789 -15.25 C++ Note: Checking Deviance 724.904 C++ Note: df105 -0.0131723 1 C++ Note: df106 -0.727715 -3.48331e+08 C++ Note: df100 35761 4 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked 0.00330023 -15.3033 C++ Note: sums checked 7549.77 2624 C++ Note: derivs checked 382210 0.000852922 C++ Note: second derivs checked 2.19201e+07 0.000852922 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7549.77 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7549.77 2624 C++ Note: risk checked 70.8885 C++ Note: risk1 checked 1942.27 6.409e-06 C++ Note: risk2 checked 111391 6.409e-06 C++ Note: df101 -449.082 -449.082 C++ Note: df102 658.861 1.38953e-06 C++ Note: df103 -39603.2 1.38953e-06 C++ Note: df104 0.00330023 -15.3033 C++ Note: Checking Deviance 726.165 C++ Note: df105 -0.0166366 1 C++ Note: df106 -0.681604 -3.2319e+08 C++ Note: df100 38774 5 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Changing back to best C++ Note: values checked 0.00231257 -15.3565 C++ Note: sums checked 7182.75 2624 C++ Note: derivs checked 361213 0.000808696 C++ Note: second derivs checked 2.06134e+07 0.000808696 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7182.75 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7182.75 2624 C++ Note: risk checked 69.0234 C++ Note: risk1 checked 1835.57 5.9168e-06 C++ Note: risk2 checked 104751 5.9168e-06 C++ Note: df101 -449.751 -449.751 C++ Note: df102 694.655 1.46876e-06 C++ Note: df103 -32968.8 1.46876e-06 C++ Note: df104 0.00231257 -15.3565 C++ Note: Checking Deviance 727.502 C++ Note: df105 -0.0210701 1 C++ Note: df106 -0.647445 -3.06211e+08 C++ Note: df100 41808 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -449.7512 -449.7512 C++ Note: df102 694.6552 1.468762e-06 C++ Note: df103 -32968.84 1.468761e-06 C++ Note: df104 0.002312575 -15.35651 C++ Note: Checking Deviance 727.5024 C++ Note: df105 -0.02107005 1.000001 C++ Note: df106 -0.6474453 -3.06211e+08 C++ Note: Starting Halves C++ Note: df501 -445.76 C++ Note: df504 0.01192011 -15.75799 C++ Note: values checked 0.0181151 -15.3253 C++ Note: sums checked 16582.9 2624 C++ Note: derivs checked 921141 0.000834366 C++ Note: second derivs checked 5.6465e+07 0.000834366 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 16582.9 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 16582.9 2624 C++ Note: risk checked 116.792 C++ Note: risk1 checked 4680.96 1.03294e-05 C++ Note: risk2 checked 286938 1.03294e-05 C++ Note: df101 -448.753 -448.753 C++ Note: df102 -1059.27 -2.48232e-06 C++ Note: df103 -222055 -2.48232e-06 C++ Note: df104 0.0181151 -15.3253 C++ Note: Checking Deviance 725.506 C++ Note: df105 0.00477029 0.999999 C++ Note: df106 0.423645 1.80779e+08 C++ Note: df100 45027 1 2 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked 0.0102138 -15.3409 C++ Note: sums checked 10800.8 2624 C++ Note: derivs checked 572020 0.000821431 C++ Note: second derivs checked 3.3903e+07 0.000821431 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 10800.8 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 10800.8 2624 C++ Note: risk checked 87.4092 C++ Note: risk1 checked 2906.83 7.61086e-06 C++ Note: risk2 checked 172285 7.61086e-06 C++ Note: df101 -445.915 -445.915 C++ Note: df102 184.596 -2.29376e-08 C++ Note: df103 -102833 -2.29391e-08 C++ Note: df104 0.0102138 -15.3409 C++ Note: Checking Deviance 719.831 C++ Note: df105 -0.0017951 0.999932 C++ Note: df106 -2.41563 1.94404e+10 C++ Note: df100 47979 2 2 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked 0.00626321 -15.3487 C++ Note: sums checked 8784.7 2624 C++ Note: derivs checked 453568 0.000815038 C++ Note: second derivs checked 2.63923e+07 0.000815038 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 8784.7 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 8784.7 2624 C++ Note: risk checked 77.164 C++ Note: risk1 checked 2304.89 6.6665e-06 C++ Note: risk2 checked 134118 6.6665e-06 C++ Note: df101 -447.336 -447.336 C++ Note: df102 508.325 8.14789e-07 C++ Note: df103 -62884.4 8.14787e-07 C++ Note: df104 0.00626321 -15.3487 C++ Note: Checking Deviance 722.672 C++ Note: df105 -0.00808349 1 C++ Note: df106 -0.880019 -5.49021e+08 C++ Note: df100 50944 3 2 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked 0.00428789 -15.3526 C++ Note: sums checked 7938.18 2624 C++ Note: derivs checked 404541 0.000811861 C++ Note: second derivs checked 2.33147e+07 0.000811861 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7938.18 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7938.18 2624 C++ Note: risk checked 72.8622 C++ Note: risk1 checked 2055.75 6.27032e-06 C++ Note: risk2 checked 118478 6.27032e-06 C++ Note: df101 -448.452 -448.452 C++ Note: df102 616.247 1.16191e-06 C++ Note: df103 -46783.7 1.16191e-06 C++ Note: df104 0.00428789 -15.3526 C++ Note: Checking Deviance 724.904 C++ Note: df105 -0.0131723 1 C++ Note: df106 -0.727715 -3.85961e+08 C++ Note: df100 53932 4 2 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked 0.00330023 -15.3546 C++ Note: sums checked 7549.77 2624 C++ Note: derivs checked 382210 0.000810277 C++ Note: second derivs checked 2.19201e+07 0.000810277 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7549.77 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7549.77 2624 C++ Note: risk checked 70.8885 C++ Note: risk1 checked 1942.27 6.08856e-06 C++ Note: risk2 checked 111391 6.08856e-06 C++ Note: df101 -449.082 -449.082 C++ Note: df102 658.861 1.32006e-06 C++ Note: df103 -39603.2 1.32005e-06 C++ Note: df104 0.00330023 -15.3546 C++ Note: Checking Deviance 726.165 C++ Note: df105 -0.0166366 1 C++ Note: df106 -0.681604 -3.402e+08 C++ Note: df100 56943 5 2 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Changing back to best C++ Note: values checked 0.00231257 -15.3565 C++ Note: sums checked 7182.75 2624 C++ Note: derivs checked 361213 0.000808696 C++ Note: second derivs checked 2.06134e+07 0.000808696 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7182.75 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7182.75 2624 C++ Note: risk checked 69.0234 C++ Note: risk1 checked 1835.57 5.9168e-06 C++ Note: risk2 checked 104751 5.9168e-06 C++ Note: df101 -449.751 -449.751 C++ Note: df102 694.655 1.46876e-06 C++ Note: df103 -32968.8 1.46876e-06 C++ Note: df104 0.00231257 -15.3565 C++ Note: Checking Deviance 727.502 C++ Note: df105 -0.0210701 1 C++ Note: df106 -0.647445 -3.06211e+08 C++ Note: df100 59946 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -449.7512 -449.7512 C++ Note: df102 694.6552 1.468762e-06 C++ Note: df103 -32968.84 1.468761e-06 C++ Note: df104 0.002312575 -15.35651 C++ Note: Checking Deviance 727.5024 C++ Note: df105 -0.02107005 1.000001 C++ Note: df106 -0.6474453 -3.06211e+08 C++ Note: Starting Halves C++ Note: df501 -445.76 C++ Note: df504 0.01192011 -15.75799 C++ Note: values checked 0.00328914 -15.3555 C++ Note: sums checked 7545.53 2624 C++ Note: derivs checked 381967 0.000809486 C++ Note: second derivs checked 2.1905e+07 0.000809486 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7545.53 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7545.53 2624 C++ Note: risk checked 70.8669 C++ Note: risk1 checked 1941.04 6.08077e-06 C++ Note: risk2 checked 111314 6.08077e-06 C++ Note: df101 -449.09 -449.09 C++ Note: df102 659.3 1.32052e-06 C++ Note: df103 -39525.7 1.32051e-06 C++ Note: df104 0.00328914 -15.3555 C++ Note: Checking Deviance 726.179 C++ Note: df105 -0.0166803 1 C++ Note: df106 -0.681161 -3.40086e+08 C++ Note: df100 63156 1 3 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked 0.00280086 -15.356 C++ Note: sums checked 7361.61 2624 C++ Note: derivs checked 371432 0.000809091 C++ Note: second derivs checked 2.12488e+07 0.000809091 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7361.61 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7361.61 2624 C++ Note: risk checked 69.9323 C++ Note: risk1 checked 1887.5 5.99764e-06 C++ Note: risk2 checked 107980 5.99764e-06 C++ Note: df101 -449.416 -449.416 C++ Note: df102 677.778 1.39572e-06 C++ Note: df103 -36182 1.39572e-06 C++ Note: df104 0.00280086 -15.356 C++ Note: Checking Deviance 726.832 C++ Note: df105 -0.0187324 1 C++ Note: df106 -0.663073 -3.21996e+08 C++ Note: df100 66166 2 3 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked 0.00255672 -15.3563 C++ Note: sums checked 7271.56 2624 C++ Note: derivs checked 366284 0.000808893 C++ Note: second derivs checked 2.09286e+07 0.000808893 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7271.56 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7271.56 2624 C++ Note: risk checked 69.4747 C++ Note: risk1 checked 1861.34 5.95694e-06 C++ Note: risk2 checked 106353 5.95694e-06 C++ Note: df101 -449.583 -449.583 C++ Note: df102 686.413 1.43251e-06 C++ Note: df103 -34559.3 1.43251e-06 C++ Note: df104 0.00255672 -15.3563 C++ Note: Checking Deviance 727.165 C++ Note: df105 -0.0198619 1 C++ Note: df106 -0.654974 -3.13843e+08 C++ Note: df100 69035 3 3 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked 0.00243465 -15.3564 C++ Note: sums checked 7227 2624 C++ Note: derivs checked 363738 0.000808794 C++ Note: second derivs checked 2.07704e+07 0.000808794 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7227 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7227 2624 C++ Note: risk checked 69.2482 C++ Note: risk1 checked 1848.41 5.9368e-06 C++ Note: risk2 checked 105549 5.9368e-06 C++ Note: df101 -449.667 -449.667 C++ Note: df102 690.582 1.4507e-06 C++ Note: df103 -33760.1 1.4507e-06 C++ Note: df104 0.00243465 -15.3564 C++ Note: Checking Deviance 727.333 C++ Note: df105 -0.0204556 1 C++ Note: df106 -0.651141 -3.09965e+08 C++ Note: df100 72051 4 3 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked 0.00237361 -15.3564 C++ Note: sums checked 7204.84 2624 C++ Note: derivs checked 362473 0.000808745 C++ Note: second derivs checked 2.06917e+07 0.000808745 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7204.84 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7204.84 2624 C++ Note: risk checked 69.1356 C++ Note: risk1 checked 1841.98 5.92678e-06 C++ Note: risk2 checked 105149 5.92678e-06 C++ Note: df101 -449.709 -449.709 C++ Note: df102 692.631 1.45975e-06 C++ Note: df103 -33363.5 1.45975e-06 C++ Note: df104 0.00237361 -15.3564 C++ Note: Checking Deviance 727.418 C++ Note: df105 -0.0207602 1 C++ Note: df106 -0.649276 -3.08073e+08 C++ Note: df100 75072 5 3 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: Changing back to best C++ Note: values checked 0.00231257 -15.3565 C++ Note: sums checked 7182.75 2624 C++ Note: derivs checked 361213 0.000808696 C++ Note: second derivs checked 2.06134e+07 0.000808696 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7182.75 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7182.75 2624 C++ Note: risk checked 69.0234 C++ Note: risk1 checked 1835.57 5.9168e-06 C++ Note: risk2 checked 104751 5.9168e-06 C++ Note: df101 -449.751 -449.751 C++ Note: df102 694.655 1.46876e-06 C++ Note: df103 -32968.8 1.46876e-06 C++ Note: df104 0.00231257 -15.3565 C++ Note: Checking Deviance 727.502 C++ Note: df105 -0.0210701 1 C++ Note: df106 -0.647445 -3.06211e+08 C++ Note: df100 78084 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: df101 -449.7512 -449.7512 C++ Note: df102 694.6552 1.468762e-06 C++ Note: df103 -32968.84 1.468761e-06 C++ Note: df104 0.002312575 -15.35651 C++ Note: Checking Deviance 727.5024 C++ Note: df105 -0.02107005 1.000001 C++ Note: df106 -0.6474453 -3.06211e+08 C++ Note: Starting Halves C++ Note: df501 -445.76 C++ Note: df504 0.01192011 -15.75799 C++ Note: values checked 0.00234309 -15.3565 C++ Note: sums checked 7193.79 2624 C++ Note: derivs checked 361842 0.00080872 C++ Note: second derivs checked 2.06525e+07 0.00080872 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7193.79 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7193.79 2624 C++ Note: risk checked 69.0795 C++ Note: risk1 checked 1838.77 5.92179e-06 C++ Note: risk2 checked 104950 5.92179e-06 C++ Note: df101 -449.73 -449.73 C++ Note: df102 693.646 1.46426e-06 C++ Note: df103 -33165.9 1.46426e-06 C++ Note: df104 0.00234309 -15.3565 C++ Note: Checking Deviance 727.46 C++ Note: df105 -0.0209144 1 C++ Note: df106 -0.648357 -3.07138e+08 C++ Note: df100 81293 1 4 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked 0.00232783 -15.3565 C++ Note: sums checked 7188.27 2624 C++ Note: derivs checked 361527 0.000808708 C++ Note: second derivs checked 2.0633e+07 0.000808708 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7188.27 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7188.27 2624 C++ Note: risk checked 69.0514 C++ Note: risk1 checked 1837.17 5.91929e-06 C++ Note: risk2 checked 104850 5.91929e-06 C++ Note: df101 -449.741 -449.741 C++ Note: df102 694.151 1.46651e-06 C++ Note: df103 -33067.3 1.46651e-06 C++ Note: df104 0.00232783 -15.3565 C++ Note: Checking Deviance 727.481 C++ Note: df105 -0.0209921 1 C++ Note: df106 -0.6479 -3.06674e+08 C++ Note: df100 84306 2 4 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked 0.0023202 -15.3565 C++ Note: sums checked 7185.51 2624 C++ Note: derivs checked 361370 0.000808702 C++ Note: second derivs checked 2.06232e+07 0.000808702 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7185.51 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7185.51 2624 C++ Note: risk checked 69.0374 C++ Note: risk1 checked 1836.37 5.91805e-06 C++ Note: risk2 checked 104801 5.91805e-06 C++ Note: df101 -449.746 -449.746 C++ Note: df102 694.403 1.46764e-06 C++ Note: df103 -33018.1 1.46764e-06 C++ Note: df104 0.0023202 -15.3565 C++ Note: Checking Deviance 727.492 C++ Note: df105 -0.021031 1 C++ Note: df106 -0.647672 -3.06442e+08 C++ Note: df100 87347 3 4 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked 0.00231639 -15.3565 C++ Note: sums checked 7184.13 2624 C++ Note: derivs checked 361291 0.000808699 C++ Note: second derivs checked 2.06183e+07 0.000808699 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7184.13 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7184.13 2624 C++ Note: risk checked 69.0304 C++ Note: risk1 checked 1835.97 5.91742e-06 C++ Note: risk2 checked 104776 5.91742e-06 C++ Note: df101 -449.749 -449.749 C++ Note: df102 694.529 1.4682e-06 C++ Note: df103 -32993.4 1.4682e-06 C++ Note: df104 0.00231639 -15.3565 C++ Note: Checking Deviance 727.497 C++ Note: df105 -0.0210505 1 C++ Note: df106 -0.647559 -3.06326e+08 C++ Note: df100 90451 4 4 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:07 2024 C++ Note: values checked 0.00231448 -15.3565 C++ Note: sums checked 7183.44 2624 C++ Note: derivs checked 361252 0.000808697 C++ Note: second derivs checked 2.06159e+07 0.000808697 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7183.44 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7183.44 2624 C++ Note: risk checked 69.0269 C++ Note: risk1 checked 1835.77 5.91711e-06 C++ Note: risk2 checked 104763 5.91711e-06 C++ Note: df101 -449.75 -449.75 C++ Note: df102 694.592 1.46848e-06 C++ Note: df103 -32981.1 1.46848e-06 C++ Note: df104 0.00231448 -15.3565 C++ Note: Checking Deviance 727.5 C++ Note: df105 -0.0210603 1 C++ Note: df106 -0.647502 -3.06269e+08 C++ Note: df100 93468 5 4 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: Changing back to best C++ Note: values checked 0.00231257 -15.3565 C++ Note: sums checked 7182.75 2624 C++ Note: derivs checked 361213 0.000808696 C++ Note: second derivs checked 2.06134e+07 0.000808696 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7182.75 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7182.75 2624 C++ Note: risk checked 69.0234 C++ Note: risk1 checked 1835.57 5.9168e-06 C++ Note: risk2 checked 104751 5.9168e-06 C++ Note: df101 -449.751 -449.751 C++ Note: df102 694.655 1.46876e-06 C++ Note: df103 -32968.8 1.46876e-06 C++ Note: df104 0.00231257 -15.3565 C++ Note: Checking Deviance 727.502 C++ Note: df105 -0.0210701 1 C++ Note: df106 -0.647445 -3.06211e+08 C++ Note: df100 96477 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df101 -449.7512 -449.7512 C++ Note: df102 694.6552 1.468762e-06 C++ Note: df103 -32968.84 1.468761e-06 C++ Note: df104 0.002312575 -15.35651 C++ Note: Checking Deviance 727.5024 C++ Note: df105 -0.02107005 1.000001 C++ Note: df106 -0.6474453 -3.06211e+08 C++ Note: Starting Halves C++ Note: df501 -445.76 C++ Note: df504 0.01192011 -15.75799 C++ Note: values checked 0.00231353 -15.3565 C++ Note: sums checked 7183.1 2624 C++ Note: derivs checked 361232 0.000808696 C++ Note: second derivs checked 2.06146e+07 0.000808696 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7183.1 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7183.1 2624 C++ Note: risk checked 69.0251 C++ Note: risk1 checked 1835.67 5.91696e-06 C++ Note: risk2 checked 104757 5.91696e-06 C++ Note: df101 -449.751 -449.751 C++ Note: df102 694.624 1.46862e-06 C++ Note: df103 -32975 1.46862e-06 C++ Note: df104 0.00231353 -15.3565 C++ Note: Checking Deviance 727.501 C++ Note: df105 -0.0210652 1 C++ Note: df106 -0.647474 -3.0624e+08 C++ Note: df100 99688 1 5 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: values checked 0.00231305 -15.3565 C++ Note: sums checked 7182.93 2624 C++ Note: derivs checked 361222 0.000808696 C++ Note: second derivs checked 2.0614e+07 0.000808696 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7182.93 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7182.93 2624 C++ Note: risk checked 69.0243 C++ Note: risk1 checked 1835.62 5.91688e-06 C++ Note: risk2 checked 104754 5.91688e-06 C++ Note: df101 -449.751 -449.751 C++ Note: df102 694.639 1.46869e-06 C++ Note: df103 -32971.9 1.46869e-06 C++ Note: df104 0.00231305 -15.3565 C++ Note: Checking Deviance 727.502 C++ Note: df105 -0.0210676 1 C++ Note: df106 -0.647459 -3.06225e+08 C++ Note: df100 102718 2 5 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: values checked 0.00231281 -15.3565 C++ Note: sums checked 7182.84 2624 C++ Note: derivs checked 361218 0.000808696 C++ Note: second derivs checked 2.06137e+07 0.000808696 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7182.84 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7182.84 2624 C++ Note: risk checked 69.0238 C++ Note: risk1 checked 1835.6 5.91684e-06 C++ Note: risk2 checked 104753 5.91684e-06 C++ Note: df101 -449.751 -449.751 C++ Note: df102 694.647 1.46873e-06 C++ Note: df103 -32970.4 1.46873e-06 C++ Note: df104 0.00231281 -15.3565 C++ Note: Checking Deviance 727.502 C++ Note: df105 -0.0210688 1 C++ Note: df106 -0.647452 -3.06218e+08 C++ Note: df100 105740 3 5 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: values checked 0.00231269 -15.3565 C++ Note: sums checked 7182.8 2624 C++ Note: derivs checked 361215 0.000808696 C++ Note: second derivs checked 2.06136e+07 0.000808696 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7182.8 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7182.8 2624 C++ Note: risk checked 69.0236 C++ Note: risk1 checked 1835.58 5.91682e-06 C++ Note: risk2 checked 104752 5.91682e-06 C++ Note: df101 -449.751 -449.751 C++ Note: df102 694.651 1.46874e-06 C++ Note: df103 -32969.6 1.46874e-06 C++ Note: df104 0.00231269 -15.3565 C++ Note: Checking Deviance 727.502 C++ Note: df105 -0.0210694 1 C++ Note: df106 -0.647449 -3.06215e+08 C++ Note: df100 108761 4 5 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: values checked 0.00231263 -15.3565 C++ Note: sums checked 7182.77 2624 C++ Note: derivs checked 361214 0.000808696 C++ Note: second derivs checked 2.06135e+07 0.000808696 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7182.77 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7182.77 2624 C++ Note: risk checked 69.0235 C++ Note: risk1 checked 1835.58 5.91681e-06 C++ Note: risk2 checked 104751 5.91681e-06 C++ Note: df101 -449.751 -449.751 C++ Note: df102 694.653 1.46875e-06 C++ Note: df103 -32969.2 1.46875e-06 C++ Note: df104 0.00231263 -15.3565 C++ Note: Checking Deviance 727.502 C++ Note: df105 -0.0210697 1 C++ Note: df106 -0.647447 -3.06213e+08 C++ Note: df100 111782 5 5 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: Changing back to best C++ Note: values checked 0.00231257 -15.3565 C++ Note: sums checked 7182.75 2624 C++ Note: derivs checked 361213 0.000808696 C++ Note: second derivs checked 2.06134e+07 0.000808696 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 7182.75 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 7182.75 2624 C++ Note: risk checked 69.0234 C++ Note: risk1 checked 1835.57 5.9168e-06 C++ Note: risk2 checked 104751 5.9168e-06 C++ Note: df101 -449.751 -449.751 C++ Note: df102 694.655 1.46876e-06 C++ Note: df103 -32968.8 1.46876e-06 C++ Note: df104 0.00231257 -15.3565 C++ Note: Checking Deviance 727.502 C++ Note: df105 -0.0210701 1 C++ Note: df106 -0.647445 -3.06211e+08 C++ Note: df100 114795 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df101 -449.7512 -449.7512 C++ Note: df102 694.6552 1.468762e-06 C++ Note: df103 -32968.84 1.468761e-06 C++ Note: df104 0.002312575 -15.35651 C++ Note: Checking Deviance 727.5024 C++ Note: df105 -0.02107005 1.000001 C++ Note: df106 -0.6474453 -3.06211e+08 C++ Note: df101 -449.751 -449.751 C++ Note: df102 694.655 1.46876e-06 C++ Note: df103 -32968.8 1.46876e-06 C++ Note: df104 0.00231257 -15.3565 C++ Note: Checking Deviance 727.502 C++ Note: df105 -0.0210701 1 C++ Note: df106 -0.647445 -3.06211e+08 C++ Note: ending guess 1 C++ Note: df501 -445.76 C++ Note: df504 0.01192011 -15.75799 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.01192011 -15.75799, -445.76<-- Best Guess 1, 0.002312575 -15.35651, -449.7512 C++ Note: starting subterms 3 in best guess 0 C++ Note: values checked 0.0119201 -15.758 C++ Note: sums checked 11828 2624 C++ Note: derivs checked 633140 0.000541285 C++ Note: second derivs checked 3.78127e+07 0.000541285 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 11828 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 11828 2624 C++ Note: risk checked 92.6292 C++ Note: risk1 checked 3217.42 5.3147e-06 C++ Note: risk2 checked 192153 5.3147e-06 C++ Note: Made Risk Side Lists C++ Note: df101 -445.76 -445.76 C++ Note: df102 -8.32807 -2.98518e-07 C++ Note: df103 -123695 -2.98519e-07 C++ Note: df104 0.0119201 -15.758 C++ Note: Checking Deviance 719.52 C++ Note: df105 6.73276e-05 0.999998 C++ Note: df106 53.525 1.49324e+09 C++ Note: Starting Halves C++ Note: df501 -445.76 C++ Note: df504 0.01192011 -15.75799 C++ Note: values checked 0.0118696 -16.4784 C++ Note: sums checked 11796.1 2624 C++ Note: derivs checked 631233 0.000263353 C++ Note: second derivs checked 3.76904e+07 0.000263353 C++ Note: dose checked 6400 6400 6400 C++ Note: non-dose checked 6400 11796.1 2624 C++ Note: LIN_non-dose checked 6400 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 6400 C++ Note: LOGLIN_non-dose checked 6400 11796.1 2624 C++ Note: risk checked 92.467 C++ Note: risk1 checked 3207.73 2.58125e-06 C++ Note: risk2 checked 191531 2.58125e-06 C++ Note: df101 -445.76 -445.76 C++ Note: df102 -2.09852 -1.40954e-07 C++ Note: df103 -123043 -1.40954e-07 C++ Note: df104 0.0118696 -16.4784 C++ Note: Checking Deviance 719.519 C++ Note: df105 1.70551e-05 0.999999 C++ Note: df106 212.417 3.16245e+09 C++ Note: df100 121860 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df100 121906 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df101 -445.7597 -445.7597 C++ Note: df102 -2.098516 -1.409538e-07 C++ Note: df103 -123043.1 -1.409539e-07 C++ Note: df104 0.01186962 -16.47844 C++ Note: Checking Deviance 719.5194 C++ Note: df105 1.705513e-05 0.9999989 C++ Note: df106 212.4166 3.162453e+09 C++ Note: df101 -445.76 -445.76 C++ Note: df102 -2.09852 -1.40954e-07 C++ Note: df103 -123043 -1.40954e-07 C++ Note: df104 0.0118696 -16.4784 C++ Note: Checking Deviance 719.519 C++ Note: df105 1.70551e-05 0.999999 C++ Note: df106 212.417 3.16245e+09 C++ Note: df501 -445.7597 C++ Note: df504 0.01186962 -16.47844 Error: Atleast one parameter must be free Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: Term checked 0 1 C++ Note: df99,24,Starting C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: starting subterms 2 C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.949 3328.001 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.949 3328.001 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.949 3328.001 C++ Note: df99,531,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: START_POIS_GUESS C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: Term checked 0 1 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.95 3328 C++ Note: derivs checked 3813.95 0.000939732 C++ Note: second derivs checked 3813.95 0.000939732 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.95 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.95 3328 C++ Note: risk checked 9787.82 C++ Note: risk1 checked 6011.82 0.000944651 C++ Note: risk2 checked 6011.82 0.000944651 C++ Note: df101 -493394 -493394 C++ Note: df102 -303241 -0.047634 C++ Note: df103 -303274 -0.047634 C++ Note: df104 0.01 -15 C++ Note: Checking Deviance 986616 C++ Note: df105 0.999891 1 C++ Note: df106 1.62707 1.0358e+07 C++ Note: Starting Halves C++ Note: df501 -493394.2 C++ Note: df504 0.01 -15 C++ Note: values checked -0.739918 -15.3574 C++ Note: sums checked 4425.73 3328 C++ Note: derivs checked 1801.73 0.000657348 C++ Note: second derivs checked 1801.73 0.000657348 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 4425.73 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 4425.73 3328 C++ Note: risk checked 6616.01 C++ Note: risk1 checked 2840.01 0.000478342 C++ Note: risk2 checked 2840.01 0.000478342 C++ Note: df101 -333413 -333413 C++ Note: df102 -143235 -0.0241165 C++ Note: df103 -143268 -0.0241165 C++ Note: df104 -0.739918 -15.3574 C++ Note: Checking Deviance 666655 C++ Note: df105 0.99977 1 C++ Note: df106 2.32774 1.38251e+07 C++ Note: df100 5049 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df100 5095 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df101 -333413.3 -333413.3 C++ Note: df102 -143235 -0.02411648 C++ Note: df103 -143268 -0.02411648 C++ Note: df104 -0.7399184 -15.35738 C++ Note: Checking Deviance 666654.6 C++ Note: df105 0.9997697 1 C++ Note: df106 2.327736 1.382512e+07 C++ Note: Starting Halves C++ Note: df501 -333413.3 C++ Note: df504 -0.7399184 -15.35738 C++ Note: values checked -1.48975 -15.8512 C++ Note: sums checked 3475.22 3328 C++ Note: derivs checked 851.224 0.000401193 C++ Note: second derivs checked 851.224 0.000401193 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 3475.22 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 3475.22 3328 C++ Note: risk checked 5117.76 C++ Note: risk1 checked 1341.76 0.000239343 C++ Note: risk2 checked 1341.76 0.000239343 C++ Note: df101 -257857 -257857 C++ Note: df102 -67653.7 -0.0120654 C++ Note: df103 -67686.7 -0.0120654 C++ Note: df104 -1.48975 -15.8512 C++ Note: Checking Deviance 515541 C++ Note: df105 0.999512 1 C++ Note: df106 3.81142 2.13716e+07 C++ Note: df100 7630 1 2 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df100 7676 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df101 -257856.7 -257856.7 C++ Note: df102 -67653.71 -0.01206537 C++ Note: df103 -67686.71 -0.01206537 C++ Note: df104 -1.489746 -15.85115 C++ Note: Checking Deviance 515541.4 C++ Note: df105 0.9995125 1 C++ Note: df106 3.81142 2.137163e+07 C++ Note: Starting Halves C++ Note: df501 -257856.7 C++ Note: df504 -1.489746 -15.85115 C++ Note: values checked -2.23938 -16.4535 C++ Note: sums checked 3026.24 3328 C++ Note: derivs checked 402.237 0.00021966 C++ Note: second derivs checked 402.237 0.00021966 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 3026.24 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 3026.24 3328 C++ Note: risk checked 4410.03 C++ Note: risk1 checked 634.034 0.000117441 C++ Note: risk2 checked 634.034 0.000117441 C++ Note: df101 -222179 -222179 C++ Note: df102 -31951.6 -0.00591976 C++ Note: df103 -31984.6 -0.00591976 C++ Note: df104 -2.23938 -16.4535 C++ Note: Checking Deviance 444187 C++ Note: df105 0.998968 1 C++ Note: df106 6.95362 3.75318e+07 C++ Note: df100 10220 1 3 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df100 10267 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df101 -222179.4 -222179.4 C++ Note: df102 -31951.63 -0.005919756 C++ Note: df103 -31984.63 -0.005919756 C++ Note: df104 -2.23938 -16.45351 C++ Note: Checking Deviance 444186.7 C++ Note: df105 0.9989683 1 C++ Note: df106 6.953616 3.753185e+07 C++ Note: Starting Halves C++ Note: df501 -222179.4 C++ Note: df504 -2.23938 -16.45351 C++ Note: values checked -2.98861 -17.1257 C++ Note: sums checked 2814.15 3328 C++ Note: derivs checked 190.15 0.000112156 C++ Note: second derivs checked 190.15 0.000112156 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2814.15 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2814.15 3328 C++ Note: risk checked 4075.73 C++ Note: risk1 checked 299.728 5.66831e-05 C++ Note: risk2 checked 299.728 5.66831e-05 C++ Note: df101 -205340 -205340 C++ Note: df102 -15087.2 -0.00285705 C++ Note: df103 -15120.2 -0.00285705 C++ Note: df104 -2.98861 -17.1257 C++ Note: Checking Deviance 410507 C++ Note: df105 0.997817 1 C++ Note: df106 13.6102 7.18712e+07 C++ Note: df100 12781 1 4 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df100 12828 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df101 -205339.6 -205339.6 C++ Note: df102 -15087.16 -0.002857052 C++ Note: df103 -15120.16 -0.002857052 C++ Note: df104 -2.988606 -17.1257 C++ Note: Checking Deviance 410507.3 C++ Note: df105 0.9978175 1 C++ Note: df106 13.61022 7.187117e+07 C++ Note: Starting Halves C++ Note: df501 -205339.6 C++ Note: df504 -2.988606 -17.1257 C++ Note: values checked -3.73697 -17.8368 C++ Note: sums checked 2713.97 3328 C++ Note: derivs checked 89.9678 5.50787e-05 C++ Note: second derivs checked 89.9678 5.50787e-05 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2713.97 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2713.97 3328 C++ Note: risk checked 3917.81 C++ Note: risk1 checked 141.814 2.70754e-05 C++ Note: risk2 checked 141.814 2.70754e-05 C++ Note: df101 -197398 -197398 C++ Note: df102 -7120.96 -0.00136467 C++ Note: df103 -7153.96 -0.00136467 C++ Note: df104 -3.73697 -17.8368 C++ Note: Checking Deviance 394624 C++ Note: df105 0.995387 1 C++ Note: df106 27.7207 1.44649e+08 C++ Note: df100 15314 1 5 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df100 15360 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df101 -197398.1 -197398.1 C++ Note: df102 -7120.961 -0.001364671 C++ Note: df103 -7153.961 -0.001364671 C++ Note: df104 -3.736969 -17.83683 C++ Note: Checking Deviance 394624.2 C++ Note: df105 0.9953872 1 C++ Note: df106 27.72071 1.446488e+08 C++ Note: df101 -197398 -197398 C++ Note: df102 -7120.96 -0.00136467 C++ Note: df103 -7153.96 -0.00136467 C++ Note: df104 -3.73697 -17.8368 C++ Note: Checking Deviance 394624 C++ Note: df105 0.995387 1 C++ Note: df106 27.7207 1.44649e+08 C++ Note: ending guess 0 C++ Note: df501 -197398.1 C++ Note: df504 -3.736969 -17.83683 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -3.736969 -17.83683, -197398.1<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked -3.73697 -17.8368 C++ Note: sums checked 2713.97 3328 C++ Note: derivs checked 89.9678 5.50787e-05 C++ Note: second derivs checked 89.9678 5.50787e-05 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2713.97 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2713.97 3328 C++ Note: risk checked 3917.81 C++ Note: risk1 checked 141.814 2.70754e-05 C++ Note: risk2 checked 141.814 2.70754e-05 C++ Note: Made Risk Side Lists C++ Note: df101 -197398 -197398 C++ Note: df102 -7120.96 -0.00136467 C++ Note: df103 -7153.96 -0.00136467 C++ Note: df104 -3.73697 -17.8368 C++ Note: Checking Deviance 394624 C++ Note: df105 0.995387 1 C++ Note: df106 27.7207 1.44649e+08 C++ Note: Starting Halves C++ Note: df501 -197398.1 C++ Note: df504 -3.736969 -17.83683 C++ Note: values checked -4.48351 -18.568 C++ Note: sums checked 2666.65 3328 C++ Note: derivs checked 42.645 2.65127e-05 C++ Note: second derivs checked 42.645 2.65127e-05 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2666.65 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2666.65 3328 C++ Note: risk checked 3843.22 C++ Note: risk1 checked 67.2201 1.286e-05 C++ Note: risk2 checked 67.2201 1.286e-05 C++ Note: df101 -193660 -193660 C++ Note: df102 -3358 -0.000648169 C++ Note: df103 -3391 -0.000648169 C++ Note: df104 -4.48351 -18.568 C++ Note: Checking Deviance 387148 C++ Note: df105 0.990268 1 C++ Note: df106 57.6711 2.9878e+08 C++ Note: df100 21054 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df100 21101 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df101 -193659.8 -193659.8 C++ Note: df102 -3358.003 -0.0006481694 C++ Note: df103 -3391.003 -0.0006481694 C++ Note: df104 -4.48351 -18.56797 C++ Note: Checking Deviance 387147.6 C++ Note: df105 0.9902684 1 C++ Note: df106 57.67112 2.987796e+08 C++ Note: df101 -193660 -193660 C++ Note: df102 -3358 -0.000648169 C++ Note: df103 -3391 -0.000648169 C++ Note: df104 -4.48351 -18.568 C++ Note: Checking Deviance 387148 C++ Note: df105 0.990268 1 C++ Note: df106 57.6711 2.9878e+08 C++ Note: df501 -193659.8 C++ Note: df504 -4.48351 -18.56797 Error: guesses_control and model_control have different strata options Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: Term checked 0 1 C++ Note: df99,24,Starting C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: starting subterms 2 C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.949 3328.001 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.949 3328.001 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.949 3328.001 C++ Note: df99,420,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: START_POIS_GUESS C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: Term checked 0 1 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.95 3328 C++ Note: derivs checked 3813.95 0.000939732 C++ Note: second derivs checked 3813.95 0.000939732 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.95 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.95 3328 C++ Note: risk checked 9787.82 C++ Note: risk1 checked 6011.82 0.000944651 C++ Note: risk2 checked 6011.82 0.000944651 C++ Note: df101 -493394 -493394 C++ Note: df102 -303241 -0.047634 C++ Note: df103 -303274 -0.047634 C++ Note: df104 0.01 -15 C++ Note: Checking Deviance 986616 C++ Note: df105 0.999891 1 C++ Note: df106 1.62707 1.0358e+07 C++ Note: Starting Halves C++ Note: df501 -493394.2 C++ Note: df504 0.01 -15 C++ Note: values checked -0.739918 -15.3574 C++ Note: sums checked 4425.73 3328 C++ Note: derivs checked 1801.73 0.000657348 C++ Note: second derivs checked 1801.73 0.000657348 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 4425.73 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 4425.73 3328 C++ Note: risk checked 6616.01 C++ Note: risk1 checked 2840.01 0.000478342 C++ Note: risk2 checked 2840.01 0.000478342 C++ Note: df101 -333413 -333413 C++ Note: df102 -143235 -0.0241165 C++ Note: df103 -143268 -0.0241165 C++ Note: df104 -0.739918 -15.3574 C++ Note: Checking Deviance 666655 C++ Note: df105 0.99977 1 C++ Note: df106 2.32774 1.38251e+07 C++ Note: df100 4834 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df100 4881 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df101 -333413.3 -333413.3 C++ Note: df102 -143235 -0.02411648 C++ Note: df103 -143268 -0.02411648 C++ Note: df104 -0.7399184 -15.35738 C++ Note: Checking Deviance 666654.6 C++ Note: df105 0.9997697 1 C++ Note: df106 2.327736 1.382512e+07 C++ Note: Starting Halves C++ Note: df501 -333413.3 C++ Note: df504 -0.7399184 -15.35738 C++ Note: values checked -1.48975 -15.8512 C++ Note: sums checked 3475.22 3328 C++ Note: derivs checked 851.224 0.000401193 C++ Note: second derivs checked 851.224 0.000401193 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 3475.22 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 3475.22 3328 C++ Note: risk checked 5117.76 C++ Note: risk1 checked 1341.76 0.000239343 C++ Note: risk2 checked 1341.76 0.000239343 C++ Note: df101 -257857 -257857 C++ Note: df102 -67653.7 -0.0120654 C++ Note: df103 -67686.7 -0.0120654 C++ Note: df104 -1.48975 -15.8512 C++ Note: Checking Deviance 515541 C++ Note: df105 0.999512 1 C++ Note: df106 3.81142 2.13716e+07 C++ Note: df100 7423 1 2 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df100 7469 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df101 -257856.7 -257856.7 C++ Note: df102 -67653.71 -0.01206537 C++ Note: df103 -67686.71 -0.01206537 C++ Note: df104 -1.489746 -15.85115 C++ Note: Checking Deviance 515541.4 C++ Note: df105 0.9995125 1 C++ Note: df106 3.81142 2.137163e+07 C++ Note: Starting Halves C++ Note: df501 -257856.7 C++ Note: df504 -1.489746 -15.85115 C++ Note: values checked -2.23938 -16.4535 C++ Note: sums checked 3026.24 3328 C++ Note: derivs checked 402.237 0.00021966 C++ Note: second derivs checked 402.237 0.00021966 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 3026.24 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 3026.24 3328 C++ Note: risk checked 4410.03 C++ Note: risk1 checked 634.034 0.000117441 C++ Note: risk2 checked 634.034 0.000117441 C++ Note: df101 -222179 -222179 C++ Note: df102 -31951.6 -0.00591976 C++ Note: df103 -31984.6 -0.00591976 C++ Note: df104 -2.23938 -16.4535 C++ Note: Checking Deviance 444187 C++ Note: df105 0.998968 1 C++ Note: df106 6.95362 3.75318e+07 C++ Note: df100 10005 1 3 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df100 10051 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df101 -222179.4 -222179.4 C++ Note: df102 -31951.63 -0.005919756 C++ Note: df103 -31984.63 -0.005919756 C++ Note: df104 -2.23938 -16.45351 C++ Note: Checking Deviance 444186.7 C++ Note: df105 0.9989683 1 C++ Note: df106 6.953616 3.753185e+07 C++ Note: Starting Halves C++ Note: df501 -222179.4 C++ Note: df504 -2.23938 -16.45351 C++ Note: values checked -2.98861 -17.1257 C++ Note: sums checked 2814.15 3328 C++ Note: derivs checked 190.15 0.000112156 C++ Note: second derivs checked 190.15 0.000112156 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2814.15 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2814.15 3328 C++ Note: risk checked 4075.73 C++ Note: risk1 checked 299.728 5.66831e-05 C++ Note: risk2 checked 299.728 5.66831e-05 C++ Note: df101 -205340 -205340 C++ Note: df102 -15087.2 -0.00285705 C++ Note: df103 -15120.2 -0.00285705 C++ Note: df104 -2.98861 -17.1257 C++ Note: Checking Deviance 410507 C++ Note: df105 0.997817 1 C++ Note: df106 13.6102 7.18712e+07 C++ Note: df100 12580 1 4 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df100 12626 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df101 -205339.6 -205339.6 C++ Note: df102 -15087.16 -0.002857052 C++ Note: df103 -15120.16 -0.002857052 C++ Note: df104 -2.988606 -17.1257 C++ Note: Checking Deviance 410507.3 C++ Note: df105 0.9978175 1 C++ Note: df106 13.61022 7.187117e+07 C++ Note: Starting Halves C++ Note: df501 -205339.6 C++ Note: df504 -2.988606 -17.1257 C++ Note: values checked -3.73697 -17.8368 C++ Note: sums checked 2713.97 3328 C++ Note: derivs checked 89.9678 5.50787e-05 C++ Note: second derivs checked 89.9678 5.50787e-05 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2713.97 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2713.97 3328 C++ Note: risk checked 3917.81 C++ Note: risk1 checked 141.814 2.70754e-05 C++ Note: risk2 checked 141.814 2.70754e-05 C++ Note: df101 -197398 -197398 C++ Note: df102 -7120.96 -0.00136467 C++ Note: df103 -7153.96 -0.00136467 C++ Note: df104 -3.73697 -17.8368 C++ Note: Checking Deviance 394624 C++ Note: df105 0.995387 1 C++ Note: df106 27.7207 1.44649e+08 C++ Note: df100 15089 1 5 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df100 15136 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df101 -197398.1 -197398.1 C++ Note: df102 -7120.961 -0.001364671 C++ Note: df103 -7153.961 -0.001364671 C++ Note: df104 -3.736969 -17.83683 C++ Note: Checking Deviance 394624.2 C++ Note: df105 0.9953872 1 C++ Note: df106 27.72071 1.446488e+08 C++ Note: df101 -197398 -197398 C++ Note: df102 -7120.96 -0.00136467 C++ Note: df103 -7153.96 -0.00136467 C++ Note: df104 -3.73697 -17.8368 C++ Note: Checking Deviance 394624 C++ Note: df105 0.995387 1 C++ Note: df106 27.7207 1.44649e+08 C++ Note: ending guess 0 C++ Note: df501 -197398.1 C++ Note: df504 -3.736969 -17.83683 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -3.736969 -17.83683, -197398.1<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked -3.73697 -17.8368 C++ Note: sums checked 2713.97 3328 C++ Note: derivs checked 89.9678 5.50787e-05 C++ Note: second derivs checked 89.9678 5.50787e-05 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2713.97 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2713.97 3328 C++ Note: risk checked 3917.81 C++ Note: risk1 checked 141.814 2.70754e-05 C++ Note: risk2 checked 141.814 2.70754e-05 C++ Note: Made Risk Side Lists C++ Note: df101 -197398 -197398 C++ Note: df102 -7120.96 -0.00136467 C++ Note: df103 -7153.96 -0.00136467 C++ Note: df104 -3.73697 -17.8368 C++ Note: Checking Deviance 394624 C++ Note: df105 0.995387 1 C++ Note: df106 27.7207 1.44649e+08 C++ Note: Starting Halves C++ Note: df501 -197398.1 C++ Note: df504 -3.736969 -17.83683 C++ Note: values checked -4.48351 -18.568 C++ Note: sums checked 2666.65 3328 C++ Note: derivs checked 42.645 2.65127e-05 C++ Note: second derivs checked 42.645 2.65127e-05 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2666.65 3328 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2666.65 3328 C++ Note: risk checked 3843.22 C++ Note: risk1 checked 67.2201 1.286e-05 C++ Note: risk2 checked 67.2201 1.286e-05 C++ Note: df101 -193660 -193660 C++ Note: df102 -3358 -0.000648169 C++ Note: df103 -3391 -0.000648169 C++ Note: df104 -4.48351 -18.568 C++ Note: Checking Deviance 387148 C++ Note: df105 0.990268 1 C++ Note: df106 57.6711 2.9878e+08 C++ Note: df100 20922 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df100 20968 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df101 -193659.8 -193659.8 C++ Note: df102 -3358.003 -0.0006481694 C++ Note: df103 -3391.003 -0.0006481694 C++ Note: df104 -4.48351 -18.56797 C++ Note: Checking Deviance 387147.6 C++ Note: df105 0.9902684 1 C++ Note: df106 57.67112 2.987796e+08 C++ Note: df101 -193660 -193660 C++ Note: df102 -3358 -0.000648169 C++ Note: df103 -3391 -0.000648169 C++ Note: df104 -4.48351 -18.568 C++ Note: Checking Deviance 387148 C++ Note: df105 0.990268 1 C++ Note: df106 57.6711 2.9878e+08 C++ Note: df501 -193659.8 C++ Note: df504 -4.48351 -18.56797 Error: Atleast one parameter must be free Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: Term checked 0 1 C++ Note: df99,24,Starting C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: starting subterms 2 C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.949 0.001957775 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.949 0.001957775 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.949 0.001957775 C++ Note: df99,410,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: START_POIS_GUESS C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: Term checked 0 1 C++ Note: df99,26,Starting C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.95 0.00195777 C++ Note: derivs checked 3813.95 0.00195777 C++ Note: second derivs checked 3813.95 0.00195777 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.95 0.00195777 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.95 0.00195777 C++ Note: risk checked 6437.95 C++ Note: risk1 checked 3813.95 0.00196938 C++ Note: risk2 checked 3813.95 0.00196938 C++ Note: df101 -324424 -324424 C++ Note: df102 -192366 -0.0993192 C++ Note: df103 -192399 -0.0993192 C++ Note: df104 0.01 -15 C++ Note: Checking Deviance 648676 C++ Note: df105 0.999828 1 C++ Note: df106 1.68649 3.26648e+06 C++ Note: Starting Halves C++ Note: df501 -324424.1 C++ Note: df504 0.01 -15 C++ Note: values checked -0.739871 -15.3056 C++ Note: sums checked 4425.81 0.00144221 C++ Note: derivs checked 1801.81 0.00144221 C++ Note: second derivs checked 1801.81 0.00144221 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 4425.81 0.00144221 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 4425.81 0.00144221 C++ Note: risk checked 4425.82 C++ Note: risk1 checked 1801.81 0.000997333 C++ Note: risk2 checked 1801.81 0.000997333 C++ Note: df101 -222944 -222944 C++ Note: df102 -90861.8 -0.0502905 C++ Note: df103 -90894.8 -0.0502905 C++ Note: df104 -0.739871 -15.3056 C++ Note: Checking Deviance 445716 C++ Note: df105 0.999637 1 C++ Note: df106 2.45366 4.43313e+06 C++ Note: df100 4947 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df100 4993 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df101 -222944.2 -222944.2 C++ Note: df102 -90861.77 -0.05029052 C++ Note: df103 -90894.77 -0.05029052 C++ Note: df104 -0.7398713 -15.30563 C++ Note: Checking Deviance 445716.4 C++ Note: df105 0.9996369 1 C++ Note: df106 2.453663 4433125 C++ Note: Starting Halves C++ Note: df501 -222944.2 C++ Note: df504 -0.7398713 -15.30563 C++ Note: values checked -1.4896 -15.7503 C++ Note: sums checked 3475.35 0.000924527 C++ Note: derivs checked 851.349 0.000924527 C++ Note: second derivs checked 851.349 0.000924527 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 3475.35 0.000924527 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 3475.35 0.000924527 C++ Note: risk checked 3475.35 C++ Note: risk1 checked 851.349 0.00050204 C++ Note: risk2 checked 851.349 0.00050204 C++ Note: df101 -175021 -175021 C++ Note: df102 -42914.3 -0.0253124 C++ Note: df103 -42947.3 -0.0253124 C++ Note: df104 -1.4896 -15.7503 C++ Note: Checking Deviance 349871 C++ Note: df105 0.999232 1 C++ Note: df106 4.07839 6.91445e+06 C++ Note: df100 7561 1 2 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df100 7608 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df101 -175021.5 -175021.5 C++ Note: df102 -42914.34 -0.02531243 C++ Note: df103 -42947.34 -0.02531243 C++ Note: df104 -1.489599 -15.75028 C++ Note: Checking Deviance 349871 C++ Note: df105 0.9992316 1 C++ Note: df106 4.078392 6914448 C++ Note: Starting Halves C++ Note: df501 -175021.5 C++ Note: df504 -1.489599 -15.75028 C++ Note: values checked -2.23902 -16.3166 C++ Note: sums checked 3026.38 0.000524773 C++ Note: derivs checked 402.38 0.000524773 C++ Note: second derivs checked 402.38 0.000524773 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 3026.38 0.000524773 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 3026.38 0.000524773 C++ Note: risk checked 3026.38 C++ Note: risk1 checked 402.38 0.00024815 C++ Note: risk2 checked 402.38 0.00024815 C++ Note: df101 -152397 -152397 C++ Note: df102 -20265.6 -0.0125105 C++ Note: df103 -20298.6 -0.0125105 C++ Note: df104 -2.23902 -16.3166 C++ Note: Checking Deviance 304623 C++ Note: df105 0.998374 1 C++ Note: df106 7.52001 1.21815e+07 C++ Note: df100 10160 1 3 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df100 10206 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df101 -152397.5 -152397.5 C++ Note: df102 -20265.58 -0.01251054 C++ Note: df103 -20298.58 -0.01251054 C++ Note: df104 -2.239023 -16.3166 C++ Note: Checking Deviance 304622.9 C++ Note: df105 0.9983743 1 C++ Note: df106 7.520014 1.218152e+07 C++ Note: Starting Halves C++ Note: df501 -152397.5 C++ Note: df504 -2.239023 -16.3166 C++ Note: values checked -2.9878 -16.967 C++ Note: sums checked 2814.3 0.000273851 C++ Note: derivs checked 190.303 0.000273851 C++ Note: second derivs checked 190.303 0.000273851 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2814.3 0.000273851 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2814.3 0.000273851 C++ Note: risk checked 2814.3 C++ Note: risk1 checked 190.303 0.000120422 C++ Note: risk2 checked 190.303 0.000120422 C++ Note: df101 -141724 -141724 C++ Note: df102 -9567.07 -0.0060708 C++ Note: df103 -9600.07 -0.0060708 C++ Note: df104 -2.9878 -16.967 C++ Note: Checking Deviance 283275 C++ Note: df105 0.996563 1 C++ Note: df106 14.8137 2.33451e+07 C++ Note: df100 12729 1 4 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df100 12776 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df101 -141723.6 -141723.6 C++ Note: df102 -9567.07 -0.006070799 C++ Note: df103 -9600.07 -0.006070799 C++ Note: df104 -2.987803 -16.96698 C++ Note: Checking Deviance 283275.3 C++ Note: df105 0.9965625 1 C++ Note: df106 14.81369 2.334514e+07 C++ Note: Starting Halves C++ Note: df501 -141723.6 C++ Note: df504 -2.987803 -16.96698 C++ Note: values checked -3.73523 -17.6664 C++ Note: sums checked 2714.12 0.000136068 C++ Note: derivs checked 90.1248 0.000136068 C++ Note: second derivs checked 90.1248 0.000136068 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2714.12 0.000136068 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2714.12 0.000136068 C++ Note: risk checked 2714.12 C++ Note: risk1 checked 90.1248 5.77042e-05 C++ Note: risk2 checked 90.1248 5.77042e-05 C++ Note: df101 -136695 -136695 C++ Note: df102 -4513.46 -0.00290896 C++ Note: df103 -4546.46 -0.00290896 C++ Note: df104 -3.73523 -17.6664 C++ Note: Checking Deviance 273217 C++ Note: df105 0.992742 1 C++ Note: df106 30.286 4.6991e+07 C++ Note: df100 15310 1 5 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df100 15356 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df101 -136694.7 -136694.7 C++ Note: df102 -4513.458 -0.002908957 C++ Note: df103 -4546.458 -0.002908957 C++ Note: df104 -3.735225 -17.66641 C++ Note: Checking Deviance 273217.4 C++ Note: df105 0.9927416 1 C++ Note: df106 30.28602 4.699096e+07 C++ Note: df101 -136695 -136695 C++ Note: df102 -4513.46 -0.00290896 C++ Note: df103 -4546.46 -0.00290896 C++ Note: df104 -3.73523 -17.6664 C++ Note: Checking Deviance 273217 C++ Note: df105 0.992742 1 C++ Note: df106 30.286 4.6991e+07 C++ Note: ending guess 0 C++ Note: df501 -136694.7 C++ Note: df504 -3.735225 -17.66641 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -3.735225 -17.66641, -136694.7<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked -3.73523 -17.6664 C++ Note: sums checked 2714.12 0.000136068 C++ Note: derivs checked 90.1248 0.000136068 C++ Note: second derivs checked 90.1248 0.000136068 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2714.12 0.000136068 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2714.12 0.000136068 C++ Note: risk checked 2714.12 C++ Note: risk1 checked 90.1248 5.77042e-05 C++ Note: risk2 checked 90.1248 5.77042e-05 C++ Note: Made Risk Side Lists C++ Note: df101 -136695 -136695 C++ Note: df102 -4513.46 -0.00290896 C++ Note: df103 -4546.46 -0.00290896 C++ Note: df104 -3.73523 -17.6664 C++ Note: Checking Deviance 273217 C++ Note: df105 0.992742 1 C++ Note: df106 30.286 4.6991e+07 C++ Note: Starting Halves C++ Note: df501 -136694.7 C++ Note: df504 -3.735225 -17.66641 C++ Note: values checked -4.47978 -18.3917 C++ Note: sums checked 2666.8 6.58842e-05 C++ Note: derivs checked 42.8043 6.58842e-05 C++ Note: second derivs checked 42.8043 6.58842e-05 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 2666.8 6.58842e-05 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 2666.8 6.58842e-05 C++ Note: risk checked 2666.8 C++ Note: risk1 checked 42.8043 2.74532e-05 C++ Note: risk2 checked 42.8043 2.74532e-05 C++ Note: df101 -134332 -134332 C++ Note: df102 -2126.32 -0.00138394 C++ Note: df103 -2159.32 -0.00138394 C++ Note: df104 -4.47978 -18.3917 C++ Note: Checking Deviance 268492 C++ Note: df105 0.984717 1 C++ Note: df106 63.1759 9.7065e+07 C++ Note: df100 21175 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df100 21222 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: df101 -134332.1 -134332.1 C++ Note: df102 -2126.318 -0.00138394 C++ Note: df103 -2159.318 -0.00138394 C++ Note: df104 -4.479781 -18.39167 C++ Note: Checking Deviance 268492.2 C++ Note: df105 0.9847174 1 C++ Note: df106 63.17594 9.706499e+07 C++ Note: df101 -134332 -134332 C++ Note: df102 -2126.32 -0.00138394 C++ Note: df103 -2159.32 -0.00138394 C++ Note: df104 -4.47978 -18.3917 C++ Note: Checking Deviance 268492 C++ Note: df105 0.984717 1 C++ Note: df106 63.1759 9.7065e+07 C++ Note: df501 -134332.1 C++ Note: df504 -4.479781 -18.39167 Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Note: 2 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: Term checked 0 C++ Note: df99,22,Starting C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: Grouping Start C++ Note: df100 65 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.11965 C++ Note: risk1r checked 6.27591 C++ Note: risk2r checked 39.4822 C++ Note: riskl checked 1.11965 C++ Note: risk1l checked 6.27591 C++ Note: risk2l checked 39.4822 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: riskr checked 1.11965 C++ Note: risk1r checked 6.27591 C++ Note: risk2r checked 39.4822 C++ Note: riskl checked 1.11965 C++ Note: risk1l checked 6.27591 C++ Note: risk2l checked 39.4822 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: ending guess 0 C++ Note: df501 0 C++ Note: df504 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1, 0<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.11965 C++ Note: risk1r checked 6.27591 C++ Note: risk2r checked 39.4822 C++ Note: riskl checked 1.11965 C++ Note: risk1l checked 6.27591 C++ Note: risk2l checked 39.4822 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: riskr checked 1.11965 C++ Note: risk1r checked 6.27591 C++ Note: risk2r checked 39.4822 C++ Note: riskl checked 1.11965 C++ Note: risk1l checked 6.27591 C++ Note: risk2l checked 39.4822 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan C++ Note: Exiting Regression C++ Note: df501 0 C++ Note: df504 -0.1 Note: starting ph_plot Note: nonStratified survival curve calculation C++ Note: START_PLOT C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: Term checked 0 C++ Note: df99,21,Starting C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: values checked -0.1 C++ Note: sums checked 3.91896 C++ Note: derivs checked 21.9591 C++ Note: second derivs checked 138.335 C++ Note: dose checked 7 C++ Note: non-dose checked 3.91896 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 3.91896 C++ Note: risk checked 3.91896 C++ Note: risk1 checked 21.9591 C++ Note: risk2 checked 138.335 C++ Note: Grouping Start C++ Note: df100 308 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.11965 C++ Note: risk1r checked 6.27591 C++ Note: risk2r checked 39.4822 C++ Note: riskl checked 1.11965 C++ Note: risk1l checked 6.27591 C++ Note: risk2l checked 39.4822 C++ Note: df101 0 C++ Note: df102 0 C++ Note: df103 0 C++ Note: df104 -0.1 C++ Note: df105 nan C++ Note: df106 nan Note: writing survival data Note: Plotting Martingale Residuals Note: Martingale Plot: d Saving 7 x 7 in image Saving 7 x 7 in image Note: Starting Censoring weight Plot Function Note: 908 risk groups Note: 908 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: Term checked 0 0 C++ Note: df99,28,Starting C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: Grouping Start C++ Note: df100 3166 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0 0 C++ Note: sums checked 1000 1000 C++ Note: derivs checked 3524.8 501 C++ Note: second derivs checked 19954.8 501 C++ Note: dose checked 1000 C++ Note: non-dose checked 1000 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 3524.8 501 C++ Note: risk2 checked 19954.8 501 C++ Note: Made Risk Side Lists C++ Note: riskr checked 494240 C++ Note: risk1r checked 2.44264e+06 246462 C++ Note: risk2r checked 1.56997e+07 246462 C++ Note: riskl checked 908 C++ Note: risk1l checked 2745.2 459 C++ Note: risk2l checked 13223.2 459 C++ Note: df101 -5536.33 -5536.33 C++ Note: df102 -2409.98 12.6913 C++ Note: df103 -4481.29 -226.265 C++ Note: df104 0 0 C++ Note: df105 0.537787 -0.0560903 C++ Note: df106 2.29725 -436.231 C++ Note: Starting Halves C++ Note: df501 -5536.328 C++ Note: df504 0 0 C++ Note: riskr checked 494240 C++ Note: risk1r checked 2.44264e+06 246462 C++ Note: risk2r checked 1.56997e+07 246462 C++ Note: riskl checked 908 C++ Note: risk1l checked 2745.2 459 C++ Note: risk2l checked 13223.2 459 C++ Note: df101 -5536.33 -5536.33 C++ Note: df102 -2409.98 12.6913 C++ Note: df103 -4481.29 -226.265 C++ Note: df104 0 0 C++ Note: df105 0.537787 -0.0560903 C++ Note: df106 2.29725 -436.231 C++ Note: ending guess 0 C++ Note: df501 -5536.328 C++ Note: df504 0 0 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0 0, -5536.328<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0 0 C++ Note: sums checked 1000 1000 C++ Note: derivs checked 3524.8 501 C++ Note: second derivs checked 19954.8 501 C++ Note: dose checked 1000 C++ Note: non-dose checked 1000 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 3524.8 501 C++ Note: risk2 checked 19954.8 501 C++ Note: Made Risk Side Lists C++ Note: riskr checked 494240 C++ Note: risk1r checked 2.44264e+06 246462 C++ Note: risk2r checked 1.56997e+07 246462 C++ Note: riskl checked 908 C++ Note: risk1l checked 2745.2 459 C++ Note: risk2l checked 13223.2 459 C++ Note: df101 -5536.33 -5536.33 C++ Note: df102 -2409.98 12.6913 C++ Note: df103 -4481.29 -226.265 C++ Note: df104 0 0 C++ Note: df105 0.537787 -0.0560903 C++ Note: df106 2.29725 -436.231 C++ Note: riskr checked 494240 C++ Note: risk1r checked 2.44264e+06 246462 C++ Note: risk2r checked 1.56997e+07 246462 C++ Note: riskl checked 908 C++ Note: risk1l checked 2745.2 459 C++ Note: risk2l checked 13223.2 459 C++ Note: df101 -5536.33 -5536.33 C++ Note: df102 -2409.98 12.6913 C++ Note: df103 -4481.29 -226.265 C++ Note: df104 0 0 C++ Note: df105 0.537787 -0.0560903 C++ Note: df106 2.29725 -436.231 C++ Note: Exiting Regression C++ Note: df501 -5536.328 C++ Note: df504 0 0 C++ Note: START_PLOT C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: Term checked 0 0 C++ Note: df99,27,Starting C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: values checked 0 0 C++ Note: sums checked 1000 1000 C++ Note: derivs checked 3524.8 501 C++ Note: second derivs checked 19954.8 501 C++ Note: dose checked 1000 C++ Note: non-dose checked 1000 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 3524.8 501 C++ Note: risk2 checked 19954.8 501 C++ Note: Grouping Start C++ Note: df100 3459 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:08 2024 C++ Note: Made Risk Side Lists C++ Note: riskr checked 494240 C++ Note: risk1r checked 2.44264e+06 246462 C++ Note: risk2r checked 1.56997e+07 246462 C++ Note: riskl checked 908 C++ Note: risk1l checked 2745.2 459 C++ Note: risk2l checked 13223.2 459 C++ Note: df101 -5536.33 -5536.33 C++ Note: df102 -2409.98 12.6913 C++ Note: df103 -4481.29 -226.265 C++ Note: df104 0 0 C++ Note: df105 0.537787 -0.0560903 C++ Note: df106 2.29725 -436.231 Saving 7 x 7 in image Note: Starting Censoring weight Plot Function Error: Atleast one parameter must be free Note: Starting Censoring weight Plot Function Error: no events Note: Starting Plot Function Note: Getting Plot Info Note: 3 risk groups Note: 3 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Term checked 0 C++ Note: df99,24,Starting C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Grouping Start C++ Note: df100 110 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 133.041 C++ Note: derivs checked 67.2507 C++ Note: second derivs checked 45.6261 C++ Note: dose checked 140 C++ Note: non-dose checked 133.041 C++ Note: LIN_non-dose checked 140 C++ Note: PLIN_non-dose checked 140 C++ Note: LOGLIN_non-dose checked 133.041 C++ Note: risk checked 133.041 C++ Note: risk1 checked 67.2507 C++ Note: risk2 checked 45.6261 C++ Note: Made Risk Side Lists C++ Note: riskr checked 57.1165 C++ Note: risk1r checked 27.8704 C++ Note: risk2r checked 18.8098 C++ Note: riskl checked 57.1165 C++ Note: risk1l checked 27.8704 C++ Note: risk2l checked 18.8098 C++ Note: df101 -179.771 C++ Note: df102 0.534988 C++ Note: df103 -5.34679 C++ Note: df104 -0.1 C++ Note: df105 -0.100058 C++ Note: df106 -336.027 C++ Note: riskr checked 57.1165 C++ Note: risk1r checked 27.8704 C++ Note: risk2r checked 18.8098 C++ Note: riskl checked 57.1165 C++ Note: risk1l checked 27.8704 C++ Note: risk2l checked 18.8098 C++ Note: df101 -179.771 C++ Note: df102 0.534988 C++ Note: df103 -5.34679 C++ Note: df104 -0.1 C++ Note: df105 -0.100058 C++ Note: df106 -336.027 C++ Note: ending guess 0 C++ Note: df501 -179.7707 C++ Note: df504 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1, -179.7707<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 C++ Note: sums checked 133.041 C++ Note: derivs checked 67.2507 C++ Note: second derivs checked 45.6261 C++ Note: dose checked 140 C++ Note: non-dose checked 133.041 C++ Note: LIN_non-dose checked 140 C++ Note: PLIN_non-dose checked 140 C++ Note: LOGLIN_non-dose checked 133.041 C++ Note: risk checked 133.041 C++ Note: risk1 checked 67.2507 C++ Note: risk2 checked 45.6261 C++ Note: Made Risk Side Lists C++ Note: riskr checked 57.1165 C++ Note: risk1r checked 27.8704 C++ Note: risk2r checked 18.8098 C++ Note: riskl checked 57.1165 C++ Note: risk1l checked 27.8704 C++ Note: risk2l checked 18.8098 C++ Note: df101 -179.771 C++ Note: df102 0.534988 C++ Note: df103 -5.34679 C++ Note: df104 -0.1 C++ Note: df105 -0.100058 C++ Note: df106 -336.027 C++ Note: riskr checked 57.1165 C++ Note: risk1r checked 27.8704 C++ Note: risk2r checked 18.8098 C++ Note: riskl checked 57.1165 C++ Note: risk1l checked 27.8704 C++ Note: risk2l checked 18.8098 C++ Note: df101 -179.771 C++ Note: df102 0.534988 C++ Note: df103 -5.34679 C++ Note: df104 -0.1 C++ Note: df105 -0.100058 C++ Note: df106 -336.027 C++ Note: Exiting Regression C++ Note: df501 -179.7707 C++ Note: df504 -0.1 C++ Note: START_PLOT C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Term checked 0 C++ Note: df99,47,Starting C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: values checked -0.1 C++ Note: sums checked 95.2158 C++ Note: dose checked 100 C++ Note: non-dose checked 95.2158 C++ Note: LIN_non-dose checked 100 C++ Note: PLIN_non-dose checked 100 C++ Note: LOGLIN_non-dose checked 95.2158 C++ Note: risk checked 95.2158 Saving 7 x 7 in image Warning: model covariate order changed Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,31,Starting C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Grouping Start C++ Note: df100 274 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: Made Risk Side Lists C++ Note: riskr checked 45411.7 C++ Note: risk1r checked 28767.4 144720 52387.3 C++ Note: risk2r checked 28767.4 514964 151495 C++ Note: riskl checked 498.666 C++ Note: risk1l checked 304.226 1582.04 793.308 C++ Note: risk2l checked 304.226 5554.38 2609.55 C++ Note: df101 -124.812 -124.812 -124.812 C++ Note: df102 -0.467622 -22.6674 2.97163 C++ Note: df103 -6.02126 -30.6469 -1.27345 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: df105 0.0776618 0.739632 -2.33354 C++ Note: df106 266.907 5.50621 -42.001 C++ Note: Starting Halves C++ Note: df501 -124.8115 C++ Note: df504 0.4260961 0.646539 0.1572781 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: df100 2981 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: ending guess 0 C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.6007434 0.09652814 1.157278, -118.395<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: Made Risk Side Lists C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: Starting Halves C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: values checked 0.469257 0.102151 0.78977 C++ Note: sums checked 1647.84 1647.84 7760.94 C++ Note: derivs checked 1060.93 3775.1 27203.7 C++ Note: second derivs checked 1060.93 11977.1 111988 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1647.84 7760.94 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1647.84 7760.94 C++ Note: risk checked 14328.5 C++ Note: risk1 checked 8953.84 33119.7 44341.6 C++ Note: risk2 checked 8953.84 104570 182492 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: df100 6313 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: Exiting Regression C++ Note: df501 -117.3104 C++ Note: df504 0.4692569 0.1021509 0.7897698 Error: Atleast one parameter must be free Warning: model covariate order changed Error: no events Warning: model covariate order changed Note: 26 risk groups Note: Initial starts: 1 , Number of iterations provided: 4 . Colossus requires one more iteration counts than number of guesses (for best guess) C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,28,Starting C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Grouping Start C++ Note: df100 215 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: Made Risk Side Lists C++ Note: riskr checked 45411.7 C++ Note: risk1r checked 28767.4 144720 52387.3 C++ Note: risk2r checked 28767.4 514964 151495 C++ Note: riskl checked 498.666 C++ Note: risk1l checked 304.226 1582.04 793.308 C++ Note: risk2l checked 304.226 5554.38 2609.55 C++ Note: df101 -124.812 -124.812 -124.812 C++ Note: df102 -0.467622 -22.6674 2.97163 C++ Note: df103 -6.02126 -30.6469 -1.27345 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: df105 0.0776618 0.739632 -2.33354 C++ Note: df106 266.907 5.50621 -42.001 C++ Note: Starting Halves C++ Note: df501 -124.8115 C++ Note: df504 0.4260961 0.646539 0.1572781 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: df100 2880 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: ending guess 0 C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.6007434 0.09652814 1.157278, -118.395<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: Made Risk Side Lists C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: Starting Halves C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: values checked 0.469257 0.102151 0.78977 C++ Note: sums checked 1647.84 1647.84 7760.94 C++ Note: derivs checked 1060.93 3775.1 27203.7 C++ Note: second derivs checked 1060.93 11977.1 111988 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1647.84 7760.94 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1647.84 7760.94 C++ Note: risk checked 14328.5 C++ Note: risk1 checked 8953.84 33119.7 44341.6 C++ Note: risk2 checked 8953.84 104570 182492 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: df100 6865 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: Exiting Regression C++ Note: df501 -117.3104 C++ Note: df504 0.4692569 0.1021509 0.7897698 Warning: model covariate order changed Note: 26 risk groups Note: Initial starts: 3 , Number of iterations provided: 2 . Colossus requires one more iteration counts than number of guesses (for best guess) C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Grouping Start C++ Note: df100 209 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: Made Risk Side Lists C++ Note: riskr checked 45411.7 C++ Note: risk1r checked 28767.4 144720 52387.3 C++ Note: risk2r checked 28767.4 514964 151495 C++ Note: riskl checked 498.666 C++ Note: risk1l checked 304.226 1582.04 793.308 C++ Note: risk2l checked 304.226 5554.38 2609.55 C++ Note: df101 -124.812 -124.812 -124.812 C++ Note: df102 -0.467622 -22.6674 2.97163 C++ Note: df103 -6.02126 -30.6469 -1.27345 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: df105 0.0776618 0.739632 -2.33354 C++ Note: df106 266.907 5.50621 -42.001 C++ Note: Starting Halves C++ Note: df501 -124.8115 C++ Note: df504 0.4260961 0.646539 0.1572781 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: df100 3014 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: ending guess 0 C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: starting subterms 2 in guess 1 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: Made Risk Side Lists C++ Note: riskr checked 45411.7 C++ Note: risk1r checked 28767.4 144720 52387.3 C++ Note: risk2r checked 28767.4 514964 151495 C++ Note: riskl checked 498.666 C++ Note: risk1l checked 304.226 1582.04 793.308 C++ Note: risk2l checked 304.226 5554.38 2609.55 C++ Note: df101 -124.812 -124.812 -124.812 C++ Note: df102 -0.467622 -22.6674 2.97163 C++ Note: df103 -6.02126 -30.6469 -1.27345 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: df105 0.0776618 0.739632 -2.33354 C++ Note: df106 266.907 5.50621 -42.001 C++ Note: Starting Halves C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: df100 6655 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: values checked 0.51342 0.371534 0.657278 C++ Note: sums checked 3370.53 3370.53 4972.82 C++ Note: derivs checked 2201.24 9415.6 15965.6 C++ Note: second derivs checked 2201.24 31933.3 62675 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3370.53 4972.82 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3370.53 4972.82 C++ Note: risk checked 20026.8 C++ Note: risk1 checked 12767.6 55905.5 53475 C++ Note: risk2 checked 12767.6 188523 210555 C++ Note: riskr checked 50427.9 C++ Note: risk1r checked 32128.2 141448 121549 C++ Note: risk2r checked 32128.2 477449 432448 C++ Note: riskl checked 694.008 C++ Note: risk1l checked 419.149 2059.62 1976.96 C++ Note: risk2l checked 419.149 7123.47 7257.54 C++ Note: df101 -119.04 -119.04 -119.04 C++ Note: df102 -0.595098 -12.7024 -0.0570081 C++ Note: df103 -5.99518 -41.9658 -9.15921 C++ Note: df104 0.51342 0.371534 0.657278 C++ Note: df105 0.0992627 0.302686 0.00622413 C++ Note: df106 200.035 9.37145 2088.13 C++ Note: df100 8565 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Changing back to best C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: riskr checked 45411.7 C++ Note: risk1r checked 28767.4 144720 52387.3 C++ Note: risk2r checked 28767.4 514964 151495 C++ Note: riskl checked 498.666 C++ Note: risk1l checked 304.226 1582.04 793.308 C++ Note: risk2l checked 304.226 5554.38 2609.55 C++ Note: df101 -124.812 -124.812 -124.812 C++ Note: df102 -0.467622 -22.6674 2.97163 C++ Note: df103 -6.02126 -30.6469 -1.27345 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: df105 0.0776618 0.739632 -2.33354 C++ Note: df106 266.907 5.50621 -42.001 C++ Note: ending guess 1 C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: starting subterms 2 in guess 2 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: Made Risk Side Lists C++ Note: riskr checked 45411.7 C++ Note: risk1r checked 28767.4 144720 52387.3 C++ Note: risk2r checked 28767.4 514964 151495 C++ Note: riskl checked 498.666 C++ Note: risk1l checked 304.226 1582.04 793.308 C++ Note: risk2l checked 304.226 5554.38 2609.55 C++ Note: df101 -124.812 -124.812 -124.812 C++ Note: df102 -0.467622 -22.6674 2.97163 C++ Note: df103 -6.02126 -30.6469 -1.27345 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: df105 0.0776618 0.739632 -2.33354 C++ Note: df106 266.907 5.50621 -42.001 C++ Note: Starting Halves C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: df100 14562 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: ending guess 2 C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.6007434 0.09652814 1.157278, -118.395 1, 0.4260961 0.646539 0.1572781, -124.8115 2, 0.6007434 0.09652814 1.157278, -118.395<-- Best Guess C++ Note: starting subterms 2 in best guess 2 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: Made Risk Side Lists C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: Starting Halves C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: values checked 0.469257 0.102151 0.78977 C++ Note: sums checked 1647.84 1647.84 7760.94 C++ Note: derivs checked 1060.93 3775.1 27203.7 C++ Note: second derivs checked 1060.93 11977.1 111988 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1647.84 7760.94 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1647.84 7760.94 C++ Note: risk checked 14328.5 C++ Note: risk1 checked 8953.84 33119.7 44341.6 C++ Note: risk2 checked 8953.84 104570 182492 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: df100 19146 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: Exiting Regression C++ Note: df501 -117.3104 C++ Note: df504 0.4692569 0.1021509 0.7897698 Warning: model covariate order changed Note: 26 risk groups Error: guesses: 50 , iterations per guess: c(1, 1) Warning: model covariate order changed Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Grouping Start C++ Note: df100 200 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: Made Risk Side Lists C++ Note: riskr checked 45411.7 C++ Note: risk1r checked 28767.4 144720 52387.3 C++ Note: risk2r checked 28767.4 514964 151495 C++ Note: riskl checked 498.666 C++ Note: risk1l checked 304.226 1582.04 793.308 C++ Note: risk2l checked 304.226 5554.38 2609.55 C++ Note: df101 -124.812 -124.812 -124.812 C++ Note: df102 -0.467622 -22.6674 2.97163 C++ Note: df103 -6.02126 -30.6469 -1.27345 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: df105 0.0776618 0.739632 -2.33354 C++ Note: df106 266.907 5.50621 -42.001 C++ Note: Starting Halves C++ Note: df501 -124.8115 C++ Note: df504 0.4260961 0.646539 0.1572781 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: df100 2774 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: ending guess 0 C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.6007434 0.09652814 1.157278, -118.395<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: Made Risk Side Lists C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: Starting Halves C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: values checked 0.469257 0.102151 0.78977 C++ Note: sums checked 1647.84 1647.84 7760.94 C++ Note: derivs checked 1060.93 3775.1 27203.7 C++ Note: second derivs checked 1060.93 11977.1 111988 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1647.84 7760.94 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1647.84 7760.94 C++ Note: risk checked 14328.5 C++ Note: risk1 checked 8953.84 33119.7 44341.6 C++ Note: risk2 checked 8953.84 104570 182492 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: df100 6059 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: Exiting Regression C++ Note: df501 -117.3104 C++ Note: df504 0.4692569 0.1021509 0.7897698 Warning: model covariate order changed Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,29,Starting C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Grouping Start C++ Note: df100 190 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: Made Risk Side Lists C++ Note: riskr checked 45411.7 C++ Note: risk1r checked 28767.4 144720 52387.3 C++ Note: risk2r checked 28767.4 514964 151495 C++ Note: riskl checked 498.666 C++ Note: risk1l checked 304.226 1582.04 793.308 C++ Note: risk2l checked 304.226 5554.38 2609.55 C++ Note: df101 -124.812 -124.812 -124.812 C++ Note: df102 -0.467622 -22.6674 2.97163 C++ Note: df103 -6.02126 -30.6469 -1.27345 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: df105 0.0776618 0.739632 -2.33354 C++ Note: df106 266.907 5.50621 -42.001 C++ Note: Starting Halves C++ Note: df501 -124.8115 C++ Note: df504 0.4260961 0.646539 0.1572781 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: df100 2765 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: ending guess 0 C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.6007434 0.09652814 1.157278, -118.395<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.600743 0.0965281 1.15728 C++ Note: sums checked 1773.98 1773.98 32135.8 C++ Note: derivs checked 1194.6 4043.19 134742 C++ Note: second derivs checked 1194.6 12805.3 616015 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1773.98 32135.8 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1773.98 32135.8 C++ Note: risk checked 58026.5 C++ Note: risk1 checked 37651.2 135360 236019 C++ Note: risk2 checked 37651.2 427814 1.08252e+06 C++ Note: Made Risk Side Lists C++ Note: riskr checked 119495 C++ Note: risk1r checked 76635.5 283568 429089 C++ Note: risk2r checked 76635.5 896488 1.77407e+06 C++ Note: riskl checked 1711.94 C++ Note: risk1l checked 1027.65 4618.5 6140.17 C++ Note: risk2l checked 1027.65 15652.6 24115.3 C++ Note: df101 -118.395 -118.395 -118.395 C++ Note: df102 -0.782638 -0.410558 -4.43759 C++ Note: df103 -5.94091 -49.8573 -9.26764 C++ Note: df104 0.600743 0.0965281 1.15728 C++ Note: df105 0.131737 0.00823466 0.478826 C++ Note: df106 151.277 288.376 26.68 C++ Note: Starting Halves C++ Note: df501 -118.395 C++ Note: df504 0.6007434 0.09652814 1.157278 C++ Note: values checked 0.469257 0.102151 0.78977 C++ Note: sums checked 1647.84 1647.84 7760.94 C++ Note: derivs checked 1060.93 3775.1 27203.7 C++ Note: second derivs checked 1060.93 11977.1 111988 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 1647.84 7760.94 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1647.84 7760.94 C++ Note: risk checked 14328.5 C++ Note: risk1 checked 8953.84 33119.7 44341.6 C++ Note: risk2 checked 8953.84 104570 182492 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: df100 6001 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: riskr checked 34488.8 C++ Note: risk1r checked 21529.9 80578.6 94839.5 C++ Note: risk2r checked 21529.9 254610 351090 C++ Note: riskl checked 470.725 C++ Note: risk1l checked 299.436 1220.36 1425.98 C++ Note: risk2l checked 299.436 4016.13 5259.82 C++ Note: df101 -117.31 -117.31 -117.31 C++ Note: df102 -0.252504 -0.212118 -1.1189 C++ Note: df103 -6.08937 -50.5934 -9.22555 C++ Note: df104 0.469257 0.102151 0.78977 C++ Note: df105 0.0414663 0.00419259 0.121283 C++ Note: df106 464.589 553.044 104.844 C++ Note: Exiting Regression C++ Note: df501 -117.3104 C++ Note: df504 0.4692569 0.1021509 0.7897698 Warning: model covariate order changed Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,29,Starting C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Grouping Start C++ Note: df100 191 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked -0.1 -0.1 0.2 C++ Note: sums checked -261.4 -261.4 341.682 C++ Note: derivs checked 531 2083 1708.41 C++ Note: second derivs checked 0 0 0 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked -261.4 341.682 C++ Note: LIN_non-dose checked -261.4 341.682 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1000 1000 C++ Error: A non-positive risk was detected: -1.111148 C++ Warning: final failing values -0.1 -0.1 0.2 Invalid risk Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: df101 -18942.2 -18942.2 -18942.2 C++ Note: df102 -12053.5 -60927.3 -21843.1 C++ Note: df103 -12141.5 -218114 -69007.6 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: Checking Deviance 37742.9 C++ Note: df105 0.992752 0.279337 0.316532 C++ Note: df106 1.57151 0.310899 0.867193 C++ Note: Starting Halves C++ Note: df501 -18942.23 C++ Note: df504 0.4260961 0.646539 0.1572781 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: df100 2026 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: df100 2073 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: df101 -9722.072 -9722.072 -9722.072 C++ Note: df102 -5791.513 -29075.02 -10520.68 C++ Note: df103 -5879.513 -101991.2 -32827.7 C++ Note: df104 0.2541947 0.4783037 0.1233221 C++ Note: Checking Deviance 19302.54 C++ Note: df105 0.9850328 0.2850738 0.3204818 C++ Note: df106 1.678676 0.3343789 0.9240916 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: ending guess 0 C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.2541947 0.4783037 0.1233221, -9722.072<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: Made Risk Side Lists C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: Starting Halves C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: values checked 0.0500616 0.312566 0.0802485 C++ Note: sums checked 2172.57 2172.57 1154.38 C++ Note: derivs checked 1178.37 5851.84 2160.22 C++ Note: second derivs checked 1178.37 19594.1 6459.87 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 2172.57 1154.38 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 2172.57 1154.38 C++ Note: risk checked 4679.98 C++ Note: risk1 checked 2533.3 12602.3 4687.51 C++ Note: risk2 checked 2533.3 42177.5 14076.6 C++ Note: df101 -5164.53 -5164.53 -5164.53 C++ Note: df102 -2787.43 -13890.9 -5084.88 C++ Note: df103 -2875.43 -47831.4 -15650.9 C++ Note: df104 0.0500616 0.312566 0.0802485 C++ Note: Checking Deviance 10187.5 C++ Note: df105 0.969396 0.290413 0.324893 C++ Note: df106 1.85279 0.371793 1.01567 C++ Note: df100 4555 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: df100 4602 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: df101 -5164.534 -5164.534 -5164.534 C++ Note: df102 -2787.432 -13890.89 -5084.875 C++ Note: df103 -2875.432 -47831.43 -15650.91 C++ Note: df104 0.05006156 0.3125659 0.0802485 C++ Note: Checking Deviance 10187.47 C++ Note: df105 0.9693959 0.2904134 0.3248932 C++ Note: df106 1.852793 0.371793 1.015666 C++ Note: df101 -5164.53 -5164.53 -5164.53 C++ Note: df102 -2787.43 -13890.9 -5084.88 C++ Note: df103 -2875.43 -47831.4 -15650.9 C++ Note: df104 0.0500616 0.312566 0.0802485 C++ Note: Checking Deviance 10187.5 C++ Note: df105 0.969396 0.290413 0.324893 C++ Note: df106 1.85279 0.371793 1.01567 C++ Note: df501 -5164.534 C++ Note: df504 0.05006156 0.3125659 0.0802485 Error: Atleast one parameter must be free Warning: model covariate order changed Error: no events Warning: model covariate order changed Note: Initial starts: 1 , Number of iterations provided: 4 . Colossus requires one more iteration counts than number of guesses (for best guess) C++ Note: START_POIS_GUESS C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: df101 -18942.2 -18942.2 -18942.2 C++ Note: df102 -12053.5 -60927.3 -21843.1 C++ Note: df103 -12141.5 -218114 -69007.6 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: Checking Deviance 37742.9 C++ Note: df105 0.992752 0.279337 0.316532 C++ Note: df106 1.57151 0.310899 0.867193 C++ Note: Starting Halves C++ Note: df501 -18942.23 C++ Note: df504 0.4260961 0.646539 0.1572781 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: df100 2006 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: df100 2053 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: df101 -9722.072 -9722.072 -9722.072 C++ Note: df102 -5791.513 -29075.02 -10520.68 C++ Note: df103 -5879.513 -101991.2 -32827.7 C++ Note: df104 0.2541947 0.4783037 0.1233221 C++ Note: Checking Deviance 19302.54 C++ Note: df105 0.9850328 0.2850738 0.3204818 C++ Note: df106 1.678676 0.3343789 0.9240916 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: ending guess 0 C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.2541947 0.4783037 0.1233221, -9722.072<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: Made Risk Side Lists C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: Starting Halves C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: values checked 0.0500616 0.312566 0.0802485 C++ Note: sums checked 2172.57 2172.57 1154.38 C++ Note: derivs checked 1178.37 5851.84 2160.22 C++ Note: second derivs checked 1178.37 19594.1 6459.87 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 2172.57 1154.38 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 2172.57 1154.38 C++ Note: risk checked 4679.98 C++ Note: risk1 checked 2533.3 12602.3 4687.51 C++ Note: risk2 checked 2533.3 42177.5 14076.6 C++ Note: df101 -5164.53 -5164.53 -5164.53 C++ Note: df102 -2787.43 -13890.9 -5084.88 C++ Note: df103 -2875.43 -47831.4 -15650.9 C++ Note: df104 0.0500616 0.312566 0.0802485 C++ Note: Checking Deviance 10187.5 C++ Note: df105 0.969396 0.290413 0.324893 C++ Note: df106 1.85279 0.371793 1.01567 C++ Note: df100 4533 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: df100 4579 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: df101 -5164.534 -5164.534 -5164.534 C++ Note: df102 -2787.432 -13890.89 -5084.875 C++ Note: df103 -2875.432 -47831.43 -15650.91 C++ Note: df104 0.05006156 0.3125659 0.0802485 C++ Note: Checking Deviance 10187.47 C++ Note: df105 0.9693959 0.2904134 0.3248932 C++ Note: df106 1.852793 0.371793 1.015666 C++ Note: df101 -5164.53 -5164.53 -5164.53 C++ Note: df102 -2787.43 -13890.9 -5084.88 C++ Note: df103 -2875.43 -47831.4 -15650.9 C++ Note: df104 0.0500616 0.312566 0.0802485 C++ Note: Checking Deviance 10187.5 C++ Note: df105 0.969396 0.290413 0.324893 C++ Note: df106 1.85279 0.371793 1.01567 C++ Note: df501 -5164.534 C++ Note: df504 0.05006156 0.3125659 0.0802485 Warning: model covariate order changed Note: Initial starts: 3 , Number of iterations provided: 2 . Colossus requires one more iteration counts than number of guesses (for best guess) C++ Note: START_POIS_GUESS C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,29,Starting C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: df101 -18942.2 -18942.2 -18942.2 C++ Note: df102 -12053.5 -60927.3 -21843.1 C++ Note: df103 -12141.5 -218114 -69007.6 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: Checking Deviance 37742.9 C++ Note: df105 0.992752 0.279337 0.316532 C++ Note: df106 1.57151 0.310899 0.867193 C++ Note: Starting Halves C++ Note: df501 -18942.23 C++ Note: df504 0.4260961 0.646539 0.1572781 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: df100 2005 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: df100 2051 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: df101 -9722.072 -9722.072 -9722.072 C++ Note: df102 -5791.513 -29075.02 -10520.68 C++ Note: df103 -5879.513 -101991.2 -32827.7 C++ Note: df104 0.2541947 0.4783037 0.1233221 C++ Note: Checking Deviance 19302.54 C++ Note: df105 0.9850328 0.2850738 0.3204818 C++ Note: df106 1.678676 0.3343789 0.9240916 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: ending guess 0 C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: starting subterms 2 in guess 1 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: df101 -18942.2 -18942.2 -18942.2 C++ Note: df102 -12053.5 -60927.3 -21843.1 C++ Note: df103 -12141.5 -218114 -69007.6 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: Checking Deviance 37742.9 C++ Note: df105 0.992752 0.279337 0.316532 C++ Note: df106 1.57151 0.310899 0.867193 C++ Note: Starting Halves C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: df100 4546 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: values checked 0.340145 0.562421 0.1403 C++ Note: sums checked 5296.79 5296.79 1296.63 C++ Note: derivs checked 3244.35 16318.8 2592.93 C++ Note: second derivs checked 3244.35 57346.2 8013.16 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 5296.79 1296.63 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 5296.79 1296.63 C++ Note: risk checked 12148.9 C++ Note: risk1 checked 7411.88 37396.1 13604.8 C++ Note: risk2 checked 7411.88 131289 42203 C++ Note: df101 -13490.5 -13490.5 -13490.5 C++ Note: df102 -8318.73 -41981.5 -15084.1 C++ Note: df103 -8406.73 -148787 -47345.2 C++ Note: df104 0.340145 0.562421 0.1403 C++ Note: Checking Deviance 26839.3 C++ Note: df105 0.989532 0.282158 0.318597 C++ Note: df106 1.6217 0.321343 0.894353 C++ Note: df100 5498 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Changing back to best C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: df101 -18942.2 -18942.2 -18942.2 C++ Note: df102 -12053.5 -60927.3 -21843.1 C++ Note: df103 -12141.5 -218114 -69007.6 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: Checking Deviance 37742.9 C++ Note: df105 0.992752 0.279337 0.316532 C++ Note: df106 1.57151 0.310899 0.867193 C++ Note: df100 6436 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: df101 -18942.23 -18942.23 -18942.23 C++ Note: df102 -12053.55 -60927.32 -21843.14 C++ Note: df103 -12141.55 -218114.1 -69007.65 C++ Note: df104 0.4260961 0.646539 0.1572781 C++ Note: Checking Deviance 37742.86 C++ Note: df105 0.9927522 0.2793369 0.3165322 C++ Note: df106 1.571507 0.3108988 0.8671935 C++ Note: df101 -18942.2 -18942.2 -18942.2 C++ Note: df102 -12053.5 -60927.3 -21843.1 C++ Note: df103 -12141.5 -218114 -69007.6 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: Checking Deviance 37742.9 C++ Note: df105 0.992752 0.279337 0.316532 C++ Note: df106 1.57151 0.310899 0.867193 C++ Note: ending guess 1 C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: starting subterms 2 in guess 2 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: df101 -18942.2 -18942.2 -18942.2 C++ Note: df102 -12053.5 -60927.3 -21843.1 C++ Note: df103 -12141.5 -218114 -69007.6 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: Checking Deviance 37742.9 C++ Note: df105 0.992752 0.279337 0.316532 C++ Note: df106 1.57151 0.310899 0.867193 C++ Note: Starting Halves C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: df100 8877 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: values checked 0.340145 0.562421 0.1403 C++ Note: sums checked 5296.79 5296.79 1296.63 C++ Note: derivs checked 3244.35 16318.8 2592.93 C++ Note: second derivs checked 3244.35 57346.2 8013.16 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 5296.79 1296.63 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 5296.79 1296.63 C++ Note: risk checked 12148.9 C++ Note: risk1 checked 7411.88 37396.1 13604.8 C++ Note: risk2 checked 7411.88 131289 42203 C++ Note: df101 -13490.5 -13490.5 -13490.5 C++ Note: df102 -8318.73 -41981.5 -15084.1 C++ Note: df103 -8406.73 -148787 -47345.2 C++ Note: df104 0.340145 0.562421 0.1403 C++ Note: Checking Deviance 26839.3 C++ Note: df105 0.989532 0.282158 0.318597 C++ Note: df106 1.6217 0.321343 0.894353 C++ Note: df100 9830 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Changing back to best C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: df101 -18942.2 -18942.2 -18942.2 C++ Note: df102 -12053.5 -60927.3 -21843.1 C++ Note: df103 -12141.5 -218114 -69007.6 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: Checking Deviance 37742.9 C++ Note: df105 0.992752 0.279337 0.316532 C++ Note: df106 1.57151 0.310899 0.867193 C++ Note: df100 10767 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: df101 -18942.23 -18942.23 -18942.23 C++ Note: df102 -12053.55 -60927.32 -21843.14 C++ Note: df103 -12141.55 -218114.1 -69007.65 C++ Note: df104 0.4260961 0.646539 0.1572781 C++ Note: Checking Deviance 37742.86 C++ Note: df105 0.9927522 0.2793369 0.3165322 C++ Note: df106 1.571507 0.3108988 0.8671935 C++ Note: df101 -18942.2 -18942.2 -18942.2 C++ Note: df102 -12053.5 -60927.3 -21843.1 C++ Note: df103 -12141.5 -218114 -69007.6 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: Checking Deviance 37742.9 C++ Note: df105 0.992752 0.279337 0.316532 C++ Note: df106 1.57151 0.310899 0.867193 C++ Note: ending guess 2 C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.2541947 0.4783037 0.1233221, -9722.072<-- Best Guess 1, 0.4260961 0.646539 0.1572781, -18942.23 2, 0.4260961 0.646539 0.1572781, -18942.23 C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: Made Risk Side Lists C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: Starting Halves C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: values checked 0.0500616 0.312566 0.0802485 C++ Note: sums checked 2172.57 2172.57 1154.38 C++ Note: derivs checked 1178.37 5851.84 2160.22 C++ Note: second derivs checked 1178.37 19594.1 6459.87 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 2172.57 1154.38 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 2172.57 1154.38 C++ Note: risk checked 4679.98 C++ Note: risk1 checked 2533.3 12602.3 4687.51 C++ Note: risk2 checked 2533.3 42177.5 14076.6 C++ Note: df101 -5164.53 -5164.53 -5164.53 C++ Note: df102 -2787.43 -13890.9 -5084.88 C++ Note: df103 -2875.43 -47831.4 -15650.9 C++ Note: df104 0.0500616 0.312566 0.0802485 C++ Note: Checking Deviance 10187.5 C++ Note: df105 0.969396 0.290413 0.324893 C++ Note: df106 1.85279 0.371793 1.01567 C++ Note: df100 13328 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: df100 13374 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: df101 -5164.534 -5164.534 -5164.534 C++ Note: df102 -2787.432 -13890.89 -5084.875 C++ Note: df103 -2875.432 -47831.43 -15650.91 C++ Note: df104 0.05006156 0.3125659 0.0802485 C++ Note: Checking Deviance 10187.47 C++ Note: df105 0.9693959 0.2904134 0.3248932 C++ Note: df106 1.852793 0.371793 1.015666 C++ Note: df101 -5164.53 -5164.53 -5164.53 C++ Note: df102 -2787.43 -13890.9 -5084.88 C++ Note: df103 -2875.43 -47831.4 -15650.9 C++ Note: df104 0.0500616 0.312566 0.0802485 C++ Note: Checking Deviance 10187.5 C++ Note: df105 0.969396 0.290413 0.324893 C++ Note: df106 1.85279 0.371793 1.01567 C++ Note: df501 -5164.534 C++ Note: df504 0.05006156 0.3125659 0.0802485 Warning: model covariate order changed Error: guesses: 50 , iterations per guess: c(1, 1) Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: df101 -18942.2 -18942.2 -18942.2 C++ Note: df102 -12053.5 -60927.3 -21843.1 C++ Note: df103 -12141.5 -218114 -69007.6 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: Checking Deviance 37742.9 C++ Note: df105 0.992752 0.279337 0.316532 C++ Note: df106 1.57151 0.310899 0.867193 C++ Note: Starting Halves C++ Note: df501 -18942.23 C++ Note: df504 0.4260961 0.646539 0.1572781 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: df100 2011 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: df100 2058 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: df101 -9722.072 -9722.072 -9722.072 C++ Note: df102 -5791.513 -29075.02 -10520.68 C++ Note: df103 -5879.513 -101991.2 -32827.7 C++ Note: df104 0.2541947 0.4783037 0.1233221 C++ Note: Checking Deviance 19302.54 C++ Note: df105 0.9850328 0.2850738 0.3204818 C++ Note: df106 1.678676 0.3343789 0.9240916 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: ending guess 0 C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.2541947 0.4783037 0.1233221, -9722.072<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: Made Risk Side Lists C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: Starting Halves C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: values checked 0.0500616 0.312566 0.0802485 C++ Note: sums checked 2172.57 2172.57 1154.38 C++ Note: derivs checked 1178.37 5851.84 2160.22 C++ Note: second derivs checked 1178.37 19594.1 6459.87 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 2172.57 1154.38 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 2172.57 1154.38 C++ Note: risk checked 4679.98 C++ Note: risk1 checked 2533.3 12602.3 4687.51 C++ Note: risk2 checked 2533.3 42177.5 14076.6 C++ Note: df101 -5164.53 -5164.53 -5164.53 C++ Note: df102 -2787.43 -13890.9 -5084.88 C++ Note: df103 -2875.43 -47831.4 -15650.9 C++ Note: df104 0.0500616 0.312566 0.0802485 C++ Note: Checking Deviance 10187.5 C++ Note: df105 0.969396 0.290413 0.324893 C++ Note: df106 1.85279 0.371793 1.01567 C++ Note: df100 4537 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: df100 4583 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: df101 -5164.534 -5164.534 -5164.534 C++ Note: df102 -2787.432 -13890.89 -5084.875 C++ Note: df103 -2875.432 -47831.43 -15650.91 C++ Note: df104 0.05006156 0.3125659 0.0802485 C++ Note: Checking Deviance 10187.47 C++ Note: df105 0.9693959 0.2904134 0.3248932 C++ Note: df106 1.852793 0.371793 1.015666 C++ Note: df101 -5164.53 -5164.53 -5164.53 C++ Note: df102 -2787.43 -13890.9 -5084.88 C++ Note: df103 -2875.43 -47831.4 -15650.9 C++ Note: df104 0.0500616 0.312566 0.0802485 C++ Note: Checking Deviance 10187.5 C++ Note: df105 0.969396 0.290413 0.324893 C++ Note: df106 1.85279 0.371793 1.01567 C++ Note: df501 -5164.534 C++ Note: df504 0.05006156 0.3125659 0.0802485 Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.426096 0.646539 0.157278 C++ Note: sums checked 7274.1 7274.1 1341.83 C++ Note: derivs checked 4601.97 23182.6 2733.27 C++ Note: second derivs checked 4601.97 82544.2 8524.37 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 7274.1 1341.83 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 7274.1 1341.83 C++ Note: risk checked 17001 C++ Note: risk1 checked 10706.4 54122.7 19625.6 C++ Note: risk2 checked 10706.4 192502 61415.9 C++ Note: df101 -18942.2 -18942.2 -18942.2 C++ Note: df102 -12053.5 -60927.3 -21843.1 C++ Note: df103 -12141.5 -218114 -69007.6 C++ Note: df104 0.426096 0.646539 0.157278 C++ Note: Checking Deviance 37742.9 C++ Note: df105 0.992752 0.279337 0.316532 C++ Note: df106 1.57151 0.310899 0.867193 C++ Note: Starting Halves C++ Note: df501 -18942.23 C++ Note: df504 0.4260961 0.646539 0.1572781 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: df100 2022 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: df100 2070 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: df101 -9722.072 -9722.072 -9722.072 C++ Note: df102 -5791.513 -29075.02 -10520.68 C++ Note: df103 -5879.513 -101991.2 -32827.7 C++ Note: df104 0.2541947 0.4783037 0.1233221 C++ Note: Checking Deviance 19302.54 C++ Note: df105 0.9850328 0.2850738 0.3204818 C++ Note: df106 1.678676 0.3343789 0.9240916 C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: ending guess 0 C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.2541947 0.4783037 0.1233221, -9722.072<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked 0.254195 0.478304 0.123322 C++ Note: sums checked 3900.36 3900.36 1253.74 C++ Note: derivs checked 2309.18 11554.8 2460.98 C++ Note: second derivs checked 2309.18 40015.3 7535.66 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 3900.36 1253.74 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 3900.36 1253.74 C++ Note: risk checked 8783.44 C++ Note: risk1 checked 5182.78 26003.4 9537.67 C++ Note: risk2 checked 5182.78 89978.1 29321.3 C++ Note: Made Risk Side Lists C++ Note: df101 -9722.07 -9722.07 -9722.07 C++ Note: df102 -5791.51 -29075 -10520.7 C++ Note: df103 -5879.51 -101991 -32827.7 C++ Note: df104 0.254195 0.478304 0.123322 C++ Note: Checking Deviance 19302.5 C++ Note: df105 0.985033 0.285074 0.320482 C++ Note: df106 1.67868 0.334379 0.924092 C++ Note: Starting Halves C++ Note: df501 -9722.072 C++ Note: df504 0.2541947 0.4783037 0.1233221 C++ Note: values checked 0.0500616 0.312566 0.0802485 C++ Note: sums checked 2172.57 2172.57 1154.38 C++ Note: derivs checked 1178.37 5851.84 2160.22 C++ Note: second derivs checked 1178.37 19594.1 6459.87 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked 2172.57 1154.38 C++ Note: LIN_non-dose checked 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 2172.57 1154.38 C++ Note: risk checked 4679.98 C++ Note: risk1 checked 2533.3 12602.3 4687.51 C++ Note: risk2 checked 2533.3 42177.5 14076.6 C++ Note: df101 -5164.53 -5164.53 -5164.53 C++ Note: df102 -2787.43 -13890.9 -5084.88 C++ Note: df103 -2875.43 -47831.4 -15650.9 C++ Note: df104 0.0500616 0.312566 0.0802485 C++ Note: Checking Deviance 10187.5 C++ Note: df105 0.969396 0.290413 0.324893 C++ Note: df106 1.85279 0.371793 1.01567 C++ Note: df100 4552 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: df100 4599 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: df101 -5164.534 -5164.534 -5164.534 C++ Note: df102 -2787.432 -13890.89 -5084.875 C++ Note: df103 -2875.432 -47831.43 -15650.91 C++ Note: df104 0.05006156 0.3125659 0.0802485 C++ Note: Checking Deviance 10187.47 C++ Note: df105 0.9693959 0.2904134 0.3248932 C++ Note: df106 1.852793 0.371793 1.015666 C++ Note: df101 -5164.53 -5164.53 -5164.53 C++ Note: df102 -2787.43 -13890.9 -5084.88 C++ Note: df103 -2875.43 -47831.4 -15650.9 C++ Note: df104 0.0500616 0.312566 0.0802485 C++ Note: Checking Deviance 10187.5 C++ Note: df105 0.969396 0.290413 0.324893 C++ Note: df106 1.85279 0.371793 1.01567 C++ Note: df501 -5164.534 C++ Note: df504 0.05006156 0.3125659 0.0802485 Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Term checked 0 0 1 C++ Note: df99,32,Starting C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked -0.1 -0.1 0.2 C++ Note: sums checked -261.4 -261.4 341.682 C++ Note: derivs checked 531 2083 1708.41 C++ Note: second derivs checked 0 0 0 C++ Note: dose checked 1000 1000 C++ Note: non-dose checked -261.4 341.682 C++ Note: LIN_non-dose checked -261.4 341.682 C++ Note: PLIN_non-dose checked 1000 1000 C++ Note: LOGLIN_non-dose checked 1000 1000 C++ Error: A non-positive risk was detected: -1.111148 C++ Warning: final failing values -0.1 -0.1 0.2 C++ Warning: final failing terms lin lin lin Invalid risk Error: Atleast one parameter must be free Note: 2 risk groups C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Term checked 0 1 1 2 C++ Note: df99,32,Starting C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: starting subterms 3 C++ Note: values checked 0.1 0.1 0.1 0.1 C++ Note: sums checked 7.420684 1.45 1.45 7.4 C++ Note: dose checked 7 7 7 C++ Note: non-dose checked 7.420684 1.45 7.4 C++ Note: LIN_non-dose checked 7 1.45 7 C++ Note: PLIN_non-dose checked 7 7 7.4 C++ Note: LOGLIN_non-dose checked 7.420684 7 7 C++ Note: df99,278,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:09 2024 Error: no events Error: Atleast one parameter must be free C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Term checked 0 1 1 2 C++ Note: df99,32,Starting C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: starting subterms 3 C++ Note: values checked 0.1 0.1 0.1 0.1 C++ Note: sums checked 7.420684 1.45 1.45 7.4 C++ Note: dose checked 7 7 7 C++ Note: non-dose checked 7.420684 1.45 7.4 C++ Note: LIN_non-dose checked 7 1.45 7 C++ Note: PLIN_non-dose checked 7 7 7.4 C++ Note: LOGLIN_non-dose checked 7.420684 7 7 C++ Note: df99,271,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:09 2024 Error: no events Error: Atleast one parameter must be free C++ Note: START_PLOT C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: values checked 0.1 -0.1 C++ Note: sums checked 4.33113 4.33113 C++ Note: dose checked 7 C++ Note: non-dose checked 4.33113 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 4.33113 C++ Note: risk checked 4.33113 Error: Atleast one parameter must be free Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Warning: model covariate order changed Note: 2 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Term checked 0 0 C++ Note: df99,26,Starting C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Grouping Start C++ Note: df100 78 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0.1 -0.1 C++ Note: sums checked 4.33113 4.33113 C++ Note: derivs checked 4.33113 24.2686 C++ Note: second derivs checked 4.33113 152.884 C++ Note: dose checked 7 C++ Note: non-dose checked 4.33113 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 4.33113 C++ Note: risk checked 4.33113 C++ Note: risk1 checked 4.33113 24.2686 C++ Note: risk2 checked 4.33113 152.884 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.2374 C++ Note: risk1r checked 1.2374 6.93596 C++ Note: risk2r checked 1.2374 43.6346 C++ Note: riskl checked 1.2374 C++ Note: risk1l checked 1.2374 6.93596 C++ Note: risk2l checked 1.2374 43.6346 C++ Note: df101 0 0 C++ Note: df102 0 0 C++ Note: df103 0 0 C++ Note: df104 0.1 -0.1 C++ Note: df105 nan nan C++ Note: df106 nan nan C++ Note: riskr checked 1.2374 C++ Note: risk1r checked 1.2374 6.93596 C++ Note: risk2r checked 1.2374 43.6346 C++ Note: riskl checked 1.2374 C++ Note: risk1l checked 1.2374 6.93596 C++ Note: risk2l checked 1.2374 43.6346 C++ Note: df101 0 0 C++ Note: df102 0 0 C++ Note: df103 0 0 C++ Note: df104 0.1 -0.1 C++ Note: df105 nan nan C++ Note: df106 nan nan C++ Note: ending guess 0 C++ Note: df501 0 C++ Note: df504 0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.1 -0.1, 0<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.1 -0.1 C++ Note: sums checked 4.33113 4.33113 C++ Note: derivs checked 4.33113 24.2686 C++ Note: second derivs checked 4.33113 152.884 C++ Note: dose checked 7 C++ Note: non-dose checked 4.33113 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 4.33113 C++ Note: risk checked 4.33113 C++ Note: risk1 checked 4.33113 24.2686 C++ Note: risk2 checked 4.33113 152.884 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.2374 C++ Note: risk1r checked 1.2374 6.93596 C++ Note: risk2r checked 1.2374 43.6346 C++ Note: riskl checked 1.2374 C++ Note: risk1l checked 1.2374 6.93596 C++ Note: risk2l checked 1.2374 43.6346 C++ Note: df101 0 0 C++ Note: df102 0 0 C++ Note: df103 0 0 C++ Note: df104 0.1 -0.1 C++ Note: df105 nan nan C++ Note: df106 nan nan C++ Note: riskr checked 1.2374 C++ Note: risk1r checked 1.2374 6.93596 C++ Note: risk2r checked 1.2374 43.6346 C++ Note: riskl checked 1.2374 C++ Note: risk1l checked 1.2374 6.93596 C++ Note: risk2l checked 1.2374 43.6346 C++ Note: df101 0 0 C++ Note: df102 0 0 C++ Note: df103 0 0 C++ Note: df104 0.1 -0.1 C++ Note: df105 nan nan C++ Note: df106 nan nan C++ Note: Exiting Regression C++ Note: df501 0 C++ Note: df504 0.1 -0.1 Note: starting ph_plot Note: nonStratified survival curve calculation C++ Note: START_PLOT C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: values checked -0.1 0.1 C++ Note: sums checked 4.33113 4.33113 C++ Note: derivs checked 24.2686 4.33113 C++ Note: second derivs checked 152.884 4.33113 C++ Note: dose checked 7 C++ Note: non-dose checked 4.33113 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 4.33113 C++ Note: risk checked 4.33113 C++ Note: risk1 checked 24.2686 4.33113 C++ Note: risk2 checked 152.884 4.33113 C++ Note: Grouping Start C++ Note: df100 345 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:09 2024 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1.2374 C++ Note: risk1r checked 6.93596 1.2374 C++ Note: risk2r checked 43.6346 1.2374 C++ Note: riskl checked 1.2374 C++ Note: risk1l checked 6.93596 1.2374 C++ Note: risk2l checked 43.6346 1.2374 C++ Note: df101 0 0 C++ Note: df102 0 0 C++ Note: df103 0 0 C++ Note: df104 -0.1 0.1 C++ Note: df105 nan nan C++ Note: df106 nan nan Note: writing survival data Note: Plotting Martingale Residuals Note: Martingale Plot: d Saving 7 x 7 in image Saving 7 x 7 in image Note: Starting Plot Function Note: Getting Plot Info Note: 2 risk groups Note: Starting Plot Function Note: Getting Plot Info Error: no events Error: Atleast one parameter must be free Warning: rmin/rmax not equal size, lin/loglin min/max used Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 C++ Note: df99,23,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.01 C++ Note: sums checked 6437.949 C++ Note: dose checked 6400 C++ Note: non-dose checked 6437.949 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 6437.949 C++ Note: df99,359,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Note: 86 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 C++ Note: df99,22,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 1212 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 6437.95 C++ Note: derivs checked 3813.95 C++ Note: second derivs checked 3813.95 C++ Note: dose checked 6400 C++ Note: non-dose checked 6437.95 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 6437.95 C++ Note: risk checked 6437.95 C++ Note: risk1 checked 3813.95 C++ Note: risk2 checked 3813.95 C++ Note: Made Risk Side Lists C++ Note: riskr checked 4185.37 C++ Note: risk1r checked 2549.37 C++ Note: risk2r checked 2549.37 C++ Note: riskl checked 86.3317 C++ Note: risk1l checked 33.3317 C++ Note: risk2l checked 33.3317 C++ Note: df101 -313.163 C++ Note: df102 -21.7172 C++ Note: df103 -19.4313 C++ Note: df104 0.01 C++ Note: df105 1.11764 C++ Note: df106 14.42 C++ Note: Starting Halves C++ Note: df501 -313.1627 C++ Note: df504 0.01 C++ Note: values checked -0.828233 C++ Note: sums checked 4273.43 C++ Note: derivs checked 1649.43 C++ Note: second derivs checked 1649.43 C++ Note: dose checked 6400 C++ Note: non-dose checked 4273.43 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 4273.43 C++ Note: risk checked 4273.43 C++ Note: risk1 checked 1649.43 C++ Note: risk2 checked 1649.43 C++ Note: riskr checked 2738.53 C++ Note: risk1r checked 1102.53 C++ Note: risk2r checked 1102.53 C++ Note: riskl checked 67.4151 C++ Note: risk1l checked 14.4151 C++ Note: risk2l checked 14.4151 C++ Note: df101 -302.091 C++ Note: df102 -4.55996 C++ Note: df103 -20.4044 C++ Note: df104 -0.828233 C++ Note: df105 0.22348 C++ Note: df106 66.2487 C++ Note: df100 3613 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Starting Halves C++ Note: df501 -302.0913 C++ Note: df504 -0.828233 C++ Note: values checked -0.995843 C++ Note: sums checked 4018.9 C++ Note: derivs checked 1394.9 C++ Note: second derivs checked 1394.9 C++ Note: dose checked 6400 C++ Note: non-dose checked 4018.9 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 4018.9 C++ Note: risk checked 4018.9 C++ Note: risk1 checked 1394.9 C++ Note: risk2 checked 1394.9 C++ Note: riskr checked 2568.4 C++ Note: risk1r checked 932.396 C++ Note: risk2r checked 932.396 C++ Note: riskl checked 65.1906 C++ Note: risk1l checked 12.1906 C++ Note: risk2l checked 12.1906 C++ Note: df101 -301.611 C++ Note: df102 -1.18635 C++ Note: df103 -19.8114 C++ Note: df104 -0.995843 C++ Note: df105 0.0598821 C++ Note: df106 254.236 C++ Note: df100 4782 1 2 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Starting Halves C++ Note: df501 -301.6112 C++ Note: df504 -0.9958427 C++ Note: values checked -1.04075 C++ Note: sums checked 3957.64 C++ Note: derivs checked 1333.64 C++ Note: second derivs checked 1333.64 C++ Note: dose checked 6400 C++ Note: non-dose checked 3957.64 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 3957.64 C++ Note: risk checked 3957.64 C++ Note: risk1 checked 1333.64 C++ Note: risk2 checked 1333.64 C++ Note: riskr checked 2527.45 C++ Note: risk1r checked 891.447 C++ Note: risk2r checked 891.447 C++ Note: riskl checked 64.6552 C++ Note: risk1l checked 11.6552 C++ Note: risk2l checked 11.6552 C++ Note: df101 -301.578 C++ Note: df102 -0.300978 C++ Note: df103 -19.6132 C++ Note: df104 -1.04075 C++ Note: df105 0.0153457 C++ Note: df106 1001.99 C++ Note: df100 5954 1 3 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Starting Halves C++ Note: df501 -301.5778 C++ Note: df504 -1.040754 C++ Note: values checked -1.05226 C++ Note: sums checked 3942.38 C++ Note: derivs checked 1318.38 C++ Note: second derivs checked 1318.38 C++ Note: dose checked 6400 C++ Note: non-dose checked 3942.38 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 3942.38 C++ Note: risk checked 3942.38 C++ Note: risk1 checked 1318.38 C++ Note: risk2 checked 1318.38 C++ Note: riskr checked 2517.25 C++ Note: risk1r checked 881.246 C++ Note: risk2r checked 881.246 C++ Note: riskl checked 64.5218 C++ Note: risk1l checked 11.5218 C++ Note: risk2l checked 11.5218 C++ Note: df101 -301.576 C++ Note: df102 -0.0755501 C++ Note: df103 -19.5599 C++ Note: df104 -1.05226 C++ Note: df105 0.0038625 C++ Note: df106 3991.73 C++ Note: df100 7120 1 4 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Starting Halves C++ Note: df501 -301.5756 C++ Note: df504 -1.052263 C++ Note: values checked -1.05516 C++ Note: sums checked 3938.56 C++ Note: derivs checked 1314.56 C++ Note: second derivs checked 1314.56 C++ Note: dose checked 6400 C++ Note: non-dose checked 3938.56 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 3938.56 C++ Note: risk checked 3938.56 C++ Note: risk1 checked 1314.56 C++ Note: risk2 checked 1314.56 C++ Note: riskr checked 2514.7 C++ Note: risk1r checked 878.697 C++ Note: risk2r checked 878.697 C++ Note: riskl checked 64.4885 C++ Note: risk1l checked 11.4885 C++ Note: risk2l checked 11.4885 C++ Note: df101 -301.576 C++ Note: df102 -0.0189072 C++ Note: df103 -19.5463 C++ Note: df104 -1.05516 C++ Note: df105 0.0009673 C++ Note: df106 15950.3 C++ Note: df100 8281 1 5 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 2514.7 C++ Note: risk1r checked 878.697 C++ Note: risk2r checked 878.697 C++ Note: riskl checked 64.4885 C++ Note: risk1l checked 11.4885 C++ Note: risk2l checked 11.4885 C++ Note: df101 -301.576 C++ Note: df102 -0.0189072 C++ Note: df103 -19.5463 C++ Note: df104 -1.05516 C++ Note: df105 0.0009673 C++ Note: df106 15950.3 C++ Note: ending guess 0 C++ Note: df501 -301.5755 C++ Note: df504 -1.05516 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -1.05516, -301.5755<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -1.05516 C++ Note: sums checked 3938.56 C++ Note: derivs checked 1314.56 C++ Note: second derivs checked 1314.56 C++ Note: dose checked 6400 C++ Note: non-dose checked 3938.56 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 3938.56 C++ Note: risk checked 3938.56 C++ Note: risk1 checked 1314.56 C++ Note: risk2 checked 1314.56 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2514.7 C++ Note: risk1r checked 878.697 C++ Note: risk2r checked 878.697 C++ Note: riskl checked 64.4885 C++ Note: risk1l checked 11.4885 C++ Note: risk2l checked 11.4885 C++ Note: df101 -301.576 C++ Note: df102 -0.0189072 C++ Note: df103 -19.5463 C++ Note: df104 -1.05516 C++ Note: df105 0.0009673 C++ Note: df106 15950.3 C++ Note: Starting Halves C++ Note: df501 -301.5755 C++ Note: df504 -1.05516 C++ Note: values checked -1.05589 C++ Note: sums checked 3937.61 C++ Note: derivs checked 1313.61 C++ Note: second derivs checked 1313.61 C++ Note: dose checked 6400 C++ Note: non-dose checked 3937.61 C++ Note: LIN_non-dose checked 6400 C++ Note: PLIN_non-dose checked 6400 C++ Note: LOGLIN_non-dose checked 3937.61 C++ Note: risk checked 3937.61 C++ Note: risk1 checked 1313.61 C++ Note: risk2 checked 1313.61 C++ Note: riskr checked 2514.06 C++ Note: risk1r checked 878.06 C++ Note: risk2r checked 878.06 C++ Note: riskl checked 64.4802 C++ Note: risk1l checked 11.4802 C++ Note: risk2l checked 11.4802 C++ Note: df101 -301.575 C++ Note: df102 -0.00472803 C++ Note: df103 -19.5429 C++ Note: df104 -1.05589 C++ Note: df105 0.00024193 C++ Note: df106 63784.6 C++ Note: df100 10914 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 2514.06 C++ Note: risk1r checked 878.06 C++ Note: risk2r checked 878.06 C++ Note: riskl checked 64.4802 C++ Note: risk1l checked 11.4802 C++ Note: risk2l checked 11.4802 C++ Note: df101 -301.575 C++ Note: df102 -0.00472803 C++ Note: df103 -19.5429 C++ Note: df104 -1.05589 C++ Note: df105 0.00024193 C++ Note: df106 63784.6 C++ Note: riskr checked 2514.06 C++ Note: risk1r checked 878.06 C++ Note: risk2r checked 878.06 C++ Note: riskl checked 64.4802 C++ Note: risk1l checked 11.4802 C++ Note: risk2l checked 11.4802 C++ Note: df101 -301.575 C++ Note: df102 -0.00472803 C++ Note: df103 -19.5429 C++ Note: df104 -1.05589 C++ Note: df105 0.00024193 C++ Note: df106 63784.6 C++ Note: Exiting Regression C++ Note: df501 -301.5755 C++ Note: df504 -1.055886 Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 1 C++ Note: df99,24,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 2 C++ Note: values checked -1.055886 -15 C++ Note: sums checked 3937.61 0.001957775 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 3937.61 0.001957775 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 3937.61 0.001957775 C++ Note: df99,1058,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Note: 86 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 1 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 1557 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked -1.05589 -15 C++ Note: sums checked 3937.61 0.00195777 C++ Note: derivs checked 1313.61 0.00195777 C++ Note: second derivs checked 1313.61 0.00195777 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 3937.61 0.00195777 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 3937.61 0.00195777 C++ Note: risk checked 3937.61 C++ Note: risk1 checked 1313.61 0.00120452 C++ Note: risk2 checked 1313.61 0.00120452 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2514.06 C++ Note: risk1r checked 878.06 0.000769057 C++ Note: risk2r checked 878.06 0.000769057 C++ Note: riskl checked 64.4802 C++ Note: risk1l checked 11.4802 1.97246e-05 C++ Note: risk2l checked 11.4802 1.97246e-05 C++ Note: df101 -301.575 -301.575 C++ Note: df102 -0.00472803 -1.08526e-20 C++ Note: df103 -19.5429 -9.74088e-21 C++ Note: df104 -1.05589 -15 C++ Note: df105 0.00024193 1.11413 C++ Note: df106 63784.6 2.77883e+22 C++ Note: Starting Halves C++ Note: df501 -301.5755 C++ Note: df504 -1.055886 -15 C++ Note: values checked -1.05607 -15 C++ Note: sums checked 3937.37 0.00195777 C++ Note: derivs checked 1313.37 0.00195777 C++ Note: second derivs checked 1313.37 0.00195777 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 3937.37 0.00195777 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 3937.37 0.00195777 C++ Note: risk checked 3937.37 C++ Note: risk1 checked 1313.37 0.00120445 C++ Note: risk2 checked 1313.37 0.00120445 C++ Note: riskr checked 2513.9 C++ Note: risk1r checked 877.901 0.000769008 C++ Note: risk2r checked 877.901 0.000769008 C++ Note: riskl checked 64.4781 C++ Note: risk1l checked 11.4781 1.9724e-05 C++ Note: risk2l checked 11.4781 1.9724e-05 C++ Note: df101 -301.575 -301.575 C++ Note: df102 -0.00118208 -6.29981e-21 C++ Note: df103 -19.5421 -6.29981e-21 C++ Note: df104 -1.05607 -15 C++ Note: df105 6.04892e-05 1 C++ Note: df106 255122 4.78706e+22 C++ Note: df100 5691 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 2513.9 C++ Note: risk1r checked 877.901 0.000769008 C++ Note: risk2r checked 877.901 0.000769008 C++ Note: riskl checked 64.4781 C++ Note: risk1l checked 11.4781 1.9724e-05 C++ Note: risk2l checked 11.4781 1.9724e-05 C++ Note: df101 -301.575 -301.575 C++ Note: df102 -0.00118208 -6.29981e-21 C++ Note: df103 -19.5421 -6.29981e-21 C++ Note: df104 -1.05607 -15 C++ Note: df105 6.04892e-05 1 C++ Note: df106 255122 4.78706e+22 C++ Note: ending guess 0 C++ Note: df501 -301.5755 C++ Note: df504 -1.056067 -15 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -1.056067 -15, -301.5755<-- Best Guess C++ Note: starting subterms 2 in best guess 0 C++ Note: values checked -1.05607 -15 C++ Note: sums checked 3937.37 0.00195777 C++ Note: derivs checked 1313.37 0.00195777 C++ Note: second derivs checked 1313.37 0.00195777 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 3937.37 0.00195777 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 3937.37 0.00195777 C++ Note: risk checked 3937.37 C++ Note: risk1 checked 1313.37 0.00120445 C++ Note: risk2 checked 1313.37 0.00120445 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2513.9 C++ Note: risk1r checked 877.901 0.000769008 C++ Note: risk2r checked 877.901 0.000769008 C++ Note: riskl checked 64.4781 C++ Note: risk1l checked 11.4781 1.9724e-05 C++ Note: risk2l checked 11.4781 1.9724e-05 C++ Note: df101 -301.575 -301.575 C++ Note: df102 -0.00118208 -6.29981e-21 C++ Note: df103 -19.5421 -6.29981e-21 C++ Note: df104 -1.05607 -15 C++ Note: df105 6.04892e-05 1 C++ Note: df106 255122 4.78706e+22 C++ Note: Starting Halves C++ Note: df501 -301.5755 C++ Note: df504 -1.056067 -15 C++ Note: values checked -1.05611 -15 C++ Note: sums checked 3937.31 0.00195777 C++ Note: derivs checked 1313.31 0.00195777 C++ Note: second derivs checked 1313.31 0.00195777 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 3937.31 0.00195777 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 3937.31 0.00195777 C++ Note: risk checked 3937.31 C++ Note: risk1 checked 1313.31 0.00120443 C++ Note: risk2 checked 1313.31 0.00120443 C++ Note: riskr checked 2513.86 C++ Note: risk1r checked 877.861 0.000768996 C++ Note: risk2r checked 877.861 0.000768996 C++ Note: riskl checked 64.4776 C++ Note: risk1l checked 11.4776 1.97238e-05 C++ Note: risk2l checked 11.4776 1.97238e-05 C++ Note: df101 -301.575 -301.575 C++ Note: df102 -0.000295526 -2.06464e-21 C++ Note: df103 -19.5419 -2.06464e-21 C++ Note: df104 -1.05611 -15 C++ Note: df105 1.51227e-05 1 C++ Note: df106 1.02047e+06 1.46067e+23 C++ Note: df100 10316 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 2513.86 C++ Note: risk1r checked 877.861 0.000768996 C++ Note: risk2r checked 877.861 0.000768996 C++ Note: riskl checked 64.4776 C++ Note: risk1l checked 11.4776 1.97238e-05 C++ Note: risk2l checked 11.4776 1.97238e-05 C++ Note: df101 -301.575 -301.575 C++ Note: df102 -0.000295526 -2.06464e-21 C++ Note: df103 -19.5419 -2.06464e-21 C++ Note: df104 -1.05611 -15 C++ Note: df105 1.51227e-05 1 C++ Note: df106 1.02047e+06 1.46067e+23 C++ Note: riskr checked 2513.86 C++ Note: risk1r checked 877.861 0.000768996 C++ Note: risk2r checked 877.861 0.000768996 C++ Note: riskl checked 64.4776 C++ Note: risk1l checked 11.4776 1.97238e-05 C++ Note: risk2l checked 11.4776 1.97238e-05 C++ Note: df101 -301.575 -301.575 C++ Note: df102 -0.000295526 -2.06464e-21 C++ Note: df103 -19.5419 -2.06464e-21 C++ Note: df104 -1.05611 -15 C++ Note: df105 1.51227e-05 1 C++ Note: df106 1.02047e+06 1.46067e+23 C++ Note: Exiting Regression C++ Note: df501 -301.5755 C++ Note: df504 -1.056113 -15 Error: guesses_control and model_control have different strata options Note: 2 strata used Note: 86 risk groups Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 1 C++ Note: df99,24,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 2 C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.949 0.001957775 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.949 0.001957775 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.949 0.001957775 C++ Note: df99,407,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Note: 1 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 1 C++ Note: df99,23,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 2 C++ Note: values checked -0.4291924 -15.30179 C++ Note: sums checked 5082.307 0.001447756 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5082.307 0.001447756 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5082.307 0.001447756 C++ Note: df99,399,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Note: 2 strata used Note: 86 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 1 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 1838 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 2 in guess 0 C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.95 0.00195777 C++ Note: derivs checked 3813.95 0.00195777 C++ Note: second derivs checked 3813.95 0.00195777 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.95 0.00195777 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.95 0.00195777 C++ Note: risk checked 6437.95 C++ Note: risk1 checked 3813.95 0.00196938 C++ Note: risk2 checked 3813.95 0.00196938 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1135 832.282 C++ Note: riskl checked 53 33.3317 C++ Note: df101 -248.958 -248.958 C++ Note: df102 2.22045e-16 -1.53525e-21 C++ Note: df103 -2.22045e-16 -1.53525e-21 C++ Note: df104 0.01 -15 C++ Note: df105 -1 1 C++ Note: df106 -1.12121e+18 1.62162e+23 C++ Note: Starting Halves C++ Note: df501 -248.9581 C++ Note: df504 0.01 -15 C++ Note: values checked 0.76 -15.8017 C++ Note: sums checked 10698.1 0.00087817 C++ Note: derivs checked 8074.13 0.00087817 C++ Note: second derivs checked 8074.13 0.00087817 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 10698.1 0.00087817 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 10698.1 0.00087817 C++ Note: risk checked 10698.1 C++ Note: risk1 checked 8074.14 0.00146793 C++ Note: risk2 checked 8074.14 0.00146793 C++ Note: riskr checked 1135 1761.94 C++ Note: riskl checked 53 70.5632 C++ Note: df101 -248.958 -248.958 C++ Note: df102 8.88178e-16 -1.1382e-21 C++ Note: df103 -8.88178e-16 -1.1382e-21 C++ Note: df104 0.76 -15.8017 C++ Note: df105 -1 1 C++ Note: df106 -2.80302e+17 2.1873e+23 C++ Note: df100 7004 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: values checked 0.385 -15.4009 C++ Note: sums checked 8173.26 0.0013112 C++ Note: derivs checked 5549.26 0.0013112 C++ Note: second derivs checked 5549.26 0.0013112 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 8173.26 0.0013112 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 8173.26 0.0013112 C++ Note: risk checked 8173.27 C++ Note: risk1 checked 5549.27 0.0016745 C++ Note: risk2 checked 5549.27 0.0016745 C++ Note: riskr checked 1135 1210.96 C++ Note: riskl checked 53 48.4973 C++ Note: df101 -248.958 -248.958 C++ Note: df102 3.33067e-16 -2.30287e-21 C++ Note: df103 -3.33067e-16 -2.30287e-21 C++ Note: df104 0.385 -15.4009 C++ Note: df105 -1 1 C++ Note: df106 -7.47472e+17 1.08108e+23 C++ Note: df100 9497 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: values checked 0.1975 -15.2004 C++ Note: sums checked 7224.5 0.0016022 C++ Note: derivs checked 4600.5 0.0016022 C++ Note: second derivs checked 4600.5 0.0016022 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 7224.5 0.0016022 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 7224.5 0.0016022 C++ Note: risk checked 7224.5 C++ Note: risk1 checked 4600.5 0.00180861 C++ Note: risk2 checked 4600.5 0.00180861 C++ Note: riskr checked 1135 1003.92 C++ Note: riskl checked 53 40.2057 C++ Note: df101 -248.958 -248.958 C++ Note: df102 4.44089e-16 1.90582e-21 C++ Note: df103 -4.44089e-16 -1.79995e-21 C++ Note: df104 0.1975 -15.2004 C++ Note: df105 -1 -1.05882 C++ Note: df106 -5.60604e+17 -1.3063e+23 C++ Note: df100 11992 3 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: values checked 0.10375 -15.1002 C++ Note: sums checked 6812.8 0.00177109 C++ Note: derivs checked 4188.8 0.00177109 C++ Note: second derivs checked 4188.8 0.00177109 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6812.8 0.00177109 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6812.8 0.00177109 C++ Note: risk checked 6812.81 C++ Note: risk1 checked 4188.81 0.00188532 C++ Note: risk2 checked 4188.81 0.00188532 C++ Note: riskr checked 1135 914.083 C++ Note: riskl checked 53 36.6077 C++ Note: df101 -248.958 -248.958 C++ Note: df102 4.44089e-16 3.17637e-22 C++ Note: df103 -4.44089e-16 3.17637e-22 C++ Note: df104 0.10375 -15.1002 C++ Note: df105 -1 1 C++ Note: df106 -5.60604e+17 -7.83781e+23 C++ Note: df100 14477 4 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: values checked 0.056875 -15.0501 C++ Note: sums checked 6620.98 0.00186209 C++ Note: derivs checked 3996.98 0.00186209 C++ Note: second derivs checked 3996.98 0.00186209 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6620.98 0.00186209 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6620.98 0.00186209 C++ Note: risk checked 6620.99 C++ Note: risk1 checked 3996.99 0.00192639 C++ Note: risk2 checked 3996.99 0.00192639 C++ Note: riskr checked 1135 872.224 C++ Note: riskl checked 53 34.9313 C++ Note: df101 -248.958 -248.958 C++ Note: df102 4.77396e-15 -8.99973e-22 C++ Note: df103 -9.32587e-15 -8.99973e-22 C++ Note: df104 0.056875 -15.0501 C++ Note: df105 -0.511905 1 C++ Note: df106 -5.21492e+16 2.76629e+23 C++ Note: df100 16956 5 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Changing back to best C++ Note: values checked 0.01 -15 C++ Note: sums checked 6437.95 0.00195777 C++ Note: derivs checked 3813.95 0.00195777 C++ Note: second derivs checked 3813.95 0.00195777 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6437.95 0.00195777 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6437.95 0.00195777 C++ Note: risk checked 6437.95 C++ Note: risk1 checked 3813.95 0.00196938 C++ Note: risk2 checked 3813.95 0.00196938 C++ Note: riskr checked 1135 832.282 C++ Note: riskl checked 53 33.3317 C++ Note: df101 -248.958 -248.958 C++ Note: df102 2.22045e-16 -1.53525e-21 C++ Note: df103 -2.22045e-16 -1.53525e-21 C++ Note: df104 0.01 -15 C++ Note: df105 -1 1 C++ Note: df106 -1.12121e+18 1.62162e+23 C++ Note: ending guess 0 C++ Note: df501 -248.9581 C++ Note: df504 0.01 -15 C++ Note: starting subterms 2 in guess 1 C++ Note: values checked -0.429192 -15.3018 C++ Note: sums checked 5082.31 0.00144776 C++ Note: derivs checked 2458.31 0.00144776 C++ Note: second derivs checked 2458.31 0.00144776 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5082.31 0.00144776 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5082.31 0.00144776 C++ Note: risk checked 5082.31 C++ Note: risk1 checked 2458.31 0.00114968 C++ Note: risk2 checked 2458.31 0.00114968 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1135 536.453 C++ Note: riskl checked 53 21.4841 C++ Note: df101 -248.958 -248.958 C++ Note: df102 5.55112e-16 -3.70577e-22 C++ Note: df103 -5.55112e-16 -3.70577e-22 C++ Note: df104 -0.429192 -15.3018 C++ Note: df105 -1 1 C++ Note: df106 -4.48483e+17 6.71812e+23 C++ Note: Starting Halves C++ Note: df501 -248.9581 C++ Note: df504 0.01 -15 C++ Note: values checked 0.320808 -16.3018 C++ Note: sums checked 7828.24 0.0005326 C++ Note: derivs checked 5204.24 0.0005326 C++ Note: second derivs checked 5204.24 0.0005326 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 7828.24 0.0005326 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 7828.24 0.0005326 C++ Note: risk checked 7828.24 C++ Note: risk1 checked 5204.24 0.000651456 C++ Note: risk2 checked 5204.24 0.000651456 C++ Note: riskr checked 1135 1135.67 C++ Note: riskl checked 53 45.4819 C++ Note: df101 -248.958 -248.958 C++ Note: df102 3.33067e-16 4.49986e-22 C++ Note: df103 -3.33067e-16 4.49986e-22 C++ Note: df104 0.320808 -16.3018 C++ Note: df105 -1 1 C++ Note: df106 -7.47472e+17 -5.53257e+23 C++ Note: df100 24417 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: values checked -0.0541923 -15.8018 C++ Note: sums checked 6200.82 0.000878109 C++ Note: derivs checked 3576.82 0.000878109 C++ Note: second derivs checked 3576.82 0.000878109 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6200.82 0.000878109 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6200.82 0.000878109 C++ Note: risk checked 6200.82 C++ Note: risk1 checked 3576.82 0.00085078 C++ Note: risk2 checked 3576.82 0.00085078 C++ Note: riskr checked 1135 780.534 C++ Note: riskl checked 53 31.2593 C++ Note: df101 -248.958 -248.958 C++ Note: df102 -3.33067e-15 -1.05879e-21 C++ Note: df103 3.33067e-15 -9.52912e-22 C++ Note: df104 -0.0541923 -15.8018 C++ Note: df105 -1 1.11111 C++ Note: df106 7.47472e+16 2.35134e+23 C++ Note: df100 26969 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: values checked -0.241692 -15.5518 C++ Note: sums checked 5589.28 0.00112751 C++ Note: derivs checked 2965.28 0.00112751 C++ Note: second derivs checked 2965.28 0.00112751 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5589.28 0.00112751 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5589.28 0.00112751 C++ Note: risk checked 5589.29 C++ Note: risk1 checked 2965.28 0.000984687 C++ Note: risk2 checked 2965.28 0.000984687 C++ Note: riskr checked 1135 647.085 C++ Note: riskl checked 53 25.9148 C++ Note: df101 -248.958 -248.958 C++ Note: df102 4.21885e-15 2.35581e-21 C++ Note: df103 -7.99361e-15 2.35581e-21 C++ Note: df104 -0.241692 -15.5518 C++ Note: df105 -0.527778 1 C++ Note: df106 -5.90109e+16 -1.05678e+23 C++ Note: df100 29452 3 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: values checked -0.335442 -15.4268 C++ Note: sums checked 5323.92 0.00127764 C++ Note: derivs checked 2699.92 0.00127764 C++ Note: second derivs checked 2699.92 0.00127764 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5323.92 0.00127764 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5323.92 0.00127764 C++ Note: risk checked 5323.92 C++ Note: risk1 checked 2699.92 0.00106282 C++ Note: risk2 checked 2699.92 0.00106282 C++ Note: riskr checked 1135 589.178 C++ Note: riskl checked 53 23.5957 C++ Note: df101 -248.958 -248.958 C++ Note: df102 3.33067e-16 1.16467e-21 C++ Note: df103 -3.33067e-16 1.6676e-21 C++ Note: df104 -0.335442 -15.4268 C++ Note: df105 -1 0.698413 C++ Note: df106 -7.47472e+17 -2.13758e+23 C++ Note: df100 31938 4 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: values checked -0.382317 -15.3643 C++ Note: sums checked 5200.28 0.00136004 C++ Note: derivs checked 2576.28 0.00136004 C++ Note: second derivs checked 2576.28 0.00136004 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5200.28 0.00136004 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5200.28 0.00136004 C++ Note: risk checked 5200.28 C++ Note: risk1 checked 2576.28 0.00110509 C++ Note: risk2 checked 2576.28 0.00110509 C++ Note: riskr checked 1135 562.198 C++ Note: riskl checked 53 22.5152 C++ Note: df101 -248.958 -248.958 C++ Note: df102 5.55112e-16 -1.21761e-21 C++ Note: df103 -5.55112e-16 -1.21761e-21 C++ Note: df104 -0.382317 -15.3643 C++ Note: df105 -1 1 C++ Note: df106 -4.48483e+17 2.04465e+23 C++ Note: df100 34414 5 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Changing back to best C++ Note: values checked -0.429192 -15.3018 C++ Note: sums checked 5082.31 0.00144776 C++ Note: derivs checked 2458.31 0.00144776 C++ Note: second derivs checked 2458.31 0.00144776 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5082.31 0.00144776 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5082.31 0.00144776 C++ Note: risk checked 5082.31 C++ Note: risk1 checked 2458.31 0.00114968 C++ Note: risk2 checked 2458.31 0.00114968 C++ Note: riskr checked 1135 536.453 C++ Note: riskl checked 53 21.4841 C++ Note: df101 -248.958 -248.958 C++ Note: df102 5.55112e-16 -3.70577e-22 C++ Note: df103 -5.55112e-16 -3.70577e-22 C++ Note: df104 -0.429192 -15.3018 C++ Note: df105 -1 1 C++ Note: df106 -4.48483e+17 6.71812e+23 C++ Note: ending guess 1 C++ Note: df501 -248.9581 C++ Note: df504 -0.4291924 -15.30179 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.01 -15, -248.9581 1, -0.4291924 -15.30179, -248.9581<-- Best Guess C++ Note: starting subterms 2 in best guess 1 C++ Note: values checked -0.429192 -15.3018 C++ Note: sums checked 5082.31 0.00144776 C++ Note: derivs checked 2458.31 0.00144776 C++ Note: second derivs checked 2458.31 0.00144776 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5082.31 0.00144776 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5082.31 0.00144776 C++ Note: risk checked 5082.31 C++ Note: risk1 checked 2458.31 0.00114968 C++ Note: risk2 checked 2458.31 0.00114968 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1135 536.453 C++ Note: riskl checked 53 21.4841 C++ Note: df101 -248.958 -248.958 C++ Note: df102 5.55112e-16 -3.70577e-22 C++ Note: df103 -5.55112e-16 -3.70577e-22 C++ Note: df104 -0.429192 -15.3018 C++ Note: df105 -1 1 C++ Note: df106 -4.48483e+17 6.71812e+23 C++ Note: Starting Halves C++ Note: df501 -248.9581 C++ Note: df504 -0.4291924 -15.30179 C++ Note: values checked 0.320808 -16.3018 C++ Note: sums checked 7828.24 0.0005326 C++ Note: derivs checked 5204.24 0.0005326 C++ Note: second derivs checked 5204.24 0.0005326 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 7828.24 0.0005326 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 7828.24 0.0005326 C++ Note: risk checked 7828.24 C++ Note: risk1 checked 5204.24 0.000651456 C++ Note: risk2 checked 5204.24 0.000651456 C++ Note: riskr checked 1135 1135.67 C++ Note: riskl checked 53 45.4819 C++ Note: df101 -248.958 -248.958 C++ Note: df102 3.33067e-16 4.49986e-22 C++ Note: df103 -3.33067e-16 4.49986e-22 C++ Note: df104 0.320808 -16.3018 C++ Note: df105 -1 1 C++ Note: df106 -7.47472e+17 -5.53257e+23 C++ Note: df100 42045 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: values checked -0.0541923 -15.8018 C++ Note: sums checked 6200.82 0.000878109 C++ Note: derivs checked 3576.82 0.000878109 C++ Note: second derivs checked 3576.82 0.000878109 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 6200.82 0.000878109 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 6200.82 0.000878109 C++ Note: risk checked 6200.82 C++ Note: risk1 checked 3576.82 0.00085078 C++ Note: risk2 checked 3576.82 0.00085078 C++ Note: riskr checked 1135 780.534 C++ Note: riskl checked 53 31.2593 C++ Note: df101 -248.958 -248.958 C++ Note: df102 -3.33067e-15 -1.05879e-21 C++ Note: df103 3.33067e-15 -9.52912e-22 C++ Note: df104 -0.0541923 -15.8018 C++ Note: df105 -1 1.11111 C++ Note: df106 7.47472e+16 2.35134e+23 C++ Note: df100 44525 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: values checked -0.241692 -15.5518 C++ Note: sums checked 5589.28 0.00112751 C++ Note: derivs checked 2965.28 0.00112751 C++ Note: second derivs checked 2965.28 0.00112751 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5589.28 0.00112751 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5589.28 0.00112751 C++ Note: risk checked 5589.29 C++ Note: risk1 checked 2965.28 0.000984687 C++ Note: risk2 checked 2965.28 0.000984687 C++ Note: riskr checked 1135 647.085 C++ Note: riskl checked 53 25.9148 C++ Note: df101 -248.958 -248.958 C++ Note: df102 4.21885e-15 2.35581e-21 C++ Note: df103 -7.99361e-15 2.35581e-21 C++ Note: df104 -0.241692 -15.5518 C++ Note: df105 -0.527778 1 C++ Note: df106 -5.90109e+16 -1.05678e+23 C++ Note: df100 47012 3 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: values checked -0.335442 -15.4268 C++ Note: sums checked 5323.92 0.00127764 C++ Note: derivs checked 2699.92 0.00127764 C++ Note: second derivs checked 2699.92 0.00127764 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5323.92 0.00127764 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5323.92 0.00127764 C++ Note: risk checked 5323.92 C++ Note: risk1 checked 2699.92 0.00106282 C++ Note: risk2 checked 2699.92 0.00106282 C++ Note: riskr checked 1135 589.178 C++ Note: riskl checked 53 23.5957 C++ Note: df101 -248.958 -248.958 C++ Note: df102 3.33067e-16 1.16467e-21 C++ Note: df103 -3.33067e-16 1.6676e-21 C++ Note: df104 -0.335442 -15.4268 C++ Note: df105 -1 0.698413 C++ Note: df106 -7.47472e+17 -2.13758e+23 C++ Note: df100 49498 4 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: values checked -0.382317 -15.3643 C++ Note: sums checked 5200.28 0.00136004 C++ Note: derivs checked 2576.28 0.00136004 C++ Note: second derivs checked 2576.28 0.00136004 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5200.28 0.00136004 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5200.28 0.00136004 C++ Note: risk checked 5200.28 C++ Note: risk1 checked 2576.28 0.00110509 C++ Note: risk2 checked 2576.28 0.00110509 C++ Note: riskr checked 1135 562.198 C++ Note: riskl checked 53 22.5152 C++ Note: df101 -248.958 -248.958 C++ Note: df102 5.55112e-16 -1.21761e-21 C++ Note: df103 -5.55112e-16 -1.21761e-21 C++ Note: df104 -0.382317 -15.3643 C++ Note: df105 -1 1 C++ Note: df106 -4.48483e+17 2.04465e+23 C++ Note: df100 51979 5 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Changing back to best C++ Note: values checked -0.429192 -15.3018 C++ Note: sums checked 5082.31 0.00144776 C++ Note: derivs checked 2458.31 0.00144776 C++ Note: second derivs checked 2458.31 0.00144776 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5082.31 0.00144776 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5082.31 0.00144776 C++ Note: risk checked 5082.31 C++ Note: risk1 checked 2458.31 0.00114968 C++ Note: risk2 checked 2458.31 0.00114968 C++ Note: riskr checked 1135 536.453 C++ Note: riskl checked 53 21.4841 C++ Note: df101 -248.958 -248.958 C++ Note: df102 5.55112e-16 -3.70577e-22 C++ Note: df103 -5.55112e-16 -3.70577e-22 C++ Note: df104 -0.429192 -15.3018 C++ Note: df105 -1 1 C++ Note: df106 -4.48483e+17 6.71812e+23 C++ Note: Starting Halves C++ Note: df501 -248.9581 C++ Note: df504 -0.4291924 -15.30179 C++ Note: values checked -0.397942 -15.333 C++ Note: sums checked 5160.34 0.00140321 C++ Note: derivs checked 2536.34 0.00140321 C++ Note: second derivs checked 2536.34 0.00140321 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5160.34 0.00140321 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5160.34 0.00140321 C++ Note: risk checked 5160.34 C++ Note: risk1 checked 2536.34 0.00113142 C++ Note: risk2 checked 2536.34 0.00113142 C++ Note: riskr checked 1135 553.481 C++ Note: riskl checked 53 22.1661 C++ Note: df101 -248.958 -248.958 C++ Note: df102 -4.77396e-15 -3.17637e-22 C++ Note: df103 9.65894e-15 1.29702e-21 C++ Note: df104 -0.397942 -15.333 C++ Note: df105 -0.494253 -0.244898 C++ Note: df106 5.21492e+16 7.83781e+23 C++ Note: df100 57039 1 2 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: values checked -0.413567 -15.3174 C++ Note: sums checked 5121.02 0.00142531 C++ Note: derivs checked 2497.02 0.00142531 C++ Note: second derivs checked 2497.02 0.00142531 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5121.02 0.00142531 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5121.02 0.00142531 C++ Note: risk checked 5121.02 C++ Note: risk1 checked 2497.02 0.00114048 C++ Note: risk2 checked 2497.02 0.00114048 C++ Note: riskr checked 1135 544.901 C++ Note: riskl checked 53 21.8225 C++ Note: df101 -248.958 -248.958 C++ Note: df102 5.55112e-16 -8.73503e-22 C++ Note: df103 -5.55112e-16 -8.73503e-22 C++ Note: df104 -0.413567 -15.3174 C++ Note: df105 -1 1 C++ Note: df106 -4.48483e+17 2.85011e+23 C++ Note: df100 59595 2 2 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: values checked -0.42138 -15.3096 C++ Note: sums checked 5101.59 0.00143649 C++ Note: derivs checked 2477.59 0.00143649 C++ Note: second derivs checked 2477.59 0.00143649 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5101.59 0.00143649 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5101.59 0.00143649 C++ Note: risk checked 5101.59 C++ Note: risk1 checked 2477.59 0.00114506 C++ Note: risk2 checked 2477.59 0.00114506 C++ Note: riskr checked 1135 540.66 C++ Note: riskl checked 53 21.6526 C++ Note: df101 -248.958 -248.958 C++ Note: df102 5.55112e-16 1.03232e-21 C++ Note: df103 -5.55112e-16 7.41154e-22 C++ Note: df104 -0.42138 -15.3096 C++ Note: df105 -1 1.39286 C++ Note: df106 -4.48483e+17 -2.41163e+23 C++ Note: df100 62089 3 2 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: values checked -0.425286 -15.3057 C++ Note: sums checked 5091.93 0.00144211 C++ Note: derivs checked 2467.93 0.00144211 C++ Note: second derivs checked 2467.93 0.00144211 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5091.93 0.00144211 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5091.93 0.00144211 C++ Note: risk checked 5091.93 C++ Note: risk1 checked 2467.93 0.00114736 C++ Note: risk2 checked 2467.93 0.00114736 C++ Note: riskr checked 1135 538.552 C++ Note: riskl checked 53 21.5682 C++ Note: df101 -248.958 -248.958 C++ Note: df102 1.22125e-15 -2.62051e-21 C++ Note: df103 -1.88738e-15 -1.45584e-21 C++ Note: df104 -0.425286 -15.3057 C++ Note: df105 -0.647059 1.8 C++ Note: df106 -2.03856e+17 9.50037e+22 C++ Note: df100 64573 4 2 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: values checked -0.427239 -15.3037 C++ Note: sums checked 5087.11 0.00144493 C++ Note: derivs checked 2463.11 0.00144493 C++ Note: second derivs checked 2463.11 0.00144493 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5087.11 0.00144493 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5087.11 0.00144493 C++ Note: risk checked 5087.11 C++ Note: risk1 checked 2463.11 0.00114852 C++ Note: risk2 checked 2463.11 0.00114852 C++ Note: riskr checked 1135 537.501 C++ Note: riskl checked 53 21.5261 C++ Note: df101 -248.958 -248.958 C++ Note: df102 5.55112e-16 1.64113e-21 C++ Note: df103 -5.55112e-16 2.30287e-21 C++ Note: df104 -0.427239 -15.3037 C++ Note: df105 -1 0.712644 C++ Note: df106 -4.48483e+17 -1.517e+23 C++ Note: df100 67052 5 2 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Changing back to best C++ Note: values checked -0.429192 -15.3018 C++ Note: sums checked 5082.31 0.00144776 C++ Note: derivs checked 2458.31 0.00144776 C++ Note: second derivs checked 2458.31 0.00144776 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5082.31 0.00144776 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5082.31 0.00144776 C++ Note: risk checked 5082.31 C++ Note: risk1 checked 2458.31 0.00114968 C++ Note: risk2 checked 2458.31 0.00114968 C++ Note: riskr checked 1135 536.453 C++ Note: riskl checked 53 21.4841 C++ Note: df101 -248.958 -248.958 C++ Note: df102 5.55112e-16 -3.70577e-22 C++ Note: df103 -5.55112e-16 -3.70577e-22 C++ Note: df104 -0.429192 -15.3018 C++ Note: df105 -1 1 C++ Note: df106 -4.48483e+17 6.71812e+23 C++ Note: Starting Halves C++ Note: df501 -248.9581 C++ Note: df504 -0.4291924 -15.30179 C++ Note: values checked -0.428216 -15.3028 C++ Note: sums checked 5084.71 0.00144634 C++ Note: derivs checked 2460.71 0.00144634 C++ Note: second derivs checked 2460.71 0.00144634 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5084.71 0.00144634 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5084.71 0.00144634 C++ Note: risk checked 5084.71 C++ Note: risk1 checked 2460.71 0.0011491 C++ Note: risk2 checked 2460.71 0.0011491 C++ Note: riskr checked 1135 536.977 C++ Note: riskl checked 53 21.5051 C++ Note: df101 -248.958 -248.958 C++ Note: df102 -5.9952e-15 -4.49986e-21 C++ Note: df103 1.19904e-14 -4.49986e-21 C++ Note: df104 -0.428216 -15.3028 C++ Note: df105 -0.5 1 C++ Note: df106 4.15262e+16 5.53257e+22 C++ Note: df100 72069 1 3 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: values checked -0.428704 -15.3023 C++ Note: sums checked 5083.51 0.00144705 C++ Note: derivs checked 2459.51 0.00144705 C++ Note: second derivs checked 2459.51 0.00144705 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5083.51 0.00144705 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5083.51 0.00144705 C++ Note: risk checked 5083.51 C++ Note: risk1 checked 2459.51 0.00114939 C++ Note: risk2 checked 2459.51 0.00114939 C++ Note: riskr checked 1135 536.715 C++ Note: riskl checked 53 21.4946 C++ Note: df101 -248.958 -248.958 C++ Note: df102 8.88178e-16 -8.20563e-22 C++ Note: df103 -8.88178e-16 7.94093e-23 C++ Note: df104 -0.428704 -15.3023 C++ Note: df105 -1 -10.3333 C++ Note: df106 -2.80302e+17 3.03399e+23 C++ Note: df100 74552 2 3 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: values checked -0.428948 -15.302 C++ Note: sums checked 5082.91 0.0014474 C++ Note: derivs checked 2458.91 0.0014474 C++ Note: second derivs checked 2458.91 0.0014474 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5082.91 0.0014474 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5082.91 0.0014474 C++ Note: risk checked 5082.91 C++ Note: risk1 checked 2458.91 0.00114953 C++ Note: risk2 checked 2458.91 0.00114953 C++ Note: riskr checked 1135 536.584 C++ Note: riskl checked 53 21.4894 C++ Note: df101 -248.958 -248.958 C++ Note: df102 -5.55112e-15 -3.20284e-21 C++ Note: df103 7.88258e-15 -2.72639e-21 C++ Note: df104 -0.428948 -15.302 C++ Note: df105 -0.704225 1.17476 C++ Note: df106 4.48483e+16 7.77303e+22 C++ Note: df100 77033 3 3 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: values checked -0.42907 -15.3019 C++ Note: sums checked 5082.61 0.00144758 C++ Note: derivs checked 2458.61 0.00144758 C++ Note: second derivs checked 2458.61 0.00144758 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5082.61 0.00144758 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5082.61 0.00144758 C++ Note: risk checked 5082.61 C++ Note: risk1 checked 2458.61 0.00114961 C++ Note: risk2 checked 2458.61 0.00114961 C++ Note: riskr checked 1135 536.518 C++ Note: riskl checked 53 21.4868 C++ Note: df101 -248.958 -248.958 C++ Note: df102 6.66134e-16 2.48816e-21 C++ Note: df103 -6.66134e-16 2.48816e-21 C++ Note: df104 -0.42907 -15.3019 C++ Note: df105 -1 1 C++ Note: df106 -3.73736e+17 -1.00057e+23 C++ Note: df100 79508 4 3 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: values checked -0.429131 -15.3019 C++ Note: sums checked 5082.46 0.00144767 C++ Note: derivs checked 2458.46 0.00144767 C++ Note: second derivs checked 2458.46 0.00144767 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5082.46 0.00144767 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5082.46 0.00144767 C++ Note: risk checked 5082.46 C++ Note: risk1 checked 2458.46 0.00114964 C++ Note: risk2 checked 2458.46 0.00114964 C++ Note: riskr checked 1135 536.485 C++ Note: riskl checked 53 21.4855 C++ Note: df101 -248.958 -248.958 C++ Note: df102 3.33067e-16 -2.11758e-22 C++ Note: df103 -3.33067e-16 -1.32349e-21 C++ Note: df104 -0.429131 -15.3019 C++ Note: df105 -1 0.16 C++ Note: df106 -7.47472e+17 1.17567e+24 C++ Note: df100 81992 5 3 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Changing back to best C++ Note: values checked -0.429192 -15.3018 C++ Note: sums checked 5082.31 0.00144776 C++ Note: derivs checked 2458.31 0.00144776 C++ Note: second derivs checked 2458.31 0.00144776 C++ Note: dose checked 6400 6400 C++ Note: non-dose checked 5082.31 0.00144776 C++ Note: LIN_non-dose checked 6400 6400 C++ Note: PLIN_non-dose checked 6400 6400 C++ Note: LOGLIN_non-dose checked 5082.31 0.00144776 C++ Note: risk checked 5082.31 C++ Note: risk1 checked 2458.31 0.00114968 C++ Note: risk2 checked 2458.31 0.00114968 C++ Note: riskr checked 1135 536.453 C++ Note: riskl checked 53 21.4841 C++ Note: df101 -248.958 -248.958 C++ Note: df102 5.55112e-16 -3.70577e-22 C++ Note: df103 -5.55112e-16 -3.70577e-22 C++ Note: df104 -0.429192 -15.3018 C++ Note: df105 -1 1 C++ Note: df106 -4.48483e+17 6.71812e+23 C++ Note: riskr checked 1135 536.453 C++ Note: riskl checked 53 21.4841 C++ Note: df101 -248.958 -248.958 C++ Note: df102 5.55112e-16 -3.70577e-22 C++ Note: df103 -5.55112e-16 -3.70577e-22 C++ Note: df104 -0.429192 -15.3018 C++ Note: df105 -1 1 C++ Note: df106 -4.48483e+17 6.71812e+23 C++ Note: Exiting Regression C++ Note: df501 -248.9581 C++ Note: df504 -0.4291924 -15.30179 Error: Atleast one parameter must be free Error: no events Error: Default Parameters used: 4, Covariates used: 6 Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,31,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.1 6 0.1 0.1 C++ Note: sums checked 254.8 254.8 8.4 8.4 C++ Note: dose checked 7 C++ Note: non-dose checked 338.8 C++ Note: LIN_non-dose checked 8.4 C++ Note: PLIN_non-dose checked 254.8 C++ Note: LOGLIN_non-dose checked 7 C++ Note: df99,228,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Note: 1 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.2215742 6.617788 0.7390184 0.9740044 C++ Note: sums checked 294.2532 294.2532 71.94696 71.94696 C++ Note: dose checked 7 C++ Note: non-dose checked 3352.422 C++ Note: LIN_non-dose checked 71.94696 C++ Note: PLIN_non-dose checked 294.2532 C++ Note: LOGLIN_non-dose checked 7 C++ Note: df99,227,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Note: 2 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,31,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.5654312 6.279162 0.3661973 1.023089 C++ Note: sums checked 294.4729 294.4729 58.35 58.35 C++ Note: dose checked 7 C++ Note: non-dose checked 2720.897 C++ Note: LIN_non-dose checked 58.35 C++ Note: PLIN_non-dose checked 294.4729 C++ Note: LOGLIN_non-dose checked 7 C++ Note: df99,230,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Note: 3 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,31,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.4540596 6.915258 0.7989374 1.006046 C++ Note: sums checked 316.5113 316.5113 75.80929 75.80929 C++ Note: dose checked 7 C++ Note: non-dose checked 3800.228 C++ Note: LIN_non-dose checked 75.80929 C++ Note: PLIN_non-dose checked 316.5113 C++ Note: LOGLIN_non-dose checked 7 C++ Note: df99,224,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Note: 4 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,31,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.005602757 6.392582 0.9584111 0.8517844 C++ Note: sums checked 275.7237 275.7237 76.02821 76.02821 C++ Note: dose checked 7 C++ Note: non-dose checked 3318.978 C++ Note: LIN_non-dose checked 76.02821 C++ Note: PLIN_non-dose checked 275.7237 C++ Note: LOGLIN_non-dose checked 7 C++ Note: df99,220,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Note: 5 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,31,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.4204453 6.836265 0.9252424 0.4260211 C++ Note: sums checked 311.7818 311.7818 56.75307 56.75307 C++ Note: dose checked 7 C++ Note: non-dose checked 2802.357 C++ Note: LIN_non-dose checked 56.75307 C++ Note: PLIN_non-dose checked 311.7818 C++ Note: LOGLIN_non-dose checked 7 C++ Note: df99,226,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Note: 6 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,37,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.05800769 6.850922 0.6988397 0.5647598 C++ Note: sums checked 297.175 297.175 53.07118 53.07118 C++ Note: dose checked 7 C++ Note: non-dose checked 2497.505 C++ Note: LIN_non-dose checked 53.07118 C++ Note: PLIN_non-dose checked 297.175 C++ Note: LOGLIN_non-dose checked 7 C++ Note: df99,236,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Note: 7 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,31,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.5803103 6.831288 0.469853 0.5463882 C++ Note: sums checked 318.2871 318.2871 42.68213 42.68213 C++ Note: dose checked 7 C++ Note: non-dose checked 2151.634 C++ Note: LIN_non-dose checked 42.68213 C++ Note: PLIN_non-dose checked 318.2871 C++ Note: LOGLIN_non-dose checked 7 C++ Note: df99,219,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Note: 8 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,31,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.004723529 6.147166 1.021718 0.6426009 C++ Note: sums checked 265.3794 265.3794 69.9014 69.9014 C++ Note: dose checked 7 C++ Note: non-dose checked 2936.739 C++ Note: LIN_non-dose checked 69.9014 C++ Note: PLIN_non-dose checked 265.3794 C++ Note: LOGLIN_non-dose checked 7 C++ Note: df99,219,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Note: 9 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.569784 6.401194 1.070144 0.3297178 C++ Note: sums checked 299.7811 299.7811 58.7942 58.7942 C++ Note: dose checked 7 C++ Note: non-dose checked 2791.148 C++ Note: LIN_non-dose checked 58.7942 C++ Note: PLIN_non-dose checked 299.7811 C++ Note: LOGLIN_non-dose checked 7 C++ Note: df99,218,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Error: tform not implemented Not Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,32,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.1 6 0.1 0.1 C++ Note: sums checked 6.978181e+23 6.978181e+23 6.978181e+23 6.978181e+23 C++ Note: dose checked 7 C++ Note: non-dose checked 6.978181e+23 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 6.978181e+23 C++ Note: df99,229,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Note: 1 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,31,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 C++ Note: values checked -1.078912 6.381868 -0.6204552 0.1403137 C++ Note: sums checked 7.148279e+18 7.148279e+18 7.148279e+18 7.148279e+18 C++ Note: dose checked 7 C++ Note: non-dose checked 7.148279e+18 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 7.148279e+18 C++ Note: df99,225,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Note: 2 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,31,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.124094 5.233358 0.7481482 0.8674378 C++ Note: sums checked 1.801258e+27 1.801258e+27 1.801258e+27 1.801258e+27 C++ Note: dose checked 7 C++ Note: non-dose checked 1.801258e+27 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 1.801258e+27 C++ Note: df99,224,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Note: 3 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.723155 5.889726 0.2044639 -0.4021117 C++ Note: sums checked 1.190181e+25 1.190181e+25 1.190181e+25 1.190181e+25 C++ Note: dose checked 7 C++ Note: non-dose checked 1.190181e+25 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 1.190181e+25 C++ Note: df99,221,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Note: 4 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,31,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.9384565 5.491963 -0.4929961 0.02297141 C++ Note: sums checked 9.295681e+15 9.295681e+15 9.295681e+15 9.295681e+15 C++ Note: dose checked 7 C++ Note: non-dose checked 9.295681e+15 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 9.295681e+15 C++ Note: df99,223,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Note: 5 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.7582357 5.622153 0.1475021 -0.6665197 C++ Note: sums checked 8.152489e+22 8.152489e+22 8.152489e+22 8.152489e+22 C++ Note: dose checked 7 C++ Note: non-dose checked 8.152489e+22 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 8.152489e+22 C++ Note: df99,226,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Note: 6 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,31,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.3285743 6.883413 -0.7341383 -0.6765644 C++ Note: sums checked 1.285792e+20 1.285792e+20 1.285792e+20 1.285792e+20 C++ Note: dose checked 7 C++ Note: non-dose checked 1.285792e+20 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 1.285792e+20 C++ Note: df99,223,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Note: 7 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,31,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.3835654 5.580549 0.8623136 0.6676176 C++ Note: sums checked 1.966433e+26 1.966433e+26 1.966433e+26 1.966433e+26 C++ Note: dose checked 7 C++ Note: non-dose checked 1.966433e+26 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 1.966433e+26 C++ Note: df99,225,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Note: 8 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 C++ Note: values checked 0.5220103 6.580932 0.07026672 0.2925053 C++ Note: sums checked 1.517451e+29 1.517451e+29 1.517451e+29 1.517451e+29 C++ Note: dose checked 7 C++ Note: non-dose checked 1.517451e+29 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 1.517451e+29 C++ Note: df99,221,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Note: 9 valid guesses C++ Note: START_RISK_CHECK C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 0 0 0 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 C++ Note: values checked -0.7559232 5.684553 -0.3870322 -0.194844 C++ Note: sums checked 9.899231e+16 9.899231e+16 9.899231e+16 9.899231e+16 C++ Note: dose checked 7 C++ Note: non-dose checked 9.899231e+16 C++ Note: LIN_non-dose checked 7 C++ Note: PLIN_non-dose checked 7 C++ Note: LOGLIN_non-dose checked 9.899231e+16 C++ Note: df99,222,Prep_Terms C++ Note: Current Time, Tue Feb 13 19:18:10 2024 Error: verbosity arguement not valid Error: verbosity arguement not valid Error: a0 arguement was not a number Error: a0 arguement was not a number Error: a0 arguement was not a number Error: item e1 in name_list has 1 items, but same item in Term_n_list has 6 items. Omit entry in Term_n_list to set to default of term 0 or add missing values Error: item e1 in name_list has 1 items, but same item in tform_list has 6 items. Omit entry in tform_list to set to default of 'loglin' or add missing values Error: item e1 in name_list has 1 items, but same item in keep_constant_list has 6 items. Omit entry in tform_list to set to default of 0 or add missing values Error: item e1 in name_list has 1 items, but same item in a_n_list has 6 items. Omit entry in a_n_list to set to default of 0 or add missing values Note: 2 strata used Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 806 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 3237 C++ Note: riskl checked 59 Note: 2 strata used Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 C++ Note: df99,22,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 821 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: Made Risk Side Lists C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: Starting Halves C++ Note: df501 -447.4645 C++ Note: df504 0.01 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: df100 2064 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: ending guess 0 C++ Note: df501 -447.4645 C++ Note: df504 0.01 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.01, -447.4645<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: Made Risk Side Lists C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: Starting Halves C++ Note: df501 -447.4645 C++ Note: df504 0.01 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: df100 3765 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: Exiting Regression C++ Note: df501 -447.4645 C++ Note: df504 0.01 Note: 2 strata used Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 775 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 3237 C++ Note: riskl checked 59 Note: 2 strata used Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 C++ Note: df99,21,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 800 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: Made Risk Side Lists C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df102 -4.51629 C++ Note: df103 -38.8061 C++ Note: df104 0.01 C++ Note: df105 0.116381 C++ Note: df106 99.0778 C++ Note: Starting Halves C++ Note: df501 -447.4645 C++ Note: df504 0.01 C++ Note: values checked -0.0772857 C++ Note: sums checked 886.858 C++ Note: risk checked 886.858 C++ Note: risk1 checked 1314.48 C++ Note: risk2 checked 3543.11 C++ Note: riskr checked 2906.58 2520.49 C++ Note: riskl checked 51.6944 47.43 C++ Note: df101 -447.218 C++ Note: df102 -1.11664 C++ Note: df103 -39.0819 C++ Note: df104 -0.0772857 C++ Note: df105 0.0285718 C++ Note: df106 400.504 C++ Note: df100 3454 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 2906.58 2520.49 C++ Note: riskl checked 51.6944 47.43 C++ Note: df101 -447.218 C++ Note: df102 -1.11664 C++ Note: df103 -39.0819 C++ Note: df104 -0.0772857 C++ Note: df105 0.0285718 C++ Note: df106 400.504 C++ Note: ending guess 0 C++ Note: df501 -447.2185 C++ Note: df504 -0.07728569 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.07728569, -447.2185<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.0772857 C++ Note: sums checked 886.858 C++ Note: risk checked 886.858 C++ Note: risk1 checked 1314.48 C++ Note: risk2 checked 3543.11 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2906.58 2520.49 C++ Note: riskl checked 51.6944 47.43 C++ Note: df101 -447.218 C++ Note: df102 -1.11664 C++ Note: df103 -39.0819 C++ Note: df104 -0.0772857 C++ Note: df105 0.0285718 C++ Note: df106 400.504 C++ Note: Starting Halves C++ Note: df501 -447.2185 C++ Note: df504 -0.07728569 C++ Note: values checked -0.0987146 C++ Note: sums checked 859.484 C++ Note: risk checked 859.484 C++ Note: risk1 checked 1241.17 C++ Note: risk2 checked 3301.92 C++ Note: riskr checked 2824.77 2437.74 C++ Note: riskl checked 49.9037 45.6007 C++ Note: df101 -447.204 C++ Note: df102 -0.27852 C++ Note: df103 -39.141 C++ Note: df104 -0.0987146 C++ Note: df105 0.00711582 C++ Note: df106 1605.64 C++ Note: df100 7619 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 2824.77 2437.74 C++ Note: riskl checked 49.9037 45.6007 C++ Note: df101 -447.204 C++ Note: df102 -0.27852 C++ Note: df103 -39.141 C++ Note: df104 -0.0987146 C++ Note: df105 0.00711582 C++ Note: df106 1605.64 C++ Note: riskr checked 2824.77 2437.74 C++ Note: riskl checked 49.9037 45.6007 C++ Note: df101 -447.204 C++ Note: df102 -0.27852 C++ Note: df103 -39.141 C++ Note: df104 -0.0987146 C++ Note: df105 0.00711582 C++ Note: df106 1605.64 C++ Note: Exiting Regression C++ Note: df501 -447.2035 C++ Note: df504 -0.09871455 Note: 2 strata used Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 774 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 3237 C++ Note: riskl checked 59 Note: 2 strata used Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 C++ Note: df99,22,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 806 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: dose checked 1000 C++ Note: non-dose checked 1016.5 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: Made Risk Side Lists C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: Starting Halves C++ Note: df501 -447.4645 C++ Note: df504 0.01 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: dose checked 1000 C++ Note: non-dose checked 1016.5 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: df100 2249 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: ending guess 0 C++ Note: df501 -447.4645 C++ Note: df504 0.01 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.01, -447.4645<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: dose checked 1000 C++ Note: non-dose checked 1016.5 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: Made Risk Side Lists C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: Starting Halves C++ Note: df501 -447.4645 C++ Note: df504 0.01 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: dose checked 1000 C++ Note: non-dose checked 1016.5 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: df100 4031 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df104 0.01 C++ Note: Exiting Regression C++ Note: df501 -447.4645 C++ Note: df504 0.01 Note: 2 strata used Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 962 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 3237 C++ Note: riskl checked 59 Note: 2 strata used Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 C++ Note: df99,21,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 801 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: derivs checked 1673.67 C++ Note: second derivs checked 4753.83 C++ Note: dose checked 1000 C++ Note: non-dose checked 1016.5 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: Made Risk Side Lists C++ Note: riskr checked 3284.26 2905.4 C++ Note: riskl checked 60.0534 56.1054 C++ Note: df101 -447.464 C++ Note: df102 -4.51629 C++ Note: df103 -38.8061 C++ Note: df104 0.01 C++ Note: df105 0.116381 C++ Note: df106 99.0778 C++ Note: Starting Halves C++ Note: df501 -447.4645 C++ Note: df504 0.01 C++ Note: values checked -0.0772857 C++ Note: sums checked 886.858 C++ Note: derivs checked 1314.48 C++ Note: second derivs checked 3543.11 C++ Note: dose checked 1000 C++ Note: non-dose checked 886.858 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 886.858 C++ Note: risk checked 886.858 C++ Note: risk1 checked 1314.48 C++ Note: risk2 checked 3543.11 C++ Note: riskr checked 2906.58 2520.49 C++ Note: riskl checked 51.6944 47.43 C++ Note: df101 -447.218 C++ Note: df102 -1.11664 C++ Note: df103 -39.0819 C++ Note: df104 -0.0772857 C++ Note: df105 0.0285718 C++ Note: df106 400.504 C++ Note: df100 3896 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 2906.58 2520.49 C++ Note: riskl checked 51.6944 47.43 C++ Note: df101 -447.218 C++ Note: df102 -1.11664 C++ Note: df103 -39.0819 C++ Note: df104 -0.0772857 C++ Note: df105 0.0285718 C++ Note: df106 400.504 C++ Note: ending guess 0 C++ Note: df501 -447.2185 C++ Note: df504 -0.07728569 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.07728569, -447.2185<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.0772857 C++ Note: sums checked 886.858 C++ Note: derivs checked 1314.48 C++ Note: second derivs checked 3543.11 C++ Note: dose checked 1000 C++ Note: non-dose checked 886.858 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 886.858 C++ Note: risk checked 886.858 C++ Note: risk1 checked 1314.48 C++ Note: risk2 checked 3543.11 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2906.58 2520.49 C++ Note: riskl checked 51.6944 47.43 C++ Note: df101 -447.218 C++ Note: df102 -1.11664 C++ Note: df103 -39.0819 C++ Note: df104 -0.0772857 C++ Note: df105 0.0285718 C++ Note: df106 400.504 C++ Note: Starting Halves C++ Note: df501 -447.2185 C++ Note: df504 -0.07728569 C++ Note: values checked -0.0987146 C++ Note: sums checked 859.484 C++ Note: derivs checked 1241.17 C++ Note: second derivs checked 3301.92 C++ Note: dose checked 1000 C++ Note: non-dose checked 859.484 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 859.484 C++ Note: risk checked 859.484 C++ Note: risk1 checked 1241.17 C++ Note: risk2 checked 3301.92 C++ Note: riskr checked 2824.77 2437.74 C++ Note: riskl checked 49.9037 45.6007 C++ Note: df101 -447.204 C++ Note: df102 -0.27852 C++ Note: df103 -39.141 C++ Note: df104 -0.0987146 C++ Note: df105 0.00711582 C++ Note: df106 1605.64 C++ Note: df100 8113 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 2824.77 2437.74 C++ Note: riskl checked 49.9037 45.6007 C++ Note: df101 -447.204 C++ Note: df102 -0.27852 C++ Note: df103 -39.141 C++ Note: df104 -0.0987146 C++ Note: df105 0.00711582 C++ Note: df106 1605.64 C++ Note: riskr checked 2824.77 2437.74 C++ Note: riskl checked 49.9037 45.6007 C++ Note: df101 -447.204 C++ Note: df102 -0.27852 C++ Note: df103 -39.141 C++ Note: df104 -0.0987146 C++ Note: df105 0.00711582 C++ Note: df106 1605.64 C++ Note: Exiting Regression C++ Note: df501 -447.2035 C++ Note: df504 -0.09871455 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 427 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 C++ Note: df99,21,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 449 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: Starting Halves C++ Note: df501 -525.8191 C++ Note: df504 0.01 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: df100 1262 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: ending guess 0 C++ Note: df501 -525.8191 C++ Note: df504 0.01 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.01, -525.8191<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: Starting Halves C++ Note: df501 -525.8191 C++ Note: df504 0.01 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: df100 2338 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: Exiting Regression C++ Note: df501 -525.8191 C++ Note: df504 0.01 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 422 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 C++ Note: df99,21,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 455 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12309.1 C++ Note: risk1r checked 19240.9 C++ Note: risk2r checked 46924.9 C++ Note: riskl checked 116.159 C++ Note: risk1l checked 218.829 C++ Note: risk2l checked 595.535 C++ Note: df101 -525.819 C++ Note: df102 -4.47019 C++ Note: df103 -39.2834 C++ Note: df104 0.01 C++ Note: df105 0.113793 C++ Note: df106 117.628 C++ Note: Starting Halves C++ Note: df501 -525.8191 C++ Note: df504 0.01 C++ Note: values checked -0.0753449 C++ Note: sums checked 889.415 C++ Note: risk checked 889.415 C++ Note: risk1 checked 1321.38 C++ Note: risk2 checked 3565.92 C++ Note: riskr checked 10823.9 C++ Note: risk1r checked 15714.3 C++ Note: risk2r checked 36253.4 C++ Note: riskl checked 99.4622 C++ Note: risk1l checked 174.499 C++ Note: risk2l checked 450.907 C++ Note: df101 -525.581 C++ Note: df102 -1.10144 C++ Note: df103 -39.6548 C++ Note: df104 -0.0753449 C++ Note: df105 0.0277758 C++ Note: df106 477.175 C++ Note: df100 1994 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 10823.9 C++ Note: risk1r checked 15714.3 C++ Note: risk2r checked 36253.4 C++ Note: riskl checked 99.4622 C++ Note: risk1l checked 174.499 C++ Note: risk2l checked 450.907 C++ Note: df101 -525.581 C++ Note: df102 -1.10144 C++ Note: df103 -39.6548 C++ Note: df104 -0.0753449 C++ Note: df105 0.0277758 C++ Note: df106 477.175 C++ Note: ending guess 0 C++ Note: df501 -525.5812 C++ Note: df504 -0.07534494 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.07534494, -525.5812<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.0753449 C++ Note: sums checked 889.415 C++ Note: risk checked 889.415 C++ Note: risk1 checked 1321.38 C++ Note: risk2 checked 3565.92 C++ Note: Made Risk Side Lists C++ Note: riskr checked 10823.9 C++ Note: risk1r checked 15714.3 C++ Note: risk2r checked 36253.4 C++ Note: riskl checked 99.4622 C++ Note: risk1l checked 174.499 C++ Note: risk2l checked 450.907 C++ Note: df101 -525.581 C++ Note: df102 -1.10144 C++ Note: df103 -39.6548 C++ Note: df104 -0.0753449 C++ Note: df105 0.0277758 C++ Note: df106 477.175 C++ Note: Starting Halves C++ Note: df501 -525.5812 C++ Note: df504 -0.07534494 C++ Note: values checked -0.0961768 C++ Note: sums checked 862.645 C++ Note: risk checked 862.645 C++ Note: risk1 checked 1249.59 C++ Note: risk2 checked 3329.49 C++ Note: riskr checked 10504.3 C++ Note: risk1r checked 14981.8 C++ Note: risk2r checked 34097.7 C++ Note: riskl checked 95.9227 C++ Note: risk1l checked 165.411 C++ Note: risk2l checked 421.981 C++ Note: df101 -525.567 C++ Note: df102 -0.274471 C++ Note: df103 -39.7399 C++ Note: df104 -0.0961768 C++ Note: df105 0.00690668 C++ Note: df106 1914.84 C++ Note: df100 4140 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 10504.3 C++ Note: risk1r checked 14981.8 C++ Note: risk2r checked 34097.7 C++ Note: riskl checked 95.9227 C++ Note: risk1l checked 165.411 C++ Note: risk2l checked 421.981 C++ Note: df101 -525.567 C++ Note: df102 -0.274471 C++ Note: df103 -39.7399 C++ Note: df104 -0.0961768 C++ Note: df105 0.00690668 C++ Note: df106 1914.84 C++ Note: riskr checked 10504.3 C++ Note: risk1r checked 14981.8 C++ Note: risk2r checked 34097.7 C++ Note: riskl checked 95.9227 C++ Note: risk1l checked 165.411 C++ Note: risk2l checked 421.981 C++ Note: df101 -525.567 C++ Note: df102 -0.274471 C++ Note: df103 -39.7399 C++ Note: df104 -0.0961768 C++ Note: df105 0.00690668 C++ Note: df106 1914.84 C++ Note: Exiting Regression C++ Note: df501 -525.5668 C++ Note: df504 -0.09617677 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 422 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 C++ Note: df99,22,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 454 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: dose checked 1000 C++ Note: non-dose checked 1016.5 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: Starting Halves C++ Note: df501 -525.8191 C++ Note: df504 0.01 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: dose checked 1000 C++ Note: non-dose checked 1016.5 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: df100 1383 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: ending guess 0 C++ Note: df501 -525.8191 C++ Note: df504 0.01 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.01, -525.8191<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: dose checked 1000 C++ Note: non-dose checked 1016.5 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: Starting Halves C++ Note: df501 -525.8191 C++ Note: df504 0.01 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: dose checked 1000 C++ Note: non-dose checked 1016.5 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: df100 2585 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: riskr checked 12309.1 C++ Note: riskl checked 116.159 C++ Note: df101 -525.819 C++ Note: df104 0.01 C++ Note: Exiting Regression C++ Note: df501 -525.8191 C++ Note: df504 0.01 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 420 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 C++ Note: df99,22,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 480 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0.01 C++ Note: sums checked 1016.5 C++ Note: derivs checked 1673.67 C++ Note: second derivs checked 4753.83 C++ Note: dose checked 1000 C++ Note: non-dose checked 1016.5 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1016.5 C++ Note: risk checked 1016.5 C++ Note: risk1 checked 1673.67 C++ Note: risk2 checked 4753.83 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12309.1 C++ Note: risk1r checked 19240.9 C++ Note: risk2r checked 46924.9 C++ Note: riskl checked 116.159 C++ Note: risk1l checked 218.829 C++ Note: risk2l checked 595.535 C++ Note: df101 -525.819 C++ Note: df102 -4.47019 C++ Note: df103 -39.2834 C++ Note: df104 0.01 C++ Note: df105 0.113793 C++ Note: df106 117.628 C++ Note: Starting Halves C++ Note: df501 -525.8191 C++ Note: df504 0.01 C++ Note: values checked -0.0753449 C++ Note: sums checked 889.415 C++ Note: derivs checked 1321.38 C++ Note: second derivs checked 3565.92 C++ Note: dose checked 1000 C++ Note: non-dose checked 889.415 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 889.415 C++ Note: risk checked 889.415 C++ Note: risk1 checked 1321.38 C++ Note: risk2 checked 3565.92 C++ Note: riskr checked 10823.9 C++ Note: risk1r checked 15714.3 C++ Note: risk2r checked 36253.4 C++ Note: riskl checked 99.4622 C++ Note: risk1l checked 174.499 C++ Note: risk2l checked 450.907 C++ Note: df101 -525.581 C++ Note: df102 -1.10144 C++ Note: df103 -39.6548 C++ Note: df104 -0.0753449 C++ Note: df105 0.0277758 C++ Note: df106 477.175 C++ Note: df100 2445 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 10823.9 C++ Note: risk1r checked 15714.3 C++ Note: risk2r checked 36253.4 C++ Note: riskl checked 99.4622 C++ Note: risk1l checked 174.499 C++ Note: risk2l checked 450.907 C++ Note: df101 -525.581 C++ Note: df102 -1.10144 C++ Note: df103 -39.6548 C++ Note: df104 -0.0753449 C++ Note: df105 0.0277758 C++ Note: df106 477.175 C++ Note: ending guess 0 C++ Note: df501 -525.5812 C++ Note: df504 -0.07534494 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.07534494, -525.5812<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.0753449 C++ Note: sums checked 889.415 C++ Note: derivs checked 1321.38 C++ Note: second derivs checked 3565.92 C++ Note: dose checked 1000 C++ Note: non-dose checked 889.415 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 889.415 C++ Note: risk checked 889.415 C++ Note: risk1 checked 1321.38 C++ Note: risk2 checked 3565.92 C++ Note: Made Risk Side Lists C++ Note: riskr checked 10823.9 C++ Note: risk1r checked 15714.3 C++ Note: risk2r checked 36253.4 C++ Note: riskl checked 99.4622 C++ Note: risk1l checked 174.499 C++ Note: risk2l checked 450.907 C++ Note: df101 -525.581 C++ Note: df102 -1.10144 C++ Note: df103 -39.6548 C++ Note: df104 -0.0753449 C++ Note: df105 0.0277758 C++ Note: df106 477.175 C++ Note: Starting Halves C++ Note: df501 -525.5812 C++ Note: df504 -0.07534494 C++ Note: values checked -0.0961768 C++ Note: sums checked 862.645 C++ Note: derivs checked 1249.59 C++ Note: second derivs checked 3329.49 C++ Note: dose checked 1000 C++ Note: non-dose checked 862.645 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 862.645 C++ Note: risk checked 862.645 C++ Note: risk1 checked 1249.59 C++ Note: risk2 checked 3329.49 C++ Note: riskr checked 10504.3 C++ Note: risk1r checked 14981.8 C++ Note: risk2r checked 34097.7 C++ Note: riskl checked 95.9227 C++ Note: risk1l checked 165.411 C++ Note: risk2l checked 421.981 C++ Note: df101 -525.567 C++ Note: df102 -0.274471 C++ Note: df103 -39.7399 C++ Note: df104 -0.0961768 C++ Note: df105 0.00690668 C++ Note: df106 1914.84 C++ Note: df100 5017 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 10504.3 C++ Note: risk1r checked 14981.8 C++ Note: risk2r checked 34097.7 C++ Note: riskl checked 95.9227 C++ Note: risk1l checked 165.411 C++ Note: risk2l checked 421.981 C++ Note: df101 -525.567 C++ Note: df102 -0.274471 C++ Note: df103 -39.7399 C++ Note: df104 -0.0961768 C++ Note: df105 0.00690668 C++ Note: df106 1914.84 C++ Note: riskr checked 10504.3 C++ Note: risk1r checked 14981.8 C++ Note: risk2r checked 34097.7 C++ Note: riskl checked 95.9227 C++ Note: risk1l checked 165.411 C++ Note: risk2l checked 421.981 C++ Note: df101 -525.567 C++ Note: df102 -0.274471 C++ Note: df103 -39.7399 C++ Note: df104 -0.0961768 C++ Note: df105 0.00690668 C++ Note: df106 1914.84 C++ Note: Exiting Regression C++ Note: df501 -525.5668 C++ Note: df504 -0.09617677 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 C++ Note: df99,21,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 458 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0 C++ Note: sums checked 1000 C++ Note: derivs checked 1626.94 C++ Note: second derivs checked 4593.87 C++ Note: dose checked 1000 C++ Note: non-dose checked 1000 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 1626.94 C++ Note: risk2 checked 4593.87 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: ending guess 0 C++ Note: df501 -525.7764 C++ Note: df504 0 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0, -525.7764<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0 C++ Note: sums checked 1000 C++ Note: derivs checked 1626.94 C++ Note: second derivs checked 4593.87 C++ Note: dose checked 1000 C++ Note: non-dose checked 1000 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 1626.94 C++ Note: risk2 checked 4593.87 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: Exiting Regression C++ Note: df501 -525.7764 C++ Note: df504 0 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 421 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 C++ Note: df99,21,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 457 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0 C++ Note: sums checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 1626.94 C++ Note: risk2 checked 4593.87 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12119 C++ Note: riskl checked 114 C++ Note: df101 -525.776 C++ Note: df104 0 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 C++ Note: df101 -525.776 C++ Note: df104 0 C++ Note: ending guess 0 C++ Note: df501 -525.7764 C++ Note: df504 0 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0, -525.7764<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0 C++ Note: sums checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 1626.94 C++ Note: risk2 checked 4593.87 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12119 C++ Note: riskl checked 114 C++ Note: df101 -525.776 C++ Note: df104 0 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 C++ Note: df101 -525.776 C++ Note: df104 0 C++ Note: Exiting Regression C++ Note: df501 -525.7764 C++ Note: df504 0 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 421 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 C++ Note: df99,21,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 456 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0 C++ Note: sums checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 1626.94 C++ Note: risk2 checked 4593.87 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: ending guess 0 C++ Note: df501 -525.7764 C++ Note: df504 0 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0, -525.7764<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0 C++ Note: sums checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 1626.94 C++ Note: risk2 checked 4593.87 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: Exiting Regression C++ Note: df501 -525.7764 C++ Note: df504 0 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 426 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 C++ Note: df99,22,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 454 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0 C++ Note: sums checked 1000 C++ Note: dose checked 1000 C++ Note: non-dose checked 1000 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1000 C++ Note: risk checked 1000 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12119 C++ Note: riskl checked 114 C++ Note: df101 -525.776 C++ Note: df104 0 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 C++ Note: df101 -525.776 C++ Note: df104 0 C++ Note: ending guess 0 C++ Note: df501 -525.7764 C++ Note: df504 0 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0, -525.7764<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0 C++ Note: sums checked 1000 C++ Note: dose checked 1000 C++ Note: non-dose checked 1000 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1000 C++ Note: risk checked 1000 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12119 C++ Note: riskl checked 114 C++ Note: df101 -525.776 C++ Note: df104 0 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 C++ Note: df101 -525.776 C++ Note: df104 0 C++ Note: Exiting Regression C++ Note: df501 -525.7764 C++ Note: df504 0 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 415 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 12119 C++ Note: riskl checked 114 Note: 114 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 C++ Note: df99,22,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 453 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0 C++ Note: sums checked 1000 C++ Note: derivs checked 1626.94 C++ Note: second derivs checked 4593.87 C++ Note: dose checked 1000 C++ Note: non-dose checked 1000 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 1626.94 C++ Note: risk2 checked 4593.87 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: ending guess 0 C++ Note: df501 -525.7764 C++ Note: df504 0 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0, -525.7764<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0 C++ Note: sums checked 1000 C++ Note: derivs checked 1626.94 C++ Note: second derivs checked 4593.87 C++ Note: dose checked 1000 C++ Note: non-dose checked 1000 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 1626.94 C++ Note: risk2 checked 4593.87 C++ Note: Made Risk Side Lists C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: riskr checked 12119 C++ Note: risk1r checked 18778.8 C++ Note: risk2r checked 45501.3 C++ Note: riskl checked 114 C++ Note: risk1l checked 212.971 C++ Note: risk2l checked 576.121 C++ Note: df101 -525.776 C++ Note: df102 -4.07712 C++ Note: df103 -39.3287 C++ Note: df104 0 C++ Note: df105 0.103668 C++ Note: df106 128.958 C++ Note: Exiting Regression C++ Note: df501 -525.7764 C++ Note: df504 0 Note: 901 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 0 C++ Note: df99,26,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Grouping Start C++ Note: df100 3062 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked 0 0 C++ Note: sums checked 1000 1000 C++ Note: derivs checked 531 C++ Note: second derivs checked 531 C++ Note: dose checked 1000 C++ Note: non-dose checked 1000 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 531 C++ Note: risk2 checked 531 C++ Note: Made Risk Side Lists C++ Note: riskr checked 94828 C++ Note: risk1r checked 50387 C++ Note: risk2r checked 50387 C++ Note: riskl checked 901 C++ Note: risk1l checked 479 C++ Note: risk2l checked 479 C++ Note: df101 -4115.03 C++ Note: df102 1.62 C++ Note: df103 -222.912 C++ Note: df104 0 0 C++ Note: df105 -0.00726744 C++ Note: df106 -2540.14 C++ Note: Starting Halves C++ Note: df501 -4115.028 C++ Note: df504 0 0 C++ Note: values checked 0 0.00545058 C++ Note: sums checked 1000 1002.9 C++ Note: derivs checked 533.902 C++ Note: second derivs checked 533.902 C++ Note: dose checked 1000 C++ Note: non-dose checked 1002.9 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1002.9 C++ Note: risk checked 1002.9 C++ Note: risk1 checked 533.902 C++ Note: risk2 checked 533.902 C++ Note: riskr checked 95103.4 C++ Note: risk1r checked 50662.4 C++ Note: risk2r checked 50662.4 C++ Note: riskl checked 903.618 C++ Note: risk1l checked 481.618 C++ Note: risk2l checked 481.618 C++ Note: df101 -4115.02 C++ Note: df102 0.405212 C++ Note: df103 -222.834 C++ Note: df104 0 0.00545058 C++ Note: df105 -0.00181845 C++ Note: df106 -10155.2 C++ Note: df100 9601 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: riskr checked 95103.4 C++ Note: risk1r checked 50662.4 C++ Note: risk2r checked 50662.4 C++ Note: riskl checked 903.618 C++ Note: risk1l checked 481.618 C++ Note: risk2l checked 481.618 C++ Note: df101 -4115.02 C++ Note: df102 0.405212 C++ Note: df103 -222.834 C++ Note: df104 0 0.00545058 C++ Note: df105 -0.00181845 C++ Note: df106 -10155.2 C++ Note: ending guess 0 C++ Note: df501 -4115.022 C++ Note: df504 0 0.005450583 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0 0.005450583, -4115.022<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0 0.00545058 C++ Note: sums checked 1000 1002.9 C++ Note: derivs checked 533.902 C++ Note: second derivs checked 533.902 C++ Note: dose checked 1000 C++ Note: non-dose checked 1002.9 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1002.9 C++ Note: risk checked 1002.9 C++ Note: risk1 checked 533.902 C++ Note: risk2 checked 533.902 C++ Note: Made Risk Side Lists C++ Note: riskr checked 95103.4 C++ Note: risk1r checked 50662.4 C++ Note: risk2r checked 50662.4 C++ Note: riskl checked 903.618 C++ Note: risk1l checked 481.618 C++ Note: risk2l checked 481.618 C++ Note: df101 -4115.02 C++ Note: df102 0.405212 C++ Note: df103 -222.834 C++ Note: df104 0 0.00545058 C++ Note: df105 -0.00181845 C++ Note: df106 -10155.2 C++ Note: riskr checked 95103.4 C++ Note: risk1r checked 50662.4 C++ Note: risk2r checked 50662.4 C++ Note: riskl checked 903.618 C++ Note: risk1l checked 481.618 C++ Note: risk2l checked 481.618 C++ Note: df101 -4115.02 C++ Note: df102 0.405212 C++ Note: df103 -222.834 C++ Note: df104 0 0.00545058 C++ Note: df105 -0.00181845 C++ Note: df106 -10155.2 C++ Note: Exiting Regression C++ Note: df501 -4115.022 C++ Note: df504 0 0.005450583 C++ Note: START_PLOT C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Term checked 0 0 C++ Note: df99,26,Starting C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: values checked 0 0 C++ Note: sums checked 1000 1000 C++ Note: derivs checked 531 C++ Note: second derivs checked 531 C++ Note: dose checked 1000 C++ Note: non-dose checked 1000 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 1000 C++ Note: risk checked 1000 C++ Note: risk1 checked 531 C++ Note: risk2 checked 531 C++ Note: Grouping Start C++ Note: df100 3277 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:10 2024 C++ Note: Made Risk Side Lists C++ Note: riskr checked 94828 C++ Note: risk1r checked 50387 C++ Note: risk2r checked 50387 C++ Note: riskl checked 901 C++ Note: risk1l checked 479 C++ Note: risk2l checked 479 C++ Note: df101 -4115.03 C++ Note: df102 1.62 C++ Note: df103 -222.912 C++ Note: df104 0 0 C++ Note: df105 -0.00726744 C++ Note: df106 -2540.14 Saving 7 x 7 in image Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,54,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 528 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -82.55461 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1683 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2199 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -82.55461 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -82.55461<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -82.55461 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3604 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: df100 4112 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -82.55461 C++ Note: df504 -0.1 -0.1 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 336 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -82.55461 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1371 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -82.55461 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -82.55461<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -82.55461 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2775 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3286 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -82.55461 C++ Note: df504 -0.1 -0.1 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 327 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1301 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1912 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -79.58847<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3221 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,26,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 320 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1271 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1746 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -79.58847<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3012 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3475 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 321 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df102 19.8692 3.2049 C++ Note: df103 -19.1334 -6.17679 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -1.03846 -0.518862 C++ Note: df106 -4.1549 -25.7589 C++ Note: Starting Halves C++ Note: df501 -82.55461 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.702609 0.405935 C++ Note: sums checked 5765.37 1265.87 C++ Note: risk checked 7235.91 C++ Note: risk1 checked 23875.5 4407.46 C++ Note: risk2 checked 95114.7 4407.46 C++ Note: riskr checked 1029.36 657.301 440.368 779.123 340.451 C++ Note: riskl checked 83.3734 40.9432 39.5706 39.8431 33.7665 C++ Note: df101 -71.2819 -71.2819 C++ Note: df102 6.53346 0.663705 C++ Note: df103 -13.6957 -6.04035 C++ Note: df104 0.702609 0.405935 C++ Note: df105 -0.477045 -0.109879 C++ Note: df106 -10.9103 -107.4 C++ Note: df100 2219 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 1029.36 657.301 440.368 779.123 340.451 C++ Note: riskl checked 83.3734 40.9432 39.5706 39.8431 33.7665 C++ Note: df101 -71.2819 -71.2819 C++ Note: df102 6.53346 0.663705 C++ Note: df103 -13.6957 -6.04035 C++ Note: df104 0.702609 0.405935 C++ Note: df105 -0.477045 -0.109879 C++ Note: df106 -10.9103 -107.4 C++ Note: ending guess 0 C++ Note: df501 -71.28193 C++ Note: df504 0.7026092 0.4059355 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.7026092 0.4059355, -71.28193<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.702609 0.405935 C++ Note: sums checked 5765.37 1265.87 C++ Note: risk checked 7235.91 C++ Note: risk1 checked 23875.5 4407.46 C++ Note: risk2 checked 95114.7 4407.46 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1029.36 657.301 440.368 779.123 340.451 C++ Note: riskl checked 83.3734 40.9432 39.5706 39.8431 33.7665 C++ Note: df101 -71.2819 -71.2819 C++ Note: df102 6.53346 0.663705 C++ Note: df103 -13.6957 -6.04035 C++ Note: df104 0.702609 0.405935 C++ Note: df105 -0.477045 -0.109879 C++ Note: df106 -10.9103 -107.4 C++ Note: Starting Halves C++ Note: df501 -71.28193 C++ Note: df504 0.7026092 0.4059355 C++ Note: values checked 1.06614 0.527334 C++ Note: sums checked 22078.7 1368.73 C++ Note: risk checked 29733.3 C++ Note: risk1 checked 119904 18677.8 C++ Note: risk2 checked 536010 18677.8 C++ Note: riskr checked 4013.84 1761.95 1075.19 2341.29 1010.29 C++ Note: riskl checked 390.452 140.821 119.569 110.838 125.172 C++ Note: df101 -69.6786 -69.6786 C++ Note: df102 2.18197 0.178373 C++ Note: df103 -10.8366 -5.93902 C++ Note: df104 1.06614 0.527334 C++ Note: df105 -0.201352 -0.0300341 C++ Note: df106 -31.9338 -390.634 C++ Note: df100 4880 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 4013.84 1761.95 1075.19 2341.29 1010.29 C++ Note: riskl checked 390.452 140.821 119.569 110.838 125.172 C++ Note: df101 -69.6786 -69.6786 C++ Note: df102 2.18197 0.178373 C++ Note: df103 -10.8366 -5.93902 C++ Note: df104 1.06614 0.527334 C++ Note: df105 -0.201352 -0.0300341 C++ Note: df106 -31.9338 -390.634 C++ Note: riskr checked 4013.84 1761.95 1075.19 2341.29 1010.29 C++ Note: riskl checked 390.452 140.821 119.569 110.838 125.172 C++ Note: df101 -69.6786 -69.6786 C++ Note: df102 2.18197 0.178373 C++ Note: df103 -10.8366 -5.93902 C++ Note: df104 1.06614 0.527334 C++ Note: df105 -0.201352 -0.0300341 C++ Note: df106 -31.9338 -390.634 C++ Note: Exiting Regression C++ Note: df501 -69.67859 C++ Note: df504 1.066135 0.5273336 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 318 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df102 19.8692 3.2049 C++ Note: df103 -19.1334 -6.17679 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -1.03846 -0.518862 C++ Note: df106 -4.1549 -25.7589 C++ Note: Starting Halves C++ Note: df501 -82.55461 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.678843 0.289146 C++ Note: sums checked 5332.15 1178.04 C++ Note: risk checked 6244.38 C++ Note: risk1 checked 20292.1 3632.95 C++ Note: risk2 checked 80174.7 3632.95 C++ Note: riskr checked 899.189 581.433 385.076 688.511 299.436 C++ Note: riskl checked 70.4668 36.2982 33.2589 35.4616 28.5259 C++ Note: df101 -71.5582 -71.5582 C++ Note: df102 6.7855 1.35947 C++ Note: df103 -13.923 -6.13436 C++ Note: df104 0.678843 0.289146 C++ Note: df105 -0.487357 -0.221615 C++ Note: df106 -10.5458 -52.6369 C++ Note: df100 2200 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 899.189 581.433 385.076 688.511 299.436 C++ Note: riskl checked 70.4668 36.2982 33.2589 35.4616 28.5259 C++ Note: df101 -71.5582 -71.5582 C++ Note: df102 6.7855 1.35947 C++ Note: df103 -13.923 -6.13436 C++ Note: df104 0.678843 0.289146 C++ Note: df105 -0.487357 -0.221615 C++ Note: df106 -10.5458 -52.6369 C++ Note: ending guess 0 C++ Note: df501 -71.55823 C++ Note: df504 0.6788427 0.2891462 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.6788427 0.2891462, -71.55823<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.678843 0.289146 C++ Note: sums checked 5332.15 1178.04 C++ Note: risk checked 6244.38 C++ Note: risk1 checked 20292.1 3632.95 C++ Note: risk2 checked 80174.7 3632.95 C++ Note: Made Risk Side Lists C++ Note: riskr checked 899.189 581.433 385.076 688.511 299.436 C++ Note: riskl checked 70.4668 36.2982 33.2589 35.4616 28.5259 C++ Note: df101 -71.5582 -71.5582 C++ Note: df102 6.7855 1.35947 C++ Note: df103 -13.923 -6.13436 C++ Note: df104 0.678843 0.289146 C++ Note: df105 -0.487357 -0.221615 C++ Note: df106 -10.5458 -52.6369 C++ Note: Starting Halves C++ Note: df501 -71.55823 C++ Note: df504 0.6788427 0.2891462 C++ Note: values checked 1.04436 0.455358 C++ Note: sums checked 20227 1306.25 C++ Note: risk checked 26056 C++ Note: risk1 checked 104097 15935.8 C++ Note: risk2 checked 462614 15935.8 C++ Note: riskr checked 3566.45 1594.5 968.276 2102.11 897.328 C++ Note: riskl checked 341.759 127.646 104.884 101.194 108.836 C++ Note: df101 -69.7559 -69.7559 C++ Note: df102 2.37027 0.59374 C++ Note: df103 -10.9895 -6.01548 C++ Note: df104 1.04436 0.455358 C++ Note: df105 -0.215686 -0.0987019 C++ Note: df106 -29.4295 -117.486 C++ Note: df100 4829 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 3566.45 1594.5 968.276 2102.11 897.328 C++ Note: riskl checked 341.759 127.646 104.884 101.194 108.836 C++ Note: df101 -69.7559 -69.7559 C++ Note: df102 2.37027 0.59374 C++ Note: df103 -10.9895 -6.01548 C++ Note: df104 1.04436 0.455358 C++ Note: df105 -0.215686 -0.0987019 C++ Note: df106 -29.4295 -117.486 C++ Note: riskr checked 3566.45 1594.5 968.276 2102.11 897.328 C++ Note: riskl checked 341.759 127.646 104.884 101.194 108.836 C++ Note: df101 -69.7559 -69.7559 C++ Note: df102 2.37027 0.59374 C++ Note: df103 -10.9895 -6.01548 C++ Note: df104 1.04436 0.455358 C++ Note: df105 -0.215686 -0.0987019 C++ Note: df106 -29.4295 -117.486 C++ Note: Exiting Regression C++ Note: df501 -69.7559 C++ Note: df504 1.044361 0.4553577 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 310 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df102 5.42704 2.14202 C++ Note: df103 -7.11684 -6.21271 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.762564 -0.34478 C++ Note: df106 -14.6652 -37.1559 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.550424 0.30353 C++ Note: sums checked 3575.85 1188.31 C++ Note: risk checked 4228.8 C++ Note: risk1 checked 12473.9 2494.15 C++ Note: risk2 checked 46827.4 2494.15 C++ Note: riskr checked 616.483 485.721 374.917 603.993 261.606 C++ Note: riskl checked 43.76 24.6658 24.1668 25.7075 19.5703 C++ Note: df101 -76.8654 -76.8654 C++ Note: df102 1.27777 0.508497 C++ Note: df103 -7.18963 -6.04474 C++ Note: df104 0.550424 0.30353 C++ Note: df105 -0.177724 -0.0841223 C++ Note: df106 -60.1559 -151.162 C++ Note: df100 1917 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 616.483 485.721 374.917 603.993 261.606 C++ Note: riskl checked 43.76 24.6658 24.1668 25.7075 19.5703 C++ Note: df101 -76.8654 -76.8654 C++ Note: df102 1.27777 0.508497 C++ Note: df103 -7.18963 -6.04474 C++ Note: df104 0.550424 0.30353 C++ Note: df105 -0.177724 -0.0841223 C++ Note: df106 -60.1559 -151.162 C++ Note: ending guess 0 C++ Note: df501 -76.86543 C++ Note: df504 0.5504238 0.3035295 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.5504238 0.3035295, -76.86543<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.550424 0.30353 C++ Note: sums checked 3575.85 1188.31 C++ Note: risk checked 4228.8 C++ Note: risk1 checked 12473.9 2494.15 C++ Note: risk2 checked 46827.4 2494.15 C++ Note: Made Risk Side Lists C++ Note: riskr checked 616.483 485.721 374.917 603.993 261.606 C++ Note: riskl checked 43.76 24.6658 24.1668 25.7075 19.5703 C++ Note: df101 -76.8654 -76.8654 C++ Note: df102 1.27777 0.508497 C++ Note: df103 -7.18963 -6.04474 C++ Note: df104 0.550424 0.30353 C++ Note: df105 -0.177724 -0.0841223 C++ Note: df106 -60.1559 -151.162 C++ Note: Starting Halves C++ Note: df501 -76.86543 C++ Note: df504 0.5504238 0.3035295 C++ Note: values checked 0.699516 0.396693 C++ Note: sums checked 5706.63 1258.54 C++ Note: risk checked 7122.36 C++ Note: risk1 checked 23453.2 4323.35 C++ Note: risk2 checked 93329.8 4323.35 C++ Note: riskr checked 1103.97 748.255 549.423 973.678 397.318 C++ Note: riskl checked 81.8797 40.3981 38.9034 39.35 33.1873 C++ Note: df101 -76.7167 -76.7167 C++ Note: df102 0.321463 0.127669 C++ Note: df103 -7.13078 -5.96512 C++ Note: df104 0.699516 0.396693 C++ Note: df105 -0.045081 -0.0214027 C++ Note: df106 -238.649 -600.901 C++ Note: df100 4144 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 1103.97 748.255 549.423 973.678 397.318 C++ Note: riskl checked 81.8797 40.3981 38.9034 39.35 33.1873 C++ Note: df101 -76.7167 -76.7167 C++ Note: df102 0.321463 0.127669 C++ Note: df103 -7.13078 -5.96512 C++ Note: df104 0.699516 0.396693 C++ Note: df105 -0.045081 -0.0214027 C++ Note: df106 -238.649 -600.901 C++ Note: riskr checked 1103.97 748.255 549.423 973.678 397.318 C++ Note: riskl checked 81.8797 40.3981 38.9034 39.35 33.1873 C++ Note: df101 -76.7167 -76.7167 C++ Note: df102 0.321463 0.127669 C++ Note: df103 -7.13078 -5.96512 C++ Note: df104 0.699516 0.396693 C++ Note: df105 -0.045081 -0.0214027 C++ Note: df106 -238.649 -600.901 C++ Note: Exiting Regression C++ Note: df501 -76.71665 C++ Note: df504 0.6995155 0.3966929 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,24,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 332 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df102 5.42704 2.14202 C++ Note: df103 -7.11684 -6.21271 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.762564 -0.34478 C++ Note: df106 -14.6652 -37.1559 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.471923 0.158585 C++ Note: sums checked 2855.18 1091.25 C++ Note: risk checked 3109.21 C++ Note: risk1 checked 8604.8 1732.23 C++ Note: risk2 checked 31265.5 1732.23 C++ Note: riskr checked 437.598 369.44 288.407 451.269 203.987 C++ Note: riskl checked 29.7555 18.4415 17.3204 19.7081 14.0257 C++ Note: df101 -77.1115 -77.1115 C++ Note: df102 1.6628 1.2965 C++ Note: df103 -7.18852 -6.1617 C++ Note: df104 0.471923 0.158585 C++ Note: df105 -0.231313 -0.210412 C++ Note: df106 -46.3745 -59.4767 C++ Note: df100 1922 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 437.598 369.44 288.407 451.269 203.987 C++ Note: riskl checked 29.7555 18.4415 17.3204 19.7081 14.0257 C++ Note: df101 -77.1115 -77.1115 C++ Note: df102 1.6628 1.2965 C++ Note: df103 -7.18852 -6.1617 C++ Note: df104 0.471923 0.158585 C++ Note: df105 -0.231313 -0.210412 C++ Note: df106 -46.3745 -59.4767 C++ Note: ending guess 0 C++ Note: df501 -77.11153 C++ Note: df504 0.4719227 0.1585847 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.4719227 0.1585847, -77.11153<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.471923 0.158585 C++ Note: sums checked 2855.18 1091.25 C++ Note: risk checked 3109.21 C++ Note: risk1 checked 8604.8 1732.23 C++ Note: risk2 checked 31265.5 1732.23 C++ Note: Made Risk Side Lists C++ Note: riskr checked 437.598 369.44 288.407 451.269 203.987 C++ Note: riskl checked 29.7555 18.4415 17.3204 19.7081 14.0257 C++ Note: df101 -77.1115 -77.1115 C++ Note: df102 1.6628 1.2965 C++ Note: df103 -7.18852 -6.1617 C++ Note: df104 0.471923 0.158585 C++ Note: df105 -0.231313 -0.210412 C++ Note: df106 -46.3745 -59.4767 C++ Note: Starting Halves C++ Note: df501 -77.11153 C++ Note: df504 0.4719227 0.1585847 C++ Note: values checked 0.645408 0.316394 C++ Note: sums checked 4787.64 1197.62 C++ Note: risk checked 5698.95 C++ Note: risk1 checked 18076.9 3359.94 C++ Note: risk2 checked 70503.7 3359.94 C++ Note: riskr checked 866.381 621.431 461.192 794.093 330.167 C++ Note: riskl checked 63.0668 33.0727 31.2711 32.9428 26.3017 C++ Note: df101 -76.7689 -76.7689 C++ Note: df102 0.612277 0.54564 C++ Note: df103 -7.1484 -6.0464 C++ Note: df104 0.645408 0.316394 C++ Note: df105 -0.0856523 -0.0902421 C++ Note: df106 -125.383 -140.695 C++ Note: df100 4111 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 866.381 621.431 461.192 794.093 330.167 C++ Note: riskl checked 63.0668 33.0727 31.2711 32.9428 26.3017 C++ Note: df101 -76.7689 -76.7689 C++ Note: df102 0.612277 0.54564 C++ Note: df103 -7.1484 -6.0464 C++ Note: df104 0.645408 0.316394 C++ Note: df105 -0.0856523 -0.0902421 C++ Note: df106 -125.383 -140.695 C++ Note: riskr checked 866.381 621.431 461.192 794.093 330.167 C++ Note: riskl checked 63.0668 33.0727 31.2711 32.9428 26.3017 C++ Note: df101 -76.7689 -76.7689 C++ Note: df102 0.612277 0.54564 C++ Note: df103 -7.1484 -6.0464 C++ Note: df104 0.645408 0.316394 C++ Note: df105 -0.0856523 -0.0902421 C++ Note: df106 -125.383 -140.695 C++ Note: Exiting Regression C++ Note: df501 -76.76892 C++ Note: df504 0.6454076 0.316394 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 342 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -82.55461 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1439 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -82.55461 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -82.55461<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -82.55461 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2882 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -82.55461 C++ Note: df504 -0.1 -0.1 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,24,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 323 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -82.55461 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1392 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1919 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -82.55461 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -82.55461<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -82.55461 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3362 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3979 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -82.55461 C++ Note: df504 -0.1 -0.1 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 325 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1318 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1789 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -79.58847<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3093 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3570 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,44,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 504 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2209 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2785 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -79.58847<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 4381 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: df100 5048 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 378 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: derivs checked 1229.85 410.233 C++ Note: second derivs checked 3319.14 410.233 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df102 19.8692 3.2049 C++ Note: df103 -19.1334 -6.17679 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -1.03846 -0.518862 C++ Note: df106 -4.1549 -25.7589 C++ Note: Starting Halves C++ Note: df501 -82.55461 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.702609 0.405935 C++ Note: sums checked 7235.91 7235.91 C++ Note: derivs checked 23875.5 4407.46 C++ Note: second derivs checked 95114.7 4407.46 C++ Note: dose checked 1000 C++ Note: non-dose checked 7235.91 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 7235.91 C++ Note: risk checked 7235.91 C++ Note: risk1 checked 23875.5 4407.46 C++ Note: risk2 checked 95114.7 4407.46 C++ Note: riskr checked 1029.36 657.301 440.368 779.123 340.451 C++ Note: riskl checked 83.3734 40.9432 39.5706 39.8431 33.7665 C++ Note: df101 -71.2819 -71.2819 C++ Note: df102 6.53346 0.663705 C++ Note: df103 -13.6957 -6.04035 C++ Note: df104 0.702609 0.405935 C++ Note: df105 -0.477045 -0.109879 C++ Note: df106 -10.9103 -107.4 C++ Note: df100 3505 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 1029.36 657.301 440.368 779.123 340.451 C++ Note: riskl checked 83.3734 40.9432 39.5706 39.8431 33.7665 C++ Note: df101 -71.2819 -71.2819 C++ Note: df102 6.53346 0.663705 C++ Note: df103 -13.6957 -6.04035 C++ Note: df104 0.702609 0.405935 C++ Note: df105 -0.477045 -0.109879 C++ Note: df106 -10.9103 -107.4 C++ Note: ending guess 0 C++ Note: df501 -71.28193 C++ Note: df504 0.7026092 0.4059355 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.7026092 0.4059355, -71.28193<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.702609 0.405935 C++ Note: sums checked 7235.91 7235.91 C++ Note: derivs checked 23875.5 4407.46 C++ Note: second derivs checked 95114.7 4407.46 C++ Note: dose checked 1000 C++ Note: non-dose checked 7235.91 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 7235.91 C++ Note: risk checked 7235.91 C++ Note: risk1 checked 23875.5 4407.46 C++ Note: risk2 checked 95114.7 4407.46 C++ Note: Made Risk Side Lists C++ Note: riskr checked 1029.36 657.301 440.368 779.123 340.451 C++ Note: riskl checked 83.3734 40.9432 39.5706 39.8431 33.7665 C++ Note: df101 -71.2819 -71.2819 C++ Note: df102 6.53346 0.663705 C++ Note: df103 -13.6957 -6.04035 C++ Note: df104 0.702609 0.405935 C++ Note: df105 -0.477045 -0.109879 C++ Note: df106 -10.9103 -107.4 C++ Note: Starting Halves C++ Note: df501 -71.28193 C++ Note: df504 0.7026092 0.4059355 C++ Note: values checked 1.06614 0.527334 C++ Note: sums checked 29733.3 29733.3 C++ Note: derivs checked 119904 18677.8 C++ Note: second derivs checked 536010 18677.8 C++ Note: dose checked 1000 C++ Note: non-dose checked 29733.3 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 29733.3 C++ Note: risk checked 29733.3 C++ Note: risk1 checked 119904 18677.8 C++ Note: risk2 checked 536010 18677.8 C++ Note: riskr checked 4013.84 1761.95 1075.19 2341.29 1010.29 C++ Note: riskl checked 390.452 140.821 119.569 110.838 125.172 C++ Note: df101 -69.6786 -69.6786 C++ Note: df102 2.18197 0.178373 C++ Note: df103 -10.8366 -5.93902 C++ Note: df104 1.06614 0.527334 C++ Note: df105 -0.201352 -0.0300341 C++ Note: df106 -31.9338 -390.634 C++ Note: df100 7155 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 4013.84 1761.95 1075.19 2341.29 1010.29 C++ Note: riskl checked 390.452 140.821 119.569 110.838 125.172 C++ Note: df101 -69.6786 -69.6786 C++ Note: df102 2.18197 0.178373 C++ Note: df103 -10.8366 -5.93902 C++ Note: df104 1.06614 0.527334 C++ Note: df105 -0.201352 -0.0300341 C++ Note: df106 -31.9338 -390.634 C++ Note: riskr checked 4013.84 1761.95 1075.19 2341.29 1010.29 C++ Note: riskl checked 390.452 140.821 119.569 110.838 125.172 C++ Note: df101 -69.6786 -69.6786 C++ Note: df102 2.18197 0.178373 C++ Note: df103 -10.8366 -5.93902 C++ Note: df104 1.06614 0.527334 C++ Note: df105 -0.201352 -0.0300341 C++ Note: df106 -31.9338 -390.634 C++ Note: Exiting Regression C++ Note: df501 -69.67859 C++ Note: df504 1.066135 0.5273336 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,26,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 335 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: derivs checked 1229.85 410.233 C++ Note: second derivs checked 3319.14 410.233 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -82.5546 -82.5546 C++ Note: df102 19.8692 3.2049 C++ Note: df103 -19.1334 -6.17679 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -1.03846 -0.518862 C++ Note: df106 -4.1549 -25.7589 C++ Note: Starting Halves C++ Note: df501 -82.55461 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.678843 0.289146 C++ Note: sums checked 6244.38 6244.38 C++ Note: derivs checked 20292.1 3632.95 C++ Note: second derivs checked 80174.7 3632.95 C++ Note: dose checked 1000 C++ Note: non-dose checked 6244.38 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 6244.38 C++ Note: risk checked 6244.38 C++ Note: risk1 checked 20292.1 3632.95 C++ Note: risk2 checked 80174.7 3632.95 C++ Note: riskr checked 899.189 581.433 385.076 688.511 299.436 C++ Note: riskl checked 70.4668 36.2982 33.2589 35.4616 28.5259 C++ Note: df101 -71.5582 -71.5582 C++ Note: df102 6.7855 1.35947 C++ Note: df103 -13.923 -6.13436 C++ Note: df104 0.678843 0.289146 C++ Note: df105 -0.487357 -0.221615 C++ Note: df106 -10.5458 -52.6369 C++ Note: df100 2836 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 899.189 581.433 385.076 688.511 299.436 C++ Note: riskl checked 70.4668 36.2982 33.2589 35.4616 28.5259 C++ Note: df101 -71.5582 -71.5582 C++ Note: df102 6.7855 1.35947 C++ Note: df103 -13.923 -6.13436 C++ Note: df104 0.678843 0.289146 C++ Note: df105 -0.487357 -0.221615 C++ Note: df106 -10.5458 -52.6369 C++ Note: ending guess 0 C++ Note: df501 -71.55823 C++ Note: df504 0.6788427 0.2891462 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.6788427 0.2891462, -71.55823<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.678843 0.289146 C++ Note: sums checked 6244.38 6244.38 C++ Note: derivs checked 20292.1 3632.95 C++ Note: second derivs checked 80174.7 3632.95 C++ Note: dose checked 1000 C++ Note: non-dose checked 6244.38 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 6244.38 C++ Note: risk checked 6244.38 C++ Note: risk1 checked 20292.1 3632.95 C++ Note: risk2 checked 80174.7 3632.95 C++ Note: Made Risk Side Lists C++ Note: riskr checked 899.189 581.433 385.076 688.511 299.436 C++ Note: riskl checked 70.4668 36.2982 33.2589 35.4616 28.5259 C++ Note: df101 -71.5582 -71.5582 C++ Note: df102 6.7855 1.35947 C++ Note: df103 -13.923 -6.13436 C++ Note: df104 0.678843 0.289146 C++ Note: df105 -0.487357 -0.221615 C++ Note: df106 -10.5458 -52.6369 C++ Note: Starting Halves C++ Note: df501 -71.55823 C++ Note: df504 0.6788427 0.2891462 C++ Note: values checked 1.04436 0.455358 C++ Note: sums checked 26056 26056 C++ Note: derivs checked 104097 15935.8 C++ Note: second derivs checked 462614 15935.8 C++ Note: dose checked 1000 C++ Note: non-dose checked 26056 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 26056 C++ Note: risk checked 26056 C++ Note: risk1 checked 104097 15935.8 C++ Note: risk2 checked 462614 15935.8 C++ Note: riskr checked 3566.45 1594.5 968.276 2102.11 897.328 C++ Note: riskl checked 341.759 127.646 104.884 101.194 108.836 C++ Note: df101 -69.7559 -69.7559 C++ Note: df102 2.37027 0.59374 C++ Note: df103 -10.9895 -6.01548 C++ Note: df104 1.04436 0.455358 C++ Note: df105 -0.215686 -0.0987019 C++ Note: df106 -29.4295 -117.486 C++ Note: df100 6027 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 3566.45 1594.5 968.276 2102.11 897.328 C++ Note: riskl checked 341.759 127.646 104.884 101.194 108.836 C++ Note: df101 -69.7559 -69.7559 C++ Note: df102 2.37027 0.59374 C++ Note: df103 -10.9895 -6.01548 C++ Note: df104 1.04436 0.455358 C++ Note: df105 -0.215686 -0.0987019 C++ Note: df106 -29.4295 -117.486 C++ Note: riskr checked 3566.45 1594.5 968.276 2102.11 897.328 C++ Note: riskl checked 341.759 127.646 104.884 101.194 108.836 C++ Note: df101 -69.7559 -69.7559 C++ Note: df102 2.37027 0.59374 C++ Note: df103 -10.9895 -6.01548 C++ Note: df104 1.04436 0.455358 C++ Note: df105 -0.215686 -0.0987019 C++ Note: df106 -29.4295 -117.486 C++ Note: Exiting Regression C++ Note: df501 -69.7559 C++ Note: df504 1.044361 0.4553577 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 316 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: derivs checked 1229.85 410.233 C++ Note: second derivs checked 3319.14 410.233 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df102 5.42704 2.14202 C++ Note: df103 -7.11684 -6.21271 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.762564 -0.34478 C++ Note: df106 -14.6652 -37.1559 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.550424 0.30353 C++ Note: sums checked 4228.8 4228.8 C++ Note: derivs checked 12473.9 2494.15 C++ Note: second derivs checked 46827.4 2494.15 C++ Note: dose checked 1000 C++ Note: non-dose checked 4228.8 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 4228.8 C++ Note: risk checked 4228.8 C++ Note: risk1 checked 12473.9 2494.15 C++ Note: risk2 checked 46827.4 2494.15 C++ Note: riskr checked 616.483 485.721 374.917 603.993 261.606 C++ Note: riskl checked 43.76 24.6658 24.1668 25.7075 19.5703 C++ Note: df101 -76.8654 -76.8654 C++ Note: df102 1.27777 0.508497 C++ Note: df103 -7.18963 -6.04474 C++ Note: df104 0.550424 0.30353 C++ Note: df105 -0.177724 -0.0841223 C++ Note: df106 -60.1559 -151.162 C++ Note: df100 2463 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 616.483 485.721 374.917 603.993 261.606 C++ Note: riskl checked 43.76 24.6658 24.1668 25.7075 19.5703 C++ Note: df101 -76.8654 -76.8654 C++ Note: df102 1.27777 0.508497 C++ Note: df103 -7.18963 -6.04474 C++ Note: df104 0.550424 0.30353 C++ Note: df105 -0.177724 -0.0841223 C++ Note: df106 -60.1559 -151.162 C++ Note: ending guess 0 C++ Note: df501 -76.86543 C++ Note: df504 0.5504238 0.3035295 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.5504238 0.3035295, -76.86543<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.550424 0.30353 C++ Note: sums checked 4228.8 4228.8 C++ Note: derivs checked 12473.9 2494.15 C++ Note: second derivs checked 46827.4 2494.15 C++ Note: dose checked 1000 C++ Note: non-dose checked 4228.8 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 4228.8 C++ Note: risk checked 4228.8 C++ Note: risk1 checked 12473.9 2494.15 C++ Note: risk2 checked 46827.4 2494.15 C++ Note: Made Risk Side Lists C++ Note: riskr checked 616.483 485.721 374.917 603.993 261.606 C++ Note: riskl checked 43.76 24.6658 24.1668 25.7075 19.5703 C++ Note: df101 -76.8654 -76.8654 C++ Note: df102 1.27777 0.508497 C++ Note: df103 -7.18963 -6.04474 C++ Note: df104 0.550424 0.30353 C++ Note: df105 -0.177724 -0.0841223 C++ Note: df106 -60.1559 -151.162 C++ Note: Starting Halves C++ Note: df501 -76.86543 C++ Note: df504 0.5504238 0.3035295 C++ Note: values checked 0.699516 0.396693 C++ Note: sums checked 7122.36 7122.36 C++ Note: derivs checked 23453.2 4323.35 C++ Note: second derivs checked 93329.8 4323.35 C++ Note: dose checked 1000 C++ Note: non-dose checked 7122.36 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 7122.36 C++ Note: risk checked 7122.36 C++ Note: risk1 checked 23453.2 4323.35 C++ Note: risk2 checked 93329.8 4323.35 C++ Note: riskr checked 1103.97 748.255 549.423 973.678 397.318 C++ Note: riskl checked 81.8797 40.3981 38.9034 39.35 33.1873 C++ Note: df101 -76.7167 -76.7167 C++ Note: df102 0.321463 0.127669 C++ Note: df103 -7.13078 -5.96512 C++ Note: df104 0.699516 0.396693 C++ Note: df105 -0.045081 -0.0214027 C++ Note: df106 -238.649 -600.901 C++ Note: df100 5566 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 1103.97 748.255 549.423 973.678 397.318 C++ Note: riskl checked 81.8797 40.3981 38.9034 39.35 33.1873 C++ Note: df101 -76.7167 -76.7167 C++ Note: df102 0.321463 0.127669 C++ Note: df103 -7.13078 -5.96512 C++ Note: df104 0.699516 0.396693 C++ Note: df105 -0.045081 -0.0214027 C++ Note: df106 -238.649 -600.901 C++ Note: riskr checked 1103.97 748.255 549.423 973.678 397.318 C++ Note: riskl checked 81.8797 40.3981 38.9034 39.35 33.1873 C++ Note: df101 -76.7167 -76.7167 C++ Note: df102 0.321463 0.127669 C++ Note: df103 -7.13078 -5.96512 C++ Note: df104 0.699516 0.396693 C++ Note: df105 -0.045081 -0.0214027 C++ Note: df106 -238.649 -600.901 C++ Note: Exiting Regression C++ Note: df501 -76.71665 C++ Note: df504 0.6995155 0.3966929 Note: 5 strata used Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 320 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: derivs checked 1229.85 410.233 C++ Note: second derivs checked 3319.14 410.233 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113 C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621 C++ Note: df101 -79.5885 -79.5885 C++ Note: df102 5.42704 2.14202 C++ Note: df103 -7.11684 -6.21271 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.762564 -0.34478 C++ Note: df106 -14.6652 -37.1559 C++ Note: Starting Halves C++ Note: df501 -79.58847 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.471923 0.158585 C++ Note: sums checked 3109.21 3109.21 C++ Note: derivs checked 8604.8 1732.23 C++ Note: second derivs checked 31265.5 1732.23 C++ Note: dose checked 1000 C++ Note: non-dose checked 3109.21 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 3109.21 C++ Note: risk checked 3109.21 C++ Note: risk1 checked 8604.8 1732.23 C++ Note: risk2 checked 31265.5 1732.23 C++ Note: riskr checked 437.598 369.44 288.407 451.269 203.987 C++ Note: riskl checked 29.7555 18.4415 17.3204 19.7081 14.0257 C++ Note: df101 -77.1115 -77.1115 C++ Note: df102 1.6628 1.2965 C++ Note: df103 -7.18852 -6.1617 C++ Note: df104 0.471923 0.158585 C++ Note: df105 -0.231313 -0.210412 C++ Note: df106 -46.3745 -59.4767 C++ Note: df100 2452 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 437.598 369.44 288.407 451.269 203.987 C++ Note: riskl checked 29.7555 18.4415 17.3204 19.7081 14.0257 C++ Note: df101 -77.1115 -77.1115 C++ Note: df102 1.6628 1.2965 C++ Note: df103 -7.18852 -6.1617 C++ Note: df104 0.471923 0.158585 C++ Note: df105 -0.231313 -0.210412 C++ Note: df106 -46.3745 -59.4767 C++ Note: ending guess 0 C++ Note: df501 -77.11153 C++ Note: df504 0.4719227 0.1585847 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.4719227 0.1585847, -77.11153<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.471923 0.158585 C++ Note: sums checked 3109.21 3109.21 C++ Note: derivs checked 8604.8 1732.23 C++ Note: second derivs checked 31265.5 1732.23 C++ Note: dose checked 1000 C++ Note: non-dose checked 3109.21 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 3109.21 C++ Note: risk checked 3109.21 C++ Note: risk1 checked 8604.8 1732.23 C++ Note: risk2 checked 31265.5 1732.23 C++ Note: Made Risk Side Lists C++ Note: riskr checked 437.598 369.44 288.407 451.269 203.987 C++ Note: riskl checked 29.7555 18.4415 17.3204 19.7081 14.0257 C++ Note: df101 -77.1115 -77.1115 C++ Note: df102 1.6628 1.2965 C++ Note: df103 -7.18852 -6.1617 C++ Note: df104 0.471923 0.158585 C++ Note: df105 -0.231313 -0.210412 C++ Note: df106 -46.3745 -59.4767 C++ Note: Starting Halves C++ Note: df501 -77.11153 C++ Note: df504 0.4719227 0.1585847 C++ Note: values checked 0.645408 0.316394 C++ Note: sums checked 5698.95 5698.95 C++ Note: derivs checked 18076.9 3359.94 C++ Note: second derivs checked 70503.7 3359.94 C++ Note: dose checked 1000 C++ Note: non-dose checked 5698.95 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 5698.95 C++ Note: risk checked 5698.95 C++ Note: risk1 checked 18076.9 3359.94 C++ Note: risk2 checked 70503.7 3359.94 C++ Note: riskr checked 866.381 621.431 461.192 794.093 330.167 C++ Note: riskl checked 63.0668 33.0727 31.2711 32.9428 26.3017 C++ Note: df101 -76.7689 -76.7689 C++ Note: df102 0.612277 0.54564 C++ Note: df103 -7.1484 -6.0464 C++ Note: df104 0.645408 0.316394 C++ Note: df105 -0.0856523 -0.0902421 C++ Note: df106 -125.383 -140.695 C++ Note: df100 5197 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 866.381 621.431 461.192 794.093 330.167 C++ Note: riskl checked 63.0668 33.0727 31.2711 32.9428 26.3017 C++ Note: df101 -76.7689 -76.7689 C++ Note: df102 0.612277 0.54564 C++ Note: df103 -7.1484 -6.0464 C++ Note: df104 0.645408 0.316394 C++ Note: df105 -0.0856523 -0.0902421 C++ Note: df106 -125.383 -140.695 C++ Note: riskr checked 866.381 621.431 461.192 794.093 330.167 C++ Note: riskl checked 63.0668 33.0727 31.2711 32.9428 26.3017 C++ Note: df101 -76.7689 -76.7689 C++ Note: df102 0.612277 0.54564 C++ Note: df103 -7.1484 -6.0464 C++ Note: df104 0.645408 0.316394 C++ Note: df105 -0.0856523 -0.0902421 C++ Note: df106 -125.383 -140.695 C++ Note: Exiting Regression C++ Note: df501 -76.76892 C++ Note: df504 0.6454076 0.316394 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 231 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 -122.891 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -122.8909 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 -122.891 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1136 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 -122.891 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1569 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 -122.891 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -122.8909 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -122.8909<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 -122.891 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -122.8909 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 -122.891 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2738 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 -122.891 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3171 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 -122.891 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 -122.891 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -122.8909 C++ Note: df504 -0.1 -0.1 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,24,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 222 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 -122.891 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -122.8909 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 -122.891 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1078 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 -122.891 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1502 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 -122.891 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -122.8909 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -122.8909<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 -122.891 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -122.8909 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 -122.891 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2646 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 -122.891 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3074 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 -122.891 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 -122.891 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -122.8909 C++ Note: df504 -0.1 -0.1 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 187 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: df100 890 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -119.9814<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1780 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2118 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 170 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: df100 844 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1181 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -119.9814<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2044 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2381 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 -119.981 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 221 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2197.44 C++ Note: risk1r checked 3174.27 1089.12 C++ Note: risk2r checked 7204.63 1089.12 C++ Note: riskl checked 19.6098 C++ Note: risk1l checked 42.0717 11.5472 C++ Note: risk2l checked 118.124 11.5472 C++ Note: df101 -122.891 -122.891 C++ Note: df102 21.2331 3.11507 C++ Note: df103 -19.7104 -6.49727 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -1.07726 -0.479443 C++ Note: df106 -5.78769 -39.4505 C++ Note: Starting Halves C++ Note: df501 -122.8909 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.732916 0.388699 C++ Note: sums checked 6380.99 1252.26 C++ Note: risk checked 7921.99 C++ Note: risk1 checked 26681.9 4784.79 C++ Note: risk2 checked 107491 4784.79 C++ Note: riskr checked 15672.9 C++ Note: risk1r checked 42701.5 9198.27 C++ Note: risk2r checked 144140 9198.27 C++ Note: riskl checked 259.026 C++ Note: risk1l checked 843.134 168.735 C++ Note: risk2l checked 3047.41 168.735 C++ Note: df101 -110.801 -110.801 C++ Note: df102 6.10212 0.649377 C++ Note: df103 -15.9738 -6.28124 C++ Note: df104 0.732916 0.388699 C++ Note: df105 -0.382009 -0.103384 C++ Note: df106 -18.1578 -170.627 C++ Note: df100 2601 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 15672.9 C++ Note: risk1r checked 42701.5 9198.27 C++ Note: risk2r checked 144140 9198.27 C++ Note: riskl checked 259.026 C++ Note: risk1l checked 843.134 168.735 C++ Note: risk2l checked 3047.41 168.735 C++ Note: df101 -110.801 -110.801 C++ Note: df102 6.10212 0.649377 C++ Note: df103 -15.9738 -6.28124 C++ Note: df104 0.732916 0.388699 C++ Note: df105 -0.382009 -0.103384 C++ Note: df106 -18.1578 -170.627 C++ Note: ending guess 0 C++ Note: df501 -110.8014 C++ Note: df504 0.732916 0.3886995 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.732916 0.3886995, -110.8014<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.732916 0.388699 C++ Note: sums checked 6380.99 1252.26 C++ Note: risk checked 7921.99 C++ Note: risk1 checked 26681.9 4784.79 C++ Note: risk2 checked 107491 4784.79 C++ Note: Made Risk Side Lists C++ Note: riskr checked 15672.9 C++ Note: risk1r checked 42701.5 9198.27 C++ Note: risk2r checked 144140 9198.27 C++ Note: riskl checked 259.026 C++ Note: risk1l checked 843.134 168.735 C++ Note: risk2l checked 3047.41 168.735 C++ Note: df101 -110.801 -110.801 C++ Note: df102 6.10212 0.649377 C++ Note: df103 -15.9738 -6.28124 C++ Note: df104 0.732916 0.388699 C++ Note: df105 -0.382009 -0.103384 C++ Note: df106 -18.1578 -170.627 C++ Note: Starting Halves C++ Note: df501 -110.8014 C++ Note: df504 0.732916 0.3886995 C++ Note: values checked 1.02333 0.493704 C++ Note: sums checked 18600.8 1338.98 C++ Note: risk checked 24538.9 C++ Note: risk1 checked 97084.4 15240.1 C++ Note: risk2 checked 428953 15240.1 C++ Note: riskr checked 39636.5 C++ Note: risk1r checked 128036 24066.7 C++ Note: risk2r checked 480878 24066.7 C++ Note: riskl checked 745.302 C++ Note: risk1l checked 2645.43 469.387 C++ Note: risk2l checked 10112.8 469.387 C++ Note: df101 -109.621 -109.621 C++ Note: df102 1.83938 0.14137 C++ Note: df103 -13.8104 -6.17729 C++ Note: df104 1.02333 0.493704 C++ Note: df105 -0.133188 -0.0228854 C++ Note: df106 -59.5969 -775.422 C++ Note: df100 5983 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 39636.5 C++ Note: risk1r checked 128036 24066.7 C++ Note: risk2r checked 480878 24066.7 C++ Note: riskl checked 745.302 C++ Note: risk1l checked 2645.43 469.387 C++ Note: risk2l checked 10112.8 469.387 C++ Note: df101 -109.621 -109.621 C++ Note: df102 1.83938 0.14137 C++ Note: df103 -13.8104 -6.17729 C++ Note: df104 1.02333 0.493704 C++ Note: df105 -0.133188 -0.0228854 C++ Note: df106 -59.5969 -775.422 C++ Note: riskr checked 39636.5 C++ Note: risk1r checked 128036 24066.7 C++ Note: risk2r checked 480878 24066.7 C++ Note: riskl checked 745.302 C++ Note: risk1l checked 2645.43 469.387 C++ Note: risk2l checked 10112.8 469.387 C++ Note: df101 -109.621 -109.621 C++ Note: df102 1.83938 0.14137 C++ Note: df103 -13.8104 -6.17729 C++ Note: df104 1.02333 0.493704 C++ Note: df105 -0.133188 -0.0228854 C++ Note: df106 -59.5969 -775.422 C++ Note: Exiting Regression C++ Note: df501 -109.6211 C++ Note: df504 1.023328 0.4937042 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 232 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2197.44 C++ Note: risk1r checked 3174.27 1089.12 C++ Note: risk2r checked 7204.63 1089.12 C++ Note: riskl checked 19.6098 C++ Note: risk1l checked 42.0717 11.5472 C++ Note: risk2l checked 118.124 11.5472 C++ Note: df101 -122.891 -122.891 C++ Note: df102 21.2331 3.11507 C++ Note: df103 -19.7104 -6.49727 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -1.07726 -0.479443 C++ Note: df106 -5.78769 -39.4505 C++ Note: Starting Halves C++ Note: df501 -122.8909 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.707943 0.259582 C++ Note: sums checked 5868.37 1157.38 C++ Note: risk checked 6754.07 C++ Note: risk1 checked 22400.3 3873.99 C++ Note: risk2 checked 89482.9 3873.99 C++ Note: riskr checked 13607.5 C++ Note: risk1r checked 36518.1 7564.8 C++ Note: risk2r checked 122057 7564.8 C++ Note: riskl checked 219.94 C++ Note: risk1l checked 713.45 137.505 C++ Note: risk2l checked 2579.26 137.505 C++ Note: df101 -111.093 -111.093 C++ Note: df102 6.4244 1.45354 C++ Note: df103 -16.1091 -6.40177 C++ Note: df104 0.707943 0.259582 C++ Note: df105 -0.398805 -0.227053 C++ Note: df106 -17.2924 -76.4296 C++ Note: df100 2564 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 13607.5 C++ Note: risk1r checked 36518.1 7564.8 C++ Note: risk2r checked 122057 7564.8 C++ Note: riskl checked 219.94 C++ Note: risk1l checked 713.45 137.505 C++ Note: risk2l checked 2579.26 137.505 C++ Note: df101 -111.093 -111.093 C++ Note: df102 6.4244 1.45354 C++ Note: df103 -16.1091 -6.40177 C++ Note: df104 0.707943 0.259582 C++ Note: df105 -0.398805 -0.227053 C++ Note: df106 -17.2924 -76.4296 C++ Note: ending guess 0 C++ Note: df501 -111.0934 C++ Note: df504 0.7079435 0.259582 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.7079435 0.259582, -111.0934<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.707943 0.259582 C++ Note: sums checked 5868.37 1157.38 C++ Note: risk checked 6754.07 C++ Note: risk1 checked 22400.3 3873.99 C++ Note: risk2 checked 89482.9 3873.99 C++ Note: Made Risk Side Lists C++ Note: riskr checked 13607.5 C++ Note: risk1r checked 36518.1 7564.8 C++ Note: risk2r checked 122057 7564.8 C++ Note: riskl checked 219.94 C++ Note: risk1l checked 713.45 137.505 C++ Note: risk2l checked 2579.26 137.505 C++ Note: df101 -111.093 -111.093 C++ Note: df102 6.4244 1.45354 C++ Note: df103 -16.1091 -6.40177 C++ Note: df104 0.707943 0.259582 C++ Note: df105 -0.398805 -0.227053 C++ Note: df106 -17.2924 -76.4296 C++ Note: Starting Halves C++ Note: df501 -111.0934 C++ Note: df504 0.7079435 0.259582 C++ Note: values checked 1.00705 0.429872 C++ Note: sums checked 17441.8 1285.18 C++ Note: risk checked 22129.4 C++ Note: risk1 checked 86917.6 13416 C++ Note: risk2 checked 382294 13416 C++ Note: riskr checked 36201.7 C++ Note: risk1r checked 115958 21431.5 C++ Note: risk2r checked 433026 21431.5 C++ Note: riskl checked 676.025 C++ Note: risk1l checked 2396.11 417.501 C++ Note: risk2l checked 9159.18 417.501 C++ Note: df101 -109.674 -109.674 C++ Note: df102 2.03825 0.531514 C++ Note: df103 -13.8822 -6.25712 C++ Note: df104 1.00705 0.429872 C++ Note: df105 -0.146825 -0.0849455 C++ Note: df106 -53.8081 -206.343 C++ Note: df100 5908 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 36201.7 C++ Note: risk1r checked 115958 21431.5 C++ Note: risk2r checked 433026 21431.5 C++ Note: riskl checked 676.025 C++ Note: risk1l checked 2396.11 417.501 C++ Note: risk2l checked 9159.18 417.501 C++ Note: df101 -109.674 -109.674 C++ Note: df102 2.03825 0.531514 C++ Note: df103 -13.8822 -6.25712 C++ Note: df104 1.00705 0.429872 C++ Note: df105 -0.146825 -0.0849455 C++ Note: df106 -53.8081 -206.343 C++ Note: riskr checked 36201.7 C++ Note: risk1r checked 115958 21431.5 C++ Note: risk2r checked 433026 21431.5 C++ Note: riskl checked 676.025 C++ Note: risk1l checked 2396.11 417.501 C++ Note: risk2l checked 9159.18 417.501 C++ Note: df101 -109.674 -109.674 C++ Note: df102 2.03825 0.531514 C++ Note: df103 -13.8822 -6.25712 C++ Note: df104 1.00705 0.429872 C++ Note: df105 -0.146825 -0.0849455 C++ Note: df106 -53.8081 -206.343 C++ Note: Exiting Regression C++ Note: df501 -109.6742 C++ Note: df504 1.007047 0.4298716 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 185 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: risk1r checked 3418.73 1095.31 C++ Note: risk2r checked 8667.81 1095.31 C++ Note: riskl checked 19.6098 C++ Note: risk1l checked 42.0717 11.5472 C++ Note: risk2l checked 118.124 11.5472 C++ Note: df101 -119.981 -119.981 C++ Note: df102 6.06579 2.41134 C++ Note: df103 -8.60689 -6.47374 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.70476 -0.37248 C++ Note: df106 -19.78 -49.7572 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.497478 0.312164 C++ Note: sums checked 3067.26 1194.55 C++ Note: risk checked 3648.05 C++ Note: risk1 checked 10299.6 2165.99 C++ Note: risk2 checked 37798.4 2165.99 C++ Note: riskr checked 9367.5 C++ Note: risk1r checked 24562.6 5580.77 C++ Note: risk2r checked 81557.6 5580.77 C++ Note: riskl checked 118.249 C++ Note: risk1l checked 351.472 78.443 C++ Note: risk2l checked 1199.14 78.443 C++ Note: df101 -117.142 -117.142 C++ Note: df102 1.31609 0.547704 C++ Note: df103 -9.05233 -6.2666 C++ Note: df104 0.497478 0.312164 C++ Note: df105 -0.145387 -0.0874005 C++ Note: df106 -89.0079 -213.879 C++ Note: df100 1532 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 9367.5 C++ Note: risk1r checked 24562.6 5580.77 C++ Note: risk2r checked 81557.6 5580.77 C++ Note: riskl checked 118.249 C++ Note: risk1l checked 351.472 78.443 C++ Note: risk2l checked 1199.14 78.443 C++ Note: df101 -117.142 -117.142 C++ Note: df102 1.31609 0.547704 C++ Note: df103 -9.05233 -6.2666 C++ Note: df104 0.497478 0.312164 C++ Note: df105 -0.145387 -0.0874005 C++ Note: df106 -89.0079 -213.879 C++ Note: ending guess 0 C++ Note: df501 -117.1424 C++ Note: df504 0.4974778 0.3121644 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.4974778 0.3121644, -117.1424<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.497478 0.312164 C++ Note: sums checked 3067.26 1194.55 C++ Note: risk checked 3648.05 C++ Note: risk1 checked 10299.6 2165.99 C++ Note: risk2 checked 37798.4 2165.99 C++ Note: Made Risk Side Lists C++ Note: riskr checked 9367.5 C++ Note: risk1r checked 24562.6 5580.77 C++ Note: risk2r checked 81557.6 5580.77 C++ Note: riskl checked 118.249 C++ Note: risk1l checked 351.472 78.443 C++ Note: risk2l checked 1199.14 78.443 C++ Note: df101 -117.142 -117.142 C++ Note: df102 1.31609 0.547704 C++ Note: df103 -9.05233 -6.2666 C++ Note: df104 0.497478 0.312164 C++ Note: df105 -0.145387 -0.0874005 C++ Note: df106 -89.0079 -213.879 C++ Note: Starting Halves C++ Note: df501 -117.1424 C++ Note: df504 0.4974778 0.3121644 C++ Note: values checked 0.617144 0.398893 C++ Note: sums checked 4379.75 1260.28 C++ Note: risk checked 5479.95 C++ Note: risk1 checked 17006.9 3344.7 C++ Note: risk2 checked 65563.9 3344.7 C++ Note: riskr checked 13683.9 C++ Note: risk1r checked 38812.2 8366.11 C++ Note: risk2r checked 134810 8366.11 C++ Note: riskl checked 180.348 C++ Note: risk1l checked 561.69 120.669 C++ Note: risk2l checked 1971.73 120.669 C++ Note: df101 -117.015 -117.015 C++ Note: df102 0.320802 0.13496 C++ Note: df103 -9.12088 -6.18217 C++ Note: df104 0.617144 0.398893 C++ Note: df105 -0.0351723 -0.0218306 C++ Note: df106 -364.756 -867.031 C++ Note: df100 3360 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 13683.9 C++ Note: risk1r checked 38812.2 8366.11 C++ Note: risk2r checked 134810 8366.11 C++ Note: riskl checked 180.348 C++ Note: risk1l checked 561.69 120.669 C++ Note: risk2l checked 1971.73 120.669 C++ Note: df101 -117.015 -117.015 C++ Note: df102 0.320802 0.13496 C++ Note: df103 -9.12088 -6.18217 C++ Note: df104 0.617144 0.398893 C++ Note: df105 -0.0351723 -0.0218306 C++ Note: df106 -364.756 -867.031 C++ Note: riskr checked 13683.9 C++ Note: risk1r checked 38812.2 8366.11 C++ Note: risk2r checked 134810 8366.11 C++ Note: riskl checked 180.348 C++ Note: risk1l checked 561.69 120.669 C++ Note: risk2l checked 1971.73 120.669 C++ Note: df101 -117.015 -117.015 C++ Note: df102 0.320802 0.13496 C++ Note: df103 -9.12088 -6.18217 C++ Note: df104 0.617144 0.398893 C++ Note: df105 -0.0351723 -0.0218306 C++ Note: df106 -364.756 -867.031 C++ Note: Exiting Regression C++ Note: df501 -117.0147 C++ Note: df504 0.6171437 0.3988932 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 168 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 851.028 949.469 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: risk1r checked 3418.73 1095.31 C++ Note: risk2r checked 8667.81 1095.31 C++ Note: riskl checked 19.6098 C++ Note: risk1l checked 42.0717 11.5472 C++ Note: risk2l checked 118.124 11.5472 C++ Note: df101 -119.981 -119.981 C++ Note: df102 6.06579 2.41134 C++ Note: df103 -8.60689 -6.47374 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.70476 -0.37248 C++ Note: df106 -19.78 -49.7572 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.42857 0.17936 C++ Note: sums checked 2537.47 1104.32 C++ Note: risk checked 2796.31 C++ Note: risk1 checked 7446.21 1576.41 C++ Note: risk2 checked 26529.4 1576.41 C++ Note: riskr checked 7268.45 C++ Note: risk1r checked 18181.7 4116.59 C++ Note: risk2r checked 58803.1 4116.59 C++ Note: riskl checked 88.5975 C++ Note: risk1l checked 256.339 56.699 C++ Note: risk2l checked 862.409 56.699 C++ Note: df101 -117.373 -117.373 C++ Note: df102 1.78502 1.30975 C++ Note: df103 -8.96103 -6.38772 C++ Note: df104 0.42857 0.17936 C++ Note: df105 -0.199199 -0.205041 C++ Note: df106 -65.7541 -89.6148 C++ Note: df100 1487 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 7268.45 C++ Note: risk1r checked 18181.7 4116.59 C++ Note: risk2r checked 58803.1 4116.59 C++ Note: riskl checked 88.5975 C++ Note: risk1l checked 256.339 56.699 C++ Note: risk2l checked 862.409 56.699 C++ Note: df101 -117.373 -117.373 C++ Note: df102 1.78502 1.30975 C++ Note: df103 -8.96103 -6.38772 C++ Note: df104 0.42857 0.17936 C++ Note: df105 -0.199199 -0.205041 C++ Note: df106 -65.7541 -89.6148 C++ Note: ending guess 0 C++ Note: df501 -117.3726 C++ Note: df504 0.4285697 0.17936 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.4285697 0.17936, -117.3726<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.42857 0.17936 C++ Note: sums checked 2537.47 1104.32 C++ Note: risk checked 2796.31 C++ Note: risk1 checked 7446.21 1576.41 C++ Note: risk2 checked 26529.4 1576.41 C++ Note: Made Risk Side Lists C++ Note: riskr checked 7268.45 C++ Note: risk1r checked 18181.7 4116.59 C++ Note: risk2r checked 58803.1 4116.59 C++ Note: riskl checked 88.5975 C++ Note: risk1l checked 256.339 56.699 C++ Note: risk2l checked 862.409 56.699 C++ Note: df101 -117.373 -117.373 C++ Note: df102 1.78502 1.30975 C++ Note: df103 -8.96103 -6.38772 C++ Note: df104 0.42857 0.17936 C++ Note: df105 -0.199199 -0.205041 C++ Note: df106 -65.7541 -89.6148 C++ Note: Starting Halves C++ Note: df501 -117.3726 C++ Note: df504 0.4285697 0.17936 C++ Note: values checked 0.577969 0.333141 C++ Note: sums checked 3883.17 1209.93 C++ Note: risk checked 4672.1 C++ Note: risk1 checked 14081.1 2784.48 C++ Note: risk2 checked 53455.8 2784.48 C++ Note: riskr checked 11783.5 C++ Note: risk1r checked 32618.6 7038.87 C++ Note: risk2r checked 111717 7038.87 C++ Note: riskl checked 152.934 C++ Note: risk1l checked 470.041 100.807 C++ Note: risk2l checked 1638.11 100.807 C++ Note: df101 -117.054 -117.054 C++ Note: df102 0.609162 0.503449 C++ Note: df103 -9.07577 -6.25818 C++ Note: df104 0.577969 0.333141 C++ Note: df105 -0.0671196 -0.0804466 C++ Note: df106 -192.156 -232.504 C++ Note: df100 3307 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 11783.5 C++ Note: risk1r checked 32618.6 7038.87 C++ Note: risk2r checked 111717 7038.87 C++ Note: riskl checked 152.934 C++ Note: risk1l checked 470.041 100.807 C++ Note: risk2l checked 1638.11 100.807 C++ Note: df101 -117.054 -117.054 C++ Note: df102 0.609162 0.503449 C++ Note: df103 -9.07577 -6.25818 C++ Note: df104 0.577969 0.333141 C++ Note: df105 -0.0671196 -0.0804466 C++ Note: df106 -192.156 -232.504 C++ Note: riskr checked 11783.5 C++ Note: risk1r checked 32618.6 7038.87 C++ Note: risk2r checked 111717 7038.87 C++ Note: riskl checked 152.934 C++ Note: risk1l checked 470.041 100.807 C++ Note: risk2l checked 1638.11 100.807 C++ Note: df101 -117.054 -117.054 C++ Note: df102 0.609162 0.503449 C++ Note: df103 -9.07577 -6.25818 C++ Note: df104 0.577969 0.333141 C++ Note: df105 -0.0671196 -0.0804466 C++ Note: df106 -192.156 -232.504 C++ Note: Exiting Regression C++ Note: df501 -117.0539 C++ Note: df504 0.5779686 0.3331409 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 228 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 0 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -122.8909 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1194 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1647 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 0 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -122.8909 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -122.8909<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 0 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -122.8909 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2868 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3317 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 0 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 0 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -122.8909 C++ Note: df504 -0.1 -0.1 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 222 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 0 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -122.8909 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1149 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1600 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 0 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -122.8909 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -122.8909<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 0 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -122.8909 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2806 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 3257 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 0 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 2197.44 C++ Note: riskl checked 19.6098 C++ Note: df101 -122.891 0 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -122.8909 C++ Note: df504 -0.1 -0.1 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,26,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 170 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1057 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1416 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -119.9814<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2364 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2721 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,24,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 165 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 906 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: ending guess 0 C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1 -0.1, -119.9814<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 1841 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: df100 2197 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: riskr checked 2125.36 C++ Note: riskl checked 19.6098 C++ Note: df101 -119.981 0 C++ Note: df104 -0.1 -0.1 C++ Note: Exiting Regression C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 242 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: derivs checked 1229.85 410.233 C++ Note: second derivs checked 3319.14 410.233 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2197.44 C++ Note: risk1r checked 3174.27 1089.12 C++ Note: risk2r checked 7204.63 1089.12 C++ Note: riskl checked 19.6098 C++ Note: risk1l checked 42.0717 11.5472 C++ Note: risk2l checked 118.124 11.5472 C++ Note: df101 -122.891 -122.891 C++ Note: df102 21.2331 3.11507 C++ Note: df103 -19.7104 -6.49727 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -1.07726 -0.479443 C++ Note: df106 -5.78769 -39.4505 C++ Note: Starting Halves C++ Note: df501 -122.8909 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.732916 0.388699 C++ Note: sums checked 7921.99 7921.99 C++ Note: derivs checked 26681.9 4784.79 C++ Note: second derivs checked 107491 4784.79 C++ Note: dose checked 1000 C++ Note: non-dose checked 7921.99 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 7921.99 C++ Note: risk checked 7921.99 C++ Note: risk1 checked 26681.9 4784.79 C++ Note: risk2 checked 107491 4784.79 C++ Note: riskr checked 15672.9 C++ Note: risk1r checked 42701.5 9198.27 C++ Note: risk2r checked 144140 9198.27 C++ Note: riskl checked 259.026 C++ Note: risk1l checked 843.134 168.735 C++ Note: risk2l checked 3047.41 168.735 C++ Note: df101 -110.801 -110.801 C++ Note: df102 6.10212 0.649377 C++ Note: df103 -15.9738 -6.28124 C++ Note: df104 0.732916 0.388699 C++ Note: df105 -0.382009 -0.103384 C++ Note: df106 -18.1578 -170.627 C++ Note: df100 3167 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 15672.9 C++ Note: risk1r checked 42701.5 9198.27 C++ Note: risk2r checked 144140 9198.27 C++ Note: riskl checked 259.026 C++ Note: risk1l checked 843.134 168.735 C++ Note: risk2l checked 3047.41 168.735 C++ Note: df101 -110.801 -110.801 C++ Note: df102 6.10212 0.649377 C++ Note: df103 -15.9738 -6.28124 C++ Note: df104 0.732916 0.388699 C++ Note: df105 -0.382009 -0.103384 C++ Note: df106 -18.1578 -170.627 C++ Note: ending guess 0 C++ Note: df501 -110.8014 C++ Note: df504 0.732916 0.3886995 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.732916 0.3886995, -110.8014<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.732916 0.388699 C++ Note: sums checked 7921.99 7921.99 C++ Note: derivs checked 26681.9 4784.79 C++ Note: second derivs checked 107491 4784.79 C++ Note: dose checked 1000 C++ Note: non-dose checked 7921.99 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 7921.99 C++ Note: risk checked 7921.99 C++ Note: risk1 checked 26681.9 4784.79 C++ Note: risk2 checked 107491 4784.79 C++ Note: Made Risk Side Lists C++ Note: riskr checked 15672.9 C++ Note: risk1r checked 42701.5 9198.27 C++ Note: risk2r checked 144140 9198.27 C++ Note: riskl checked 259.026 C++ Note: risk1l checked 843.134 168.735 C++ Note: risk2l checked 3047.41 168.735 C++ Note: df101 -110.801 -110.801 C++ Note: df102 6.10212 0.649377 C++ Note: df103 -15.9738 -6.28124 C++ Note: df104 0.732916 0.388699 C++ Note: df105 -0.382009 -0.103384 C++ Note: df106 -18.1578 -170.627 C++ Note: Starting Halves C++ Note: df501 -110.8014 C++ Note: df504 0.732916 0.3886995 C++ Note: values checked 1.02333 0.493704 C++ Note: sums checked 24538.9 24538.9 C++ Note: derivs checked 97084.4 15240.1 C++ Note: second derivs checked 428953 15240.1 C++ Note: dose checked 1000 C++ Note: non-dose checked 24538.9 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 24538.9 C++ Note: risk checked 24538.9 C++ Note: risk1 checked 97084.4 15240.1 C++ Note: risk2 checked 428953 15240.1 C++ Note: riskr checked 39636.5 C++ Note: risk1r checked 128036 24066.7 C++ Note: risk2r checked 480878 24066.7 C++ Note: riskl checked 745.302 C++ Note: risk1l checked 2645.43 469.387 C++ Note: risk2l checked 10112.8 469.387 C++ Note: df101 -109.621 -109.621 C++ Note: df102 1.83938 0.14137 C++ Note: df103 -13.8104 -6.17729 C++ Note: df104 1.02333 0.493704 C++ Note: df105 -0.133188 -0.0228854 C++ Note: df106 -59.5969 -775.422 C++ Note: df100 7106 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 39636.5 C++ Note: risk1r checked 128036 24066.7 C++ Note: risk2r checked 480878 24066.7 C++ Note: riskl checked 745.302 C++ Note: risk1l checked 2645.43 469.387 C++ Note: risk2l checked 10112.8 469.387 C++ Note: df101 -109.621 -109.621 C++ Note: df102 1.83938 0.14137 C++ Note: df103 -13.8104 -6.17729 C++ Note: df104 1.02333 0.493704 C++ Note: df105 -0.133188 -0.0228854 C++ Note: df106 -59.5969 -775.422 C++ Note: riskr checked 39636.5 C++ Note: risk1r checked 128036 24066.7 C++ Note: risk2r checked 480878 24066.7 C++ Note: riskl checked 745.302 C++ Note: risk1l checked 2645.43 469.387 C++ Note: risk2l checked 10112.8 469.387 C++ Note: df101 -109.621 -109.621 C++ Note: df102 1.83938 0.14137 C++ Note: df103 -13.8104 -6.17729 C++ Note: df104 1.02333 0.493704 C++ Note: df105 -0.133188 -0.0228854 C++ Note: df106 -59.5969 -775.422 C++ Note: Exiting Regression C++ Note: df501 -109.6211 C++ Note: df504 1.023328 0.4937042 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 239 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: derivs checked 1229.85 410.233 C++ Note: second derivs checked 3319.14 410.233 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2197.44 C++ Note: risk1r checked 3174.27 1089.12 C++ Note: risk2r checked 7204.63 1089.12 C++ Note: riskl checked 19.6098 C++ Note: risk1l checked 42.0717 11.5472 C++ Note: risk2l checked 118.124 11.5472 C++ Note: df101 -122.891 -122.891 C++ Note: df102 21.2331 3.11507 C++ Note: df103 -19.7104 -6.49727 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -1.07726 -0.479443 C++ Note: df106 -5.78769 -39.4505 C++ Note: Starting Halves C++ Note: df501 -122.8909 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.707943 0.259582 C++ Note: sums checked 6754.07 6754.07 C++ Note: derivs checked 22400.3 3873.99 C++ Note: second derivs checked 89482.9 3873.99 C++ Note: dose checked 1000 C++ Note: non-dose checked 6754.07 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 6754.07 C++ Note: risk checked 6754.07 C++ Note: risk1 checked 22400.3 3873.99 C++ Note: risk2 checked 89482.9 3873.99 C++ Note: riskr checked 13607.5 C++ Note: risk1r checked 36518.1 7564.8 C++ Note: risk2r checked 122057 7564.8 C++ Note: riskl checked 219.94 C++ Note: risk1l checked 713.45 137.505 C++ Note: risk2l checked 2579.26 137.505 C++ Note: df101 -111.093 -111.093 C++ Note: df102 6.4244 1.45354 C++ Note: df103 -16.1091 -6.40177 C++ Note: df104 0.707943 0.259582 C++ Note: df105 -0.398805 -0.227053 C++ Note: df106 -17.2924 -76.4296 C++ Note: df100 3121 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 13607.5 C++ Note: risk1r checked 36518.1 7564.8 C++ Note: risk2r checked 122057 7564.8 C++ Note: riskl checked 219.94 C++ Note: risk1l checked 713.45 137.505 C++ Note: risk2l checked 2579.26 137.505 C++ Note: df101 -111.093 -111.093 C++ Note: df102 6.4244 1.45354 C++ Note: df103 -16.1091 -6.40177 C++ Note: df104 0.707943 0.259582 C++ Note: df105 -0.398805 -0.227053 C++ Note: df106 -17.2924 -76.4296 C++ Note: ending guess 0 C++ Note: df501 -111.0934 C++ Note: df504 0.7079435 0.259582 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.7079435 0.259582, -111.0934<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.707943 0.259582 C++ Note: sums checked 6754.07 6754.07 C++ Note: derivs checked 22400.3 3873.99 C++ Note: second derivs checked 89482.9 3873.99 C++ Note: dose checked 1000 C++ Note: non-dose checked 6754.07 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 6754.07 C++ Note: risk checked 6754.07 C++ Note: risk1 checked 22400.3 3873.99 C++ Note: risk2 checked 89482.9 3873.99 C++ Note: Made Risk Side Lists C++ Note: riskr checked 13607.5 C++ Note: risk1r checked 36518.1 7564.8 C++ Note: risk2r checked 122057 7564.8 C++ Note: riskl checked 219.94 C++ Note: risk1l checked 713.45 137.505 C++ Note: risk2l checked 2579.26 137.505 C++ Note: df101 -111.093 -111.093 C++ Note: df102 6.4244 1.45354 C++ Note: df103 -16.1091 -6.40177 C++ Note: df104 0.707943 0.259582 C++ Note: df105 -0.398805 -0.227053 C++ Note: df106 -17.2924 -76.4296 C++ Note: Starting Halves C++ Note: df501 -111.0934 C++ Note: df504 0.7079435 0.259582 C++ Note: values checked 1.00705 0.429872 C++ Note: sums checked 22129.4 22129.4 C++ Note: derivs checked 86917.6 13416 C++ Note: second derivs checked 382294 13416 C++ Note: dose checked 1000 C++ Note: non-dose checked 22129.4 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 22129.4 C++ Note: risk checked 22129.4 C++ Note: risk1 checked 86917.6 13416 C++ Note: risk2 checked 382294 13416 C++ Note: riskr checked 36201.7 C++ Note: risk1r checked 115958 21431.5 C++ Note: risk2r checked 433026 21431.5 C++ Note: riskl checked 676.025 C++ Note: risk1l checked 2396.11 417.501 C++ Note: risk2l checked 9159.18 417.501 C++ Note: df101 -109.674 -109.674 C++ Note: df102 2.03825 0.531514 C++ Note: df103 -13.8822 -6.25712 C++ Note: df104 1.00705 0.429872 C++ Note: df105 -0.146825 -0.0849455 C++ Note: df106 -53.8081 -206.343 C++ Note: df100 7000 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 36201.7 C++ Note: risk1r checked 115958 21431.5 C++ Note: risk2r checked 433026 21431.5 C++ Note: riskl checked 676.025 C++ Note: risk1l checked 2396.11 417.501 C++ Note: risk2l checked 9159.18 417.501 C++ Note: df101 -109.674 -109.674 C++ Note: df102 2.03825 0.531514 C++ Note: df103 -13.8822 -6.25712 C++ Note: df104 1.00705 0.429872 C++ Note: df105 -0.146825 -0.0849455 C++ Note: df106 -53.8081 -206.343 C++ Note: riskr checked 36201.7 C++ Note: risk1r checked 115958 21431.5 C++ Note: risk2r checked 433026 21431.5 C++ Note: riskl checked 676.025 C++ Note: risk1l checked 2396.11 417.501 C++ Note: risk2l checked 9159.18 417.501 C++ Note: df101 -109.674 -109.674 C++ Note: df102 2.03825 0.531514 C++ Note: df103 -13.8822 -6.25712 C++ Note: df104 1.00705 0.429872 C++ Note: df105 -0.146825 -0.0849455 C++ Note: df106 -53.8081 -206.343 C++ Note: Exiting Regression C++ Note: df501 -109.6742 C++ Note: df504 1.007047 0.4298716 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,25,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 176 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: derivs checked 1229.85 410.233 C++ Note: second derivs checked 3319.14 410.233 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: risk1r checked 3418.73 1095.31 C++ Note: risk2r checked 8667.81 1095.31 C++ Note: riskl checked 19.6098 C++ Note: risk1l checked 42.0717 11.5472 C++ Note: risk2l checked 118.124 11.5472 C++ Note: df101 -119.981 -119.981 C++ Note: df102 6.06579 2.41134 C++ Note: df103 -8.60689 -6.47374 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.70476 -0.37248 C++ Note: df106 -19.78 -49.7572 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.497478 0.312164 C++ Note: sums checked 3648.05 3648.05 C++ Note: derivs checked 10299.6 2165.99 C++ Note: second derivs checked 37798.4 2165.99 C++ Note: dose checked 1000 C++ Note: non-dose checked 3648.05 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 3648.05 C++ Note: risk checked 3648.05 C++ Note: risk1 checked 10299.6 2165.99 C++ Note: risk2 checked 37798.4 2165.99 C++ Note: riskr checked 9367.5 C++ Note: risk1r checked 24562.6 5580.77 C++ Note: risk2r checked 81557.6 5580.77 C++ Note: riskl checked 118.249 C++ Note: risk1l checked 351.472 78.443 C++ Note: risk2l checked 1199.14 78.443 C++ Note: df101 -117.142 -117.142 C++ Note: df102 1.31609 0.547704 C++ Note: df103 -9.05233 -6.2666 C++ Note: df104 0.497478 0.312164 C++ Note: df105 -0.145387 -0.0874005 C++ Note: df106 -89.0079 -213.879 C++ Note: df100 2044 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 9367.5 C++ Note: risk1r checked 24562.6 5580.77 C++ Note: risk2r checked 81557.6 5580.77 C++ Note: riskl checked 118.249 C++ Note: risk1l checked 351.472 78.443 C++ Note: risk2l checked 1199.14 78.443 C++ Note: df101 -117.142 -117.142 C++ Note: df102 1.31609 0.547704 C++ Note: df103 -9.05233 -6.2666 C++ Note: df104 0.497478 0.312164 C++ Note: df105 -0.145387 -0.0874005 C++ Note: df106 -89.0079 -213.879 C++ Note: ending guess 0 C++ Note: df501 -117.1424 C++ Note: df504 0.4974778 0.3121644 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.4974778 0.3121644, -117.1424<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.497478 0.312164 C++ Note: sums checked 3648.05 3648.05 C++ Note: derivs checked 10299.6 2165.99 C++ Note: second derivs checked 37798.4 2165.99 C++ Note: dose checked 1000 C++ Note: non-dose checked 3648.05 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 3648.05 C++ Note: risk checked 3648.05 C++ Note: risk1 checked 10299.6 2165.99 C++ Note: risk2 checked 37798.4 2165.99 C++ Note: Made Risk Side Lists C++ Note: riskr checked 9367.5 C++ Note: risk1r checked 24562.6 5580.77 C++ Note: risk2r checked 81557.6 5580.77 C++ Note: riskl checked 118.249 C++ Note: risk1l checked 351.472 78.443 C++ Note: risk2l checked 1199.14 78.443 C++ Note: df101 -117.142 -117.142 C++ Note: df102 1.31609 0.547704 C++ Note: df103 -9.05233 -6.2666 C++ Note: df104 0.497478 0.312164 C++ Note: df105 -0.145387 -0.0874005 C++ Note: df106 -89.0079 -213.879 C++ Note: Starting Halves C++ Note: df501 -117.1424 C++ Note: df504 0.4974778 0.3121644 C++ Note: values checked 0.617144 0.398893 C++ Note: sums checked 5479.95 5479.95 C++ Note: derivs checked 17006.9 3344.7 C++ Note: second derivs checked 65563.9 3344.7 C++ Note: dose checked 1000 C++ Note: non-dose checked 5479.95 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 5479.95 C++ Note: risk checked 5479.95 C++ Note: risk1 checked 17006.9 3344.7 C++ Note: risk2 checked 65563.9 3344.7 C++ Note: riskr checked 13683.9 C++ Note: risk1r checked 38812.2 8366.11 C++ Note: risk2r checked 134810 8366.11 C++ Note: riskl checked 180.348 C++ Note: risk1l checked 561.69 120.669 C++ Note: risk2l checked 1971.73 120.669 C++ Note: df101 -117.015 -117.015 C++ Note: df102 0.320802 0.13496 C++ Note: df103 -9.12088 -6.18217 C++ Note: df104 0.617144 0.398893 C++ Note: df105 -0.0351723 -0.0218306 C++ Note: df106 -364.756 -867.031 C++ Note: df100 4412 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 13683.9 C++ Note: risk1r checked 38812.2 8366.11 C++ Note: risk2r checked 134810 8366.11 C++ Note: riskl checked 180.348 C++ Note: risk1l checked 561.69 120.669 C++ Note: risk2l checked 1971.73 120.669 C++ Note: df101 -117.015 -117.015 C++ Note: df102 0.320802 0.13496 C++ Note: df103 -9.12088 -6.18217 C++ Note: df104 0.617144 0.398893 C++ Note: df105 -0.0351723 -0.0218306 C++ Note: df106 -364.756 -867.031 C++ Note: riskr checked 13683.9 C++ Note: risk1r checked 38812.2 8366.11 C++ Note: risk2r checked 134810 8366.11 C++ Note: riskl checked 180.348 C++ Note: risk1l checked 561.69 120.669 C++ Note: risk2l checked 1971.73 120.669 C++ Note: df101 -117.015 -117.015 C++ Note: df102 0.320802 0.13496 C++ Note: df103 -9.12088 -6.18217 C++ Note: df104 0.617144 0.398893 C++ Note: df105 -0.0351723 -0.0218306 C++ Note: df106 -364.756 -867.031 C++ Note: Exiting Regression C++ Note: df501 -117.0147 C++ Note: df504 0.6171437 0.3988932 Note: 26 risk groups C++ Note: START_COX_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 0 C++ Note: df99,26,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Grouping Start C++ Note: df100 179 0 0 -1,Prep_List C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 1 in guess 0 C++ Note: values checked -0.1 -0.1 C++ Note: sums checked 807.883 807.883 C++ Note: derivs checked 1229.85 410.233 C++ Note: second derivs checked 3319.14 410.233 C++ Note: dose checked 1000 C++ Note: non-dose checked 807.883 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 807.883 C++ Note: risk checked 807.883 C++ Note: risk1 checked 1229.85 410.233 C++ Note: risk2 checked 3319.14 410.233 C++ Note: Made Risk Side Lists C++ Note: riskr checked 2125.36 C++ Note: risk1r checked 3418.73 1095.31 C++ Note: risk2r checked 8667.81 1095.31 C++ Note: riskl checked 19.6098 C++ Note: risk1l checked 42.0717 11.5472 C++ Note: risk2l checked 118.124 11.5472 C++ Note: df101 -119.981 -119.981 C++ Note: df102 6.06579 2.41134 C++ Note: df103 -8.60689 -6.47374 C++ Note: df104 -0.1 -0.1 C++ Note: df105 -0.70476 -0.37248 C++ Note: df106 -19.78 -49.7572 C++ Note: Starting Halves C++ Note: df501 -119.9814 C++ Note: df504 -0.1 -0.1 C++ Note: values checked 0.42857 0.17936 C++ Note: sums checked 2796.31 2796.31 C++ Note: derivs checked 7446.21 1576.41 C++ Note: second derivs checked 26529.4 1576.41 C++ Note: dose checked 1000 C++ Note: non-dose checked 2796.31 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 2796.31 C++ Note: risk checked 2796.31 C++ Note: risk1 checked 7446.21 1576.41 C++ Note: risk2 checked 26529.4 1576.41 C++ Note: riskr checked 7268.45 C++ Note: risk1r checked 18181.7 4116.59 C++ Note: risk2r checked 58803.1 4116.59 C++ Note: riskl checked 88.5975 C++ Note: risk1l checked 256.339 56.699 C++ Note: risk2l checked 862.409 56.699 C++ Note: df101 -117.373 -117.373 C++ Note: df102 1.78502 1.30975 C++ Note: df103 -8.96103 -6.38772 C++ Note: df104 0.42857 0.17936 C++ Note: df105 -0.199199 -0.205041 C++ Note: df106 -65.7541 -89.6148 C++ Note: df100 2038 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 7268.45 C++ Note: risk1r checked 18181.7 4116.59 C++ Note: risk2r checked 58803.1 4116.59 C++ Note: riskl checked 88.5975 C++ Note: risk1l checked 256.339 56.699 C++ Note: risk2l checked 862.409 56.699 C++ Note: df101 -117.373 -117.373 C++ Note: df102 1.78502 1.30975 C++ Note: df103 -8.96103 -6.38772 C++ Note: df104 0.42857 0.17936 C++ Note: df105 -0.199199 -0.205041 C++ Note: df106 -65.7541 -89.6148 C++ Note: ending guess 0 C++ Note: df501 -117.3726 C++ Note: df504 0.4285697 0.17936 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.4285697 0.17936, -117.3726<-- Best Guess C++ Note: starting subterms 1 in best guess 0 C++ Note: values checked 0.42857 0.17936 C++ Note: sums checked 2796.31 2796.31 C++ Note: derivs checked 7446.21 1576.41 C++ Note: second derivs checked 26529.4 1576.41 C++ Note: dose checked 1000 C++ Note: non-dose checked 2796.31 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 2796.31 C++ Note: risk checked 2796.31 C++ Note: risk1 checked 7446.21 1576.41 C++ Note: risk2 checked 26529.4 1576.41 C++ Note: Made Risk Side Lists C++ Note: riskr checked 7268.45 C++ Note: risk1r checked 18181.7 4116.59 C++ Note: risk2r checked 58803.1 4116.59 C++ Note: riskl checked 88.5975 C++ Note: risk1l checked 256.339 56.699 C++ Note: risk2l checked 862.409 56.699 C++ Note: df101 -117.373 -117.373 C++ Note: df102 1.78502 1.30975 C++ Note: df103 -8.96103 -6.38772 C++ Note: df104 0.42857 0.17936 C++ Note: df105 -0.199199 -0.205041 C++ Note: df106 -65.7541 -89.6148 C++ Note: Starting Halves C++ Note: df501 -117.3726 C++ Note: df504 0.4285697 0.17936 C++ Note: values checked 0.577969 0.333141 C++ Note: sums checked 4672.1 4672.1 C++ Note: derivs checked 14081.1 2784.48 C++ Note: second derivs checked 53455.8 2784.48 C++ Note: dose checked 1000 C++ Note: non-dose checked 4672.1 C++ Note: LIN_non-dose checked 1000 C++ Note: PLIN_non-dose checked 1000 C++ Note: LOGLIN_non-dose checked 4672.1 C++ Note: risk checked 4672.1 C++ Note: risk1 checked 14081.1 2784.48 C++ Note: risk2 checked 53455.8 2784.48 C++ Note: riskr checked 11783.5 C++ Note: risk1r checked 32618.6 7038.87 C++ Note: risk2r checked 111717 7038.87 C++ Note: riskl checked 152.934 C++ Note: risk1l checked 470.041 100.807 C++ Note: risk2l checked 1638.11 100.807 C++ Note: df101 -117.054 -117.054 C++ Note: df102 0.609162 0.503449 C++ Note: df103 -9.07577 -6.25818 C++ Note: df104 0.577969 0.333141 C++ Note: df105 -0.0671196 -0.0804466 C++ Note: df106 -192.156 -232.504 C++ Note: df100 4394 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: riskr checked 11783.5 C++ Note: risk1r checked 32618.6 7038.87 C++ Note: risk2r checked 111717 7038.87 C++ Note: riskl checked 152.934 C++ Note: risk1l checked 470.041 100.807 C++ Note: risk2l checked 1638.11 100.807 C++ Note: df101 -117.054 -117.054 C++ Note: df102 0.609162 0.503449 C++ Note: df103 -9.07577 -6.25818 C++ Note: df104 0.577969 0.333141 C++ Note: df105 -0.0671196 -0.0804466 C++ Note: df106 -192.156 -232.504 C++ Note: riskr checked 11783.5 C++ Note: risk1r checked 32618.6 7038.87 C++ Note: risk2r checked 111717 7038.87 C++ Note: riskl checked 152.934 C++ Note: risk1l checked 470.041 100.807 C++ Note: risk2l checked 1638.11 100.807 C++ Note: df101 -117.054 -117.054 C++ Note: df102 0.609162 0.503449 C++ Note: df103 -9.07577 -6.25818 C++ Note: df104 0.577969 0.333141 C++ Note: df105 -0.0671196 -0.0804466 C++ Note: df106 -192.156 -232.504 C++ Note: Exiting Regression C++ Note: df501 -117.0539 C++ Note: df504 0.5779686 0.3331409 Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 1 2 C++ Note: df99,29,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 3 in guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: Starting Halves C++ Note: df501 -467.6607 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df100 1118 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df100 1615 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df100 2108 3 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df100 2599 4 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df100 3097 5 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df100 3144 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df101 -467.6607 -467.6607 -467.6607 C++ Note: df104 0.1 0.1 0.01 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: ending guess 0 C++ Note: df501 -467.6607 C++ Note: df504 0.1 0.1 0.01 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.1 0.1 0.01, -467.6607<-- Best Guess C++ Note: starting subterms 3 in best guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: Made Risk Side Lists C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: Starting Halves C++ Note: df501 -467.6607 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df100 4433 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df100 4926 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df100 5416 3 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df100 5907 4 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df100 6402 5 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df100 6449 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df101 -467.6607 -467.6607 -467.6607 C++ Note: df104 0.1 0.1 0.01 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df501 -467.6607 C++ Note: df504 0.1 0.1 0.01 Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 1 2 C++ Note: df99,29,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 3 in guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: Starting Halves C++ Note: df501 -463.5098 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df100 1106 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df100 1601 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df100 2096 3 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df100 2589 4 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df100 3087 5 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df100 3134 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df101 -463.5098 -463.5098 -463.5098 C++ Note: df104 0.1 0.1 0.01 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: ending guess 0 C++ Note: df501 -463.5098 C++ Note: df504 0.1 0.1 0.01 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.1 0.1 0.01, -463.5098<-- Best Guess C++ Note: starting subterms 3 in best guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: Made Risk Side Lists C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: Starting Halves C++ Note: df501 -463.5098 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df100 4440 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df100 4936 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df100 5431 3 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df100 5938 4 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df100 6436 5 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df100 6483 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df101 -463.5098 -463.5098 -463.5098 C++ Note: df104 0.1 0.1 0.01 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df501 -463.5098 C++ Note: df504 0.1 0.1 0.01 Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 1 2 C++ Note: df99,29,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 3 in guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: derivs checked 2662.16 2662.16 1673.67 C++ Note: second derivs checked 8088.51 8088.51 4753.83 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 135.17 C++ Note: risk1 checked 302.14 121.78 68.7623 C++ Note: risk2 checked 928.77 380.955 194.839 C++ Note: df101 -467.661 -467.661 -467.661 C++ Note: df102 -94.3101 -39.4194 -9.93487 C++ Note: df103 -1040.45 -259.573 -93.8514 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 707.321 C++ Note: df105 0.0906437 0.151862 0.105857 C++ Note: df106 4.95875 11.8637 47.0727 C++ Note: Starting Halves C++ Note: df501 -467.6607 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked 0.0320172 -0.0138968 -0.0693931 C++ Note: sums checked 1066.29 973.12 897.344 C++ Note: derivs checked 2170.09 1895.1 1342.81 C++ Note: second derivs checked 6452.98 5549.74 3636.92 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1066.29 973.12 897.344 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1066.29 973.12 897.344 C++ Note: risk checked 102.86 C++ Note: risk1 checked 208.566 69.9862 48.0225 C++ Note: risk2 checked 619.655 207.132 129.963 C++ Note: df101 -463.451 -463.451 -463.451 C++ Note: df102 10.3802 4.17009 9.3252 C++ Note: df103 -694.198 -76.4056 -27.9422 C++ Note: df104 0.0320172 -0.0138968 -0.0693931 C++ Note: Checking Deviance 698.903 C++ Note: df105 -0.0149527 -0.0545783 -0.333732 C++ Note: df106 -44.6478 -111.137 -49.6988 C++ Note: df100 2490 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df100 2537 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df101 -463.4514 -463.4514 -463.4514 C++ Note: df102 10.38017 4.170085 9.325204 C++ Note: df103 -694.1983 -76.40556 -27.94216 C++ Note: df104 0.03201725 -0.01389683 -0.06939307 C++ Note: Checking Deviance 698.9028 C++ Note: df105 -0.01495275 -0.05457829 -0.3337324 C++ Note: df106 -44.64776 -111.1372 -49.69879 C++ Note: df101 -463.451 -463.451 -463.451 C++ Note: df102 10.3802 4.17009 9.3252 C++ Note: df103 -694.198 -76.4056 -27.9422 C++ Note: df104 0.0320172 -0.0138968 -0.0693931 C++ Note: Checking Deviance 698.903 C++ Note: df105 -0.0149527 -0.0545783 -0.333732 C++ Note: df106 -44.6478 -111.137 -49.6988 C++ Note: ending guess 0 C++ Note: df501 -463.4514 C++ Note: df504 0.03201725 -0.01389683 -0.06939307 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.03201725 -0.01389683 -0.06939307, -463.4514<-- Best Guess C++ Note: starting subterms 3 in best guess 0 C++ Note: values checked 0.0320172 -0.0138968 -0.0693931 C++ Note: sums checked 1066.29 973.12 897.344 C++ Note: derivs checked 2170.09 1895.1 1342.81 C++ Note: second derivs checked 6452.98 5549.74 3636.92 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1066.29 973.12 897.344 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1066.29 973.12 897.344 C++ Note: risk checked 102.86 C++ Note: risk1 checked 208.566 69.9862 48.0225 C++ Note: risk2 checked 619.655 207.132 129.963 C++ Note: Made Risk Side Lists C++ Note: df101 -463.451 -463.451 -463.451 C++ Note: df102 10.3802 4.17009 9.3252 C++ Note: df103 -694.198 -76.4056 -27.9422 C++ Note: df104 0.0320172 -0.0138968 -0.0693931 C++ Note: Checking Deviance 698.903 C++ Note: df105 -0.0149527 -0.0545783 -0.333732 C++ Note: df106 -44.6478 -111.137 -49.6988 C++ Note: Starting Halves C++ Note: df501 -463.4514 C++ Note: df504 0.03201725 -0.01389683 -0.06939307 C++ Note: values checked 0.0432318 0.0270369 0.180906 C++ Note: sums checked 1091.03 1055.56 1388.12 C++ Note: derivs checked 2243.81 2138.21 2787.22 C++ Note: second derivs checked 6696.56 6347.84 8719.98 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1091.03 1055.56 1388.12 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1091.03 1055.56 1388.12 C++ Note: risk checked 126.33 C++ Note: risk1 checked 260.899 81.7736 101.847 C++ Note: risk2 checked 778.474 246.131 318.199 C++ Note: df101 -464.18 -464.18 -464.18 C++ Note: df102 -47.7167 -15.934 -19.8545 C++ Note: df103 -870.336 -126.985 -214.851 C++ Note: df104 0.0432318 0.0270369 0.180906 C++ Note: Checking Deviance 700.36 C++ Note: df105 0.0548256 0.125479 0.0924107 C++ Note: df106 9.72783 29.1314 23.379 C++ Note: df100 5413 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.0376245 0.00657003 0.0557566 C++ Note: sums checked 1078.56 1013.1 1098.33 C++ Note: derivs checked 2206.61 2012.57 1909.31 C++ Note: second derivs checked 6573.57 5934.53 5569.82 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1078.56 1013.1 1098.33 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1078.56 1013.1 1098.33 C++ Note: risk checked 112.808 C++ Note: risk1 checked 231.02 75.6258 69.025 C++ Note: risk2 checked 688.083 225.739 201.15 C++ Note: df101 -462.759 -462.759 -462.759 C++ Note: df102 -14.5654 -5.21187 0.637868 C++ Note: df103 -770.184 -99.8931 -90.8891 C++ Note: df104 0.0376245 0.00657003 0.0557566 C++ Note: Checking Deviance 697.518 C++ Note: df105 0.0189115 0.0521745 -0.00701809 C++ Note: df106 31.7712 88.7894 -725.478 C++ Note: df100 6695 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df100 6742 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df101 -462.7591 -462.7591 -462.7591 C++ Note: df102 -14.56536 -5.211874 0.6378678 C++ Note: df103 -770.1842 -99.89313 -90.88914 C++ Note: df104 0.03762453 0.006570034 0.05575656 C++ Note: Checking Deviance 697.5182 C++ Note: df105 0.01891153 0.0521745 -0.007018085 C++ Note: df106 31.7712 88.78939 -725.4781 C++ Note: df101 -462.759 -462.759 -462.759 C++ Note: df102 -14.5654 -5.21187 0.637868 C++ Note: df103 -770.184 -99.8931 -90.8891 C++ Note: df104 0.0376245 0.00657003 0.0557566 C++ Note: Checking Deviance 697.518 C++ Note: df105 0.0189115 0.0521745 -0.00701809 C++ Note: df106 31.7712 88.7894 -725.478 C++ Note: df501 -462.7591 C++ Note: df504 0.03762453 0.006570034 0.05575656 Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 1 2 C++ Note: df99,33,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 3 in guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: derivs checked 2662.16 2662.16 1673.67 C++ Note: second derivs checked 8088.51 8088.51 4753.83 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 116.849 C++ Note: risk1 checked 89.4661 89.4661 56.218 C++ Note: risk2 checked 271.789 271.789 159.656 C++ Note: df101 -463.51 -463.51 -463.51 C++ Note: df102 -12.0037 -12.0037 -0.410377 C++ Note: df103 -143.316 -143.316 -59.8747 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 699.02 C++ Note: df105 0.0837566 0.0837566 0.00685392 C++ Note: df106 38.614 38.614 1129.47 C++ Note: Starting Halves C++ Note: df501 -463.5098 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked 0.0371826 0.0371826 0.00485956 C++ Note: sums checked 1077.58 1077.58 1007.96 C++ Note: derivs checked 2203.71 2203.71 1649.45 C++ Note: second derivs checked 6563.98 6563.98 4670.84 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1077.58 1077.58 1007.96 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1077.58 1077.58 1007.96 C++ Note: risk checked 106.323 C++ Note: risk1 checked 74.0612 74.0612 55.4045 C++ Note: risk2 checked 220.567 220.567 156.868 C++ Note: df101 -462.873 -462.873 -462.873 C++ Note: df102 0.991755 0.991755 5.79074 C++ Note: df103 -89.711 -89.711 -50.9916 C++ Note: df104 0.0371826 0.0371826 0.00485956 C++ Note: Checking Deviance 697.746 C++ Note: df105 -0.011055 -0.011055 -0.113563 C++ Note: df106 -466.721 -466.721 -79.9334 C++ Note: df100 2382 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df100 2430 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df101 -462.873 -462.873 -462.873 C++ Note: df102 0.991755 0.991755 5.790736 C++ Note: df103 -89.71102 -89.71102 -50.99157 C++ Note: df104 0.03718258 0.03718258 0.004859558 C++ Note: Checking Deviance 697.7461 C++ Note: df105 -0.011055 -0.011055 -0.1135626 C++ Note: df106 -466.7211 -466.7211 -79.93336 C++ Note: df101 -462.873 -462.873 -462.873 C++ Note: df102 0.991755 0.991755 5.79074 C++ Note: df103 -89.711 -89.711 -50.9916 C++ Note: df104 0.0371826 0.0371826 0.00485956 C++ Note: Checking Deviance 697.746 C++ Note: df105 -0.011055 -0.011055 -0.113563 C++ Note: df106 -466.721 -466.721 -79.9334 C++ Note: ending guess 0 C++ Note: df501 -462.873 C++ Note: df504 0.03718258 0.03718258 0.004859558 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.03718258 0.03718258 0.004859558, -462.873<-- Best Guess C++ Note: starting subterms 3 in best guess 0 C++ Note: values checked 0.0371826 0.0371826 0.00485956 C++ Note: sums checked 1077.58 1077.58 1007.96 C++ Note: derivs checked 2203.71 2203.71 1649.45 C++ Note: second derivs checked 6563.98 6563.98 4670.84 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1077.58 1077.58 1007.96 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1077.58 1077.58 1007.96 C++ Note: risk checked 106.323 C++ Note: risk1 checked 74.0612 74.0612 55.4045 C++ Note: risk2 checked 220.567 220.567 156.868 C++ Note: Made Risk Side Lists C++ Note: df101 -462.873 -462.873 -462.873 C++ Note: df102 0.991755 0.991755 5.79074 C++ Note: df103 -89.711 -89.711 -50.9916 C++ Note: df104 0.0371826 0.0371826 0.00485956 C++ Note: Checking Deviance 697.746 C++ Note: df105 -0.011055 -0.011055 -0.113563 C++ Note: df106 -466.721 -466.721 -79.9334 C++ Note: Starting Halves C++ Note: df501 -462.873 C++ Note: df504 0.03718258 0.03718258 0.004859558 C++ Note: values checked 0.0454738 0.0454738 0.0900315 C++ Note: sums checked 1096.08 1096.08 1167.18 C++ Note: derivs checked 2258.88 2258.88 2112.17 C++ Note: second derivs checked 6746.42 6746.42 6283.7 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1096.08 1096.08 1167.18 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1096.08 1096.08 1167.18 C++ Note: risk checked 112.914 C++ Note: risk1 checked 75.9152 75.9152 70.9449 C++ Note: risk2 checked 226.697 226.697 211.036 C++ Note: df101 -462.685 -462.685 -462.685 C++ Note: df102 -4.74661 -4.74661 -1.37928 C++ Note: df103 -100.025 -100.025 -101.757 C++ Note: df104 0.0454738 0.0454738 0.0900315 C++ Note: Checking Deviance 697.37 C++ Note: df105 0.0474545 0.0474545 0.0135546 C++ Note: df106 97.4769 97.4769 335.454 C++ Note: df100 5249 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df100 5296 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df101 -462.6849 -462.6849 -462.6849 C++ Note: df102 -4.746612 -4.746612 -1.37928 C++ Note: df103 -100.0246 -100.0246 -101.757 C++ Note: df104 0.04547382 0.04547382 0.09003152 C++ Note: Checking Deviance 697.3697 C++ Note: df105 0.04745446 0.04745446 0.01355464 C++ Note: df106 97.47686 97.47686 335.4539 C++ Note: df101 -462.685 -462.685 -462.685 C++ Note: df102 -4.74661 -4.74661 -1.37928 C++ Note: df103 -100.025 -100.025 -101.757 C++ Note: df104 0.0454738 0.0454738 0.0900315 C++ Note: Checking Deviance 697.37 C++ Note: df105 0.0474545 0.0474545 0.0135546 C++ Note: df106 97.4769 97.4769 335.454 C++ Note: df501 -462.6849 C++ Note: df504 0.04547382 0.04547382 0.09003152 Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 1 2 C++ Note: df99,29,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 3 in guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: Starting Halves C++ Note: df501 -4464.359 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df100 1072 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df100 1566 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df100 2115 3 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df100 2609 4 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df100 3100 5 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df100 3146 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df101 -4464.359 -4464.359 -4464.359 C++ Note: df104 0.1 0.1 0.01 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: ending guess 0 C++ Note: df501 -4464.359 C++ Note: df504 0.1 0.1 0.01 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.1 0.1 0.01, -4464.359<-- Best Guess C++ Note: starting subterms 3 in best guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: Made Risk Side Lists C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: Starting Halves C++ Note: df501 -4464.359 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df100 4440 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df100 4935 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df100 5474 3 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df100 5969 4 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df100 6461 5 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df100 6508 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df101 -4464.359 -4464.359 -4464.359 C++ Note: df104 0.1 0.1 0.01 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df501 -4464.359 C++ Note: df504 0.1 0.1 0.01 Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 1 2 C++ Note: df99,30,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 3 in guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: Starting Halves C++ Note: df501 -3870.252 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df100 1049 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df100 1543 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df100 2038 3 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df100 2530 4 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df100 3020 5 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df100 3067 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df101 -3870.252 -3870.252 -3870.252 C++ Note: df104 0.1 0.1 0.01 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: ending guess 0 C++ Note: df501 -3870.252 C++ Note: df504 0.1 0.1 0.01 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, 0.1 0.1 0.01, -3870.252<-- Best Guess C++ Note: starting subterms 3 in best guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: Made Risk Side Lists C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: Starting Halves C++ Note: df501 -3870.252 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df100 4354 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df100 4844 2 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df100 5340 3 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df100 5832 4 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df100 6320 5 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df100 6367 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df101 -3870.252 -3870.252 -3870.252 C++ Note: df104 0.1 0.1 0.01 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df501 -3870.252 C++ Note: df504 0.1 0.1 0.01 Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 1 2 C++ Note: df99,29,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 3 in guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: derivs checked 2662.16 2662.16 1673.67 C++ Note: second derivs checked 8088.51 8088.51 4753.83 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 4021.52 C++ Note: risk1 checked 8990.66 3623.84 2047.21 C++ Note: risk2 checked 27640.9 11337.7 5801.4 C++ Note: df101 -4464.36 -4464.36 -4464.36 C++ Note: df102 -9823.7 -3961.6 -2223.36 C++ Note: df103 -30965.7 -12538.3 -6371.77 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 8700.72 C++ Note: df105 0.317244 0.315959 0.34894 C++ Note: df106 0.454448 1.12691 2.00793 C++ Note: Starting Halves C++ Note: df501 -4464.359 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked -0.137933 -0.136969 -0.251705 C++ Note: sums checked 775.553 776.836 702.601 C++ Note: derivs checked 1328.21 1331.8 841.86 C++ Note: second derivs checked 3721.09 3732.5 2034.61 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 775.553 776.836 702.601 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 775.553 776.836 702.601 C++ Note: risk checked 1943.25 C++ Note: risk1 checked 3180.78 914.006 655.882 C++ Note: risk2 checked 8802.59 2426.63 1587.74 C++ Note: df101 -2228.98 -2228.98 -2228.98 C++ Note: df102 -3323.52 -952.67 -688.275 C++ Note: df103 -9864.88 -2573.61 -1698.13 C++ Note: df104 -0.137933 -0.136969 -0.251705 C++ Note: Checking Deviance 4229.97 C++ Note: df105 0.336904 0.370169 0.405314 C++ Note: df106 0.67067 2.33972 3.23851 C++ Note: df100 2136 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df100 2183 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df101 -2228.983 -2228.983 -2228.983 C++ Note: df102 -3323.517 -952.6701 -688.2751 C++ Note: df103 -9864.881 -2573.61 -1698.127 C++ Note: df104 -0.1379333 -0.1369691 -0.2517047 C++ Note: Checking Deviance 4229.966 C++ Note: df105 0.336904 0.3701688 0.4053143 C++ Note: df106 0.6706698 2.339722 3.238506 C++ Note: df101 -2228.98 -2228.98 -2228.98 C++ Note: df102 -3323.52 -952.67 -688.275 C++ Note: df103 -9864.88 -2573.61 -1698.13 C++ Note: df104 -0.137933 -0.136969 -0.251705 C++ Note: Checking Deviance 4229.97 C++ Note: df105 0.336904 0.370169 0.405314 C++ Note: df106 0.67067 2.33972 3.23851 C++ Note: ending guess 0 C++ Note: df501 -2228.983 C++ Note: df504 -0.1379333 -0.1369691 -0.2517047 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1379333 -0.1369691 -0.2517047, -2228.983<-- Best Guess C++ Note: starting subterms 3 in best guess 0 C++ Note: values checked -0.137933 -0.136969 -0.251705 C++ Note: sums checked 775.553 776.836 702.601 C++ Note: derivs checked 1328.21 1331.8 841.86 C++ Note: second derivs checked 3721.09 3732.5 2034.61 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 775.553 776.836 702.601 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 775.553 776.836 702.601 C++ Note: risk checked 1943.25 C++ Note: risk1 checked 3180.78 914.006 655.882 C++ Note: risk2 checked 8802.59 2426.63 1587.74 C++ Note: Made Risk Side Lists C++ Note: df101 -2228.98 -2228.98 -2228.98 C++ Note: df102 -3323.52 -952.67 -688.275 C++ Note: df103 -9864.88 -2573.61 -1698.13 C++ Note: df104 -0.137933 -0.136969 -0.251705 C++ Note: Checking Deviance 4229.97 C++ Note: df105 0.336904 0.370169 0.405314 C++ Note: df106 0.67067 2.33972 3.23851 C++ Note: Starting Halves C++ Note: df501 -2228.983 C++ Note: df504 -0.1379333 -0.1369691 -0.2517047 C++ Note: values checked -0.390611 -0.414596 -0.55569 C++ Note: sums checked 532.749 516.988 517.87 C++ Note: derivs checked 677.199 637.561 432.04 C++ Note: second derivs checked 1711.97 1594.9 857.807 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 532.749 516.988 517.87 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 532.749 516.988 517.87 C++ Note: risk checked 1160.77 C++ Note: risk1 checked 1287.6 260.671 231.783 C++ Note: risk2 checked 3158.62 543.41 460.892 C++ Note: df101 -1440.04 -1440.04 -1440.04 C++ Note: df102 -1204.6 -248.036 -228.728 C++ Note: df103 -3543.56 -513.003 -465.909 C++ Note: df104 -0.390611 -0.414596 -0.55569 C++ Note: Checking Deviance 2652.09 C++ Note: df105 0.339942 0.483498 0.49093 C++ Note: df106 1.19545 5.80578 6.29587 C++ Note: df100 4795 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df100 4842 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df101 -1440.044 -1440.044 -1440.044 C++ Note: df102 -1204.604 -248.0364 -228.7284 C++ Note: df103 -3543.556 -513.0035 -465.9085 C++ Note: df104 -0.3906113 -0.4145957 -0.5556904 C++ Note: Checking Deviance 2652.088 C++ Note: df105 0.3399422 0.4834984 0.4909299 C++ Note: df106 1.19545 5.805777 6.295868 C++ Note: df101 -1440.04 -1440.04 -1440.04 C++ Note: df102 -1204.6 -248.036 -228.728 C++ Note: df103 -3543.56 -513.003 -465.909 C++ Note: df104 -0.390611 -0.414596 -0.55569 C++ Note: Checking Deviance 2652.09 C++ Note: df105 0.339942 0.483498 0.49093 C++ Note: df106 1.19545 5.80578 6.29587 C++ Note: df501 -1440.044 C++ Note: df504 -0.3906113 -0.4145957 -0.5556904 Warning: model covariate order changed C++ Note: START_POIS_GUESS C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: Term checked 0 1 2 C++ Note: df99,29,Starting C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: starting subterms 3 in guess 0 C++ Note: values checked 0.1 0.1 0.01 C++ Note: sums checked 1229.91 1229.91 1016.5 C++ Note: derivs checked 2662.16 2662.16 1673.67 C++ Note: second derivs checked 8088.51 8088.51 4753.83 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 1229.91 1229.91 1016.5 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5 C++ Note: risk checked 3476.32 C++ Note: risk1 checked 2662.16 2662.16 1673.67 C++ Note: risk2 checked 8088.51 8088.51 4753.83 C++ Note: df101 -3870.25 -3870.25 -3870.25 C++ Note: df102 -2892.89 -2892.89 -1814.56 C++ Note: df103 -8899.28 -8899.28 -5219.6 C++ Note: df104 0.1 0.1 0.01 C++ Note: Checking Deviance 7512.5 C++ Note: df105 0.32507 0.32507 0.347644 C++ Note: df106 1.33785 1.33785 2.13288 C++ Note: Starting Halves C++ Note: df501 -3870.252 C++ Note: df504 0.1 0.1 0.01 C++ Note: values checked -0.143803 -0.143803 -0.250733 C++ Note: sums checked 767.821 767.821 703.42 C++ Note: derivs checked 1306.57 1306.57 843.84 C++ Note: second derivs checked 3652.41 3652.41 2040.66 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 767.821 767.821 703.42 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 767.821 767.821 703.42 C++ Note: risk checked 2239.06 C++ Note: risk1 checked 1306.57 1306.57 843.84 C++ Note: risk2 checked 3652.41 3652.41 2040.66 C++ Note: df101 -2541.39 -2541.39 -2541.39 C++ Note: df102 -1381.02 -1381.02 -889.259 C++ Note: df103 -3933.71 -3933.71 -2190.79 C++ Note: df104 -0.143803 -0.143803 -0.250733 C++ Note: Checking Deviance 4854.78 C++ Note: df105 0.351073 0.351073 0.405908 C++ Note: df106 1.84023 1.84023 2.85787 C++ Note: df100 2106 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df100 2153 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df101 -2541.39 -2541.39 -2541.39 C++ Note: df102 -1381.017 -1381.017 -889.2586 C++ Note: df103 -3933.706 -3933.706 -2190.791 C++ Note: df104 -0.1438028 -0.1438028 -0.2507329 C++ Note: Checking Deviance 4854.78 C++ Note: df105 0.3510728 0.3510728 0.4059076 C++ Note: df106 1.84023 1.84023 2.857875 C++ Note: df101 -2541.39 -2541.39 -2541.39 C++ Note: df102 -1381.02 -1381.02 -889.259 C++ Note: df103 -3933.71 -3933.71 -2190.79 C++ Note: df104 -0.143803 -0.143803 -0.250733 C++ Note: Checking Deviance 4854.78 C++ Note: df105 0.351073 0.351073 0.405908 C++ Note: df106 1.84023 1.84023 2.85787 C++ Note: ending guess 0 C++ Note: df501 -2541.39 C++ Note: df504 -0.1438028 -0.1438028 -0.2507329 C++ Note: Refreshing matrices after all guesses C++ Note: Guess Results Guess number, parameter values, Log-Likelihood 0, -0.1438028 -0.1438028 -0.2507329, -2541.39<-- Best Guess C++ Note: starting subterms 3 in best guess 0 C++ Note: values checked -0.143803 -0.143803 -0.250733 C++ Note: sums checked 767.821 767.821 703.42 C++ Note: derivs checked 1306.57 1306.57 843.84 C++ Note: second derivs checked 3652.41 3652.41 2040.66 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 767.821 767.821 703.42 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 767.821 767.821 703.42 C++ Note: risk checked 2239.06 C++ Note: risk1 checked 1306.57 1306.57 843.84 C++ Note: risk2 checked 3652.41 3652.41 2040.66 C++ Note: Made Risk Side Lists C++ Note: df101 -2541.39 -2541.39 -2541.39 C++ Note: df102 -1381.02 -1381.02 -889.259 C++ Note: df103 -3933.71 -3933.71 -2190.79 C++ Note: df104 -0.143803 -0.143803 -0.250733 C++ Note: Checking Deviance 4854.78 C++ Note: df105 0.351073 0.351073 0.405908 C++ Note: df106 1.84023 1.84023 2.85787 C++ Note: Starting Halves C++ Note: df501 -2541.39 C++ Note: df504 -0.1438028 -0.1438028 -0.2507329 C++ Note: values checked -0.407107 -0.407107 -0.555164 C++ Note: sums checked 521.807 521.807 518.098 C++ Note: derivs checked 649.637 649.637 432.492 C++ Note: second derivs checked 1630.48 1630.48 858.997 C++ Note: dose checked 1000 1000 1000 C++ Note: non-dose checked 521.807 521.807 518.098 C++ Note: LIN_non-dose checked 1000 1000 1000 C++ Note: PLIN_non-dose checked 1000 1000 1000 C++ Note: LOGLIN_non-dose checked 521.807 521.807 518.098 C++ Note: risk checked 1561.71 C++ Note: risk1 checked 649.637 649.637 432.492 C++ Note: risk2 checked 1630.48 1630.48 858.997 C++ Note: df101 -1840.51 -1840.51 -1840.51 C++ Note: df102 -652.83 -652.83 -432.167 C++ Note: df103 -1682.85 -1682.85 -882.861 C++ Note: df104 -0.407107 -0.407107 -0.555164 C++ Note: Checking Deviance 3453.02 C++ Note: df105 0.387933 0.387933 0.489507 C++ Note: df106 2.81927 2.81927 4.25879 C++ Note: df100 4692 1 1 0,Update_calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df100 4739 0 0 0,Update_Calc C++ Note: Current Time, Tue Feb 13 19:18:11 2024 C++ Note: df101 -1840.508 -1840.508 -1840.508 C++ Note: df102 -652.8304 -652.8304 -432.1668 C++ Note: df103 -1682.845 -1682.845 -882.8612 C++ Note: df104 -0.4071074 -0.4071074 -0.5551637 C++ Note: Checking Deviance 3453.016 C++ Note: df105 0.3879325 0.3879325 0.4895071 C++ Note: df106 2.819274 2.819274 4.258791 C++ Note: df101 -1840.51 -1840.51 -1840.51 C++ Note: df102 -652.83 -652.83 -432.167 C++ Note: df103 -1682.85 -1682.85 -882.861 C++ Note: df104 -0.407107 -0.407107 -0.555164 C++ Note: Checking Deviance 3453.02 C++ Note: df105 0.387933 0.387933 0.489507 C++ Note: df106 2.81927 2.81927 4.25879 C++ Note: df501 -1840.508 C++ Note: df504 -0.4071074 -0.4071074 -0.5551637 [ FAIL 0 | WARN 0 | SKIP 0 | PASS 1095 ] > > proc.time() user system elapsed 24.67 2.75 23.23